A clinical trial combining stereotactic body radiation therapy with erlotinib improved overall and progression-free survival times for stage 4 lung cancer patients. The treatment combination increased survival rates by more than doubling, from 6-9 months to 20 months.
Researchers found conserved sequences and inverse relationships between RBP binding and RNA structure, suggesting a regulatory role in gene expression. They also identified unique patterns around start codons and links to alternative splicing and polyadenylation processes.
Belgian researchers used patient-derived stem cells to model frontotemporal dementia, a condition that affects about half of dementia cases before age 60. The study found a targetable defect in the Wnt signaling pathway, which can be corrected with genetic therapy or compounds inhibiting this pathway.
Tropical Cyclone Kate experienced rapid weakening after passing over NASA's Aqua satellite on December 31. The storm lost significant cloud cover in the northern and eastern quadrants due to northeasterly wind shear.
The American Cancer Society's annual cancer statistics report found a 22% drop in cancer mortality rates over two decades, resulting in the avoidance of more than 1.5 million cancer deaths. The report also shows substantial variation in decline rates by state, with the Northeast experiencing the largest decline and the South the smallest.
Tropical Depression Jangmi encountered strong southeasterly vertical wind shear, causing its north, northeast, and eastern quadrants to become almost cloud-free. The satellite image revealed the effects of this wind shear, showing weakening thunderstorms northwest of the center.
A new species of fanged frog has been discovered, giving birth to live tadpoles through internal fertilization, a rare reproductive method among frogs. The frog's unique behavior is just one example of the island's incredible biodiversity and adaptive radiation of species.
Researchers found that fast food portions remained relatively consistent in terms of calories, saturated fat, and sodium, but showed variation among chains. The exception was a decline in trans fat content, likely due to legislative efforts.
A Mayo Clinic study found that women with atypical hyperplasia have an increased risk of developing breast cancer over time. After five years, 7% had developed the disease, and after 10 years, 13%. The study suggests that these women should be considered high-risk and screened more intensively.
A study published in Neurology found that exercise programs can reduce falls and improve mobility in people with Parkinson's disease, particularly those with less severe symptoms. Participants who exercised showed a 70% reduction in falls and better overall mood and quality of life compared to those who did not participate.
Researchers have developed a new model system to grow both normal and cancerous pancreatic cells in the laboratory, offering a powerful tool in the fight against pancreatic cancer. The 3D culture system, known as an organoid, can be grown from human patient tissue, providing a path to personalized treatment approaches.