A compound from the South African toothbrush tree has been shown to effectively treat tuberculosis by binding to a novel site on DNA gyrase, an enzyme essential for bacterial growth. This discovery offers hope for developing new antibiotics to combat drug-resistant strains of TB.
Researchers found that blocking a particular pathway in cancer cells makes it easier for common drugs to annihilate tumors. By targeting this pathway, scientists aim to enhance the impact of current therapies and design new drugs to disrupt it.
NASA's research models show that the CMEs left the sun at speeds of 275 miles per second, causing geomagnetic storms when they connect with the Earth's magnetic envelope. The recent flares caused weak radio blackouts, but their effects have already subsided.
Researchers at Rice University used the AWSEM-MD software to simulate protein folding and found a surprising twist: short sequences can self-recognize and stick together, leading to misfolding. This discovery provides new insights into degenerative diseases and may lead to drug design.
Research reveals that a gene switch in the liver is responsible for lowering blood fat levels in cancer patients, leading to dramatic weight loss. The study found that silencing this gene switch in the liver can restore normal lipid levels and muscle mass.
Survivors of heart attacks are three times more likely to develop depression due to their thought pattern about the event. Addressing threat perception through psychological interventions can help reduce this risk and promote a smoother recovery.
Susan Solomon, a leading atmospheric chemist, and Jean Jouzel, a French geochemist, have made groundbreaking contributions to climate science. They won the 2012 Vetlesen Prize for their work on the Antarctic ozone hole and longest-yet ice core record, respectively.
Research examines data from multiple studies to better understand how obesity impacts kidney transplant patients. Obese patients experience more adverse outcomes, including wound infections and cardiac disease, leading to poorer health outcomes after surgery.
Researchers identified 24 new copy number variants with strong links to autism, providing potential genetic diagnosis for up to 10-12% of children with ASD. The study validates the genetic markers used in a commercial test, advancing early detection and treatment methods.
A new study found that doctors who are culturally aware provide better quality of care to HIV patients from ethnic minorities. These patients tend to manage their treatment and condition better and have improved health outcomes. Increasing healthcare provider cultural competence can reduce racial disparities in both the quality of care...
The Children's Hospital of Philadelphia has been awarded a $2 million grant from the Patient-Centered Outcomes Research Institute to study the effectiveness of different antibiotic treatment options for children returning home after hospitalization. The research aims to inform healthcare decisions and improve patient outcomes.
Researchers at Fox Chase Cancer Center found that the NEDD9 gene controls the growth of progenitor cells that give rise to tumors, suggesting a new approach to treating breast cancer. The study also identified a link between NEDD9 levels and sensitivity to certain drugs.
Researchers identified 25 additional copy number variations associated with autism, which could serve as predictive markers. The study found that these variants have a strong effect in raising an individual's risk for autism and may be incorporated into clinical tests.
A study by Dr. Mark Ebell found that patients expect to cough for 7-9 days, while the actual duration is closer to 18 days. This mismatch may contribute to over-prescription of antibiotics, which can lead to antibiotic resistance and increased healthcare costs.
A new study published in Pediatrics reveals that 30% of teen girls have met offline with someone they met online. Abuse or neglect increases this risk, with victims more likely to present themselves provocatively online. High-quality parenting and parental monitoring can reduce these risks.
A new study led by UCLA researcher Dr. Derjung Tarn found that a simple training program improved physicians' ability to communicate key facts about prescribed medications, including potential side effects and medication adherence. The intervention resulted in higher ratings from patients on communication about medications.
Researchers played the Ultimatum Game with six adult chimpanzees and 20 human children, finding that both groups responded similarly to adults. Chimpanzees split rewards equally when cooperation was required, similar to human behavior. This study provides evidence for a shared preference for fair outcomes between humans and apes.
Women who have undergone tubal ligation are more likely to go without regular Pap tests, increasing their risk of cervical cancer. The study found that women with tubal ligation were less frequent with Pap screenings in all age groups compared to those using other forms of contraception.
Researchers at NIH and OHSU found that an experimental Ebola vaccine elicits antibodies that protect nonhuman primates from Ebola virus infection. The study's results showed that antibodies induced by the vaccine appeared to be critical to protecting the animals, while immune cells had a minimal role.
Researchers found no link between dietary patterns and cardiovascular disease, diabetes, or metabolic syndrome in older adults. However, a Western diet was associated with an increased risk of hypertension. The study suggests that overly restrictive diets may not be beneficial for older adults.
A study led by a Virginia Commonwealth University professor found that nearly 30% of knee-replacement surgery patients gained 5% or more of their body weight over five years. This is significantly higher than the 20% gain rate in comparison group without surgery.
Researchers create mathematical model of plant petals to understand iridescence and its role in attracting pollinators. The study, published in Journal of the Royal Society Interface, provides a first analysis of how petal surface patterns might be produced.
Research suggests that childhood environments can program life history strategies, influencing responses to resource scarcity. People who grew up in poorer homes tend towards impulsive decisions, while those from wealthier backgrounds delay gratification.
A study at Massachusetts General Hospital finds reduced local and long-range brain activity coordination in individuals with autism spectrum disorders. Local connectivity was previously thought to be higher in autistic brains, but the current research reveals a more complex connection between brain regions.
Fox Chase Cancer Center has received a grant to expand its community-based patient navigation services, which will help women with abnormal mammography results obtain follow-up care. The grant also supports 10 breast cancer education programs in the community and provides mammography screening services for under-insured women.
A new study found that the Safe Routes to School program significantly reduced pedestrian injury rates among school-age children in New York City. The program's interventions, including improved traffic signals and crosswalks, led to a 44% drop in injuries during peak walking times.
A study of 93,600 women aged 25-42 found that consuming three or more servings of blueberries and strawberries weekly reduced heart attack risk by 32% compared to those eating less than once a month. The flavonoids in these berries may help dilate arteries and prevent plaque buildup.
Researchers have discovered a method to induce sexual reproduction in Penicillium chrysogenum, leading to the development of new strains with improved industrial characteristics. This breakthrough aims to increase penicillin production, making it cheaper to produce, and potentially applicable to other economically important fungi.
A proof-of-concept clinical trial showed improved tissue growth after implanting a hydrogel scaffolding in 15 patients. New cartilage filled an average of 86% of the defect, and patients reported a greater decrease in knee pain.
A systematic review of four studies suggests that acupuncture may have a positive effect on exercise performance and recovery after exercise. However, additional trials with larger sample sizes and randomized designs are required to confirm these findings.
A study of 1,837 women found that early surgical menopause is associated with faster declines in long-term memory and overall thinking abilities. Women on hormone replacement therapies had slower declines.
A recent study published in PNAS found evidence of gene flow from India to Australia around 4,230 years ago, challenging the notion that Australia remained isolated between initial colonization and European arrival. This migration also shares a common origin with populations from New Guinea and the Philippines.
A new study reveals that a mutation in the Timothy syndrome gene causes abnormal brain circuitry by retraction of dendrites in response to neural activity, leading to cognitive impairment. The finding may have implications for understanding neurodevelopmental disorders such as autism, bipolar disorder, and schizophrenia.
The REVIVE-IT study will investigate the potential benefits of left ventricular assist devices for patients with advanced heart failure. Researchers aim to determine if implanting these devices earlier can improve patient outcomes.
The Jordan Baruch Stem Cell Research Fund was dedicated at Ben-Gurion University to support scholarly collaboration and the Center for Regenerative Medicine, Cellular Therapy and Stem Cell Research. The fund aims to develop treatments for debilitating diseases such as diabetes, ALS, Parkinson's, and leukemia.
Researchers found that marine bacteria prefer specific temperatures, nutrients, light, and salinity levels, contradicting the 'everything is everywhere' hypothesis. The discovery suggests dispersal limitation plays a crucial role in shaping bacterial distributions.
A new study by De Montfort University reveals worrying inconsistencies in how NHS hospital trusts in England define and report surgical site infections. The findings suggest that published rates do not accurately reflect the true scale of surgical infections, highlighting the need for improved data collection and reporting systems.
A study found that countries consuming large amounts of milk have a higher number of Nobel laureates, possibly due to the boost in vitamin D levels which can enhance cognitive function. However, the relationship may not be solely driven by education, as some nations with high milk consumption also exhibit strong educational systems.
Researchers at Indiana University identify a molecular 'switch' in clathrin that may play a role in suppressing tumors. The discovery could lead to new strategies for controlling cancer.
The adoption of electronic health records by family physicians has doubled since 2005, reaching 68% nationally in 2011. Researchers found that family physicians are adopting EHRs at a higher rate than other office-based physicians and are likely to exceed 80% penetration by 2013 if the current trend continues. Meanwhile, patients' expe...
Researchers found significant influence of seabird activity on methane and nitrous oxide emissions in the Arctic tundra, contributing to global warming. Meanwhile, a new assessment reveals U.S. cities are less susceptible to water scarcity issues than previously thought.
Tropical Cyclone Emang developed with strong convection and moderate to heavy rainfall around its center. The storm is expected to slowly intensify over the next couple of days as it travels over open ocean, reaching peak intensity by the end of the week.
An ASH international clinical network collaboration improved APL survival rates by replicating a high cure rate of 85% in patients in Central and South America. The standard-of-care protocol, including oral ATRA and daunorubicin-based chemotherapy, showed promising results with low cumulative incidence of relapse.
A Knowledge Transfer Partnership between Cornwall Council and Plymouth University improved social care training, resulting in the development of a new training programme for staff. The programme incorporates aspects of safeguarding adults, the Mental Capacity Act, and Equality and Diversity legislation.
New research reveals that salmon stocks varied greatly on centuries-long time cycles, with fluctuations lasting up to 200 years. The study found that natural variations in salmon abundance were as large as those due to human harvests, and that some regions showed different changes over time.
A CU-led study reveals that pine beetle outbreaks do not harm adjacent stream water quality, but instead increase the uptake of nitrates by smaller trees and understory vegetation. This compensatory response provides potent water quality protection in western forests.
A study published in Neurology found that smoking and poor blood pressure and cholesterol levels significantly increase the risk of death for patients who have survived subarachnoid hemorrhage. The research, which followed over 64,000 Finns, revealed that lifestyle changes can help prevent early deaths among SAH survivors.
Future climate changes are predicted to benefit most mammals in the Arctic and sub-Arctic regions today, except for some specialists like the Arctic fox and lemming. Human activities will hinder these species from adapting, reducing their distribution instead.
A new study of 1.4 million children found that injecting the DTaP vaccine into the thigh muscle reduces the risk of injection-site reactions by around half compared to the arm. The research supports current recommendations to administer intramuscular vaccinations in the thigh for children under 3 years old.
Researchers found that users who focus on close friends' updates experience increased self-esteem, but also display less self-control. This can lead to higher body-mass indexes, credit-card debt, and binge eating. Social network use is linked to poorer offline behaviors in individuals with strong social connections.
Stem-cell therapy has been shown to prevent the decline in heart function associated with Duchenne muscular dystrophy. The treatment involves transplanting stem cells derived from normal mouse blood vessels into the hearts of mice with DMD, where it prevents dilated cardiomyopathy and promotes angiogenesis.
A recent study by Massachusetts General Hospital and Boston Health Care for the Homeless Program found that drug overdose deaths have surpassed HIV as the leading cause of death among homeless adults in Boston, with a significant increase in opioid-related overdoses. The study highlights the dire need to address the epidemic of drug ov...
A study published in Climatic Change reveals that global warming has increased monthly heat records by a factor of 5 worldwide. The researchers found that 80% of observed monthly records would not have occurred without human influence on climate, highlighting the urgent need for adaptation.
Research suggests hard-hitting graphic tobacco warnings may help smokers of all backgrounds quit, with consistent reactions across racial/ethnic and socioeconomic groups. The study found that pictorial warning labels were more effective at highlighting the dangers of smoking and encouraging quitters.
A new study published in Neurology shows that people with early Parkinson's disease often experience non-motor symptoms like anxiety, constipation, and drooling. These symptoms can significantly impact quality of life and are treatable if addressed.
Researchers at USDA and University of California-Davis discovered distinctive amino acid profiles in oranges grown on HLB-positive or -negative trees. These profiles could serve as an early indicator of the pathogen's presence.
The completed genome sequencing of DBM provides insights into insect adaptation to host plants and opens new ways for more sustainable pest management. The study identified gene families involved in detoxification, including ABC transporters, P450 monooxygenases, glutathione S-transferases, and carboxylesterase.
Researchers developed an imaging system enclosed in a capsule about the size of a multivitamin pill that creates detailed, microscopic images of the esophageal wall. The system has several advantages over traditional endoscopy and reveals subsurface structures not easily seen with endoscopy.
Researchers have developed a graphene plasmonics device that can detect even trace amounts of substances in minutes, revolutionizing drug testing for athletes and detecting viruses. The breakthrough uses artificial materials with topological darkness to achieve high sensitivity.
Scientists at the Universities of York and Leeds have made a significant discovery about the cause of ozone destruction over oceans. The research team found that the principal source of iodine oxide can be explained by emissions of hypoiodous acid and molecular iodine.