Researchers at Case Western Reserve University identified a promising new pathway to disabling bacterial infection: blocking bacteria's access to iron in the body. They found that bacteria can feed on iron supplied by both bacterial and mammalian siderophore, allowing them to proliferate and make the host ill.
Researchers successfully silenced the Nogo-66 receptor gene in BMSCs, blocking its inhibitory effect and promoting neuronal growth. This breakthrough enhances the therapeutic effects of BMSC transplantation for spinal cord injury repair, offering new hope for patients.
Researchers created nanopyramids made of DNA that can flag and kill bacteria, with a success rate of 65% for Staphylococcus aureus and 48% for Escherichia coli compared to traditional medicine. The innovation offers a new approach to delivering drugs directly into bacterial cells.
Researchers found that only five trials were focused specifically on drug safety, and 14 drugs were approved without condition-specific trials or trials in children. The study calls for increased regulatory emphasis on long-term safety and efficacy, particularly for chronic use medications.
A new medication called dupilumab has shown promising results in treating atopic dermatitis, a chronic and debilitating skin disease. Dupilumab blocks the action of two proteins involved in inflammation, leading to a marked improvement in disease activity and itch.
Researchers captured the first molecular-level images of photosynthesis, revealing how water is split into oxygen and hydrogen. The breakthrough could lead to the development of artificial systems that mimic and surpass the efficiency of natural photosynthesis.
A review article by scientists from VIB and KU Leuven suggests that thorough research into the cell metabolism of stromal cells, endothelial cells, and immune cells could result in new treatment options for these diseases. This would also improve current cancer treatments.
Researchers found distinct bacterial communities in healthy and incontinent women, suggesting a potential link between bacteria and female urinary health. The study identified new bacteria not detected by standard culture techniques, which may contribute to the lack of response to conventional treatments for urinary incontinence.
A study by Concordia University found that siblings naturally teach each other skills like counting, building towers, and recognizing shapes. The researchers observed spontaneous interactions between two children aged four and six, revealing that both older and younger siblings initiate learning activities.
A UCLA study found that depressed men with localized prostate cancer were more likely to be diagnosed with aggressive cancer, received less effective treatments, and had shorter survival times. The study identified demographic factors that contributed to the disparity in treatment and outcomes.
Research published in Tobacco Control finds that people with mental health issues who smoke incur significant economic costs due to premature death, lost productivity, and healthcare expenses. The total estimated annual cost is around £2.5 billion, highlighting the need for targeted interventions to help this group quit smoking.
Researchers developed olive oil 'bulking agents' to replace pork fat in hot dogs, maintaining texture and reducing calories. The substitutes contain 55% olive oil, which contains more healthful unsaturated fats, making them suitable for summer BBQs.
A new study by Monash University researchers links night-time light intensity to regional favouritism and GDP growth, finding that countries where political leaders were born tend to have higher night-time light levels and regional GDP. The study also highlights the impact of authoritarian leadership on foreign aid distribution.
Levothyroxine treatment improved cognitive and learning abilities in naturally aged mice by increasing choline acetyltransferase and acetylcholine levels. The supplement also enhanced superoxide dismutase activity and synapse function, suggesting a potential therapeutic strategy for age-related cognitive deficits.
A study from Harvard School of Public Health found that vasectomy is associated with an increased risk of prostate cancer, including advanced and lethal forms. The association remained even among men who received regular PSA screening, suggesting a potential link between the procedure and aggressive prostate cancer.
A drug candidate developed to treat sickle cell disease has been acquired by Baxter International, advancing its clinical development activities. Aes-103 significantly reduces patients' pain in Phase II clinical trials, offering a potential breakthrough treatment.
Researchers at Tel Aviv University have developed a new holography technology based on nanoantennas, enabling dynamic and complex three-dimensional projections without replotted images. The technology has vast applications in security, medical, recreational, and scientific research.
A range of food descriptors is used in medicine to identify conditions and ailments, from 'anchovy sauce' to 'oat cell carcinoma.' Dairy products and fruit also feature prominently in the medical lexicon., These time-honored allusions serve as a lively learning inducement for generations of physicians.
A study published in Functional Ecology found that long-term pesticide exposure hampers bumblebees' ability to collect pollen. Bees exposed to neonicotinoid pesticides became less successful at collecting pollen and developed different flower preferences over time.
Scientists have identified a novel mechanism of memory loss in Alzheimer's disease and propose new therapeutic targets, including the production and release mechanisms of GABA in reactive astrocytes. A MAO-B inhibitor showed promise in treating Alzheimer's disease model mice for a short time.
A UCLA School of Nursing study found that 57% of young adults believe hookah smoking is not harmful to their health. Despite this, hookahs contain toxic chemicals and nicotine, posing serious health risks. The study aims to increase public knowledge on the dangers of hookah smoking among young adults.
A study found that variations in the TANC1 gene are associated with a greater risk of radiation-driven side effects in prostate cancer patients. The research team developed a predictive genomic test to optimize treatment plans, allowing for improved quality of life for many cancer survivors.
The Association of American Universities (AAU) has launched the AAU STEM Initiative Hub, a website providing resources for universities to showcase innovative efforts improving undergraduate STEM teaching. The hub will also profile efforts by eight AAU STEM Project Sites and provide a platform for sharing strategies and challenges.
A meta-analysis of 17 clinical trials found that early filiform needle acupuncture significantly improved depression symptoms and was safer than conventional medications. This study provides evidence for the effectiveness of acupuncture in managing poststroke depression.
A new study by Fraunhofer Institute explores the biomechanical loads resulting from collisions between robots and humans. Researchers use a pendulum to measure force, pressure distribution, and impact velocity to identify thresholds for injuries.
A Saint Louis University pediatrician is developing an educational video game to train military physicians on pediatric emergency room cases. The game-based tool aims to improve physicians' skills in treating life-threatening emergencies, with potential applications for humanitarian missions.
A study found that African American women with HIV struggle to manage age-related diseases, social responsibilities, and work-related changes. Researchers suggest increased prevalence of HIV among women of color is a growing concern by 2015.
The new journal aims to encourage scientific debate by sharing unpublished, negative study results. Published work will include research articles and short communications covering fundamental plant sciences.
Researchers evaluated 459 patients who underwent transcatheter valve-in-valve implantation for failed bioprosthetic aortic valves. The study found that survival rates were associated with surgical valve size and mechanism of failure, with patients experiencing better outcomes for regurgitation compared to stenosis.
A recent study of over 500,000 Danish women found no increased risk of venous thromboembolism following quadrivalent HPV vaccination. The research, published in JAMA, used data from national registers to evaluate the potential link between the vaccine and blood clots.
Researchers used extensive observations to develop the first high-resolution 3D model of the Homunculus Nebula, confirming features like arm-like protrusions and trenches. The new model suggests intense interactions between Eta Carinae's stars played a significant role in shaping the nebula.
Researchers have discovered that invading glioblastoma cells hijack cerebral blood vessels to extract nutrients, damaging the brain's protective barrier and potentially leading to new cancer treatments. This finding could enable earlier delivery of anti-invasive agents to attack tumor cells.
A new study found that underage drinkers between 18 and 20 years old are heavily exposed to magazine advertising for the alcohol brands they consume most frequently. The study suggests a relationship between exposure to alcohol ads and consumption of specific brands, particularly among young females.
Researchers will analyze data from 6,000 patients with Alzheimer's and 5,000 elderly individuals without the disease to identify rare genetic variants that may protect or contribute to risk. The project aims to develop novel approaches to delay or prevent Alzheimer's disease.
Researchers discovered that trace amounts of HCV RNA in successfully treated patients can be infectious. The study used an animal model to show that blood from these patients could cause HCV infection, which may be hard to detect due to delayed onset of disease.
Researchers used exceptionally preserved fossils and computer graphics to recreate the most likely walking gait of a 410-million-year-old arachnid. The study, published in the Journal of Paleontology, provides new insights into the evolution of early land animals.
A new study finds that minimally invasive surgery is underutilized in many US hospitals, with significant variability in procedure types and complication rates. The study suggests that differences in physician training and hospital practices contribute to this disparity.
A synchronized lock and dam system failed during a severe flood in April 2013, resulting in seven unmoored barges crashing into the dam. The incident caused significant damage to the navigation channel, flooding adjacent land and disrupting agricultural shipments.
New estimates suggest that over 650,000 children develop TB annually in high-burden countries, with India accounting for 27% of the total burden. The study highlights an enormous opportunity for preventive antibiotic treatment among exposed children to reduce the number of cases.
A study by Duke University scientists identified a highly virulent strain of Mucor circinelloides fungus in Chobani yogurt that caused severe symptoms in consumers. The researchers found that the fungus can survive passage through the gastrointestinal tract and produce a lethal systemic infection in diabetic mice.
The Environmental Crime Program Training (Project EnCriPT) offers a range of free, online courses on environmental enforcement and public health issues. These courses will help strengthen enforcement efforts across various levels and provide hands-on experience in processing hazardous materials scenes.
Researchers found genetically identical bacteria respond differently to sugars, exhibiting a wide range of behaviors. The study highlights the complexity of bacterial behaviors and their response to environmental conditions.
University of Iowa researchers have identified a biomarker that can predict preeclampsia at least 6 weeks into pregnancy, enabling early detection and potentially preventing severe health issues. The study's findings hold significant implications for obstetric care in rural and underserved communities.
Researchers at Rockefeller University developed the first model system to understand the DNA 'replication fork' process in eukaryotic cells. This breakthrough enables scientists to study the molecular tools involved in cell division and may have significant implications for human disease research, particularly cancer.
A new study in the Journal of Clinical Investigation identifies a specific gene expression profile and microbial community associated with Crohn's disease. Pediatric Crohn's disease patients exhibit altered expression of genes DUOX2 and APOA1, as well as a distinct microbial community.
Researchers at the Telescope Array observatory detected a disproportionate number of high-energy cosmic rays emanating from a specific area in the northern sky. The discovery provides a promising lead in identifying the sources of these enigmatic particles, which are believed to originate from beyond our galaxy.
Researchers at KAIST have developed TransWall, a two-sided, touchable, and transparent display wall. It allows users to collaborate via shared see-through displays and communicate through talking or touching each other.
A study found that genetic mutations in liver cells drive tumor formation in iCCA, with mutant proteins impairing liver cell development and increasing the risk of metastasis. Researchers discovered a potential treatment option by targeting IDH1/2 mutations, opening a new line of investigation for biomarkers and life-saving decisions.
Patients with possible common duct stones who underwent immediate laparoscopic cholecystectomy had a shorter median length of hospital stay compared to those who received endoscopic evaluation first. The study found fewer common duct investigations in the former group, with no significant difference in illness or quality of life measures.
Typhoon Neoguri was analyzed by NASA's Aqua, TRMM, and CloudSat satellites, gathering data on its eye wall structure, cloud heights, and rainfall rates. The storm showed a large eye with meso vorticies and moderate to heavy rainfall south of the eyewall.
A study led by Michigan State University found a positive economic impact of the Travel Promotion Act, increasing the value of the hospitality industry by $1 billion. The program is associated with an increase in hotel firm values and may lead to expansion and job creation.
A study published in JAMA found that combining varenicline with nicotine replacement therapy significantly improved smoking cessation rates at 6 months compared to varenicline alone. The combination treatment resulted in higher continuous abstinence and point prevalence abstinence rates, but also more side effects.
A mid-level solar flare peaked at 12:20 p.m. EDT on July 8, 2014, and was captured by NASA's Solar Dynamics Observatory. The event had an M6.5-class rating and may have affected Earth's atmosphere, potentially disturbing GPS and communications signals.
Researchers developed a porous silicon material to replace traditional graphite in lithium-ion batteries, allowing for more energy storage capacity and longer runtime. The new material maintained over 80% of its initial capacity after 1,000 charge-and-discharge cycles.
A study published in Nature Communications found that around half of the genes influencing reading ability also impact mathematics skills. The research suggests a substantial overlap in genetic variants affecting both traits, with complex interactions between genetics and learning environment playing a crucial role.
A new study reveals that underage drinkers are disproportionately exposed to the brand names of their preferred alcohols in magazine ads, which may encourage drinking initiation. The findings suggest that industry self-regulatory guidelines are inadequate in limiting ad placements to minimize exposure to young readers.
A recent study published at Experimental Biology 2014 demonstrated the long-term efficacy of KoACT in reducing bone loss in post-menopausal women. The supplement, which combines a proprietary formulation of calcium and collagen, prevented whole body bone mineral density loss at twelve months compared to a control group.
Working memory skills in children are linked strongly to reading and academic achievement. The study found that a child's ability to hold and work with information predicted success in all aspects of learning, regardless of IQ or socio-economic status.
A new study finds that sibling obesity is more strongly associated with a child's risk of obesity than parental obesity, particularly among same-gender siblings. The risk is more than five times greater when an obese sibling is present, and physical activity levels can mitigate this effect.
A team of researchers at Brown University developed a wireless virtual reality system to study how pedestrians interact with each other and how their individual behaviors generate patterns of crowd movement. The system, which allows for the creation of virtual crowds, has shown that people tend to match the speed and direction of their...