Researchers at Caltech have identified a specific sugar, GlcNAc, that plays a key role in keeping cancerous tumors fed. By altering the addition of carbohydrates to proteins, tumor cells can survive under harsh conditions and thrive. This finding offers new potential targets for therapeutic intervention.
Astronomers collected evidence indicating that the progenitor system of a Type 1a supernova contains a red giant star. The discovery provides an explanation for why these events vary slightly from galaxy to galaxy, refining the accuracy of cosmic measurements.
In a population of rock sparrows, researchers found that older and more successful males sang with higher pitches and slower tempos, while younger males sang with lower pitches and faster tempos. Cuckolded males, regardless of age, sang louder in an attempt to re-establish their pair bond with an unfaithful mate.
Researchers have identified melanoma stem cells marked by the enzyme ALDH, which exhibit high tumorigenicity and resistance to chemotherapy. Targeting these cells with a new therapy could boost the effectiveness of existing drugs.
Researchers develop smart catheter that senses infection and releases nitric oxide to stop bacterial growth, reducing healthcare-associated infections. The device has shown promising results in lab experiments, with the ability to extend NO release for up to weeks.
Fit Brains, a top online brain fitness platform, has achieved 75 million brain game scores played by over 5 million users. The company is celebrating with a charitable incentive, donating $10 to a brain research foundation for each new membership in September.
Scientists at North Carolina State University discovered a novel protein controller that regulates gene expression in tree cells during wood formation. The controller protein prevents abnormal growth and promotes healthy wood formation by suppressing the expression of certain genes.
A new study published in The Journal of Urology reports that PSA testing has led to improved survival rates for patients with newly diagnosed prostate cancer that has spread to the bones or other parts of the body. The disparity between African American and Caucasian men has been resolved, with African American men now having a compara...
A new study reveals that human airways rely on a 'brush-like' layer to clear mucus, which protects cells from sticky mucus and captures foreign particles. The findings may lead to the development of novel therapies for lung diseases.
Researchers at MIT have successfully produced complex electronic components from molybdenum disulfide, a material that naturally comes with a bandgap and could enable new products such as glowing walls, clothing with embedded electronics, and glasses with built-in display screens. The discovery opens up a new realm of research on two-d...
New research reveals that fat-derived stem cells secrete VEGF and other factors that inhibit cartilage regeneration. Pre-treating the cells with antibodies against VEGF can neutralize these effects, promoting chondrocyte survival and cartilage repair.
A new study explores the largest kill-off in Earth history, shedding light on the competing roles of tectonics and climate in shaping landscapes. Researchers also investigate the early diagenesis of sulfur in a tropical upwelling system and uncover the origins of belemnites, a group of Mesozoic cephalopods.
A team of researchers from UNIGE, Switzerland, discovers a molecular mechanism that links body temperature to the expression of 'clock genes' and local oscillators. They also find that this mechanism affects detoxification and drug metabolism, with potential implications for understanding human physiology.
The study discovered that the claudin-10 gene plays a crucial role in reabsorbing sodium chloride in the kidney. In its absence, mice exhibit elevated magnesium levels and excess calcium deposition in the kidneys, highlighting the importance of this gene in maintaining salt balance.
A recent study found that waiting to treat cytomegalovirus infections in transplant recipients until they reach a certain threshold is more beneficial than prophylactically treating all recipients. This approach led to less kidney scaring and better long-term organ survival among patients.
Researchers at MIT have developed a method to create alloys with extremely tiny grains that remain stable even under high heat. The new material, made of tungsten and titanium, has exceptional strength and impact resistance, making it suitable for various applications.
A team of astronomers has discovered that at least some thermonuclear (Type Ia) supernovae originate from recurrent novae, contradicting previous theories. The study, led by Ben Dilday, reveals multiple ways to make a Type Ia supernova and has implications for understanding the differences seen in these 'standard candles'.
Researchers at Northwestern University have found that the influenza virus reduces immune system-regulating protein production in human cells by activating specific microRNAs. This discovery sheds light on a new mechanism of viral immune evasion and may lead to the development of therapeutics to preserve the immune response.
NASA has detected a newborn Tropical Storm Joyce in the Central Atlantic, with organized circulation and cold cloud top temperatures indicating strength. The storm is being affected by a dry Saharan air layer, which is unusual for tropical cyclones, and is expected to follow a southern edge of high pressure over the ocean.
The conference aimed to examine recent developments in active galactic nuclei and their effect on star formation. Researchers now believe that the energy released by supermassive black holes controls this process, which is crucial for galaxy evolution.
A study led by Vanderbilt-Ingram Cancer Center finds that black men with prostate cancer receive lower quality surgical care than white men. Black men are less likely to use high-volume surgeons and hospitals, resulting in longer hospital stays and higher mortality rates.
Researchers have developed a non-invasive biosensor that can detect minute concentrations of glucose in saliva, tears, and urine, with the potential to reduce the frequency of pinprick testing for diabetes. The sensor uses graphene nanosheets and platinum nanoparticles, enabling it to distinguish between glucose and other compounds.
Researchers at IBN have developed a more powerful and longer lasting fuel cell material using a mixture of gold and copper nanoparticles. The new hybrid material can produce 5 times higher activity and much greater stability than commercial platinum catalysts.
Maternal presence is crucial for juvenile moose survival, with orphaned calves facing up to 47 times more aggression. The study's findings suggest policy changes are needed to protect young moose, highlighting the importance of conservation planning and non-invasive data collection methods.
New study reveals that genetic variations in DNA methylation patterns contribute to human susceptibility to cancer and other diseases. Researchers found hundreds of genes with distinct methylation profiles, many linked to specific human diseases.
A multi-university team is developing techniques for creating two-dimensional materials that can fold themselves into three-dimensional structures when exposed to light. The research aims to advance understanding of photoresponsive materials with applications in electronics, manufacturing, and humanitarian relief.
A Canadian researcher is working to create a more comprehensive classification system for the Paralympics, addressing the limitations of current methods. The system will assess cardiovascular function, allowing athletes to compete fairly and safely.
A new video protocol has been developed to synthesize durable nanocrystals that can harvest solar energy efficiently. The technique, published in JoVE, focuses on the liquid phase synthesis of two nanocrystals that produce hydrogen gas or electricity when exposed to light.
Researchers discovered a 'switch' called MOZ that modifies the Tbx1 gene, essential for normal heart development, to explain variations in DiGeorge syndrome severity. The study found that MOZ activity can be influenced by environmental factors, such as diet, particularly vitamin A, which can exacerbate birth defects.
Researchers at Stowers Institute for Medical Research reveal that histone exchange occurs over a large proportion of genes, controlling gene expression. They also find that the Set2 protein plays a complex role in regulating transcription, preventing cryptic RNA transcripts and maintaining chromosomal stability.
A global assessment found that the rise of oesophageal adenocarcinoma began in the UK during the 1950s and has continued to increase rapidly across eight countries. The exact cause remains unknown, but risk factors such as obesity, smoking, and acid reflux have contributed to its growth.
Mario Santiago has been awarded the ICAAC Young Investigator Award for his work on HIV research, particularly in understanding retroviral resistance genes and their mechanisms of action. His research has contributed significantly to the development of new approaches to HIV vaccine development.
New research at UCLA found that students who sacrifice sleep to cram for a test or complete more homework tend to experience more academic problems the following day. The study suggests that maintaining a consistent study schedule and using time efficiently can help students achieve better grades without sacrificing sleep.
Researchers capture video footage of protein traffic inside a neuron using bioluminescent proteins, showing proteins are directed to compartments and then stopped. The new imaging technique provides insight into the brain's continuous renovation process.
Researchers found that clonazepam alleviated autistic-like behavior in mice with a sodium ion channel defect. The study reveals how the mutated gene leads to overly excited brain circuits and impaired social interactions, shedding light on Dravet syndrome's underlying mechanisms.
The University of Minnesota has been awarded two grants from the US Department of Energy to fund research on capturing greenhouse gases and improving solar energy conversion. The grants will support the development of new materials and software tools for these applications.
A University of New Hampshire researcher is studying the effectiveness of two distinct strength-training regimens on older adults. The study compares traditional resistance training exercises with a light-load program that uses blood flow restriction, which has been shown to increase muscle mass and strength in older adults despite ver...
Locally managed marine protected areas in Fiji will effectively protect between 12-18 percent of all coastal and inshore marine habitats by 2020. This 'people power' approach is on track to meet the national government's goal to protect at least 30 percent of Fiji's inshore habitats.
The Iowa State researchers discovered the structure of a regulator that controls the expression of a multidrug efflux pump in Mycobacterium tuberculosis. This finding is crucial for understanding how tuberculosis bacteria develop drug resistance, providing a starting point for developing new strategies to combat the disease.
Two parasitic wasp species show similar memory consolidation patterns when rewarded with different qualities. This suggests that higher rewards lead to better memory retention. The researchers propose that this behavior makes sense given the energetic cost of consolidating shorter-lasting memories into long-term ones.
A new hand-held sensor detects high levels of carbon dioxide in classroom air, which can cause drowsiness and negatively impact learning. The sensor's data can help optimize HVAC systems to improve indoor air quality.
A study by UCSF researchers found that HIV-infected individuals living in San Francisco's urban poor are more likely to visit emergency rooms and have hospital stays if they lack access to sufficient quality and quantity of food. The study found that nearly half of the participants were classified as food insecure.
A study found that only 31.1% of moderate-to-severe IBD patients would qualify for biologic trial participation due to strict inclusion criteria. The study highlights the need for more pragmatic approaches to capture real-world treatment effects.
Researchers at Moffitt Cancer Center report on immune-related adverse events associated with ipilimumab and tremelimumab, two anti-CTLA-4 antibodies used in treating metastatic melanoma. The study highlights the importance of early recognition and management of these side effects to improve treatment outcomes.
Researchers study a person with extensive brain damage to regions believed critical for self-awareness, finding he remains self-aware despite damaged areas. The study suggests that self-awareness emerges from distributed interactions among networks of brain regions, not confined to specific areas.
Typhoons Tembin and Bolaven continue to churn in the Philippine Sea, with Tembin showing a wide area of very high cloud top temperatures and Bolaven strengthening into a typhoon. Bolaven is expected to intensify further, moving northwest and posing a significant threat to the region.
Scientists have identified (S)-NNN as a strong oral carcinogen in smokeless tobacco, found to induce large numbers of oral and esophageal tumors in laboratory rats. The US government is urged to regulate or ban the substance to protect the health of the 9 million US users of chewing tobacco and snuff products.
A new UCLA study identifies uniquely human patterns of gene activity in the brain that could deepen our understanding of human evolution and brain diseases. The research suggests that complex signaling pathways and enhanced cellular function in the frontal lobe created a bridge to human evolution, enabling higher rates of learning.
Intensive LSAT training strengthens brain connections involved in thinking and reasoning, potentially improving IQ scores. Brain imaging reveals increased connectivity between frontal lobes, and between frontal and parietal lobes.
Andrew Lovering, a renowned structural biologist, has received the ICAAC Young Investigator Award for his seminal research on bacterial cell wall synthesis and modification. His work has significantly advanced our understanding of antibacterial targets and membrane-anchored proteins in bacteria.
Researchers warn of CNTs' potential harm to environment and human health due to toxicity in aquatic organisms like mussels, worms, and crustaceans. The study calls for proper waste management and monitoring to minimize risks associated with composite materials manufacturing.
Researchers at Carnegie Institution find nickel oxide becomes metallic at enormous pressures of 2.4 million times atmospheric pressure, a goal in physics that ranks as high as achieving metallic hydrogen.
The West Nile virus has caused 26 deaths and nearly 700 cases in the US this year, with Texas being a hotspot. The cause of the increased cases remains unclear, but experts emphasize the need for continued research and public health efforts.
Researchers at the University of Strathclyde have developed a new approach to delivering green tea extract, epigallocatechin gallate, directly to tumors. In initial laboratory tests, nearly two-thirds of treated tumors shrank or disappeared within one month with no side effects to normal tissues.
A study published in Biological Psychiatry found that chronic social stress caused by unstable cage composition in adolescent mice led to increased anxiety and poor social interactions in their female offspring. The effects were observed across multiple generations, with stressed male mice also passing on these behaviors to their femal...
Researchers are testing whether lowering inflammation with methotrexate can reduce rates of recurrent heart attack, stroke, and cardiovascular death in high-risk patients. The 7,000-patient trial will follow participants for 3-5 years to determine the treatment's effectiveness.
Scientists have developed a spray-on coating made from chitosan that can delay the ripening of bananas. By slowing down respiration and killing bacteria, this coating can keep bananas fresh for almost two weeks. Researchers are now working on improving the coating to make it commercially viable.
Dartmouth medical research has made a breakthrough in developing a new tuberculosis vaccine, DAR-901. The vaccine, produced by growing bacteria related to TB on agar plates and then inactivating them with heat, has shown a statistically significant reduction of 39% in the rate of tuberculosis among HIV-infected patients.
A new study suggests MR enterography as a replacement for small bowel x-rays or CT enterography in pediatric patients with Crohn disease. The procedure accurately detects inflammation in the terminal ileum, right colon, and left colon, with minimal radiation exposure and low side effects.
Researchers found that early exposure to antibiotics can alter the gut microbiome, leading to increased fat mass and percent body fat in mice. The study suggests a potential link between antibiotic use in childhood and later development of obesity. Further research is needed to confirm this theory.