A NIH study reveals that age-related DNA methylation changes may contribute to increased cancer incidence. The researchers identified sites across the human genome that become increasingly methylated with advancing age and are also disproportionately methylated in various human cancers.
The study found that domesticated camels arrived in the southern Levant, including Israel, around the 9th century BCE. This challenges the biblical account and highlights a significant turning point in Israel's engagement with the world.
Early use of biologic drugs in children with moderate to severe Crohn's disease achieves higher clinical remission rates and normal growth velocity compared to standard treatment. Researchers found that anti-TNF-α therapy is more effective at achieving remission than immunomodulatory drugs.
A new algorithm, developed by NYU researchers, resolves conflicts over divisible goods like cake or land in an envy-free way. The algorithm prioritizes self-identified preferences of parties, ensuring a fair division of resources.
A study by IRCM neuroethics experts highlights shortcomings in transitional care, particularly among youth with complex health needs and disabilities. The research emphasizes the importance of respectful care, autonomy support, and personalized approaches to address transition challenges.
Researchers analyzed data on over 65,000 women and found no association between NSAID use during the first trimester and miscarriage risk. However, they discovered an increased risk of miscarriage after exposure to indomethacin due to potential 'reverse causation bias'.
A large-scale study found that almost 90 percent of children with low-grade gliomas are alive 20 years after treatment, with a significant difference in survival rates between those who received and did not receive radiation. The study highlights the importance of reducing long-term toxicity risk when treating these tumors.
Researchers found distinct cervical and vaginal microbiota patterns in women destined for preterm birth compared to those with term births. The study revealed significant differences in microbial communities, particularly lower levels of non-CST III bacteria, weeks before the actual preterm birth.
Researchers discovered that fluphenazine, a mood stabilizer, reduces ATZ accumulation and reverses liver scarring in α-1 antitrypsin deficiency models. The study demonstrates the power of the worm model for rapid drug screening.
Research suggests that intensive blood pressure and cholesterol lowering treatment does not lower the risk of cognitive decline in older patients with long-standing type 2 diabetes mellitus. In contrast, a lower brain volume was observed in patients who received intensive blood pressure-lowering therapy.
Elsevier has launched a new open-access journal called MethodsX, which provides a platform for researchers to publish their customised methods without the need for full research articles. This initiative aims to save time and money for scientists by making it easier to discover and build upon existing techniques.
Researchers found that malignant astrocytoma patients with the IDH1 mutation benefit greatly from surgical removal of as much tumor tissue as possible. This approach significantly improves survival, with average patient survival rates of 13.5 years for those with mutant tumors compared to less than 1.5 years for non-mutant tumors.
A new study found that adults with low education levels live longer if they feel in control of their lives. Conversely, those who feel little control are three times as likely to die. Researchers believe innate and external factors contribute to perceived control.
A large international study identified an 'invisible-risk' group of adolescents with psychiatric symptoms, despite low risk behaviours being overlooked by parents and teachers. The study found that 13% of adolescents were classified as 'high-risk', while a third group showed similar prevalence of mental health issues.
Researchers found that babies born at home by midwives had a four times higher risk of neonatal deaths than those born in hospitals. The study, using nearly 14 million data points, also revealed an increased risk for first-time mothers and pregnancies beyond 41 weeks.
A recent study found that community-focused agriculture has a measurable effect on economic growth in certain US regions. For every $1 increase in agricultural sales, personal income rose by 22 cents over five years.
NASA's Aqua satellite captured a final image of Tropical Storm Kajiki on January 31 as it made landfall in the Philippines. The storm weakened to a depression with maximum sustained winds near 30 knots/34.5 mph, displacing over 18,000 people.
Research found that organic farms supported 34% more plant, insect, and animal species than conventional farms. This effect has remained stable over time and shows no signs of decreasing.
A study by RAND Corporation found that telemedicine programs can provide good quality care for acute medical problems, with little evidence of misdiagnosis or treatment failure. Patients who used the service were younger, had fewer chronic conditions, and were more likely to be women and live in affluent areas.
A study published in two papers found that relocating Gujjar communities outside of forests can increase tiger populations by up to 68% and provide a rare conservation opportunity. The research suggests that prioritizing the socio-economic needs of local people, such as education and healthcare, can coexist with tiger conservation.
Researchers found that pesticides inhibiting aldehyde dehydrogenase enzyme increase Parkinson's disease risk, especially in people with ALDH2 gene variant. Exposure to multiple pesticides at work and home also increases risk.
A new study by UCLA researchers found that certain pesticides inhibit an enzyme called ALDH, which converts toxic aldehydes into less harmful agents, increasing the risk of Parkinson's disease. The study identified 11 pesticides that increase the risk, particularly in individuals with a common genetic variant of the ALDH2 gene.
Johns Hopkins surgeons have developed a new technique to replace bone removed from the skull after brain surgery, resulting in fewer complications than standard restoration. The approach causes less harm to the brain and reduces infection risk by providing access to blood supply from both top and bottom.
Researchers explore different models of recovery after brain injury, highlighting the importance of combining clinical intuition with CRT theory. Studies also investigate the impact of pediatric CRT on intellectual functioning and nonverbal communication processing after TBI.
Researchers at VCU Massey Cancer Center have discovered a new signaling pathway linked to IL-1 and IRF1 in sterile inflammation. This discovery offers insight into the role of IRF1 in producing chemokines and recruiting immune cells, potentially leading to new treatments for autoinflammatory diseases.
Researchers found a mechanism that helps HIV evade antibodies and stabilize key proteins. By sulfating amino acids on the gp120 protein, the virus can be made more susceptible to neutralizing antibodies, which could lead to more effective HIV vaccines.
Research reveals that obesity in pregnancy is a significant risk factor for long-term cardiovascular morbidity. Women with pre-pregnancy body mass index of 30 kg/m2 or more had higher rates of simple cardiovascular events and non-invasive cardiac procedures ten years later.
A new study confirms a variant in the SERPINE1 gene is linked to cerebral palsy and death in very preterm babies. The findings add to evidence that genes may play a role in brain injury and death risk in preterm infants.
A new longitudinal study of 816 toddlers found that shy children understand language as well as their less shy peers but struggle to express themselves. The research suggests that interventions targeting confidence and social competence can support the development of expressive language in these children.
Jakobshavn Isbrå reaches unprecedented summer speeds of over 46m per day, exceeding 4 times the speed of the 1990s. The glacier's increasing speed contributes to sea-level rise as it adds more ice to the ocean.
A study led by UCSF breast cancer expert Laura J. Esserman recommends biennial mammography screening for women aged 50-74 to save $4.3 billion in healthcare costs. This approach is equally effective as annual screening while reducing false positive results and improving women's well-being.
A study conducted by the World Health Organisation found that South Africa has the highest rate of high blood pressure among people aged 50 and over. The condition affects a staggering 78% of those tested, with only 8% having their condition under control.
Researchers found that volatile market conditions and technological substitutes like Bt cotton significantly impacted the value of bat pest control services, resulting in a 79% drop. The study's findings fuel a discussion on whether conserving biodiversity is economically worthwhile.
A University of Waterloo study finds Arctic lakes froze up later and thawed earlier, resulting in a 24-day shorter winter ice season. Climate change has also caused a significant decrease in lake ice thickness, with some lakes losing up to 38 centimeters of ice.
A Harvard University study found that cows which gestated back-to-back daughters produce as much as 1,000 pounds more milk than those that give birth to sons over the first two lactations. This could lead to significant economic benefits for U.S. dairy farmers if artificial insemination techniques are used to increase female calves.
A Johns Hopkins study found nearly half of HIV-infected teenagers and young adults delay treatment until their disease is advanced, putting them at risk for serious infections and long-term complications. Males and members of minority groups are more likely to show up in clinic with advanced infections.
Researchers at the University of Michigan found that mice exposed to BPA via their mothers developed liver tumors and precancerous lesions. The study suggests a significant association between BPA and cancer development, with findings that may have implications for human health.
Researchers at Mainz University have built a pilot prototype of a single-ion heat engine with the potential to operate at high efficiency. The nano-heat engine could exceed the Carnot limit, making it theoretically possible to improve efficiency beyond current standards.
A study found that non-invasive prenatal testing (NIPT) detected over 83% of chromosomal abnormalities, including trisomies 13, 18, and 21. The test was more accurate for women over 40, but had lower sensitivity for younger women.
A study found remifentanil patient-controlled analgesia to be less effective in managing pain relief during labor compared to epidural analgesia. The study, which involved 709 women, showed that patients who received remifentanil patient-controlled analgesia had lower pain appreciation scores and overall satisfaction with pain relief.
A new study by University of Toronto researchers finds that reported oil sands emissions of hazardous air pollutants are greatly underestimated. The team's comprehensive modeling assessment indicates that evaporation from tailings ponds may introduce more pollutants into the atmosphere than direct emissions.
A study of over 1,700 premature babies found that about one in five had cerebral palsy or neurologic impairment by age 2. Babies with serious complications in the NICU also had a higher risk of these conditions.
A study by Cornell University found that weight loss and gain cycles follow a weekly pattern, with participants losing weight on weekdays and gaining weight on weekends. The results suggest that weight fluctuations are normal and can be managed through mindful eating habits.
Researchers at Brigham Young University have discovered a potential target for tumor suppression, Programmed Cell Death Protein 5 (PDCD5), which may help prevent cancer cell growth by blocking the production of tubulin. The study provides new insights into how PDCD5 functions and offers a promising direction for future research.
Researchers used a defective form of HIV to track CD4+ T cells in HIV patients, distinguishing dividing cells from dying ones and discovering they can persist for at least 17 years. The study sheds light on the lifespan of effector memory T cells, which were previously thought to last only days or weeks.
A new study examining the issue to date found no conclusive evidence that single-sex classrooms offer educational or social benefits. The analysis of 184 studies representing 1.6 million students worldwide found no advantage in science and math performance, self-concept, or gender stereotyping.
Bariatric surgery is the most effective treatment for both obesity and type 2 diabetes, offering substantial benefits in terms of weight loss, metabolic status, and quality of life. In people with type 2 diabetes, bariatric surgery can reverse complications and improve end-organ health, including pancreatic, renal, retinal, peripheral ...
Researchers at European Molecular Biology Laboratory identify microglia cells as major players in brain wiring and behavior. Mice with fewer microglia display weaker connections between neurons and repetitive behaviors associated with autism spectrum disorders.
Two new studies have found that genetically modified, insect-resistant crops have no negative effects on beneficial insect predators or a beneficial, entomopathogenic nematode. The research demonstrated that Bt proteins used in corn and cotton crops do not harm two important insect predators that help suppress pest populations.
Melbourne scientists found that the immune system eliminates potentially cancerous immune B cells on a daily basis. This discovery could lead to an early-warning test identifying patients at high risk of developing B-cell lymphomas.
Researchers decoded the flatfish genome, providing insights into ZW sex chromosome evolution and benthic adaptation. The study also uncovered epigenetic mechanisms underlying temperature-dependent sexual reversal and trans-generational inheritance of such phenomena.
A randomized controlled study found significant decreases in perceived stress, emotional exhaustion, and depressive symptoms among teachers practicing Transcendental Meditation. The four-month study included 40 teachers and support staff, with high compliance rates.
The UEA project aims to understand the chemical exchanges between ocean, sea ice, snow, and atmosphere in polar regions. It will use a unique sea ice chamber and computer models to predict the effect of global warming on Arctic ice melt.
Researchers at the University of Iowa have developed a non-invasive chemical probe that can detect Staphylococcus aureus bacteria in the body, potentially leading to quicker and more accurate diagnoses. The probe uses the bacteria's propensity to cleave DNA, allowing doctors to pinpoint its location and detect infections sooner.
A new study suggests that high doses of vitamin C and E supplements can blunt the improvement of muscular endurance through cellular adaptions. The study found that markers for muscle mitochondria production increased only in the group without supplements.
Scientists have developed a new DNA-based, super-resolution microscopy method called Exchange-PAINT that can visualize up to dozens of different biomolecules at once in a single cell. This allows for a more accurate understanding of complex cellular functions and potential new ways to diagnose disease.
A new study from South Africa reveals that genetically modified maize has a comparable diversity of insects to conventional crops. The research collected over 8,700 arthropod individuals and found no significant differences in abundance or diversity across different functional groups.
A protein called Lis1 regulates asymmetric division of hematopoietic stem cells, ensuring proper blood cell generation. Deleting Lis1 from mouse stem cells accelerates differentiation, leading to a bloodless mouse. The finding has implications for cancer treatment, as cancer stem cells also rely on Lis1.
A study published in the Bulletin of the World Health Organization suggests that governments can slow and reverse the growing obesity epidemic by regulating fast food consumption. The study found that countries with stricter market regulations had lower increases in fast food transactions per capita, indicating a potential link between...
The New York Botanical Garden is launching a program to conserve the Brazilian Amazon forest, part of the world's largest intact forest. The four initiatives will improve forestry practices, train workers to identify tree species, develop sustainable management protocols, and contribute baseline knowledge.