Researchers developed a mouse model of Fukuyama's muscular dystrophy that accurately replicates human disease pathology. The study found that removing the fukutin gene at different stages of development led to varying degrees of muscle impairment.
Researchers find that certain RNAs can pause without being degraded, enabling protein production, and suggesting multiple proteins could be made from the same mRNA
A new study in Neurology questions the validity of a quality measure for stroke care, suggesting that patient decisions may account for up to 40% of hospital deaths within 30 days. The study found that 41% of patients could have been kept alive with continuous medical interventions, effectively reducing mortality rates by 3.2%.
Drs. Blazar and June will present their lecture on adoptive T-cell therapy, which has potential to establish tolerance to hematopoietic or solid organs allografts, treat autoimmunity, and promote immunity to cancer and chronic infection. The researchers have made significant contributions to advancing the field of BMT.
Patients with psoriasis are at higher risk of new-onset diabetes mellitus due to chronic inflammation. The study found that the risk increases with severity of psoriasis, with patients having severe psoriasis being more than twice as likely to develop diabetes.
A new study by Cornell University finds that employed mothers spend three-and-half fewer hours per day on children's diet and exercise compared to stay-at-home mothers. Meanwhile, working fathers devote just 13 minutes daily to such activities.
Tropical Storm Isaac is showing signs of consolidation according to NASA's infrared time series data, indicating a more organized circulation center. The storm is expected to strengthen into a hurricane over warm waters of the Gulf of Mexico.
Research at ESC Congress 2012 found that renal denervation regenerates blood vessels, reducing cardiovascular events. The procedure improves central hemodynamics and arterial stiffness in patients with resistant hypertension, suggesting a potential 'fountain of youth' for blood vessels.
A new study suggests that nicotinamide, a form of vitamin B3, can increase the ability of immune cells to kill staph bacteria by 1,000 times. This could offer a new tool in the fight against 'superbugs' and potentially reduce dependence on antibiotics.
The PROTECT study found that zotarolimus-eluting and sirolimus-eluting stents have comparable rates of stent thrombosis at three years. The study also showed that dual antiplatelet therapy use can affect the long-term clinical relevance of stent type.
A recent Special Focus in Human Vaccines & Immunotherapeutics discusses the mistakes of past cancer vaccine programs and provides critical insights into the future of cancer vaccines. The study emphasizes the importance of antigen discovery and personalized approaches to overcome the challenges of tumor heterogeneity.
Cytomegalovirus (CMV) infection is a significant risk factor for type 2 diabetes in the elderly, according to new research. CMV infection can cause inflammation and damage pancreatic cells, leading to insulin resistance and increased glucose levels.
Researchers at the University of Delaware found that beneficial bacteria in soil can signal plants' stomata to close, preventing disease infection. This discovery highlights the potential for probiotics to bolster plant immunity naturally.
Researchers have discovered that methane from lakebeds is present in fish tissue through the food chain. The study uses two biomarkers to confirm the finding, increasing the certainty of its results. Methane oxidizing bacteria are consumed by zooplankton and other aquatic organisms, which eventually end up in fish stomachs.
The University of Tennessee team will combine molecular biology, ecological analysis and environmental remediation to create mathematical models of ecosystem function and provide a strategy for Chinese government officials to balance Lake Taihu's ecosystem. They will examine all contributing organisms to toxic algal blooms and develop ...
Dr. James George is recognized for his pioneering work on platelet glycoproteins, diagnosis and clinical management of idiopathic thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP). He has also made significant contributions to education, research, and practice through various initiatives.
A study examined the long-term safety of two different types of drug-eluting stents, finding no significant difference in stent thrombosis rates over three years. However, differences emerged when dual antiplatelet therapy was used low, suggesting its importance for patients with these stents.
Scientists have discovered a way to manipulate superconducting materials using light. This breakthrough allows for the creation of ideal superconductors with continuous electrical current without losing any power. The research has potential applications in developing non-dissipated memories and improving energy efficiency.
A drug trial found that TAS-102 improved survival time, reduced risk of death, and controlled disease progression in patients with advanced, inoperable colorectal cancer. Patients treated with TAS-102 had a median overall survival of 9 months, compared to 6.6 months for the placebo group.
The study found a decline in mortality rates among STEMI patients in France from 1995 to 2010, attributed to increased use of reperfusion therapy and recommended treatments. The proportion of younger women with STEMI also increased, consistent with declining prevalence of hypertension, diabetes, and hypercholesterolemia.
A team of scientists has discovered the oldest record of arthropods, including insects and mites, preserved in 100 million-year-old amber. The findings, published in the Proceedings of the National Academy of Sciences, provide new insights into the evolution of life on Earth.
Renal denervation significantly and sustainably lowers blood pressure in patients with resistant hypertension, reducing risk of kidney disease and cardiovascular events. The Symplicity HTN-2 trial demonstrates the procedure's effectiveness in achieving substantial blood pressure reductions for up to 18 months.
The ASGE initiative focuses on developing guidelines for real-time imaging of Barrett's esophagus, addressing the need for more accurate surveillance protocols. High-risk individuals require regular endoscopy screenings, but current methods have shortcomings due to dysplasia and cancer sampling errors.
A new method, SPR microscopy, allows for quantitative analysis of protein interactions on cell surfaces, streamlining drug development and diagnostic biomarker identification. The technique provides high-resolution spatial and temporal information, revealing dynamic processes evolving over time.
The IABP-SHOCK II trial randomized 600 patients to receive either an intraaortic balloon pump or conventional optimal medical treatment, but found no reduction in 30-day mortality rates. The study also showed that the IABP did not improve blood pressure, organ perfusion, or reduce treatment time in the intensive care unit.
A recent study from Rhode Island Hospital found that nearly seven percent of urologic multi-detector CT scans for hematuria resulted in clinically important incidental findings. The most common findings were lung nodules, aneurysms, and ovarian cysts, with only a small percentage requiring immediate medical attention.
A recent study by San Diego Zoo Global researchers found that giant pandas make specific choices when selecting trees for scent marking. The choice of tree is influenced by factors such as bark roughness, presence of moss on the trunk, tree diameter, and distance to trails.
Scientists at Vienna University of Technology developed a method called 3D-photografting, which allows them to attach molecules at exact positions. This technique can be used to grow artificial biological tissue with specific inner structures and create tiny three-dimensional 'labs on a chip' for sensor technology.
A new study from the University of Missouri finds that separated parents who use technology effectively can coordinate exchanges about their children more easily, reducing stress on kids. In contrast, hostile couples use communication tech to manipulate or withhold info, causing pain to children.
Dr. Keith Crandall's research in the journal Ecology and Evolution found that Cerataspis monstrosa is a larval stage of the deep-water aristeid shrimp Plesiopenaeus armatus. The discovery sheds light on biodiversity and life history of the organism.
Researchers found that midlife fitness levels can lower the onset of chronic diseases such as congestive heart failure, Alzheimer's disease, and colon cancer decades later. Fitter individuals aged well with fewer chronic illnesses to impact their quality of life.
The ASTRID study found that patients with high and very high risk benefited from transfemoral TAVI, with mortality rates of 4.7% and 7.7%, respectively. The registry also showed differences in vascular complications and residual aortic regurgitation between valve types.
A new genre of young adult literature, 'teen sick-lit,' portrays chronically ill protagonists as vessels for others' emotional development rather than self-actualized women. The study found little empowerment in these books, instead reinforcing negative stereotypes and societal norms.
The researchers successfully packaged siRNA in a hydrogel complex that can be injected into target tissues, allowing for prolonged control over cell behavior. The technology has the potential to guide stem cells to grow into desired cell types, starve tumors by blocking blood vessel growth, and induce cancer cell death.
The Wilderness Medical Society has released new guidelines to prevent and treat lightning injuries, with recommendations for effective medical treatments post-strike. These guidelines aim to lower the likelihood of being killed or injured from lightning strikes.
A study led by Iliana Baums found that coral larvae are unable to traverse the Eastern Pacific Barrier, corroborating Charles Darwin's 1880 prediction. The research has significant implications for climate-change research, species-preservation efforts, and economic stability in the eastern Pacific region.
Researchers propose that certain dietary fats encourage the growth of harmful bacteria, leading to low-level inflammation and chronic disease. Unsaturated fats, like omega-3 fatty acids, have strong antimicrobial properties, weakening bacterial cell membranes.
A University of Oregon team has developed a formula to refrigerate coal-plant emissions, reducing carbon dioxide by 90%, sulfur dioxide by 98%, mercury by 100% and other pollutants. The process would save society 38% through reduced health-care and climate-change costs.
A new imaging technique has been developed to measure catalytical reactions of single nanoparticles and multiple particles printed in arrays. This allows researchers to determine the relationship between efficiency and nanoparticle size, shape, and composition, enabling fast screening of different nanoparticles.
A longitudinal study of over 1,000 New Zealanders found that persistent cannabis use before age 18 led to significant declines in IQ, attention, and memory. The study suggests that adolescence is a critical period for brain development and vulnerability to substance-induced harm.
Scientists at Duke University Medical Center found that breast milk fosters colonies of microbiotic flora in a newborn's intestinal tract, while infant formulas do not. This unique property of breast milk aids nutrient absorption and immune system development, suggesting potential approaches for developing substitutes.
Recent studies suggest genes play a significant role in shaping political preferences and traits. Twin studies have implicated several genes in influencing political issues such as the death penalty, unemployment, and abortion, with future research holding promise for deeper insights into genetic influences on politics.
Researchers found that successive leg compressions trigger natural protective mechanisms reducing damage after a stroke. The technique, called remote ischemic perconditioning, reduced stroke size by 25.7% in animal models, doubling its efficacy when combined with tPA, the current FDA-approved stroke therapy.
Recent studies suggest that mesalamine and probiotics may help prevent recurrence of diverticulitis. Inflammation after an acute episode is a risk factor for recurrence, highlighting the need for new therapeutic approaches to managing the disease.
A second specimen of Ernanodon antelios sheds new light on the mysterious ancient mammal, revealing it was highly specialized for digging. The fossil skeleton provides key information about its habits, lifestyle, and affinities, resolving long-standing controversies in the scientific community.
Researchers found that wallabies regulate growth of their young by selectively imprinted insulin gene, similar to human placenta. Insulin expression in mammary gland increases after birth, indicating critical role for genomic imprinting in post-natal growth.
A new study found that grasses coated with latex paints show a notable reduction in photosynthesis. The researchers discovered that red paint is more damaging to total canopy photosynthesis (TCP) than white paint, while diluting each color with water reduces their negative effects.
Scientists developed a tool to identify bays with suitable habitats for resting spinner dolphins, allowing conservation efforts to focus on specific areas. The maps aim to minimize human disturbances and protect the dolphins' ability to rest, forage, and communicate effectively.
A new formulation of cisplatin has been developed to improve the effectiveness and safety of cancer treatment. The pH-sensitive liposome was able to reduce cancer cell proliferation and increase survival in animal models with no known toxicity clinical signs.
A new study finds that everyday discrimination against pregnant women of color may contribute to low birth weight babies. Women who experienced more discrimination reported higher levels of depressive symptoms, leading to babies with lower birth weights. The study suggests reducing discrimination could eliminate health disparities in b...
Dr. Ley's work on whole genome sequencing in AML has provided unprecedented insights into the disease, highlighting the importance of unbiased methods for discovering cancer-initiated mutations. His research also revealed that most AML mutations are benign background events, with only a handful contributing to pathogenesis.
Research from the European Society of Cardiology reveals that normal-weight individuals with belly fat have a higher death risk than obese individuals. The study found that those with central obesity, even at a normal weight, had the highest cardiovascular death risk and death risk from all causes.
Researchers analyzed data from US Army vehicle crashes to identify risk factors for injuries involving Humvees. Combat involvement and operating as a gunner posed the greatest risk for injury.
Research demonstrates that plants trigger their defense mechanisms against freezing temperatures with shortening daylight, unlike trees which do it with waning sunlight. This understanding gives potential tools to fine-tune regulation and increase crop productivity.
Researchers found a correlation between low solar activity and cold Central European winters, with the Rhine River serving as a proxy. The study suggests that periods of low sunspot numbers lead to regional cooling, with implications for climate research and the debate on anthropogenic climate change.
A new study found that reducing television viewing among adolescents can lead to a decrease in excess weight gain over one year. The intervention included limiting TV hours, setting up home-based activities, and sending monthly newsletters.
The ORIGIN-GRACE study found that insulin glargine significantly reduced secondary outcomes of atherosclerosis progression, but had no effect on primary outcomes. Omega-3 fatty acid supplements also showed no significant effect on either outcome.
A study by Berkeley Lab scientists found that older men who consume more vitamin C, E, folate, and zinc have less sperm DNA damage. This suggests that adequate micronutrient intake can help counteract the detrimental effects of aging on sperm genome health.
A research-based report by an international Media Violence Commission confirms that media violence exposure increases the relative risk of aggression. The commission recommends that parents know what media their children and adolescents are using and set limits on screen time to promote critical thinking and healthy consumption.
High doses of vitamin B3 stimulate a specific gene to enhance white blood cells' ability to combat staph infections. The study found that vitamin B3 increased the body's immune system by up to 1,000 fold, killing staph bacteria in laboratory tests