Researchers discovered a novel compound that promotes motor neuron survival, offering a new approach to treating ALS. The study used stem-cell-derived motor neurons and screened over 5,000 compounds, finding kenpaullone to be more effective than existing treatments.
The U.S. Food and Drug Administration has approved only one new antibiotic since the Infectious Diseases Society of America launched its 10 x '20 Initiative in 2010. Despite this, only seven new drugs are in development to treat infections caused by multidrug-resistant gram-negative bacilli bacteria.
Professor Socrates Papapoulos has made significant contributions to advancing osteoporosis research and advocacy worldwide. He is a renowned researcher at the Leiden University Medical Center and IOF Board member, with over 300 publications and several awards.
Researchers investigate how surface-derived fluids can penetrate deep levels in Earth's crust, a challenge to widely accepted notions. They also explore the kill mechanism for a mass extinction event and the formation of hydrothermal base metal ore deposits. Additional studies focus on polar reversals, earthquakes, and archeological fi...
The most distant known source of very high-energy gamma rays, PKS 1424+240, deviates from expected emission spectrum despite being detected at a great distance of over 7.4 billion light-years. The findings may indicate new insights into blazar emission mechanisms or the extragalactic background light.
Researchers studied data on economic and social conditions, utilization of health services, and health outcomes in Greece. They found that key public health indicators declined during the recession and austerity policies, leading to increased suicide and homicide mortality rates, mental disorders, substance abuse, and infectious diseases.
The U.S. Geological Survey's Biodiversity Information Serving Our Nation (BISON) system has launched, offering a vast repository of nearly 100 million mapped records of living US species. The database provides detailed information on species occurrences, including location, collector data, and environmental context.
A new review highlights the need for additional legislation and guidelines for surrogate pregnancies in modern obstetrics. The lack of clear guidance puts women, babies, and parents at risk of exploitation, making it essential for healthcare professionals to have practical advice on managing these cases.
Dr. Susan E. Clare's research aims to deliver chemotherapy directly to brain metastases using immune cells and nanoparticles, targeting HER2 positive and triple negative breast cancers. The system uses nanoshells coated with gold to release drugs at will in the appropriate spot in the brain.
Researchers discover adult progenitor cells are subject to cellular senescence, leading to age-related deterioration of skeletal muscle and fat tissue. The study suggests a potential therapeutic target for future treatments, particularly the tumor suppressor p53.
Scientists at Benaroya Research Institute and Baylor Institute for Immunology Research report a comparative study of molecular immune responses to influenza and pneumococcal vaccines. The study utilized cutting-edge web technology to improve data dissemination, allowing researchers to investigate the primary data from a web portal.
Researchers identified a specific profile of patients suffering from acute-on-chronic liver failure syndrome, characterized by high mortality rates and organ malfunctions. The study provides new diagnostic criteria for the condition, which is associated with cirrhosis and can be linked to patient age and medical history.
Researchers found that a small meat-eating dinosaur called Troodon likely hatched its young in a way similar to brooding birds. The study provides insights into how dinosaurs incubated their eggs and supports the close evolutionary relationship between birds and dinosaurs.
A new species of leaf miner from the Gracillariidae family has been discovered in Brazil, exhibiting a unique life cycle. The species, Spinivalva gaucha, does not have a sap-feeding instar and instead feeds on upper leaf tissue from hatching.
Researchers used a method to test for evolutionary adaptation in genes regulated by FOXP2, a key factor in human development and language. The study found strong evidence for selection of FOXP2-regulated genes in European populations, highlighting their potential roles in neural cell development and immunity.
A Concordia University study compares how early adolescents from Montreal and Barranquilla, Colombia, assess their self-worth. The researchers found significant commonalities but also differences in the factors considered most important by the children.
A study has found that slower walking speed is associated with increased mortality risk in kidney disease patients. The research suggests that lower extremity physical performance tests may help identify those at higher risk of premature death.
Researchers have discovered that the surface of the eye produces 'lubricin,' a substance similar to joint lubricant, reducing friction between cornea and conjunctiva. This finding holds promise for treating conditions like dry eye disease, postmenopausal vaginal atrophy, and xerostomia.
The new ASTRO white paper recommends 10 fundamental elements for safe and effective IGRT practices, including establishing a multi-professional team and performing end-to-end testing for new procedures. The paper aims to improve the safety and effectiveness of image-guided radiation therapy in radiation oncology.
The Clinical Research Forum has selected ten projects for its Annual Top 10 Clinical Research Achievement Awards, recognizing groundbreaking work in disease prevention, genetic disorders, and cancer treatment. The winning projects were published in top medical journals and have made significant impacts on human health.
Two studies presented at EuroPRevent 2013 found that physically demanding work increases the risk of coronary heart disease. The research suggests that job strain and high physical demands may exacerbate cardiovascular risks, even when leisure-time activity is taken into account.
Outpatient antibiotic use poses similar but sometimes more severe resistance risks as hospital cases, new study reveals. More than half of outpatient antibiotics for acute respiratory infections are unnecessary, accelerating bacterial resistance.
Multispectral photoacoustic imaging distinguishes between benign and malignant prostate tissue with a high degree of accuracy. The new technique, which combines laser optics and ultrasound imaging technologies, predicts 25 out of 26 benign tissues and 13 out of 16 malignant tissues correctly.
A new study from St. Michael's Hospital found that dietary supplements accounted for more than half of the Class 1 drugs recalled by the US Food and Drug Administration between 2004-12. The majority of these recalls were for bodybuilding, weight loss, or sexual enhancement products containing unapproved medicinal ingredients, including...
A Kaiser Permanente study found that nearly 30% of women with osteoporosis fail to pick up their bisphosphonate prescriptions within 60 days. The study identified patient and physician characteristics, such as age, emergency department utilization, and prescription medication use, that contribute to nonadherence.
Professor Diez-Perez has advanced understanding of osteoporosis through original scientific contributions, including epidemiology and clinical care. He is recognized for promoting medical innovation and improving patient outcomes.
Researchers discovered that brain's 'slow waves' start in the cerebral cortex and are initiated by a local cluster of neurons. This finding provides new insights into processes like memory consolidation and learning, and could lead to a better understanding of diseases like Alzheimer's.
Children with SLDs frequently have co-occurring conditions and require specialized support. The study clarifies the causes of SLDs and provides guidance on tailoring education to meet individual needs.
Early season prescribed burns, such as those conducted by the NASA-backed Ecofire program, are more effective at containing fires and reducing long-term damage. By mimicking traditional Aboriginal fire practices, these early-season burns can help reestablish vegetation and prevent the formation of extensive burn scars.
A team of scientists has discovered that a toxic protein, FMRpolyG, is made in an abnormal way due to a gene mutation, leading to Fragile X-associated Tremor Ataxia Syndrome (FXTAS). This unusual translation process, known as RAN translation, may hold the key to better treatments for older adults with the condition.
A high-salt diet significantly increases the risk of gastric cancer in animals infected with Helicobacter pylori. The study found that CagA, a bacterial oncoprotein produced by H. pylori, plays a key role in cancer development.
Scientists track Egyptian fruit bat flights using miniature wireless devices and find that place cells respond to spherical volumes of space, suggesting uniform perception of all three dimensions. The study provides new insights into navigation, spatial memory, and spatial perception.
Researchers investigate early social experiences and their impact on adolescent brain function, exploring factors like negative life events and relationship quality. The study aims to understand long-term associations between early social experiences and later brain development.
Researchers identified three BRCA1 gene variants as pathogenic, increasing breast and ovarian cancer risk. These findings will improve genetic counseling and allow for personalized cancer assessment.
A new study reveals that Antarctic clams' reaction to environmental changes varies depending on their age. Younger clams are more active in responding to hypoxia, while older, sedentary clams remain relatively unchanged. This has implications for future clam populations and ecosystems.
A new study reveals that white sharks occur in Hawai'i waters across a broader annual cycle than previously thought, with observations recorded every month except November. The research also identifies a simple method to distinguish between white sharks and close relatives like mako sharks based on the shape of their head.
A combination of two licensed antiviral drugs, ribavirin and interferon-alpha 2b, has been shown to inhibit the replication of novel coronavirus in laboratory-grown cells. The study suggests that this drug combination could be used to treat patients infected with the new coronavirus.
A Michigan State University education scholar argues that US K-12 teachers are not fully prepared to meet the Next Generation Science Standards due to inadequate professional training. The voluntary guidelines call for more hands-on learning and analysis, but many teachers lack the knowledge base to implement them effectively.
A previously unpublished work by Francis Crick and Jeffries Wyman from 1965 is now available, proposing a different formulation of the Monod-Wyman-Changeux hypothesis. The paper analyzes how regulatory performances of monomeric proteins are enhanced by assembly into cooperative structures.
A new study reveals that a particular style of thinking can be contagious and increase symptoms of depression. College freshmen who were assigned to roommates with high levels of cognitive vulnerability showed an increase in their own vulnerability and depressive symptoms six months later.
A recent study from Columbia University Medical Center suggests that high levels of glutamate in the brain may trigger psychosis in individuals at risk for schizophrenia. This finding could lead to the development of a diagnostic tool to identify those at risk and new treatment strategies to prevent or slow disease progression.
A study by University of Utah researchers found that community gardeners have a significantly lower body mass index (BMI) and lower odds of being overweight or obese compared to their non-gardening neighbors. The study, which used unique administrative data, also found health benefits for spouses of married gardeners.
A Vanderbilt University Medical Center study found that physical activity is not a significant factor in health disparities between African-Americans and whites. Sedentary behaviors, such as sitting and screen time, were linked to poorer health outcomes more than physical activity.
Kristina Fasteson Simacek, an Indiana University doctoral candidate, has won the Regenstrief Institute's People's Choice for Healthcare Delivery contest with her proposed computer application that translates doctor visits into actionable items. The app aims to improve patient care and reduce healthcare costs by providing a customized s...
The European Commission needs to reform its science funding programme by reducing red tape and improving transparency to get the most out of €70 billion in research funding. This includes better mapping and linking of funded projects, open data drives, and ending discriminatory salary policies.
Researchers have identified five planets within the habitable zone of a Sun-like star, including two planets similar in size to Earth. The discovery was made using data from the Kepler spacecraft and validated by high statistical confidence.
The symposium aims to address family dynamics and nutrition policies to prevent childhood obesity. Research focuses on mealtime behavior, parenting strategies, and the impact of changes to the Special Supplemental Program for Women, Infants, and Children (WIC) on low-income minority families.
Researchers discover that expanded DNA regions in Fragile X-associated Tremor syndrome cause the production of an abnormal FMR1polyG protein, leading to neurodegeneration. The protein's translation is critical to elicit toxicity, and blocking its production can suppress neuron damage.
A symposium hosted by the Society for Research in Child Development aims to investigate how educational media fosters early learning in young children. The event will focus on topics such as interactive media characters, touchscreens, and popular shows like Sesame Street.
Researchers found that topical anakinra significantly reduced dry eye symptoms, eliminating corneal staining and improving signs of ocular surface disease. The treatment was well-tolerated and effective in reducing dry eye symptoms six times more than the current standard treatment.
Researchers have found that high-frequency bursts in the brain improve the ratio of healthy amyloid-beta 40 to unhealthy 42, potentially protecting against Alzheimer's. The study suggests environmental changes and experiences can modify synapse properties, leading to increased production of amyloid-beta 40.
A new study from Stanford University School of Medicine found that using anesthesia during the external cephalic version procedure can increase the likelihood of successful breech baby turns, resulting in fewer cesarean sections. This leads to cost savings for women and their families.
A Michigan State University researcher found that Twitter can be a better source of information than traditional news sources and online search engines. Tweets tagged with hashtags provide multiple perspectives on topics like the Occupy Wall Street movement. The study suggests using Twitter as a complement to formal teaching and learni...
A new study reveals that breast ultrasound screening after mammography can detect an additional 3.4 cancers per thousand women screened in those with greater than 50% breast density. The detection rate is comparable to that of screening mammography for women with less dense breasts.
A study found that the development of the sea-ice ecosystem in Antarctica possibly triggered the evolution of larger organisms like baleen whales and penguins. The researchers analyzed sediment samples from drill cores, which provided new insights into the past.
A SwRI-led remote-sensing study has revealed accelerated loss of surface water in shallow lakes and ponds in Arctic Alaskan wetlands, with a recent 27-year period showing a 5.5% decrease in water-body surface area. The analysis also found changes in permafrost degradation and ice-wedge polygon morphology.
Researchers analyzed data from eight sexual health services across Australia, finding a significant decline in genital warts diagnoses among vaccinated young women and men. The HPV vaccination has been shown to protect against the types of HPV that cause 90% of genital warts and cancer-causing HPV types.
The law impacts self-esteem, risky behavior, community safety, stress, and health among Latino youth and families. The symposium explores the effects of S.B. 1070 on their well-being.
The Abess Center honored Terrence 'Rock' Salt with the 2013 Environmental Stewardship Award for his decades-long commitment to championing the Everglades. Karlisa Callwood received the inaugural Orion Herbs Fieldwork Grant to study the Bahamian spiny lobster fishery.
Researchers have discovered that protein machines that copy DNA pause frequently during the process, creating potential for dangerous mutations. Efficient repair of these breakdowns is crucial to prevent corruption of the genetic code.