Researchers have identified a new potential treatment for squamous cell lung cancer by targeting a specific protein called DDR2, which interacts with collagen to protect against cancer growth. The findings could lead to the development of targeted therapies for this previously untreatable form of lung cancer.
A $6 million CU Boulder instrument will study lunar dust behavior, helping answer why astronauts saw a pre-sunrise glow on the moon. The LADEE mission, launched on Sept. 6, will orbit the moon for a month to collect data and answer questions about lunar dust transport.
New research published in The FASEB Journal found that dieting prior to or at conception can be detrimental, leading to poor metabolic consequences for the offspring. Epigenetic damage might have already been done, even if weight loss occurs just before conception.
Research from University of Kent suggests perfectionism and high work motivation contribute to workaholism. Self-oriented perfectionists tend to exhibit higher levels of workaholism due to internal drivers such as self-control and rewards.
A study by researchers at Princeton University found that poverty can impair cognitive function, making it difficult for individuals to focus on tasks unrelated to financial concerns. This impairment can lead to poor decision-making and increased mistakes in other areas of life.
A new gene mutation in FBXL4 has been linked to rare but devastating mitochondrial disorders. The discovery enables genetic testing for affected families, providing them with peace of mind and potentially leading to new treatments for the disorders.
A genetic mutation in the androgen-synthesizing enzyme 3βHSD1 enables tumors to produce their own supply of androgens, leading to the growth of castration-resistant prostate cancer. This discovery could lead to the development of biomarkers and targeted therapies for personalized medicine.
The Broad Institute's Cancer Therapeutics Response Portal (CTRP) has launched to match patients with potentially effective drugs. Researchers can use the portal to find therapeutically exploitable vulnerabilities in different cancer types, identifying genes that may provide new therapeutic targets.
A Cedars-Sinai researcher has been awarded $5.18 million to advance stem cell technologies in segmental bone defects. The team aims to develop a novel approach to treat the condition without grafting bone, using stem cells and ultrasound to deliver a bone-forming gene.
A team of neuroscientists found that better coordination between two brain regions is associated with less forgetting and longer-lasting memories. The study suggests that the brain strengthens memories by distributing them across networks, a process that takes time.
Researchers found that statins can activate telomerase, slowing down senescent cells and potentially leading to healthy lifespan extension. The study suggests that statins could be used as an anti-aging therapy, mitigating age-related diseases like heart disease and cancer.
Research suggests that familiar voices sharpen auditory perception and help individuals focus on one voice at a time. Middle-aged adults can use familiarity to ignore their spouse's voice and better understand unfamiliar voices, while older adults struggle with this task.
A team of 8 researchers from Kansas State University is studying the Smoky Hill Watershed to improve Great Plains water sustainability, focusing on human activity and climate change impacts. The project aims to build resiliency in both human and natural systems for economic, cultural, and ecological benefits.
A University of Maryland-led research team found that young whooping cranes learn their migration route from older birds and get better at it with age. The study shows that individual birds' ability to stick to the route increases steadily each year up to about age 5, and remains roughly constant from that point on.
The Rim Fire in California has burned over 192,000 acres, with 30% containment achieved through aircraft and water/chemical dumping. Large burnout operations are planned for the southeastern edge of the fire in Yosemite National Park, hampered by remote terrain and extreme fire behavior.
University of Arizona researchers have discovered a new secret in spider venom, finding that the venom produces a different chemical product in the human body than previously thought. This discovery has implications for understanding how brown recluse spider bites affect humans and developing possible treatments.
Indigenous groups from 17 countries deploy powerful mapping tools combined with traditional knowledge to mark and safeguard their lands. The technology helps document history, catalog natural resources, and bolster fights against destruction of forests, peatlands, and waterways.
A study has identified a metabolic network associated with Huntington's disease progression, allowing for predictive assessment of time to symptom onset. This discovery provides biomarkers for evaluating disease progression in carriers and supports the incorporation of this assessment into clinical trials.
Patients with postoperative surgical complications were six times more likely to be readmitted, according to a study in Plastic and Reconstructive Surgery. Obesity and anemia were also independent risk factors for hospital readmission, highlighting the importance of early recognition and intervention.
Research suggests that lifelong exposure to low levels of food contaminants can lead to metabolic diseases, with females showing a deterioration in glucose tolerance and liver-related changes. The study highlights the potential impact of pollutants on public health when combined in realistic mixtures.
A new study finds Arrhythmogenic Right Ventricular Cardiomyopathy, a human heart disease, in chimpanzees. The condition was detected in two half-brother chimps who died suddenly during physical exertion at a UK zoo.
A new genomic characterization of remission in juvenile rheumatoid arthritis patients reveals that their immune systems remain perturbed even during symptom-free periods. The study highlights the importance of HNF4a as a master switch regulating therapeutic response, and its potential to inform personalized treatment strategies.
A study from the University of Hawaii – SOEST found that sea-level rise is a primary driver of shoreline change in Hawaii, with historical rates of erosion being about two orders of magnitude greater than SLR. The research highlights the importance of targeting SLR impacts in coastal zone decision-making and planning.
Tropical Storm Juliette weakened near Mexico's Baja California on Aug 29, 2013, with maximum sustained winds near 40 mph/65 kph. Two other low-pressure areas in the Eastern Pacific were also being monitored for development.
New research finds that a subpopulation of immune cells, known as T lymphocytes, have platelets bound to their surface, reducing activation and proliferation. This discovery opens the door to potential treatments targeting platelet binding to lymphocytes.
St. Jude Children's Research Hospital scientists have identified a protein that blocks death of high-risk acute lymphoblastic leukemia cells, leading to a new two-drug combination therapy approach. The study shows promise for treating Ph-positive ALL, a high-risk cancer with limited treatment options.
The North American Menopause Society (NAMS) has published new guidance for diagnosing and treating vulvovaginal atrophy (VVA), a condition affecting up to 45% of women after menopause. The guidance emphasizes the importance of effective treatments, including simple vaginal lubricants, estrogen therapy, and nonhormonal options.
Tropical cyclones rely on hundreds of thunderstorms with coldest cloud top temperatures to produce heavy rain. Infrared imagery from NASA's Aqua satellite revealed that wind shear was pushing storm systems away from the center of Tropical Storm Kong-Rey.
Researchers developed a way to change pancreatic cells to produce insulin, reducing the need for two pancreas donations for successful islet cell transplants. This breakthrough could save months of waiting time for Type 1 diabetes patients and make more organs available.
A new PRA gene has been identified in the Phalene and Papillon dog breeds, causing progressive blindness in dogs. The CNGB1 mutation is linked to human retinitis pigmentosa, highlighting the shared genetic etiology of canine and human diseases. Genetic testing can help breeders avoid affected puppies and provide a diagnostic tool.
A transparent disk using a saltwater gel and ionic conductor produces sounds across the entire audible spectrum, demonstrating capabilities of ionic conductors. This technology has potential applications in biomedical devices, fast-moving robotics, and adaptive optics.
Three NIH scientists, Drs. Warner Greene, Richard Sutton, and Timothy Cardozo, receive $500,000 each to support groundbreaking HIV/AIDS research. Their projects focus on modifying the immune response to prevent further CD4 T-cell loss, identifying protective genes against HIV infection, and developing a combined cocaine/HIV vaccine.
Researchers at Johns Hopkins Medicine found that a blood pressure medication speeds up TB treatment in mice, potentially making it easier for infected people to complete their therapy. The study suggests verapamil, commonly used to treat high blood pressure and headaches, could be an effective add-on therapy when combined with standard...
A study published in the Journal of the American Society of Nephrology found that African Americans with lower incomes have lower rates of living kidney donation compared to White Americans. However, among high-income African Americans, they actually have higher rates of donation. The findings highlight the importance of targeting soci...
Researchers found that alcohol intoxication reduces coupling between the amygdala and prefrontal cortex, impairing ability to accurately appraise environment and respond to social signals. This study provides insight into maladaptive behaviors seen in alcohol intoxication, including social disinhibition and aggression.
Computer models predict coral reef ecosystem shifts due to warming and acidification, with the Western Pacific becoming less suitable by 2070. Coral Triangle biodiversity is also at risk, while some areas like the eastern Pacific may remain suitable.
A recent UCSB study analyzed whole-body fish samples from oil-and-gas production platforms and natural sites for heavy metal pollutants. The results showed that most elements were consistently present at both types of locations, with some species exhibiting varying levels of pollutants between juveniles and adults.
A team of geneticists identified five different alleles in the Ethiopian population that cause adult lactase production, highlighting a soft selective sweep. This phenomenon allows individuals to digest milk via different mutations, increasing their chances of survival under scarce food conditions.
Researchers from Notre Dame and Moi University are examining the unique manifestation of breast cancer in Kenya. The collaboration aims to identify novel insights into the mechanisms of breast cancer progression, which could ultimately help women worldwide.
Researchers extended mouse lifespan by 20% through gene manipulation, with some organs aging better than others. This increase is equivalent to a 16-year boost in human lifespan, offering insights into aging and potential therapies for age-related diseases.
A new study finds that better-educated middle-aged Americans are more inclined to make healthy behavior changes in response to new medical conditions. The research reveals significant differences in health habits between education levels, with college graduates more likely to quit smoking and engage in physical activity.
Research reveals a significant relationship between chronic illness and household food insecurity, with adults experiencing more severe food insecurity as their health problems increase. The study suggests that managing chronic illnesses imposes additional financial burdens, limiting individuals' ability to afford food.
A team of researchers led by WPI's Gregory Fischer will test a new minimally invasive approach to treating brain tumors using a robot designed to work within an MRI scanner. The system promises to accurately destroy malignant tissue while leaving surrounding tissue unaffected, offering a significant improvement over current treatments.
Scientists discovered a new weakness in cancer cells that makes them more susceptible to chemotherapy by targeting the HDAC5 protein. Cancer cells with longer telomeres tend to be resistant to therapies, while shorter telomeres make them more vulnerable to treatment.
A recent study published in the Clinical Journal of the American Society of Nephrology found that individuals with type 2 diabetes and normal kidney function who have persistent albuminuria (protein in the urine) are at a greater risk for cognitive decline. The study, which followed 2977 diabetics over four to five years, showed that t...
A 150-year-old moss bank on the Antarctic Peninsula reveals rapid ecological changes driven by warming temperatures, showing sensitive flora and fauna responses to climate change. The study suggests future terrestrial biota changes will track projected temperature increases closely.
Researchers used PET scanning to map changes in brain metabolism in Huntington's disease gene carriers, identifying a characteristic network of abnormalities. This finding enables the tracking of disease progression and will aid in evaluating the effects of new drugs before symptoms appear.
A study published by the American Psychological Association found that men subconsciously feel worse about themselves when their female partner succeeds, regardless of whether they excel or fail in a specific area. Women's self-esteem, however, is not affected by their male partners' successes or failures.
Northwestern University researchers develop method to change molecular properties by altering surface geometry, mimicking nature's simplicity. The technique enables the creation of patchy nanoparticles with unique chemical properties, opening doors for new materials and applications.
Researchers found that excessive noise activates certain cells in the ear, causing them to detach and damage the blood barrier. A new compound, PEDF, shows promise in preventing this type of damage, offering hope for treating tinnitus and sound hypersensitivity.
A new method developed by Michael DiMarzio identifies and tracks antibiotic-resistant Salmonella Typhimurium strains, which account for 15% of human salmonellosis infections. The study uses CRISPR sequences to separate isolates with common resistance patterns in both animals and humans.
A pilot study by UC Davis researchers found that glucose monitoring systems with an autocorrect feature can produce more accurate blood glucose measurements, improving insulin dosing and glucose control for burn patients. This technology can help reduce mortality and morbidity in these patients.
An international team of researchers has confirmed theoretically-predicted interactions between single oxygen molecules and titanium dioxide, revealing a new atomic crystal dynamic. This discovery could lead to the development of more active oxygen-rich photocatalysts for converting CO2 into useful hydrocarbons.
Researchers at Gladstone Institutes and UCSF uncovered a molecular process causing neurons to degenerate, a hallmark of conditions like Alzheimer's disease and frontotemporal dementia. The study used human stem cells with genetic mutations, allowing for the comparison of diseased and healthy neurons.
Researchers at Columbia University's Mailman School of Public Health call for President Obama to create a National Commission on the Health of Americans to address the country's declining health status. The US ranks last among peer nations in health, with high rates of adverse birth outcomes, heart disease, and infant mortality.
A new model system developed by Salk researchers completes the bridge between cellular and human studies of schizophrenia, enabling faster development of therapeutics. The model uses non-invasive scalp EEGs to detect brain activity, providing insights into sensory integration and neurotransmitter function.
Researcher Sendhil Mullainathan discovers that poverty's financial constraints can lead to significant cognitive deficits, affecting IQ and impulse control. The 'cognitive tax' caused by poverty can result in reduced adherence to medication regimens, among other behaviors.
Researchers found that certain genes, such as CXCL12 and IGF1, make breast cancer cells more likely to survive in bone tissue by mimicking the environment of their preferred organ. This discovery could lead to new drugs that prevent cancer spread to bone or other organs.
Researchers at the Joint Center for Artificial Photosynthesis have developed a method to interface molecular hydrogen-producing catalysts with a semiconductor that absorbs visible light. This breakthrough enables the production of hydrogen fuel from sunlight without external electrical potential.
A newly discovered compound has been identified as a potential diagnostic marker for zinc status, which can help detect the harmful effects of zinc deficiency in blood vessel cells. This discovery may lead to faster and easier methods for detecting low zinc levels in the body.