Researchers identified FYCO1 as a key gene in the development of autosomal-recessive CCs. The study found that FYCO1 mutations lead to abnormal protein accumulation, disrupting lens transparency.
Researchers at University of Louisville identified a protein sorting mechanism used by the salivary gland, which could lead to advanced therapies for patients with damaged or non-functioning salivary glands. The study found that a specific lipid molecule, PtdIns(3,4)P2, plays a crucial role in sorting proteins into vesicles for secretion.
A multidisciplinary team will collect water and biological samples, take ocean current measurements, and analyze radionuclides to understand the impact of radiation on marine life and human health. The expedition aims to establish a baseline for radioactive contaminants in the ocean.
Scientists at Penn State College of Medicine have created a new approach to treating brain tumors by targeting the ferritin protein with siRNA. By reducing ferritin levels in cancer cells, the sensitivity to chemotherapy can be increased, allowing for lower doses and potentially fewer side effects.
Recent developments in protein kinase inhibitors include innovative drug development paradigms, improved inhibitor profiling, and expanded disease targets such as Alzheimer's disease. Researchers are focusing on inactive kinase states and using selectivity strategies to overcome obstacles in the field.
Research by Baylor College of Medicine reveals MeCP2 is required throughout life to maintain healthy brain function. The findings suggest that certain treatments may need to be maintained throughout the lifetime of individuals with Rett Syndrome.
A Spanish research team used 3D reflection seismology to create detailed images of the Ebro river basin six million years ago. The study reveals that the sea level dropped dramatically during this period, exposing continental margins to atmospheric agents.
The study's findings suggest that mass vaccinations deployed strategically could prevent future cholera epidemics in Zimbabwe and other nations. The research team analyzed how cultural, political, and economic factors influenced routes of transmission and identified funeral feasts as a key factor contributing to the spread of the disease.
A new slow-release compound, JM6, protects mice against neurodegenerative effects of Huntington's and Alzheimer's disease by increasing production of a neuroprotective compound. JM6 extends lifespan, improves motor coordination and preserves synapses in both models.
Researchers at Scripps Research Institute found a way to disrupt a critical enzyme interaction that prevents cell death, potentially leading to new treatments for heart attack and stroke. The discovery could provide a new therapeutic target against conditions including neurodegenerative diseases like Parkinson's.
Elastography and serum markers are non-invasive diagnostic options reviewed in an editorial, showing promise in detecting liver fibrosis. The use of diagnostic liver biopsy is declining due to its limitations, and these alternatives may be more advantageous to patients.
Researchers found that stressed bees display pessimistic judgment, expecting bitter tastes in unfamiliar scents, mirroring human-like cognitive bias. This study suggests that bees can be used as models for emotion research in invertebrates, potentially reducing animal welfare concerns.
A new study by University of Wisconsin professor Martha Alibali and colleagues reveals that body movements significantly impact problem-solving. Participants who were restricted from using their hands or feet used abstract, mathematical strategies more often than those with free movement.
Researchers identified a key role for hedgehog in breast cancer cellular cross-talk, finding that silencing the molecule slows tumour growth and spread. The discovery applies to all breast cancers, particularly basal breast cancer, which has no current targeted therapy.
Research from the University of Utah Health identifies toddlers as early as 14 months at risk for autism syndrome disorder. A partnership between autism experts and pediatricians using widely accepted questionnaires leads to the identification of 10 toddlers with early signs of ASD, previously missed.
Researchers have discovered a mechanism by which green tea's EGCG compound increases regulatory T cells, improving immune function and potentially treating autoimmune diseases. This natural approach may provide a long-term, sustainable solution without toxicity, offering hope for disease prevention and treatment.
A new study finds that color red increases the speed and force of human reactions, likely due to its association with danger cues. The effect is short-lived and may tax mental resources.
A new study calls for an overhaul of current practices to ensure seriously ill prisoners are identified and released. The researchers propose standardized national guidelines and a recall mechanism to address inequities faced by illiterate, cognitively impaired, or unsupported prisoners.
Researchers are working closely with indigenous communities to develop interventions to address the health impacts of climate change. Pilot projects include medicinal herb gardens, online traditional health knowledge banks, and agricultural training programs.
A new experimental vaccine made from frozen immune cells has shown promise in extending the survival of metastatic prostate cancer patients. The vaccine, APC8015F, was found to increase median survival by approximately 10 months compared to those not treated with it.
Scientists from Monell Center and Integral Molecular have discovered a compound that inhibits bitterness by acting directly on a subset of bitter taste receptors, opening doors to better nutrition and therapeutic compliance. The discovery of probenecid as a bitter blocker may lead to the development of novel and more effective blockers.
A new study suggests people with depression struggle to turn their attention away from bad thoughts due to difficulties with working memory. Researchers found that individuals with depression took longer to reorder words in reverse order, especially when the words had negative meanings.
University of Illinois researchers used a high-resolution single-molecule study technique to see subtle differences between two branches of neurotransmitter-gated ion channels. They found that changing the position of an amino acid changes its properties, allowing cation-selective channels to regulate excitation.
Researchers found that about three percent of new mutations are 'multi-nucleotide mutations,' which may allow organisms to leap across fitness valleys and reach a higher-fitness state by acquiring multiple mutations simultaneously. The study provides evidence for a possible new mechanism of adaptation.
The study identifies thousands of sites of DNA methylation in a large set of physiological and pathological tissues, providing insight into human body processes and disease. The research may lead to finding the unknown origin of metastasis and developing more effective therapies.
Survival rates for wealthier patients with glioblastoma have improved since 2000, while those in poorer areas and older than 70 have remained stagnant. The addition of temozolomide to post-operative radiation therapy has been shown to improve overall survival in younger patients.
A new study reveals that a high-fat diet during pregnancy can decrease blood flow from the mother to the placenta and increase the risk of stillbirth. Researchers found this effect regardless of whether the mother was obese or slender, and in monkeys with hyper-insulinemia.
Research by Northwestern University and Wake Forest University found that fast disclaimers undermine consumers' trust in unfamiliar brands, while trusted brands remain unaffected. Trusted brands can use fast disclaimers without impact on purchase intention.
A study of over 100 popular websites found that three-quarters directly leak private information and unique identifiers to third-party tracking sites. The leaked data can be used to create detailed profiles of individuals, including browsing histories and search terms.
Researchers successfully recreated Rett syndrome in adult mice by 'switching off' a critical disease-causing gene, challenging the notion that early expression of the gene protects against the development of symptoms. The study suggests therapies for Rett syndrome may need to be continuously maintained throughout an individual's life.
The Stevens Institute of Technology engineering team created a smart wallet prototype that protects credit card user privacy using software-defined radio technology. The system defaults to defensive mode but allows communication with near-field readers with the push of a button.
A multicenter clinical trial found stereotactic body radiation therapy (SBRT) to be an effective treatment option for patients with localized prostate cancer, delivering results in just five 30-minute sessions. The study's findings suggest that higher doses of radiation are safe and can lead to improved outcomes.
Researchers aim to determine how vitamin D affects cardiac structure and function, vascular function, and left ventricular hypertrophy in blacks with hypertension. The study could identify vitamin D as a safe and effective therapy to stop or reverse cardiac ravages caused by high blood pressure.
A new, global database of large dams and reservoirs has been created to inform sustainable river-flow management. The Global Reservoir and Dam database (GRanD) contains information on 6,862 dams and their associated reservoirs, providing a holistic view of entire river basins.
Researchers at King's College London have identified a way to eliminate leukaemic stem cells, which could lead to new treatments enabling complete remission for leukemia patients. The study found that suppressing two proteins, Bmi1 and Hoxa9, can abolish the ability of MLL leukaemic stem cells to proliferate.
Researchers used internet traffic modeling to study brain networks, revealing that timing patterns of information emission are indicative of info flow. This method can be applied to study neurological development, aging, and disease, indicating a potential new approach in neuroscience.
A University of Houston biologist discovered that beneficial gene mutations can interfere with each other, leading to a decline in population fitness. This finding has implications for predicting the progression of chronic diseases and could lead to new treatments.
A new study by Simone Polillo argues that the recent financial crisis was rooted in the politics of creditworthiness, which excluded marginalized groups from traditional mortgage lending criteria. This led to the rise of wildcat financial innovators who created more inclusive but unstable credit systems.
Researchers found that increasing CRP levels resulted in increasingly poor prognosis, with a five-year survival rate decreasing from 90% to 74% and deaths from breast cancer increasing from 11% to 20%. Elevated CRP at diagnosis remained predictive of overall survival rates even after excluding patients with suspected bacterial infections.
A new HIV investment model is proposed to achieve a more targeted and strategic approach to HIV/AIDS funding. The model would require 30% more funding, estimated at $22 billion annually by 2015, to avoid 12.2 million new infections and 7.4 million deaths between 2011 and 2020.
A study by the University of Southampton reveals copper's antimicrobial property, killing 10 million E. coli bacteria within 10 minutes on dry surfaces and 45 minutes on wet ones. Copper deployed as a touch surface in food preparation areas can reduce cross-contamination risk.
A new study by Columbia Business School researchers found that Walmart was more likely to propose and open stores in RTW states near the borders of non-RTW states despite protests. The study suggests that firms engage in regulatory arbitrage, selecting businesses-friendly policies to maximize profits.
Researchers have discovered a potential therapeutic strategy for Huntington's disease by targeting an enzyme in the brain. The study, published in Current Biology and Cell, found that inhibiting this enzyme can slow down neurodegeneration and improve symptoms.
A research team at Caltech has outlined exactly how specific sets of cells in sea-urchin embryos differentiate to become the endoderm, the early domain of the embryo that eventually forms the gut. They found that certain regulatory genes are expressed in the cells of each domain and that this process is dynamic, with gene expression ch...
Project ECHO demonstrates that primary care providers can be trained to manage complex chronic conditions via videoconferencing technology, expanding their ability to treat very sick patients. The model has been shown to improve treatment outcomes and reduce racial and ethnic disparities in minority communities.
Scientists identify novel MRSA strain with highly divergent genes not detected by traditional methods, suggesting transmission from animals to humans. The study highlights the emergence of new MRSA strains from animal reservoirs in Ireland and Europe.
Ependymoma, a devastating brain tumor in children, is chemo-resistant and incurable in up to 40 percent of cases. Researchers will investigate the role of the Ephb2 gene in ependymoma development.
A new study by the American Sociological Association finds that racial-ethnic differences in exercise type do not narrow with increasing education, but rather expand. More educated blacks and Mexican Americans are less likely to participate in 'high-status' sports like golf or tennis.
Researchers found that hip strengthening exercises reduced patellofemoral pain in female runners and improved their gaits. The study involved four runners who performed single-leg squats and resistance band exercises, which were then repeated for six weeks.
Researchers discovered that people tend to gamble on double-or-nothing wins when relying on past experiences, whereas they avoid risky choices for losses. This finding suggests a reversal in decision-making strategies based on abstract possibilities versus memory of past outcomes.
A recent study found that high out-of-pocket costs were a significant factor in the public's willingness to use PrEP, outweighing its effectiveness in preventing HIV infection. Participants expressed a desire for a 100% effective pill and reported concerns over sexual risk disinhibition and stigma associated with PrEP use.
The Hartford Faculty Scholars Program has granted 11 geriatric social work researchers a two-year award to improve healthy outcomes for the country's aging population. The program partners with the Veterans Health Administration (VA) to support applied research on older veterans and their caregivers.
Researchers discovered Sox6 gene regulator that maintains fast muscle type and inhibits slow muscle development. Adult mice lacking Sox6 in fast muscles showed changes in muscle performance, including slower contraction speed and reduced fatigue.
Scientists have identified a drug combination that shows a survival advantage in advanced lung cancer patients who no longer respond to existing therapies. The combination of bexarotene and erlotinib broadens the reach to include patients resistant due to ras mutations, offering new hope for those with limited treatment options.
A nationwide study found that unwed mothers face poorer health at midlife than women who have children after marriage. The study suggests that single motherhood has long-term negative health consequences, and government efforts to promote marriage may not address these issues.
A new phase-change memory-based 'Moneta' system offers unprecedented performance, with read speeds up to seven times faster than current SSDs. The device uses PCM technology to store data in a metal alloy, providing lower latency and reduced energy requirements for high-performance computing applications.
The University of Arizona has received a $2.95 million grant to study the ecological processes influenced by the monsoon phenomenon. The five-year project will use advanced computer modeling approaches to understand how summer rains affect plant growth and spread invasive grasses, as well as explore connections between lower elevation ...
Researchers have discovered that protein kinase C inhibitors can block kidney damage caused by the cancer drug cisplatin. This finding suggests using these inhibitors as an adjunct therapy to reduce toxicity and improve treatment outcomes.
Researchers are conducting a clinical trial called MANTICORE to detect and treat cardiovascular disease in breast cancer patients before treatment begins. The study aims to use special blood tests and imaging scans to identify potential cardiac risk factors.
A revised college science course design improved overall student performance and narrowed the achievement gap for educationally disadvantaged students. The highly structured format, which includes daily practice with problem-solving and data analysis, reduced the gap by 45%, according to research published in Science.