Research reveals T cells from elite controllers are resistant to HIV infection due to selective upregulation of p21, an enzyme inhibitor. Blocking p21 increases viral gene expression, highlighting potential treatment strategies for vulnerable patients.
Ivory wave has emerged as a new legal high, replacing banned substance mephedrone, with reports of hospital admissions and deaths in various parts of England. The drug's effects include euphoria, paranoia, and cardiovascular problems, leading to violent behavior and organ damage.
A new tool, developed by Prof. Shmuel Marco, can analyze wave patterns in sediment to understand past earthquake intensity. The 'fossil seismograph' helps geophysicists predict future earthquakes in areas with bodies of water.
A telemedicine program called Hospital VIHrtual has been shown to provide comprehensive control over HIV-infected patients in medical, pharmaceutical, psychological, and quality of life aspects. The virtual hospital allows for efficient management of stable HIV patients, reducing costs and time spent on travel and waiting for visits.
Researchers at UCSD School of Medicine identified Twist1's role in promoting invadopodia formation and matrix degradation in tumor cells. This process facilitates the spread of cancer to surrounding tissues and other parts of the body.
Researchers at the University of Edinburgh identified a critical protein that maintains nerve fibre health, potentially improving understanding of neurodegenerative disorders. The discovery could lead to new insights into conditions like epilepsy, dementia, and stroke by unraveling the complexities of brain function.
A study published in Cancer suggests that tamoxifen can significantly reduce breast cancer risk in post-menopausal women under 55 with a high risk of developing the disease. The medication not only saves lives but also reduces medical costs, preventing 29 breast cancer cases and 9 deaths per 1,000 treated women.
Scientists at NIAID discovered how E. coli O157:H7 infects humans by altering the host's immune responses, allowing it to evade elimination and prolong survival. This mechanism could be relevant to other pathogens involved in foodborne diseases, such as Shigella and Salmonella.
A four-year study aims to develop drugs that inhibit the degradation of protective metabolites in the kidneys, which are damaged by diabetes. Researchers hope these inhibitors could halt the progression of diabetic nephropathy and slow the rise of end-stage renal disease.
Researchers reconstructed a 226-year fire history in southern Illinois by analyzing fire scars on post oak trees. The study found that repeated fires dating back to early European settlement permanently altered the region's ecology.
The Khalaf Al Habtoor Harvard Research Fellowship offers a postdoctoral researcher from the UAE or Middle East region a chance to work at Harvard Medical School for up to three years. The fellowship aims to explore fundamental scientific questions and contribute knowledge to the host laboratory.
A study published in Neurology found that stroke survivors with depression are at a higher risk of dependence after three months. The research also showed that other factors, such as age and comorbidities, can contribute to this risk.
Researchers developed two peptide inhibitors targeting HER-2 and VEGF pathways, showing additive benefits in reducing tumor burdens with minimal side effects. The strategy aims to overcome acquired resistance and provide clinical benefit in several types of cancer.
Researchers found that Frizzled-9 upregulates during osteoblast differentiation and is essential for bone mineralization. Mice lacking Fzd9 have fragile bones due to low rates of bone formation, highlighting its potential as a drug target for treating osteoporosis.
A University of Pittsburgh study found that if eligible patients filled prescriptions through a $4 generic drug program, the societal savings could amount to nearly $6 billion. The study examined a large group of people who used generic medications or their brand-name counterparts and found that less than 6% used the discount programs.
Scientists have created a comprehensive framework for understanding fly evolution, revealing surprising relationships between species. The study provides new insights into the origins and diversification of flies, which comprise over 10% of all life on Earth.
Researchers created mini magnetic disks with slanted edges, which favor the formation of tiny magnetic vortices. This allows for efficient data processing and reduced power consumption compared to traditional memory storage systems.
A three-year study on the Nauset Marsh Estuary's red tide problem begins next week. The researchers will collect water samples and analyze them for concentrations of toxic algae to better understand environmental factors influencing the incidence of red tides.
University of Utah researchers built spintronic transistors that aligned magnetic spins of electrons for a record period of time at room temperature. The achievement is a significant step towards the development of faster and more power-efficient spintronic devices using silicon chips.
A new Johns Hopkins study suggests that older, less expensive medications like metformin can be just as effective in controlling type 2 diabetes as newer, more expensive options. The research also found that metformin was associated with fewer side effects, including weight gain and cholesterol level increases.
A five-year grant will fund research on simple yet authoritative strategies to promote healthy food choices and portion sizes among low-income pre-schoolers. The study aims to reduce the risk of childhood obesity by providing mothers with straightforward feeding guidance.
Research from the BEACON Consortium found no association between heavy drinking and esophageal adenocarcinoma, contrasting with a well-established link to squamous cell carcinoma. Light drinkers had lower risk of these cancers than non-drinkers.
Casey Dunn, a Brown University biologist, has been awarded the National Science Foundation's Alan T. Waterman Award for his groundbreaking research on the origins of diversity in life. The award recognizes his use of genomic and computational techniques to study complex multicellular organisms, including humans.
Researchers at Washington University School of Medicine are developing new approaches to reduce health-care-associated infections. Investigating the use of probiotics to prevent pneumonia in ventilated patients and evaluating the effectiveness of a new antibiotic in preventing Clostridium difficile infection are two key areas of focus.
A large population study found that regular consumption of fish and omega-3 fatty acids was associated with a significantly reduced risk of developing age-related macular degeneration in women. The study, published in Archives of Ophthalmology, found that higher intake of DHA and EPA was linked to a 38% lower risk of the condition.
A new integrative climate model recognizes the significance of human-induced causes, such as deforestation and agro-industry, in addition to carbon dioxide emissions. This approach aims to achieve a more effective and socially democratic climate policy, responsive to local conditions.
The Hebrew University of Jerusalem will digitize its Albert Einstein Archives with a $500,000 grant from the Polonsky Foundation. The project aims to preserve over 80,000 documents and make them accessible online.
Researchers found that American children as young as second grade adopt the cultural stereotype that math is for boys, leading to a lower association with math among girls. Parental and educational practices can help broaden interests and aspirations in elementary school.
A new mouse model has been developed to study pilocytic astrocytoma (PA), a common pediatric brain tumor. The model uses expression of a mutant BRAF kinase domain in mice and shows that this is sufficient to induce the formation of PA, closely resembling human disease.
A study of over 7,000 Australians found that poor-quality jobs have a significant impact on mental health, often worse than unemployment. Those in the poorest quality jobs experienced the sharpest decline in mental health, with each additional adverse condition lowering their score.
Researchers discovered that slime mold cells organize into an epithelial layer with a structure and function similar to those in some animals. The layer secretes proteins, coating the fruiting body stalk with rigidity.
A retrospective cohort study found that patients with retinal vein occlusion (RVO) had an almost two-fold higher incidence of stroke compared to age- and sex-matched controls. The study suggests that RVO may be associated with an increased risk of cerebrovascular accidents but not myocardial infarctions.
Researchers found that hospitals with low AMI mortality rates shared an overall vision of excellence and had more senior management involvement, broad staff presence, and better communication among physicians. A new low-radiation alternative to CT angiography also shows promise in diagnosing coronary artery disease, with good specifici...
Astronomers using NASA's Hubble Space Telescope have recalculated the universe's expansion rate with unprecedented accuracy, ruling out an alternate theory on dark energy. The new measurement reduces uncertainty by 30% and solidifies understanding of cosmic ingredients.
The article discusses the need for targeted care in adolescents and young adults with cancer, who require collaboration between pediatric and medical oncologists. Research has shown that AYA cancer patients often deal with ongoing developmental and psychosocial issues, making it essential to address these challenges.
Researchers have discovered that polymers of amino acid lysine can block the propagation of prions, halting their spread in test tubes and cultured cells. In animal models, mice treated with polylysines showed improved symptoms, longer survival, and lower prion levels
Researchers found that seedlings grow best with distant relatives in field soils but struggle with close relatives. This contradicts Darwin's idea that competition will be strongest between close relatives.
Researchers discovered that lower SMAD3 levels result in faster maturation, while absent levels lead to abnormal responses to testosterone. This finding has implications for altered pubertal timing, affecting adult height and bone density.
San Diego Zoo Global takes management responsibility for Cocha Cashu Biological Station in Peru's Manu Biosphere Reserve, a UNESCO World Heritage Site. The station is home to over 1,000 bird species, rare mammals, and indigenous communities.
Peter Mumby is recognized for his work on coral reef conservation strategies, influencing conservation policy and contributing to the implementation of marine park protections. His research has provided insight into the consequences of conserving herbivorous fishes, reducing nutrient runoff, and restoring urchin populations.
A new curriculum aims to develop argumentative reasoning skills in students through discussion and debate. Students who participated in the program made more of the higher forms of arguments and listed more questions of substance than those taught in a conventional way.
Research published in The Journal of Physiology found a link between maternal and offspring obesity in lambs, shedding light on the mechanisms of human obesity. Hormonal changes, including leptin and cortisol, were observed in lambs born to obese mothers, suggesting a predisposition to increased appetite and obesity.
Research from Brigham and Women's Hospital shows rapid adoption of newer, more expensive prostate cancer treatments between 2002-2005 without proof of cost-effectiveness. This trend is reflected in increased Medicare spending on these treatment options, which rose nearly $350 million in 2005.
A new Johns Hopkins study shows that each strain of the cat-borne parasite Toxoplasma gondii triggers a unique reaction in human nerve cells, varying the severity of infection. The research found alterations triggered by the most virulent strain to be linked to brain development and central nervous system function.
Research found that used woodwind and brass instruments are heavily contaminated with bacteria and fungi, including species of Staphylococcus and molds. Proper sanitation and regular cleaning are crucial to prevent the spread of illness and infection in children who play these instruments.
Patient-centered medical homes in Ontario's Family Health Team Model show high patient satisfaction and improved income for primary care physicians. Additionally, a novel approach to detecting white-coat hypertension using automated serial blood pressure measurements is found to be valid and useful.
Alum, a common vaccine adjuvant, interacts with dendritic cells to activate T cells that control antibody production. The breakthrough study uses single cell force spectroscopy to understand alum's properties, potentially leading to new vaccines for major diseases.
A new study reveals that Neanderthals consistently used fire for approximately 400,000 years in Europe, contrary to previous assumptions about their abilities. The findings, based on scores of ancient archaeological sites, show evidence of sustained fire control through the presence of charcoal, heated stone artifacts, and burned bones.
A new study uses statistical methods to assess the authenticity of items sold on internet auction sites, revealing over 80% of artwork claimed to be by Henry Moore was actually fake. The results suggest strengthening laws on misrepresentation is necessary for public protection.
The University of Michigan has received a $4.9 million grant from the USDA's National Institute of Food and Agriculture to develop an obesity intervention program for Head Start preschoolers. The program aims to enhance children's ability to control emotions and behaviors, leading to healthier eating habits and reduced obesity rates.
A new analysis of 69 studies involving 143,000 healthy children has identified new reference ranges for heart rate and respiratory rate that differ significantly from existing guidelines. The study found a decline in respiratory rate from birth to early adolescence, with infants under 2 years showing the steepest fall.
Researchers at Children's Hospital of Philadelphia found that feeding rats antioxidants during pregnancy prevented obesity and glucose intolerance in their offspring. The study suggests that preventing oxidative stress during pregnancy may lower the risk of childhood obesity.
A large randomized control trial found no evidence that osteopathic therapy improves movement, quality of life, or pain in children with cerebral palsy. However, parents whose children received osteopathy reported a slightly better overall wellbeing for their child compared to those who did not receive treatment.
Researchers at the University of Texas M. D. Anderson Cancer Center have identified a new mechanism driving lung cancer metastasis, involving the suppression of microRNA miR-200 by Jagged2. The study found that low levels of miR-200 may indicate susceptibility to Notch inhibitors currently in clinical trial.
Researchers are exploring traditional medicine as a starting point for developing new antimalarial treatments. Plant extracts and natural compounds have shown anti-malarial properties and potential synergies.
A new study in Honduras found that climate-related weather disasters can lead to increased land wealth and earnings for the rural poor. The poorest residents of a small village were able to recoup their losses and even triple their average holdings after Hurricane Mitch devastated their village in 1998.
New research from St. Jude Children's Research Hospital scientists shows that mutations in three pathways cooperate to launch glioblastoma, an aggressive brain tumor. Tumors develop in multiple regions of the brain, highlighting the complexity and cooperation of genetic changes driving cancer.
A team of scientists has developed new methods for mapping carbon in Hawaii's forests, resulting in more accurate estimates and a lower cost. The approach reveals fundamental ecological controls over carbon storage and provides valuable insights into the state and dynamics of the world's forests.
A study found that people who are dissatisfied with their appearance spend more time looking at ideal body images when the editorial content is about body improvement, compared to general interest articles. People satisfied with their bodies don't feel the need to avoid or seek inspiration from these images.
A collaborative care approach with nurse care managers significantly improves treatment outcomes for patients with opioid addiction. The study found that 51% of patients achieved successful treatment at 12 months and 93% were no longer using illicit opioids after three months.