The new iGXT Platform combines genetically engineered mouse models with patient-derived tumor xenograft models for more accurate cancer drug testing. The partnership aims to improve treatment outcomes by identifying effective biomarkers and personalized therapy options.
A USDA-led consortium has sequenced the genome of Mycosphaerella graminicola, a pathogen causing significant yield losses in wheat crops. The sequencing effort may lead to new strategies to control this disease, which affects every wheat-growing area worldwide.
A recent study by Yale University economists found that microloans can increase ability to cope with risk and strengthen community ties, but may not lead to increased investment in businesses. The researchers also discovered that awardees' subjective well-being slightly declined, contradicting previous claims.
A new study by Thomas Jefferson University researchers finds that receiving radiation therapy immediately after a radical prostatectomy is a cost-effective treatment for prostate cancer patients. Urologists were less likely than radiation oncologists to recommend adjuvant radiation therapy or believe it improves overall survival.
Researchers studied four Tagish Lake meteorites, finding large concentrations of essential biochemistry components like monocarboxylic acids and amino acids. The findings suggest that hydrothermal activity played a crucial role in shaping the chemical diversity of these samples.
Researchers have identified a wood-digesting enzyme in bacteria that could make sustainable biofuels more economically viable. The discovery could unlock currently unattainable sources of biofuels, particularly from fast-growing woody plants and crop byproducts.
Professor Helen Rees and colleagues emphasize the need for immunization policy reform, public-private collaboration, and addressing vaccine inequities to achieve polio eradication. Experts also highlight the importance of understanding the value of life worldwide in informing new actions.
Researchers found smaller brain volumes associated with the severity of ADHD symptoms in preschool children, particularly in the caudate nucleus. Cortical volumes were not significantly correlated with symptom severity, suggesting other factors may contribute to ADHD development.
The AGA Research Foundation has awarded $25,000 to ten high school students to support their research in digestive diseases. The recipients will participate in a minimum of 10 weeks of research at prestigious institutions.
Dr. Frank Fisher, Associate Professor of Mechanical Engineering at Stevens Institute of Technology, has been added to the Fulbright Specialist Roster as a candidate for grants to cooperate internationally on academic development.
Developing vaccines against diseases with extensive antigenic variability, such as HIV and malaria, poses significant technical challenges. Tailored vaccination programmes based on individual genetic predispositions could increase safety and efficacy.
Scientists at Oregon State University have confirmed the safety and cancer-targeting ability of sulforaphane in a new study. Sulforaphane selectively kills cancer cells while leaving healthy prostate cells untouched, suggesting it could be used for cancer prevention and treatment.
Research from the University of Minnesota's Chicago Longitudinal Study found that high-quality early education significantly impacts well-being, educational attainment, socioeconomic status, and crime rates. Participants who received extended preschool services had better outcomes in adulthood.
Researchers developed a new technique for using multi-core chips more efficiently, enhancing computer models of biological systems by over seven-fold. This could impact areas like drug development and biofuel engineering.
NASA's Aqua satellite and GOES-13 provided high-resolution images and a video showing the Puyehue-Cordón Caulle volcano eruption in Chile. The ash plume moved from southeast to east over several days, influenced by changing winds., Satellite data will help airlines determine safe air travel routes.
The article highlights the factors influencing vaccine production, access, and uptake, including technologies used to manufacture vaccines, national regulations, and cold chain requirements. The authors emphasize the need for improved surge capacity within the vaccine industry to meet global demand during pandemics.
Researchers identified a critical node, defective proventriculus (dve), in a network regulating Rhodopsin gene expression. This interlocked feed-forward loop (FFL) motif controls cell-type specific expression, restricting and inducing Rhodopsin presence in different photoreceptors.
The Research Institute of the McGill University Health Centre (RI-MUHC) has been awarded a $1.4M grant to develop Personalized Medicine for Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH). The project aims to identify new biomarkers and disease predictors to improve diagnosis and treatment options.
Scientists discovered diverse amino acid amounts in Tagish Lake meteorites, suggesting water alteration played a role in their formation. The findings provide new insights into pre-biotic chemistry on asteroids and may impact our understanding of the origin of life on Earth.
An integrated approach combining agriculture and forestry is more effective than sparing land for forests through agricultural intensification. Agroforestry enriches soil conditions and acts as a carbon stock, helping mitigate climate change.
The Scripps Research Institute has received a $2.2 million grant to develop novel therapeutics for treating substance abuse. The researchers aim to disrupt the addictive cycle by targeting the kappa opioid receptor, which plays a critical role in drug addiction.
Breast cancer stem cells can be induced to transition into a mesenchymal and stem cell-like state by signals from breast epithelial cells. Blocking these autocrine signals inhibits the growth of tumors in animal models. The study suggests that targeting these signals could lead to effective treatment for breast cancer.
A Mayo Clinic research team has demonstrated a promising alternative strategy for treating type 2 diabetes by blocking the breakdown of insulin. In mouse studies, these mice showed increased insulin levels, weight loss, and improved blood sugar control.
New opportunities exist to overcome remaining vaccine challenges and save 6.4 million lives over the next decade, Health Affairs reports. The Bill & Melinda Gates Foundation has committed $10 billion to make life-saving vaccines available to millions of children.
Scientists at Dana-Farber Cancer Institute discovered that cyclin D1 helps cancer cells repair DNA damage caused by radiation treatments, making tumors resistant to the therapy. Blocking cyclin D1 levels in cancer cells makes them more sensitive to radiation and certain cancer drugs.
A team of physicists has devised a theoretical framework that explains the real-time behavior of superfluids made of fermions, a crucial step towards studying neutron stars. The researchers used the world's most powerful supercomputer to simulate complex calculations, shedding light on the properties of these enigmatic objects.
A study by the Technical University of Munich reveals that non-alcoholic wheat beer can reduce inflammation, strengthen the immune system, and prevent upper respiratory infections in athletes. The 'Be-MaGIC' study found that consuming the test beverage daily reduced infection frequency and severity.
Research reveals how fragile X protein, FMRP, hooks up with microRNAs to switch the production of other proteins on and off. This process is crucial for learning and memory, as neurons need to make new proteins at specific synapses.
Researchers are close to producing super varieties of wheat that will resist the deadly Ug99 pathogen, while boosting yields by as much as 15 percent. The new varieties have genetic resistance to rusts, including stem rust, yellow rust, and leaf rust, which has infected up to 90% of global wheat production.
Aging stem cells struggle to produce strong bones due to malnutrition and inadequate signals. Researchers explore the role of amino acids and satiety hormone leptin in rejuvenating these cells.
Rice was domesticated at least twice, with substantial gene sharing between the southern and northern varieties, challenging long-held theories. Researchers found that certain traits were borrowed extensively from one another, leading to a reevaluation of rice's origins.
A new Texas AgriLife Research study reveals that fathers' role in childhood obesity is more significant than previously thought. Lenient dads are more likely to allow their kids frequent fast-food restaurant visits, which have been linked to obesity. Fathers need education on nutritional content and taking a responsible parenting role.
A new study by University of Michigan researchers suggests that banning federal funding for human embryonic stem cell research would have disastrous consequences on the use of induced pluripotent stem cells (iPS cells). The two cell types are complementary and interdependent research tools, and their use has become intertwined. As a re...
A blood test for AMH can help predict IVF success, with women having higher AMH levels yielding more eggs and a higher rate of pregnancy. The study found that women with low AMH levels had an average of six eggs harvested, while those with higher levels had around 20.
The Lancet's new Series on vaccines highlights four key elements: intensified research, advocacy at the highest level, developing countries' responsibility, and expanded communication of benefits. Experts emphasize the need for $3.7 billion funding to save 4 million lives through immunization programs.
A low-pressure system stretching over the Caribbean Sea is causing heavy rainfall and flooding in various islands. The GOES-13 satellite captured an image of System 94L on June 9, revealing a minimum central pressure of 1001 millibars and cloud cover centered over eastern Cuba and Jamaica.
A team of scientists has discovered that nicotine suppresses appetite by activating a specific set of neurons in the hypothalamus. The researchers believe this could lead to the development of a drug that helps smokers stay thin and potentially aids non-smokers struggling with obesity.
A new study by researchers at Stanford University School of Medicine and others found that curtailing human embryonic stem cell research would negatively impact induced pluripotent stem cell research. The study refutes the idea that iPS cells can replace embryonic stem cells in research.
Scientists at Tufts University found that mice born to mothers fed a B vitamin-rich diet had fewer intestinal tumors, while those from deficient diets showed more aggressive tumors. The study suggests epigenetic effects of maternal B vitamin intake may protect against colorectal cancer in offspring.
Scientists discovered that a single amino acid prevents perforin from killing host cells, protecting cytotoxic lymphocytes from destruction. The findings shed light on the immune system's ability to regulate cell death and disease.
Researchers at Ohio State University have discovered a new way to make steel 7 percent stronger than any steel on record using a heat-treatment called flash processing. The unique microstructure formed by the process boosts ductility, making it a potential impact-absorber for automotive applications.
A gene linked to emphysema is also found to contribute to lung cancer development, with men showing a higher incidence of the disease. The study suggests that PLAGL2 expression could be used as a marker for cells at risk of malignant transformation.
USDA scientists recommend controlling starch buildup in sugar factories by using an intermediate-temperature stable amylase to break down unwanted starch. The solution involves adding diluted concentrated amylase solutions to factory tanks, resulting in improved product quality and reduced costs.
Researchers at Penn propose two-dimensional graphene metamaterials that can manipulate electromagnetic waves in the infrared spectrum. The metamaterials' conductivity can be altered using voltage, enabling transformation optics and applications in telecommunications, imaging, and signal processing.
Researchers analyzed a pristine meteorite, finding that its organic compounds changed over time due to asteroid geology changes. Amino acids and monocarboxylic acids were present, essential for the evolution of first life forms on Earth.
A team of UW-Madison chemistry professors has devised a novel approach to synthesizing substituted aromatic molecules by utilizing a palladium catalyst. This method enables the efficient production of various aromatic compounds with specific substitution patterns, which will have practical applications in drug companies.
A study funded by NIH has found a brain pathway that could be targeted to help people quit smoking without gaining weight. The research identifies a specific subclass of nicotinic receptor involved in nicotine's ability to reduce food intake.
A MSU scholar argues that current teacher-preparation programs for middle-school math instructors are inadequate, leading to a lack of internationally competitive math knowledge. The researcher recommends adopting more rigorous and uniform standards for math teachers to improve US math education.
Researchers found that orphan disease genes encode hub proteins with multiple protein-to-protein interactions vital to cell function. Deleting about 43% of these gene homologs is lethal or causes premature death, highlighting their essential survival role.
The introduction of a new vaccine, MenAfriVac, has led to a dramatic fall in cases of meningitis A in Burkina Faso, Mali, and Niger. The vaccine, which costs less than $0.50 per dose, is highly effective and protects children as young as one.
Researchers discovered that light-capturing pigment molecules can be triggered by heat, producing false alarms. The study found that red-sensing pigment triggers false alarms most frequently.
Decertification of physicians participating in lethal injections by professional certifying organizations goes too far, argue Lawrence Nelson and Brandon Ashby. The authors examine the role of physicians in lethal injections and find that they can reduce risk while not advancing or harming ethical medicine principles.
Researchers at UCSB successfully reproduced the Josephson junction using Einstein's general theory of relativity, a breakthrough that sheds new light on non-gravitational physics. The discovery has significant implications for understanding superconductivity and the development of room-temperature superconductors.
A Yale University study found that microloans in the Philippines led to fewer businesses and lower self-reported well-being among recipients, contrary to initial expectations. However, the practice did provide a buffer against income fluctuations and increased access to informal credit.
Researchers discovered that Mtr4p, a RNA helicase, controls the number of adenosines appended to RNAs by TRAMP complex. This tagging is critical for cell function and preservation of normal cell process initiation.
Hurricane Adrian has plenty of strong thunderstorms over 9 miles high, fueled by warm ocean water. The storm's eye is confirmed by NASA's infrared image, with coldest cloud top temperatures as cold as -63 Fahrenheit.
New research reveals quantum mechanical tunneling as a driving force for chemical reactions, changing how scientists understand and devise reactions. The discovery has potential applications in materials science, biochemistry, and more.
The vaccine community demands evidence on vaccine efficacy but neglects research on public trust. Building trust depends on understanding perceptions of vaccines and addressing historical experiences, socioeconomic status, and misinformation.
Researchers are developing a new class of drugs targeting protein structures within cell membranes to treat autoimmune diseases. The 'membrane mimic' technology could provide a direct view of mechanical movements that take place during cell signalling.
A team of international scientists, led by University of Pennsylvania geneticists, have discovered genetic variations in humans that may help resist malaria. The research found that certain mutations in genes related to red blood cell proteins could be linked to lower malaria susceptibility.