Scientists at Case Western Reserve University have developed a method to create three-dimensional gradients of signals that guide stem cell behavior. The system can help discern recipes for tissue and organ repair and replacements by controlling the spatial presentation of growth factors, physical triggers, and adhesion ligands.
A new trial will test an anti-amyloid treatment in 650 adults at highest genetic risk for late-onset Alzheimer's, using the Alzheimer's Prevention Registry for enrollment. The study aims to prevent clinical onset of Alzheimer's and find effective treatments as soon as possible.
A new study from MIT reveals a gene essential for memory extinction, which could benefit people with posttraumatic stress disorder (PTSD). Enhancing the activity of this gene, Tet1, might make it easier to replace fearful memories with more positive associations.
A new study published in Obesity found that physical activity and weight loss conducted together results in improved body composition and reduced cardiovascular disease risk. The study showed that intentional weight loss can have positive health benefits for older adults, particularly when accompanied by physical activity.
A study found that socially dominant red deer individuals have faster heart rates and higher body temperatures during winter, leading to greater body mass loss when food is scarce. In contrast, subordinate individuals are better adapted to survive harsh conditions by reducing their metabolism and conserving energy.
Researchers used a mathematical method to simplify olfactory information into coherent categories, similar to compressing digital audio files. The team identified 10 basic odor qualities, including fragrant, fruity, and pungent smells.
A new study has found that a smartphone app can quickly screen for cognitive dysfunction often found in patients with cirrhosis. The app, called EncephalApp_Stroop, is a valid method for screening minimal hepatic encephalopathy (MHE) and may improve treatment rates in potential patients.
A newly discovered role for a protein family could provide a path to modifying crop traits. The discovery reveals that this protein regulates gene expression in response to light color changes, potentially allowing for new approaches to trait modification in agriculturally significant plant species.
A study by UC Davis MIND Institute found that none of the children with 22q11.2 deletion syndrome met strict diagnostic criteria for autism. Evaluations should be performed to assess autism and guide therapy selection based on symptoms such as language delay.
A new clinical trial has launched, aiming to prevent Alzheimer's disease by giving new drug treatments before dementia symptoms appear. The trial, led by principal investigator Randall Bateman, is testing two innovative treatments and has been made possible through a unique collaboration of private and public resources.
Scientists at UTHealth Medical School developed a brown fat detection method that worked in an animal model, providing a new tool to fight obesity. The peptide probe can be used for whole-body imaging and localization of brown fat tissue.
A MU researcher found that certain types of stories in patient decision-aids can inform patients' decisions without influencing their choices. Process narratives helped women search for information, while experience narratives improved their ability to envision treatment outcomes and evaluate their decisions more favorably.
Researchers have developed a lens that combines the focusing ability of a human eye with the wide-angle view of an insect eye, enabling objects to appear in sharp focus even at varying distances. This technology could lead to improved smartphone camera quality and enhanced depth perception for medical imaging.
A new study will offer young people living in residential care homes or with foster carers the chance to speak out about why they self-harm. The project aims to identify common themes leading to self-harm behavior and highlight successful services supporting looked-after youth in recovery.
Scientists at Brown University have discovered a novel compound that can kill the TB bacterium by inhibiting ClpP, a cellular enzyme not targeted by any antibacterial drugs. The findings could lead to new treatments for tuberculosis and other infections resistant to traditional antibiotics.
A study found nearly 1 in 10 U.S. watersheds are stressed due to high demand for water exceeding natural supply. Climate change is projected to exacerbate this trend, creating challenges for agriculture, electrical suppliers, and municipalities.
A study published in Clinical Chemistry found that SHBG levels are significantly associated with type 2 diabetes risk in women, with age, estrogen therapy, and coffee consumption being key predictors. The research also suggests that adjusting these factors may impact SHBG levels and ultimately diabetes risk.
The Society for Neuroscience announced the winners of its third annual Brain Awareness Video Contest, featuring videos on a little-known brain disorder, memory, and mind reading. The top ten videos will compete for a People's Choice Award and will join over 1,000 resources on BrainFacts.org.
The National Institutes of Health (NIH) is funding new bird flu vaccine studies to protect against a deadly strain that caused severe disease in China last spring. The study aims to fine-tune the process of creating an effective vaccine, with the goal of preventing future pandemics.
Researchers at NYU College of Dentistry have discovered a new way HIV-1 reproduces itself without integrating its genetic material into cell DNA, allowing the virus to persist in vivo and evade antiviral drugs. This finding may lead to the development of new treatments aimed at eliminating the virus from infected individuals.
The Johns Hopkins Berman Institute of Bioethics has been selected to establish a Center of Excellence to study the ethical, legal, and social implications of genomic research in infectious disease. The center will explore public health genomics in two case studies: pandemic influenza and Hepatitis C.
Researchers have developed a novel treatment for gonorrhea that works like a live vaccine, reversing immunosuppression and preventing reinfection. The treatment, administered intravaginally, uses microsphere technology to stimulate an immune response against the bacterium.
A study has found that market bubbles leading to financial crashes may be self-made due to brain processes that help traders predict others' behavior. This research offers insight into the biology of financial decision-making, suggesting that unproductive behaviors can drive cycles of boom and bust.
Researchers measured undersea current of warm water driven by fresh water from the melting glacier. The measurements will be used with physical and computer models to predict future changes in the ice shelf and glacial melt rates.
A two-year experiment at Clemson University found that steers grazing on various forages showed significant differences in growth, carcass quality, and meat taste. Finishing on legumes like alfalfa and cowpea increased carcass quality, while bermuda grass and pearl millet improved healthy fatty acid levels.
Researchers found that 30 minutes of daily exercise is just as beneficial as an hour-long workout in improving energy levels and motivation for a healthy lifestyle. The study suggests that moderate exercise can significantly impact daily practices and overcome cultural barriers to change.
The American College of Cardiology's clinical data registries report a significant increase in radial stenting, reducing complications and recovery times. The study also highlights successes in heart disease care, including improved Door-to-Balloon times and optimal medical therapy prescriptions.
A study in Malawian children found chronic inflammation in blood vessels after recurrent malaria episodes, predisposing future infections and cardiovascular disease. The findings explain high childhood mortality rates in malaria-endemic areas.
Researchers find removing MBD3 protein increases efficiency of stem cell reprogramming from 1% to 100%, allowing for faster production of cells for medical use. This breakthrough provides a deeper understanding of embryonic development and could advance treatment of various diseases.
A new study published in the New England Journal of Medicine reinforces the value of colonoscopy screening for colorectal cancer prevention. Researchers analyzed data from nearly 90,000 people and found that colonoscopy lowered cancer-occurrence rates in both the distal and proximal sections of the colorectum.
Romanian scientists have discovered a novel approach for the optical manipulation of macromolecules and biological cells using green photon beams. This method enables precise control over macrostructures, such as biological proteins, outperforming traditional optical tweezers.
Researchers at the University of Maryland are developing a vaccine to protect adults from the H7N9 influenza virus, which has caused 135 human cases and 44 deaths in China. The study aims to gather critical information on the safety and effectiveness of the vaccine and its ability to induce an immune response.
Scientists at A*STAR's Singapore Immunology Network have discovered a new mechanism involving p53, the famous tumor suppressor, to fight against aggressive cancers. The strategy works by sabotaging cancer cells' ability to hide from the immune system, opening a new avenue for targeted therapy.
Tropical Depression 18W formed in the South China Sea and is forecast to quickly make landfall in central Vietnam on September 19. The depression has sustained winds of near 25 knots and is expected to dissipate within a day after landfall.
A new thermocouple developed by researchers at the University of Cambridge can reduce drift by up to 90% at temperatures above 1300 degrees Celsius, potentially doubling the lifespan of engine components. This could lead to significant cost savings for manufacturers and improved fuel efficiency.
The National Science Foundation has awarded $50 million to Cold Spring Harbor Laboratory and other institutions to create a national cyberinfrastructure for the biological sciences. This grant will enable scientists worldwide to analyze large datasets efficiently, addressing global research priorities.
A study published in PLOS ONE found that e-readers with short lines of text increased reading speed and comprehension among some dyslexic high school students. This suggests that the use of short lines on e-readers may help reduce visual distractions and improve focus for individuals with dyslexia.
A University of Alberta research team found that inhaled corticosteroid use was associated with a 90% increase in risk for repeat pneumonia episodes among elderly patients. The study, published in Clinical Infectious Diseases, suggests health professionals should exercise caution when prescribing the drugs to high-risk patients.
A 22-year study of 88,902 participants found that colonoscopy reduced death from colorectal cancer by up to 40% compared to sigmoidoscopy. The study suggests that colonoscopy is the most effective screening method for preventing colorectal cancer.
A large study found that colonoscopy screening can prevent up to 40% of colorectal cancers, with more frequent intervals recommended for those with a personal history of adenoma or family history of colorectal cancer. The study also suggests that sigmoidoscopy alone is insufficient for reducing the incidence of proximal colon cancer.
The root microbiome plays a vital role in plant functions and ecosystem well-being, influencing genetic structure, health, and interactions with other plants. Microbial organisms associated with plant roots have far-flung global influences, from regulating plant performance to facilitating crop production in harsh climates.
Scientists tap into bug biology to design new materials, such as artificial ligaments and chemical-free pest control methods. The study of caddisfly silk reveals its unique properties, including water resistance and collagen-like behavior. Additionally, researchers use X-ray technology to better understand human muscle mechanics and po...
University of Adelaide researchers have identified a likely molecular pathway that causes neurodegenerative diseases such as Huntington's and Lou Gehrig's. The team found that RNA plays a key role in the development of these diseases, which share similar genetic mutation mechanisms.
UT Southwestern researchers discover that a protein overactivity sabotages cellular recycling, leading to heightened cancer growth and chemotherapy resistance. Autophagy inhibition may worsen chemotherapy outcomes for patients with specific cancer mutations, according to the study published in Cell.
Research finds high levels of Fragile X Mental Retardation Protein (FMRP) in human breast tissue correlate with increased risk and spread of breast cancer. FMRP acts as a master regulator controlling aggressive cancer progression.
A new observational study suggests that bioidentical hormones in transdermal patches may be associated with a lower risk of heart attack, while FDA-approved products may carry a slightly lower risk of stroke compared to synthetic hormones. The findings are inconclusive and require confirmation by randomized trials.
Researchers at NC State have developed a technique for personalized searches that can handle complex queries and scale up to support thousands of concurrent users. The new approach uses ambient query context to determine user intent in real-time, allowing for more accurate results and better handling of ambiguous searches.
Researchers at NIST and Applied Research Associates developed a microfluidic technique to recover DNA from complex mixtures like dirt. This method delivers optimal DNA concentrations for human identification procedures, potentially miniaturized for use outside the laboratory.
Researchers have developed a new temperature-regulated delivery system that can release drugs or fragrances in response to body heat, offering greater control over delivery. The system uses microscopic bottle-like structures with melting corks made of fatty acids, which can be tailored to specific temperatures.
According to a recent study, over 43 million adverse events caused by substandard care occur in hospitals annually. The burden is highest in low and middle-income countries, where blood clots are the most common type of substandard care.
Researchers estimate Earth's habitable lifetime to be between 1.75 and 3.25 billion years, after which temperatures will become too high to support liquid water. This timeline suggests that complex life like humans may only emerge within a fraction of the planet's total habitable time.
A research team identified two genes, IRE1 and XBP1, that control response to proteasome inhibitors, which are commonly used to treat multiple myeloma. The study found that these underlying progenitor cells can survive treatment and lead to disease relapse.
A study by James Cook University found that early publication is a key factor in predicting success in scientific research. Women face disadvantages due to language barriers and family responsibilities, hindering their progress. Publishing early and often helps scientists gain a competitive edge and become superstars in their field.
Researchers have discovered that non-coding genes are regulated by protein-DNA interactions and can be targeted with more effective drugs. Using high-resolution technology, scientists identified 150,000 complexes along non-coding stretches of DNA in leukemia cell lines.
A new report from NREL and MIT reveals that China's dominance in solar manufacturing is largely due to its production scale advantages, including access to capital and supply chain benefits. The study suggests that these advantages can be replicated in the US with innovative technology and scale-up.
A new study by Brigham Young University professor Arden Pope found a 35% reduction in deaths and disability attributable to air pollution in the US since 1990. This improvement is attributed to cleaner air quality, with significant reductions in cardiovascular disease and respiratory problems.
Tropical Storm Humberto re-formed over two days, with significant changes observed in rainfall patterns by NASA's TRMM satellite. The HS3 mission uses Global Hawk aircraft to investigate storm processes and gather data on the environment of the storm.
A study from Concordia University's John Molson School of Business found that physical contact and ethical marketing can boost consumer preference. The research shows that utilitarian claims should be paired with practical products, while symbolic claims should be paired with symbolic products.
A new marker called isocitrate dehydrogenase (IDH1) has been identified as a non-invasive diagnostic marker for lung cancer, with high sensitivity and specificity in detecting non-small cell lung cancers (NSCLC). IDH1 levels were found to be significantly higher in patients with lung cancer compared to healthy controls.
A review study of 1,500 patients found that financial incentives can increase exercise amounts, helping to overcome time commitment and discomfort barriers. The study suggests providing short-term incentives can drive long-term behavior change, preventing repeat heart events and saving the health system millions.