Researchers found that itraconazole can delay the progression of prostate cancer and reduce PSA levels, with 48.4% of patients experiencing stable or declining PSA after high-dose treatment. The antifungal also disrupted a key cancer-initiating biological pathway called Hedgehog.
A study by Hyun Sik Kim finds that children of divorce experience developmental setbacks in math and social skills, particularly after the divorce process begins. These effects persist even after the divorce is finalized, with children showing increased anxiety, loneliness, and low self-esteem.
A population of the freshwater limpet Rhodacmea filosa, thought to be extinct since the mid-20th century, has been rediscovered in a tributary of the Coosa River in Alabama. The discovery is a conservation success story and highlights the importance of preserving biodiversity in rapidly changing environments.
A recent study from the University of Michigan found that young people who have sustained a head injury are more likely to engage in violent behavior. The research also showed that recent head injuries were even more strongly linked to violent behavior.
Researchers at VCU Massey Cancer Center have successfully completed a Phase I clinical trial evaluating the combination of Bortezomib and Alvocidib in patients with relapsed or refractory blood cancers. The therapy showed encouraging results, with 44% of patients responding to the treatment.
Researchers developed a new technique to identify self-proteins targeted in autoimmune diseases. Using phage display technology, they created a proteome library to examine molecular details of immune responses.
Researchers are testing a new treatment for triple-negative breast cancer using the experimental drug entinostat, which aims to reprogram tumor cells to respond to hormone therapy. The clinical trial is evaluating the effectiveness of combining entinostat with an aromatase inhibitor in postmenopausal patients.
Stanford researchers discovered that local farmers' social and economic networks are key to adopting new technologies, with credit unions playing a significant role. The study found that most farmers rely on credit unions for technical expertise and management advice rather than external experts.
A team of scientists flew microscopic worms into space to test the effectiveness of RNA interference (RNAi) as a treatment for muscle degradation caused by space travel. The experiment showed promising results, suggesting that RNAi could be used to prevent muscle loss in astronauts and help people suffering from similar conditions.
A new US study found that single mothers who had their first child outside of marriage reported poorer health at age 40 compared to other moms. The study suggests that later marriage does not generally help reverse the negative health consequences of having a first birth out of wedlock.
USDA scientists used GPS-equipped conductivity meters to map manure distribution on feedlot surfaces, estimating manure amounts and quality. They also developed a computer program to associate high soil conductivity levels with manure solids and chloride content.
Researchers found that recent hospitalizations significantly increase the likelihood of emergency department re-admissions, highlighting the importance of emergency departments in preventing readmissions. The study suggests that emergency physicians can play a crucial role in reducing re-admissions by taking care of patients and sendin...
A study published in the American Journal of Infection Control found that fire stations are contaminated with MRSA, with the most common areas being medic trucks and kitchens. The research suggests that transmission between personnel and environmental surfaces may be occurring, highlighting the need for further studies.
The Society of Gynecologic Oncology has released guidelines for surveillance of gynecologic cancer recurrence in women who have had a complete response to primary cancer therapy. The recommendations focus on clinical effectiveness and cost-effectiveness, advising against routine cytologic procedures or imaging unless necessary.
A study by Mayo Clinic researchers found that discussing end-of-life care preferences with patients and families before LVAD surgery can provide relief to families, ease subsequent medical care, and help clinicians address end-of-life decision-making effectively.
NIH-funded researchers identified three types of odor molecules that disrupt mosquito carbon dioxide-sensing machinery. These findings could lead to the development of more effective repellents and lures to prevent mosquito-borne diseases.
A low-pressure area, System 93L, has formed off the North Carolina coast and is now located off northeastern Florida. The storm is expected to move over northern Florida later today, bringing scattered strong thunderstorms and isolated thunderstorms to the region.
Researchers found Asian non-small cell lung cancer patients survived longer than Caucasians regardless of the number of chemotherapy drugs given, with improved survival rates after targeted therapies were introduced in the early 2000s.
Bacteria can evade the immune system by mimicking human proteins, allowing them to resist antibiotics. This 'molecular mimicry' helps explain the resurgence of highly infectious pathogens.
A study by the University of the Basque Country found that insecure individuals, particularly those with anxious-ambivalent tendencies, struggle with conflict in their sexual desire and relationships. Controlling partners tend to exhibit greater conflict, while avoidant types evince more problems in intimacy.
Researchers at OHSU Knight Cancer Institute discovered a gene called Src that plays a key role in kidney cancer growth. This finding could lead to more effective treatments for patients who don't respond to current therapies. The study's authors are now initiating clinical trials to test how these tumors respond to existing FDA-approve...
Researchers have discovered that combinations of a mother's body size and the shape and size of her baby's placenta can predict heart disease in men in later life. The study found three specific combinations where this prediction is accurate, including an oval-shaped placental surface in short mothers who had not been pregnant before.
A University of Michigan Health System study shows surgery mortality dropped substantially for eight different high-risk surgeries performed on 3.2 million Medicare patients from 1999 to 2008. High-volume hospitals and their expertise drove a significant decline in deaths, particularly in pancreatectomy and cystectomy.
Computer science researchers at Brown University have developed a new way to visualize the human brain's neural connections using 2D maps. These simplified representations can help medical professionals identify potential pathologies, such as autism, and understand how neural bundles differ among individuals.
A Rhode Island Hospital study found that female victims of community violence are more likely to be injured by a non-partner or intimate partner, and less likely to be injured by a weapon. The study also highlights the importance of accurate documentation and charting of youth injuries.
A new saliva test has been developed to identify cytomegalovirus (CMV) in newborns with high accuracy, enabling early detection of potential hearing loss. The test, which shows promise in a multi-center study, may revolutionize the way CMV infections are detected and treated in infants.
Researchers discovered a compound that prevents further injury to damaged livers, improving clinical outcomes for patients. The study, published in ACS' journal Molecular Pharmaceutics, offers hope for increasing the number of available livers for organ donation.
Researchers at Fox Chase Cancer Center discovered that a low lymphocyte count is a simple and effective prognostic indicator in patients with renal cell carcinoma. The study found that lower lymphocyte levels are associated with a higher tumor grade, pathologic tumor stage, presence of distant metastases, and lower overall survival rate.
Researchers at UCR identified three classes of volatile odor molecules that can impair or completely disrupt mosquitoes' carbon dioxide detection machinery. The findings offer powerful advantages as potential tools for reducing mosquito-human contact and could lead to the development of new generations of insect repellents and lures.
A recent study by Oregon State University researchers found that breast cancer survivors used online forums to share their personal experiences and challenge scientific authority. The women's reactions were intensified by their online connection to others who shared similar experiences, leading to a shift in the balance of power betwee...
Researchers at Fox Chase Cancer Center have found a less toxic combination of erlotinib and bevacizumab to be effective in treating advanced non-small cell lung cancer. The treatment regimen resulted in improved progression-free survival and overall survival rates, with fewer patients experiencing severe side effects.
A new microscopic theory describes interactions between components of complex polymer mixtures, enabling realistic modeling and macroscopic property predictions. The method has been experimentally proven using neutron scattering experiments, opening up possibilities for studying complex mixtures with improved properties.
A new study from the University of Missouri found that CEOs who prioritize employee job satisfaction can significantly improve customer satisfaction and loyalty. The researchers discovered a strong link between high employee satisfaction and customer loyalty, with twice as strong a positive impact compared to low employee satisfaction.
A study by University of Pennsylvania researchers found that even with private health insurance, newly diagnosed cancer patients often struggle to schedule an appointment with an oncologist. The authors suggest that patient navigator programs and staff training could help improve access to care.
Algal turf scrubbers use sunlight to extract excess nutrients from polluted waters, restoring oxygen levels and producing nutrient-rich fertilizer and biofuel. The technology has commercial potential and could help address global phosphorus supplies concerns.
New research links fear of dying during a heart attack to increased inflammation, which can predict worse outcomes for patients. Fear of dying is associated with larger inflammatory responses and reduced heart rate variability.
The Deutsche Forschungsgemeinschaft will establish 21 new Collaborative Research Centers (CRCs) as of July 2011, focusing on topics such as additive manufacturing, biological systems, and quantum physics. The centers aim to improve manufacturing methods, investigate novel materials, and explore social structures.
The US is experiencing an 'epidemic of mass incarceration' due to inadequate treatment of addiction and mental illness in the community. Millions of Americans are cycling in and out of correctional facilities each year, with devastating consequences for their health and well-being.
Research suggests the thalamus acts as a center for transmitting migraine pain, regulating its intensity and sensitivity to environmental stimuli. This new understanding may lead to future treatments targeting the thalamus.
A survey of young adults in Montreal, Halifax, and New York City reveals a strong desire for sustainable lifestyles, with respondents willing to adopt eco-friendly practices such as reducing car usage and energy consumption. The study highlights the need for better communication and collective action to address global problems like cli...
Research published in the British Journal of Surgery found a significant association between surgical site infections and noise levels in operating theatres. The study found that patients who underwent surgery in noisy environments were more likely to develop SSIs.
The study found that the vaccine improved response rates by 16% and progression-free survival by 2.2 months in patients compared to those without the vaccine. The researchers aim to broaden their approach using mixtures of peptides and other immune-stimulatory agents.
Researchers found that gain-framed, positive messages are more effective in curbing college students' binge drinking habits than loss-framed, negative messages. The study showed that messages focusing on relationships and academic success were most effective in convincing students to avoid binge drinking.
A recent literature review analyzed nearly 100 scientific articles on the effects of nanoparticles on edible plants. The study found that nanoparticle uptake and build-up vary depending on plant type, nanoparticle size, and chemical composition, highlighting a need for further research in nanoecotoxicology.
Researchers gather to share new scientific data on migraine disease, exploring its unique role of the thalamus, recent gene identification, and childhood abuse correlations. Migraine specialists welcome a new era of discovery and advancement in understanding and treating this disabling disease.
Scientists have created the first high-resolution topographic map of the Aurora Subglacial Basin, revealing vast channels cut through mountain ranges by ancient glaciers. The data will help improve computer simulations of past and future Antarctic ice sheet behavior.
Researchers found that migraine sufferers often experience fatigue, anxiety, mood changes, and yawning before an attack. Early intervention using triptans during the premonitory phase may help prevent or reduce the severity of attacks.
Researchers at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors. The Jak2/Stat3 pathway was found to be elevated in these cells, and a drug specifically aimed at blocking this pathway halted tumor growth in mice.
Two winning projects were selected to provide clean and sustainable water to communities in need. The Tagore-SenGupta Foundation project will install arsenic removal units in remote villages and schools in Cambodia, while Jenna Forsyth's project focuses on low-resource chlorine generation for safe drinking water in western Kenya.
A study of over 2,900 pediatric patients found that 12% returned to the ER within six months of their initial visit, despite having an outpatient mental health provider. The majority of ER visits stemmed from behavioral problems or minor psychiatric crises.
Researchers at George Washington University School of Medicine and Health Sciences have shown that the Mta1 gene is essential for Schistosoma haematobium to establish a productive infection and survival in the host. The study found that mice lacking the Mta1 gene were unable to support worm growth and egg production, highlighting the c...
Researchers identified PKC-delta as a critical regulator of cisplatin-mediated kidney toxicity, and inhibiting it protected the kidneys without blocking chemotherapy efficacy in mouse models. Additionally, studies divided breast cancers into subtypes to identify effective therapies for triple-negative breast cancer patients.
A new study by UBC researchers found that both shame and honour can increase cooperation by up to 50%, challenging traditional assumptions about the role of reputation in social interactions. The experiment, which involved over 180 participants, used a public goods game to test the impact of shame and honour on individual behaviour.
The Gang of Four, including Davis, Efstathiou, Frenk and White, receives the prize for their pioneering use of numerical simulations to model the Universe's large-scale distribution. Their work, which began with a survey of 2400 galaxies in 1981, showed that observations were consistent with a simulated Universe based on cold dark matter.
Scientists find that honeysuckle extract improves UV-blocking ability of wool fabrics, providing significant potential as a natural UV-blocking agent for clothing. The extract remains effective after exposure to sunlight and laundering, offering an eco-friendly alternative to traditional sunblocks.
The EUREKA IPC Resolution aims to expand services to support R&D through all phases of value change. This includes becoming an investment promotion centre to interact with public and private financial stakeholders.
Researchers have discovered that quantum entanglement can create a cooling effect when deleting data, which could be used to mitigate heat generation in supercomputers. By understanding the connection between information theory and thermodynamics, they found that entropy is a lack of knowledge that can be exploited for cooling purposes.
A Johns Hopkins University study reveals that two identical beads dropped into a turbulent flow will follow different and random paths. The phenomenon, called 'spontaneous stochasticity,' suggests that even everyday particles can behave randomly in chaotic flows.
A pilot study found that Transcendental Meditation significantly reduces stress and depression in veterans, improving relationships and overall quality of life. The technique produced a 50% reduction in PTSD symptoms in just eight weeks, with long-term changes in sympathetic nervous system activity.
A new study led by the University of Colorado Boulder found that female hominids preferred to move away from their residential groups, suggesting a dispersal pattern similar to modern humans and some primates. The team used high-tech analysis of strontium isotope ratios in tooth enamel to identify specific areas of landscape use.