Scientists at Fox Chase Cancer Center have discovered compounds that enhance the effects of gemcitabine, improving its ability to kill pancreatic cancer cells. This breakthrough could lead to a lower dose of chemotherapy with fewer side effects, potentially increasing survival rates for patients.
The American College of Rheumatology (ACR) has endorsed six standardized measures to determine rheumatoid arthritis disease activity. These measures are sensitive to change, can discriminate between low, moderate, and high disease activity states, and include remission criteria, making them feasible to perform in a clinical setting.
Research using tDCS shows promise in speeding up word finding in stroke patients and enhancing memory in Parkinson's and Alzheimer's disease patients. Numerical skills can also be improved using tDCS applied to the posterior parietal cortex, with observed improvements lasting up to 6 months.
The program is designed for undergraduate nursing students, providing a rigorous curriculum and mentorship to accelerate completion of a Ph.D. in five years. The scholars will examine complex health issues through innovative approaches, aiming to design and implement research that improves patient care.
The incidence of twin births in the US has increased significantly over the past three decades, with one in every 30 babies born being a twin in 2009. Fertility treatments are a key factor in this increase, accounting for two-thirds of the rise.
Researchers found a decrease in cerebrospinal fluid biomarker P-tau following treatment with bapineuzumab, suggesting potential benefits for Alzheimer's patients. However, further examination is needed to determine if these changes correlate with clinical improvements.
A new study found that robotic-assisted surgery for bladder cancer results in fewer deaths, in-patient complications, and reduced need for intravenous nutrition compared to traditional open surgeries. However, the procedure is more costly due to longer operation times and greater use of disposable instruments.
A recent study published in the Journal of the American College of Radiology found that multi-detector CT scans pose a lower risk of developing secondary cancers among older adults. The researchers analyzed data from Medicare claims spanning eight years and estimated that only 0.03-0.04 percent of the population would develop radiation...
Researchers at Georgia Tech discovered the importance of a hydrogen bonding water network in photosystem II, a critical step in photosynthesis. The study suggests that mimicking this process could provide new supplies of oxygen and hydrogen as a by-product of electricity production.
A study at Wake Forest Baptist Medical Center found that patients prefer immediate access to radiology test results, even for complex diagnoses. The study showed that about half of participants preferred instant access, while a third preferred access within three days.
Research reveals that systemic inflammation causes an increase in depressive symptoms and metabolic changes in the brain's mood-regulating regions. This finding opens doors for testing potential treatments for depression in patients experiencing inflammatory-related symptoms.
A proactive solution could help prevent injuries by restricting driving privileges under favourable conditions. Exemptions would be granted for certified healthy seniors, shifting the onus from others to seek exemptions.
A PET imaging agent has been shown to reverse neurotoxicity and improve motor skills and memory in animal models of Parkinson's disease. The compound works as a scavenger of peroxynitrite, reducing neuronal death and promoting revival of neuronal function.
Researchers have found that individuals with specific gene variants are more likely to develop PTSD symptoms after exposure to trauma. The study suggests a genetic link to PTSD, which could lead to new screening methods and targeted treatments.
Researchers found that stimulating specific neurons can reverse age-related memory defects in fruit flies, which may have implications for human memory disorders. The study used functional cellular imaging to monitor neuron activity and showed that cold-activated ion channels can rescue intermediate-term memory.
Researchers at Yale University have created a compound that prevents the growth of the malaria parasite within red blood cells. The compound, developed by Sidney Altman and his team, shows promise in combating drug-resistant strains of the disease, which kills over 1 million people annually.
A landmark study by University of Leicester researcher Dr Patrick White found that participation in adult learning neither increased nor widened during the first decade of the 21st Century. Despite easier access to the internet, online technologies failed to break down barriers to learning and expand access to previously excluded groups.
A new phase III study comparing the efficacy of Bacillus Calmette Guérin strains Tice and Connaught for non-muscle invasive bladder cancer treatment found that Connaught significantly reduced cancer recurrence rates, with a five-year recurrence-free survival rate of 75% compared to 46% for Tice. The study has the potential to shift the...
A study published in Archives of General Psychiatry found that most teenagers who use alcohol and drugs start using them during adolescence, with the median age of onset at 14 years old. By late adolescence, nearly three-quarters of teens reported having consumed alcohol, and one-fifth had met criteria for lifetime abuse.
The study found that a small amount of money can be an effective motivator, encouraging drivers to arrive earlier or leave later during peak hours. By leveraging social responsibility and game theory, the Capri program aims to reduce rush hour traffic by a few hundred cars.
A study by UBC and IIASA researchers reveals that picky females can promote diversity in species through selective mating. They must occupy different resource hotspots and pay a cost for their preferences to prevent invasion of undesirable areas.
The Lenfest Forage Fish Task Force recommends reducing global fishing for forage fish by half to support larger species in the water. This would contribute an estimated US$11.3 billion to the economy by serving as food for commercially important fish, supporting industries and ecosystems.
Research reveals that death anxiety makes atheists more unconsciously receptive to religious beliefs, while religious individuals strengthen their beliefs at both conscious and unconscious levels. This study contributes to understanding why religion endures as a fundamental aspect of human culture.
Scientists at WashU Medicine are using DNA sequencing to map the genetic evolution of disease and monitor response to treatment. By analyzing tumor samples, they can identify 'driver' mutations and determine whether cells carrying those mutations have been eliminated by treatment.
Scientists have made breakthroughs in reprogramming scar tissue from myocardial infarction (MI) into viable heart muscle cells using viral vectors. The new approach has shown promising results in adult mice and offers a potential solution to the major problem of cardiac regeneration after MI.
A new study found that sleep protects positive memories just as it does negative ones, with significant implications for treating post-traumatic stress disorder. Sleep enhances emotionally positive memories while these memories decay over wake, prioritizing them for processing during sleep.
Researchers have discovered gene variations that predispose cystic fibrosis patients to develop an intestinal blockage while still in the uterus. These variants involve genes responsible for ion transport in the lower end of the small intestine, increasing the risk of meconium ileus and serious health problems.
The South Pole Telescope's data analysis provides strong support for the cosmological constant as the source of dark energy, accelerating the universe's expansion. The results also place tight limits on neutrino masses, shedding light on these mysterious particles' properties.
Epigenetic changes in gene structure lead to higher incidents of obesity and diabetes for mothers with poor nutrition at the time of conception. The study found that dieting around the time of conception and early pregnancy can alter genes controlling food intake and glucose levels, increasing the risk of obesity and type 2 diabetes.
Researchers at Rutgers University found a protein defect that leads to axtaxia-telangiectasia, a degenerative disease affecting cerebellum and brain function. Treating the defective protein with TSA restored motor coordination in mice, suggesting potential reversal of symptoms.
Researchers at Imperial College London found that allowing heart muscle cells to rest can reverse structural changes caused by heart failure. This discovery could lead to new treatment strategies without the need for serious procedures like LVAD implants.
Cardiomyopathy is a deterioration of the heart muscle affecting its pumping ability. MDC-researchers identified RNA binding motif protein 20 (RBM20) as a gene regulating titin splicing, a process connected to the disease. Understanding this mechanism may lead to more efficient molecular diagnosis and therapies for cardiomyopathy.
A new study reveals a global ocean warming trend spanning at least 100 years, with an average increase of .33-degree Celsius in upper ocean temperatures. The research uses historical temperature readings from HMS Challenger's 1872-1876 voyage and modern data from the Argo program.
Researchers found that patients with high levels of Aurora-A protein had shorter survival after surgery compared to those with normal levels. This suggests Aurora-A plays a role in head and neck cancer development and could serve as a new treatment target.
Researchers at Fox Chase Cancer Center found that survivin levels were associated with longer disease-free survival and better response to chemotherapy in patients with pancreatic cancer. The study suggests that survivin could be a useful tool for identifying patients who may benefit from specific treatments.
A new study finds a protective gene in fat cells that helps regulate blood sugar and insulin levels, potentially leading to a new therapeutic strategy for preventing and treating type 2 diabetes. The discovery challenges popular notions of body fat and health.
Researchers identified a rare immune cell's role in antibody production and 'memory' of infectious agents, crucial for vaccine development and potential treatment of immune disorders. T follicular helper cells can remember past infections, enabling rapid responses to future attacks.
A study by UCLA's Jonsson Comprehensive Cancer Center found that patients with both MEK1 and BRAF mutations respond equally well to BRAF inhibitor drugs, challenging conventional wisdom. The presence of both mutations does not contribute to drug resistance in melanoma patients.
A recent study found that raising the school leaving age was met with significant controversy and sacrifice in the past, highlighting potential difficulties in adapting to future changes. The UK's decision to raise the education participation age to 17 in 2013 and potentially 18 in 2015 may face similar challenges.
Researchers have discovered multiple genes associated with meconium ileus, a severe intestinal obstruction present at birth in CF patients. This finding suggests the possibility of personalized approaches to treatment and novel therapeutic targets for individuals with cystic fibrosis.
A University of Utah astrophysicist has proposed that supermassive black holes in galaxy centers grow by consuming single stars from wandering binary pairs. The study found that this process is an efficient way to bring stars close to black holes, outperforming gas clouds as a growth mechanism.
Scientists have discovered that the platelet activating factor receptor plays a crucial role in graft-versus-host disease, which can cause significant tissue damage and mortality. Blocking this receptor may lead to reduced tissue injury and improved survival rates for patients undergoing bone marrow transplants.
The Titanic's sinking was attributed to a combination of structural deficiencies and the Gulf Stream's unusual alignment, weakening the ship's hull. Researchers found that non-uniform rivet composition and insertion contributed to the vessel's vulnerability.
A study by University of North Carolina at Charlotte researchers confirms the connection between metastatic breast cancer and autoimmune arthritis. Mast cells play a critical role in facilitating breast cancer metastasis, with SCF/Kit signaling inducing mast cell differentiation in arthritic conditions. This finding suggests a potentia...
Researchers found four proteins dysregulated by the PI3K/mTOR pathway associated with poor survival in hormone receptor-positive breast cancer. These findings suggest potential new prognostic factors and therapeutic targets for treatment.
Researchers at Fox Chase Cancer Center have identified two proteins that could restore treatment sensitivity to hormone-resistant breast cancer cells. These proteins may help develop a new therapy combining estrogen and interferon-alpha, offering more treatment options for patients with resistant disease.