A new study found that danoprevir added to the current treatment regimen for patients with hepatitis C leads to high rates of remission and a well-tolerated safety profile. The drug demonstrated an 85% sustained virologic response rate, making it a potential breakthrough in treating this serious liver disease.
Researchers at Harvard University have found that genes produce extracoding RNA to prevent silencing by DNA methylase 1. This discovery has therapeutic potential as an 'on-off switch' for gene expression.
Researchers at Rice University have created an 'artificial nose' that can detect dangerous fumes from solvents by trapping metallic compounds inside zeolite cages. The technology uses a 'ship in a bottle' type of chemical assembly, with each gas having a unique photoluminescent fingerprint.
The Cancer Genome Atlas has characterized the genomic abnormalities driving glioblastoma multiforme, identifying 61 new mutated genes. Detailed clinical information is available for most cases, providing a resource for researchers to develop targeted therapies.
The Journal of High Energy Astrophysics aims to publish impactful and rigorous papers on high energy phenomena, including black holes, neutron stars, and supernovae. The journal offers free online access for all articles published in the first year.
LSU researchers have received a nearly $1 million grant to develop software and infrastructure enabling Big Data research on the university's campus. The project, titled CC-NIE Integration, will empower scientific breakthroughs by providing advanced information technologies and cyberinfrastructure.
Scientists have successfully assembled model cell membranes on graphene surfaces using Lipid Dip-Pen Nanolithography (L-DPN). This breakthrough enables the study of complex systems and processes in a controlled environment.
Researchers at the University of Houston will gain faster data upload and processing capabilities, enabling innovation in education and healthcare. The upgrade aims to facilitate the creation, sharing, and analysis of large datasets.
A new study suggests that a 'stadium wave' signal in ocean, ice, and atmospheric circulation regimes may explain the recent global warming hiatus. The 'stadium wave' propagates like a sports stadium crowd standing and sitting, with different regions responding to changes in temperature and sea ice extent.
Research reveals super-enhancers play crucial roles in both healthy cell regulation and disease, with mutations associated with diseases occurring in these regions. The discovery may lead to the development of personalized medicine approaches for cancer treatment and diagnosis.
The Singapore Centre for Nutritional Sciences, Metabolic Diseases, and Human Development (SiNMeD) will focus on fundamental, clinical, and translational research to understand the role of nutrition and early development in obesity and metabolic diseases. The center aims to improve knowledge of optimal nutrition and lifestyle in Asians.
A team of scientists has discovered that the Yellowstone hotspot is less likely to erupt again soon, as evidenced by crystals found in Idaho rocks. The analysis suggests that the magma chambers are 'recycled', meaning they have been re-used before, and that this process could lead to a longer eruption cycle for the region.
Scientists have discovered that mammals use the RNA interference (RNAi) process to destroy viruses within their own cells, similar to plants and invertebrate animals. This finding could lead to the creation of vaccines against deadly infections such as SARS, West Nile, dengue, hepatitis C, and influenza.
Scientists at Albert Einstein College of Medicine have identified a previously unstudied gene crucial for normal nerve development. The gene, mnr-1, produces an extracellular protein that triggers branching of dendrites in sensory nerves during development.
Researchers found that ancient hunter-gatherers in Central Europe coexisted with immigrant farmers for over 2,000 years. Genetic analysis reveals a specialized diet of fish and other seafood among the hunter-gatherers until their way of life died out around 5,000 years ago.
The University of Utah Center for Clinical and Translational Science has received a $20.4 million grant from the NIH to advance translational research in medicine, particularly in rare conditions such as spinal muscular atrophy. The center will utilize this funding to support all aspects of translational research over the next five years.
EPFL scientists have created a hydrogel that promotes cartilage regeneration by delivering therapeutic drugs in response to mechanical stimulation. This method has the potential to revolutionize the treatment of joint injuries and degenerative conditions such as arthritis.
A study by University of Alberta researcher Deryk Beal found that children who stutter have less grey matter in brain regions responsible for speech production. This discovery highlights the importance of early treatment approaches like those pioneered by the Institute for Stuttering Treatment and Research.
A study published in Science found that reducing phosphorus levels in lakes can lead to decreased nitrogen removal processes, resulting in nitrogen accumulation. This has significant implications for global pollution control efforts, as many large lakes are affected by successful phosphorus control measures.
A large-scale study found no evidence of an increased risk of depression, self-harm, or suicidal behavior among patients prescribed varenicline or bupropion compared to those using nicotine replacement therapies. The findings are reassuring for users and prescribers of smoking cessation medicines.
For the first time, researchers have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma (HCC) tumors. These cells can be identified long before actual tumors are apparent, suggesting a new approach for early detection and therapeutic intervention.
Researchers have identified irisin, a molecule produced during endurance exercise, as having neuroprotective effects on the brain. Artificially increasing irisin levels in mice improved cognition and reduced symptoms of neurological diseases.
A novel surgical intervention involves placing an intestinal barrier sleeve in the small intestine to correct obesity and improve glucose metabolism. The method is less invasive and can be removed at any time.
A study found that Hispanics are less likely to receive a kidney transplant, despite being equally likely to be placed on the waitlist as non-Hispanic whites. The disparity is largely attributed to differences in patient blood type and regional variability of organ supply.
A recent study found that high-risk travelers, including those with medical comorbidities and pregnant women, account for nearly 20 percent of patients using the Boston Area Travel Medicine Network. These travelers often visited destinations with malaria and typhoid risk, highlighting the need for pre-travel care.
Researchers at Rice University have created a polymer material infused with graphene nanoribbons that can contain pressurized gases for extended periods. The material has potential applications in the automotive industry, food packaging, and beverage containers.
A recent study reconstructed the first detailed genetic history of modern-day Europeans using ancient DNA from 364 prehistoric skeletons. The research found dramatic population changes with waves of migration from Western and Eastern Europe, contradicting previous assumptions about the Near East's role in shaping European genetics.
Researchers found a brain-to-body signaling circuit in roundworms that enables weight loss independently of food intake, involving serotonin and octopamine neurotransmitters. The discovery hints at a similar circuit in humans and other mammals, potentially leading to more potent weight-loss therapies combining serotonin and adrenaline.
Researchers have identified a genetic target, BCL11A enhancer, that controls hemoglobin production in red blood cells. This discovery opens the door to precise targeting of sickle cell disease with potential benefits without off-target effects.
Three BIDMC researchers, Mark Andermann, Zoltan Arany, and Daniel Leffler, receive Dvorak Young Investigator Awards for their work on brain pathways, blood vessels in pregnancy, and monitoring sedation. The awards aim to advance research programs at BIDMC.
A genetic variation that enhances p53's activity has been identified as a common mutation increasing the risk of testicular cancer in light-skinned individuals. This SNP, named KITLG p53 RE SNP, was positively selected in Caucasian gene pools due to its potential protective effect against UV radiation-induced skin damage.
A University of Michigan study found that the brain's natural painkiller system responds to social rejection, releasing chemicals called opioids to ease social pain. Individuals with high resilience scores exhibited greater opioid release during social rejection, suggesting a protective or adaptive response.
Researchers at Scripps Research Institute have identified key signaling proteins that contribute to the development of inflammatory diseases such as rheumatoid arthritis and psoriasis. By targeting these proteins, a new class of anti-inflammatory therapy may be developed.
Researchers found that African elephants can use human pointing cues to find hidden food, demonstrating an understanding of this complex gesture. This study reveals that the ability to understand pointing is not unique to humans but has evolved in a lineage of animals.
C-Voltaics, a University of Houston nanotech company, has won the $50,000 Goradia Innovation Prize for its commercially viable nano-coatings that protect various products from environmental hazards. The company's win is confirmation of market demand for its product, which was launched this fall in the Energy Research Park.
Researchers at ETH Zurich have discovered a new antiviral response in mammals, utilizing the RNA interference pathway to combat viral infections. This discovery sheds light on a previously overlooked aspect of innate immunity and highlights the simplicity and universality of this system.
Scientists propose iron in Earth's core weakens dramatically just before melting, affecting seismic wave speeds. This discovery provides a compelling explanation for observed wave velocities at the Earth's inner core.
Researchers from Uppsala University used a 3D model to study the subsurface of Ardnamurchan volcano and found that it had a single elongate magma chamber. This challenges the long-held theory of three successive magma chambers, which has been widely studied by geology students and experts.
A large meta-analysis of 23 studies involving over 4,000 healthy adults found no significant benefit from vitamin D supplements in preventing osteoporosis. The study's authors conclude that continuing widespread use of vitamin D for osteoporosis prevention in healthy adults without specific risk factors is inappropriate.
Case Western Reserve University School of Medicine has received a five-year, $1 million NIH grant to develop the Cleveland Stroke Clinical Trials Regional Coordinating Center. The project aims to improve prevention and treatment of strokes and rehabilitation for stroke patients through collaboration among five Cleveland institutions.
A new clinical trial combines NK cell therapy with an immunocytokine to target children with relapsed/refractory neuroblastoma, promising a less toxic treatment option. Researchers at the University of Wisconsin-Madison will use haploidentical natural killer cells infused with hu14.18-IL2 to destroy cancer cells.
Research from Princeton University found that Christmas Island red crab's reproductive cycle closely follows precipitation patterns, suggesting a potential decline in population due to climate change. The study highlights the importance of studying tropical species' migration patterns in response to changing environmental conditions.
Scientists have developed a new method to create self-renewing stem cells specific to the human foregut, opening up possibilities for regenerative therapies. The breakthrough technique allows for the growth of pure liver or pancreatic cells in sufficient quantities for clinical use, overcoming current limitations.
Approximately 1.4 million people suffer minor traumatic brain injuries (mTBI) each year, with falls and motor vehicle accidents being common causes. Orthopedic surgeons can play a critical role in diagnosing mTBI, ensuring patients receive proper care and referrals for management.
Researchers Dr. Joan Seoane and Dr. Eduard Batlle from Barcelona have been recognized for their outstanding contributions to cancer research, with a focus on brain cancer and colorectal tumors. Their work aims to identify tumor stem cells and develop new therapeutic strategies to block metastasis.
Human skin stem cells have been found to possess a natural internal clock, which helps them regulate functions such as UV protection in response to circadian changes. This finding could lead to new strategies for preventing premature aging and cancer.
A new study by MIT economists Christopher Knittel and Aaron Smith challenges the notion that increasing ethanol content in gasoline reduces its price. The study found no causal link between ethanol and lower gas prices, contradicting previous claims of a $0.89 to $1.09 per gallon reduction.
Researchers discover sodium lignosulfonate can immobilize and remove toxic chromium compounds from contaminated soil and water. The compound reduces chromium mobility, making it less likely to leach into waterways.
A genetic variant associated with a high risk of testicular cancer in Caucasians may also offer protection against harmful ultraviolet rays, suggesting it may have evolved to benefit light-skinned individuals. The study identifies a DNA sequence variation in the p53 gene that regulates cell functions and tumor formation.
A novel device that combines microbial fuel cells and photoelectrochemical cells generates hydrogen gas from sunlight and wastewater, achieving self-biased solar hydrogen generation. The device demonstrates efficient wastewater treatment and potential for large-scale applications.
Researchers at Louisiana State University found that microorganisms can repair their DNA even under freezing conditions, challenging previous assumptions about their survival in permafrost. This discovery has implications for the search for life on Mars and other icy worlds in the solar system.
Researchers found 145 top websites use hidden scripts to extract user devices' fingerprints, evading cookie restrictions and ignoring Do Not Track headers. The study highlights secret tracking's widespread nature.
Researchers have discovered how plants recognize and respond to bacterial proteins, leading to the development of crops with enhanced immunity. This breakthrough has significant implications for increasing crop yields and improving food quality worldwide.
A new method called TGV (TALE-mediated Genome Visualization) allows researchers to observe the localization of specific DNA sequences inside the nucleus of living cells. This study tracked male and female genes after fertilization, revealing new prospects for understanding cell cycle dynamics, DNA behavior, and parent gene expression.
A study found that people living in areas with mountaintop coal mining face an increased risk of major depression. The research explored the relationship between environmental degradation and psychological health, highlighting the importance of nature for human wellbeing.
Researchers identified 13 metabolites that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls. Twelve of the metabolites are linked to mitochondrial function, suggesting suppressed mitochondria as a fundamental characteristic of diabetic kidney disease.
The Institute for Operations Research and the Management Sciences (INFORMS) has presented 12 new Fellows, acknowledging their groundbreaking contributions to analytics, operations research, and management science. The recipients include experts in education, healthcare, research, and service to INFORMS.
A study finds that African Americans and individuals with less education are more likely to receive lower-quality kidneys, highlighting racial and social disparities in the allocation of transplanted organs. The findings suggest that addressing these inequalities is crucial for improving patient outcomes.
A team of forensic experts found no genetic link between the mummified head and three Bourbon descendants of King Henry IV. The analysis ruled out a maternal connection as well, making it highly unlikely that the head belonged to the French king.
The joint initiative aims to generate practical measures to improve health systems in LMICs through multidisciplinary research. The scheme will facilitate successful adoption of effective interventions into routine practice, benefiting the most vulnerable populations.