A University of Colorado Cancer Center study found that crizotinib treatment reduces kidney function in ALK positive non-small cell lung cancer patients. Kidney function recovered after treatment, but additional tests are recommended if concerns arise.
The Total solar irradiance Calibration Transfer Experiment (TCTE) was launched by NASA using a combination of enthusiasm, spare parts, and resources. The instrument was assembled in just five months to fill a gap in the data record after an aging satellite's battery life expired.
A team of scientists at the University of California, San Francisco has identified a previously unknown pocket on the K-Ras protein that can be targeted by a new compound. This compound inhibits only mutant K-Ras and leaves normal protein untouched, offering real translational implications for cancer patients.
Early data from a Polish patient study suggest the investigational bioengineered vessel may be effective as a dialysis graft, with 100% of patients regaining blood flow after initial loss. The technology uses human tissue and has shown no signs of infection or immune reaction.
Scientists confirm the extinction of Darwin's frogs caused by chytridiomycosis, a fungal disease affecting amphibians. Conservation efforts are crucial to protect the remaining species, emphasizing the importance of preserving biodiversity.
Research at St. Michael's Hospital found that bedside handover, where patients are involved in the transfer of accountability with their care team, can reduce potential errors and improve patient engagement. The study also showed that this approach increases patient safety, satisfaction, and better informs care plans.
Studies show that concussions can lead to brain abnormalities four months after symptoms have resolved, with memory and behavioral issues improving more quickly than physical injuries. These findings suggest that healing from concussions may be similar to recovering from burns, with tissue scabs forming before the body is fully healed.
A new study has found that long-term unemployment may accelerate aging in men by shortening their telomeres, which protect genetic code from degradation. This association was found in a study of over 5,600 Finnish men born in 1966.
Researchers have discovered the human enzyme PrimPol, which recognises and repairs DNA lesions during replication, preventing breaks in chromosomes. This ancient enzyme has been found in archaebacteria and is thought to have played a key role in genome evolution and cancer development.
A University of Tennessee professor has received a $100,000 grant from the Bill and Melinda Gates Foundation to develop an improved condom design that enhances pleasure while preventing disease and unplanned pregnancies. The new condom incorporates superelastomers, allowing for thinner, more comfortable designs.
A study of 27 healthy adults showed that drinking caffeinated coffee significantly improved blood flow in a finger, with a 30% increase compared to decaffeinated coffee. The researchers suggest that caffeine may help open blood vessels and reduce inflammation, providing new insights into how coffee may benefit cardiovascular health.
A groundbreaking discovery in 1993 led to the development of a cancer treatment, Erivedge, which targets the hedgehog signaling pathway. The breakthrough was made by researchers investigating fundamental mechanisms regulating vertebrate brain development.
A new study highlights the long-term benefits of rotator cuff surgery, showing significant cost savings and improved quality of life for patients. The study estimates that surgeries result in a lifetime societal savings of approximately $3.44 billion annually.
A recent study published in the New England Journal of Medicine found an inverse association between nut consumption and total mortality in both men and women. Nuts contain essential nutrients and phytochemicals that may offer cardioprotective, anticarcinogenic, anti-inflammatory, and antioxidant properties.
Researchers found that harvesting invasive plants for biofuels is hindered by high costs, lack of specialized equipment, and variable cell wall composition. Despite this, alternative uses for invasive biomass, such as combustion for electricity, may offer a more practical solution.
The University of Illinois has won Grand Challenges Explorations grants to develop a single-dose vaccine for multiple animal diseases and a system to study the microscopic parasite Cryptosporidium. This funding aims to address pressing disease problems in developing nations, improving animal health and productivity.
Close to 1,400 tons of chemical weapons remain in Syria, requiring multiple strategies for destruction. Destroying the stockpile will require specialized equipment and careful handling of precursor chemicals.
Researchers at UCSF have developed a new strategy to block the mutated ras protein, which drives three out of ten cancers, including lung and colon cancers. The small molecules efficiently kill ras-driven cancer cells in human lung cancer cell cultures.
A 24,000-year-old Siberian individual's genome shows close affinity to modern Native Americans and west Eurasians, contradicting the traditional East Asian origin story. This finding indicates two distinct Old World populations contributed to the formation of the First American gene pool.
Researchers at Scripps Institution of Oceanography have developed a method to genetically engineer marine algae to produce more lipids, the fat molecules that store energy for fuel. This breakthrough enhances biofuel production and has the potential to lower costs and increase efficiency.
Researchers found that house sparrows' immune cells become more attuned to finding dangerous parasites at the edge of their range in Kenya. This adaptation may help the birds thrive in new areas with novel pathogens. The study aims to understand what gives invasive species an edge, informing efforts to manage and eradicate them.
Researchers develop technique to make curved surfaces appear flat to electromagnetic waves, enabling bespoke antenna design for increased efficiency and reduced weight. This breakthrough could lead to ultra-fast wireless communication over surface in near future.
Researchers at Brigham and Women's Hospital found a link between insomnia symptoms and higher mortality risk in men, particularly those with difficulty falling asleep and non-restorative sleep. The study, published online in Circulation, followed over 23,000 men for six years and found modest increases in cardiovascular-related death.
Researchers found that surgical patients in US children's hospitals account for 43% of all antibiotic use, with pneumonia, appendicitis, cystic fibrosis, and skin infections being high-usage conditions. The studies provide insights into antibiotic resistance patterns and opportunities for targeted antimicrobial stewardship efforts.
A Dartmouth-led study reveals that arsenic exposure can be significant through dietary means, especially from consuming alcohol and Brussels sprouts. Researchers found a strong correlation between toenail clippings and arsenic levels, particularly in those who drank more alcohol and ate more dark meat fish.
A new study published in Human Genetics found that 180 DNA variants predict tall stature in Europeans with an accuracy of 0.75.
Research finds that treating arteriovenous malformations (AVMs) in the brain can increase risks of stroke and death, while managing symptoms may be safer. The study suggests observing patients with AVMs for at least five more years to confirm this finding.
Researchers at MIT have discovered a way to boost heat transfer using magnetic nanoparticles, which could lead to more efficient cooling systems. The system relies on a slurry of tiny magnetite particles that are attracted to the heated surface by magnets, resulting in significantly improved heat transfer.
The study analyzed ASTER images of Tacloban before and after the typhoon, revealing widespread destruction. The storm surge caused mud-covered ground, bare trees, and destroyed buildings, with some areas showing no vegetation.
Researchers found that genetic differences in a vitamin D carrier protein referred to as D-binding protein could explain the discrepancy between diagnosed vitamin D deficiency and lack of symptoms in black Americans. The study suggests that current methods may not accurately determine vitamin D deficiency, leading to unnecessary treatm...
Researchers at the Buck Institute identified a suite of epigenetic markers that separated younger from older individuals, with changes associated to genes regulating neuromuscular junction activity. The study provides a method for studying sarcopenia and offers potential targets for intervention.
Economic downturns in mid-life may lead to lower cognitive ability and memory problems later on, with men experiencing more severe effects. Analyzing data from 12,000 Europeans, researchers found that those who faced economic recessions during their 40s had poorer cognitive performance at age 50.
Researchers identified epigenetic alterations associated with the aging process in disease-free breast tissues, which are further altered in breast tumors. These changes may contribute to the development of breast cancer by increasing cancer risk.
A significant X-class solar flare occurred on Nov. 19, 2013, peaking at 5:26 a.m. EST, causing disturbances in the atmosphere where GPS and communications signals travel. The flare was classified as an X1.0 class, indicating its intensity.
Researchers at Mount Sinai found long-term cocaine abuse linked to deficits in parts of the brain monitoring behavior, suggesting targeted treatments based on quantifiable biological abnormalities. The study's findings challenge clinical assumptions about addicted individuals' motivations and behaviors.
A new Cornell study found that larger bowl sizes lead to increased requests for cereal and milk by kids, resulting in higher intake and waste. Using smaller dishware may be a simple solution for caregivers concerned about their kids' caloric intake.
The Henry Samueli School of Engineering at UC Irvine has received a $100,000 grant to further develop its stored energy solar stove, which enables carbon emissions-free cooking. The technology uses a solar collector to concentrate sunlight on an energy storage device, storing heat that can be released as needed.
A 10-year study on national wildlife refuges found frog abnormalities at less than 2% overall rate, but higher rates in specific 'hotspots'. The study suggests that these hotspots have local causes and can recover over time.
Kytai Nguyen, associate bioengineering professor at UT Arlington, has been elected as a fellow of the American Heart Association. Her research focuses on cellular engineering, tissue engineering, and stem cell therapies to develop new strategies for combating cardiovascular diseases.
Researchers found specific neurons in the amygdala of autistic individuals respond differently to faces, with reduced processing of the eye region compared to control-group individuals. These neurons also responded more strongly to mouths than eyes, shedding light on abnormal face processing in autism.
A new rabies vaccine aims to develop a single dose contraceptive vaccine, reducing child deaths and controlling dog rabies. The vaccine targets dendritic cells to induce strong immune responses against rabies and foreign antigens.
A recent study published in the British Medical Journal found that top-performing hospitals had fewer readmissions from all diagnoses and time periods after discharge. The researchers concluded that preventing complications is key to reducing readmissions, suggesting a more holistic approach to patient care.
Breastfeeding and introducing solid foods between 17-24 weeks of age can help develop a stronger immune system against food allergies. This approach is supported by the American Academy of Pediatrics and European Society of Paediatric Gastroenterology recommendations.
A recent study from Queen Mary University of London found that high levels of control, emotional support, and low job strain significantly contribute to better wellbeing. The research suggests increasing positive aspects of work, rather than just reducing negative ones, may lead to improved morale and greater wellbeing.
Researchers at U of T's IBBME and McEwen Centre for Regenerative Medicine identified the optimal human heart cell composition and ratio associated with heart function. The discovery has led to the engineering of the first-ever living, three-dimensional human arrhythmic tissue.
A study published by The Endocrine Society found that older men with optimal testosterone levels lived longer, while those with high or low levels had a higher mortality risk. Higher DHT levels were also associated with reduced ischemic heart disease mortality.
A Michigan State University study discovered anatomical differences in the brains of children with nonverbal learning disability compared to those with Asperger's and high-functioning autism. The research found smaller spleniums in children with NLVD, which may lead to more targeted intervention strategies.
UC Riverside plant geneticists Mikeal Roose and Timothy Close are developing a genetic tool to improve citrus breeding. They will use high-density SNP genotyping arrays to study citrus varieties and hybrids, identifying genes for disease resistance, fruit quality, and other essential traits.
Researchers at Massachusetts General Hospital have developed an approach to increase beneficial HDL cholesterol levels in non-human primates by targeting shared nucleotide sequences that inhibit microRNAs. This strategy showed a nearly 40% increase in HDL levels, outperforming current therapies.
The job market is forecasted to be mixed for college graduates, with hiring for MBAs declining by 25% due to huge layoffs in the banking industry. However, many other fields are expected to see significant increases in hiring, including manufacturing, nonprofits, and retail.
The hospital achieved excellence through strategies such as reducing overhead paging and establishing daily hospital huddles to prioritize patient needs. UT Southwestern's neurology and neurosurgery programs are nationally ranked.
NASA's TRMM satellite monitored Tropical Storm Melissa's transition to a tropical storm, revealing intense rainfall rates of up to 55 mm/hour. The satellite's Precipitation Radar data also showed the storm's structure, including towering convection near its center.
A study found that older people who smoked less than 32 pack years and quit smoking 15 or fewer years ago had similar cardiovascular death risks as those who never smoked. Many participants reduced their risk in under 15 years, contradicting previous estimates of a longer waiting period.
Research reveals that treating prisoners with schizophrenia both during imprisonment and after release can substantially reduce the risk of violent reoffending. Maintaining psychiatric treatment for these individuals is essential to prevent violence.
Researchers at USC Viterbi School of Engineering have developed a new 3D printing process that can fabricate heterogeneous objects in minutes, not hours. This breakthrough enables the creation of complex prototypes with multiple materials, such as dental and robotics models, more efficiently and cost-effectively.
A study found that college students intended to have children about one year earlier after reading a brief online brochure about age-related fertility decline. The brochure increased their knowledge of fertility decline and in-vitro fertilization success rates, prompting them to accelerate their planned timelines.
Researchers have made a significant discovery in adult heart repair by identifying the Hippo pathway as a key regulator of cardiomyocyte proliferation. This breakthrough has the potential to improve heart function after a heart attack and reduce the severity of heart disease.
Researchers create a new computer model that combines cutting-edge simulations of weather and fire with satellite observations to predict the extent and behavior of wildfires. The technique, called CAWFE, allows for updated forecasts every 12 hours, enabling accurate predictions throughout a fire's lifetime.
Researchers found that individuals with exceptional autobiographical memory (HSAM) are vulnerable to false memories, similar to those with average memory. The study suggests that no one is immune to memory distortion.
Researchers create a new 3D imaging technique using anisotropic triangles to provide more accurate approximations of object shapes and improve simulation results. The technique can generate images up to 125 times faster than current approaches while maintaining higher accuracy, particularly for wrinkles and movement.