The North American Menopause Society (NAMS) has honored several individuals for their outstanding contributions to menopause science, care, and communication. NAMS has awarded JoAnn E. Manson, MD, DrPH, NCMP, for her leadership in clinical trials and research on cardiovascular disease, diabetes, and cancer.
A modular system of proteins can detect a specific DNA sequence in a cell and trigger a response, such as cell death. The system can be customized to detect any DNA sequence and trigger a desired response, including killing cancer cells or cells infected with a virus.
A new study found that patients on one-fourth the suggested dose of beta-blockers survived at the same rate or even better than those on higher doses, increasing survival by 20-25%. The research suggests that beta-blocker dosing needs to be personalized for individual patients.
Researchers at ICFO have developed a new light source that detects minute changes in spectral features, ideal for identifying DNA mutations and cellular malfunctions. The mid-wave infrared range is crucial for resonantly exciting molecular vibrations, leaving fingerprints in the spectrum for identification.
A collaborative study will synthesize scattered information about butterflies, placing it in an evolutionary context to study broad-scale patterns of ecology and evolution. The project aims to assemble a database of biological information about each species, making it available to the public via a website.
The EORTC 1320 trial, coordinated by the EORTC Brain Tumor Group, aims to assess the efficacy and safety of YONDELIS (trabectedin) compared to standard care in patients with recurrent grade II or III meningioma. The study plans to accrue 86 patients across 47 sites in ten countries.
Albert La Spada, a UC San Diego professor, has received a $900,000 Harrington Scholar Award to develop a therapy for Spinocerebellar ataxia type 7 (SCA7), a rare neurological disorder. His research may also have implications for Parkinson's and ALS.
A multi-agency study found that severe El Niño and La Niña events will cause an increase in storm events leading to extreme coastal flooding and erosion across the Pacific. The research analyzed data from 48 beaches across three continents, suggesting the predicted increase will exacerbate coastal erosion irrespective of sea level rise.
Researchers have found that parasites resistant to artemisinin-based therapies can also resist other antimalarial drugs, making combination therapies less effective. This new multi-drug resistance is a serious threat to malaria treatments in Southeast Asia.
The upcoming Connecting Phytobiomes with Soil and Plant Health symposium aims to understand the interactions between plants and soils as they relate to crops, agronomy, and entomology. This research focuses on the importance of the microbiome in enhancing soil and water sustainability.
A new study found that a Medicare payment model reduced the number of low-value services used by patients, with a 4.5% reduction in spending on these services. Providers targeted low-value services to lower spending, and those who previously used more of these services saw the greatest reductions.
A team of scientists developed a new system using stem cells to model features of the developing human brain that could be targeted by toxic chemicals or drugs. The approach, described in PNAS, uses machine learning to build a predictive model from RNA sequencing data collected from neural tissue constructs exposed to different chemicals.
A recent study identified a significant association between childhood kidney stones and thickened arteries, a precursor to cardiovascular diseases. The research found that children with kidney stones showed increased thickness of key arteries, potentially leading to future cardiovascular complications.
Researchers at University of Alaska Fairbanks discovered 11,500-year-old chum salmon bones indicating Ice Age humans in North America used salmon as a food source. The findings suggest ancient Beringian diets were broader and human colonization of North America may have been influenced by salmon fishing.
Researchers from IMCB identified 303 genes linked to proviral silencing, revealing coordinated mechanisms involving multiple cellular pathways. The study found that Chaf1a and Sumo2 are the key factors controlling this process, with potential implications for stem cell therapy and disease diagnosis.
A phase 2 clinical study shows finafloxacin was more effective than ciprofloxacin in treating complicated urinary tract infections and acute pyelonephritis. Finafloxacin demonstrated rapid antimicrobial activity against resistant pathogens, including ESBL-producing bacteria.
Researchers found that patients with lower baseline microbial diversity are more likely to develop infections during chemotherapy. Monitoring the microbiome could help doctors predict infection risk and reduce antibiotic overuse.
A new study from the University of East Anglia found that nearly a quarter of teenagers in England and Wales who have had an abortion have been pregnant before. The research also showed that teenagers who become pregnant are at a higher risk of further pregnancies in their teenage years.
A new study explores the potential of Pressure Retarded Osmosis technology to extract energy from salinity gradients in Australian waters. The research suggests that brine, rejected during desalination, can be used as a source of osmotic energy, offering a carbon emission-free alternative to fossil fuels.
The introduction of both pneumococcal conjugate vaccines (PCVs) and rotavirus vaccines (RVs) led to a significant reduction in hospital admissions for winter diarrhea and respiratory infections. Within <5 years post-vaccine introduction, hospital admissions dropped by 78% for rotavirus diarrhea and 46% for pneumonia.
Researchers compared clinical outcomes between patients receiving nafcillin and cefazolin for MSSA bacteremia, finding that cefazolin had similar treatment failure rates but fewer adverse events. The study suggests that cefazolin may be a cost-effective alternative to nafcillin due to lower costs.
The silicone vaginal ring delivers hydrophilic molecules like tenofovir and acyclovir for extended periods, preventing viral infections such as HIV-1, hepatitis B, and genital herpes. Preliminary results demonstrate its potential to prevent STIs in young women with high risk of exposure.
The Women's Antiretroviral Efficacy and Safety Study found that women receiving Stribild had a higher rate of HIV suppression compared to those on ritonavir-boosted atazanavir plus Truvada. No one on Stribild developed resistant mutations, in contrast to three women in the comparator group.
Researchers developed a DNA sequencing device that can detect bacteria and antibiotic resistance in urine samples four times faster than traditional methods. The new method allows for quicker treatment and better stewardship of diminishing antibiotic reserves.
A study found that inadequate protein intake during pregnancy activates a genetic pathway leading to muscle atrophy and autophagy in the fetus. This can result in low birth weight and stunted growth in male offspring, increasing the risk of chronic health problems such as cardiovascular disease and Type 2 diabetes.
Researchers mapped antigenic differences in dengue virus strains, finding overlap among previously thought distinct groups. The findings suggest a continuum rather than separate groups, making vaccine development harder.
Scientists from OIST and Nagoya University have decoded the first lingulid brachiopod genome, showing that despite being referred to as 'living fossils', these animals are actively evolving. The study highlights significant changes in genomic structure and gene families, contradicting the idea of a genuine living fossil.
The IKK complex plays an unexpected role in protecting cells from death by inactivating RIPK1. This discovery reveals a new mechanism of action for the IKK complex beyond its well-known NF-kB-dependent functions, providing potential therapeutic targets for inflammatory conditions.
Trevor Greene, a former Canadian soldier who survived a debilitating brain injury in Afghanistan, has recovered his ability to walk again with the help of a customized exoskeleton. Dr. Ryan D'Arcy's research team discovered that physical functions can be recovered through rehabilitation even six years after an injury.
Researchers developed a new method to capture how brain cells interact, discovering novel proteins necessary for myelin production. This breakthrough provides insights into myelin diseases and improves understanding of cellular interactions.
A new study reveals that GLP-1 agonists may activate glucagon receptors, potentially promoting high blood sugar levels in patients with diabetes. The researchers emphasize the need for a more comprehensive understanding of how these drugs interact with receptors in different parts of the body.
Research led by Duke-NUS scientists has linked abnormal behavior of BDNF and DTNBP1 genes to the underlying cause of schizophrenia. By understanding how these genes interact, researchers have identified potential treatments that could rescue signalling balance in the brain, offering new hope for schizophrenia patients.
Typhoon Krovanh's strongest winds were found tightly wrapped around its center, reaching 67 mph/108 kph at 20-30 miles from the center. The storm was weakening and moving north at 13.8 mph/22.2 kph, with winds expected to curve northeast over the next few days
Western University researchers have developed an artificial intelligence-powered tool that can predict a patient's response to paclitaxel and gemcitabine chemotherapy medications. The tool uses genetic analysis of tumours to identify the genetic signatures most important for determining resistance and remission for each medication. Wit...
Researchers reconstruct environmental conditions in the Southern Ocean over the past 30,000 years, showing that seasonal sea-ice zones had significant influences on ecosystems and carbon cycling. The study reveals that nutrient-rich waters allowed phytoplankton to store CO2, contributing to global cooling during ice ages.
A recent study by TSRI researchers has uncovered a novel pathway between the cell's powerhouses (mitochondria) and the immune system. RIPK3, an enzyme involved in cell death, relays signals between mitochondria and NKT cells, regulating both cancer and inflammatory responses.
Researchers at the University of Exeter found that high nitrate beetroot juice improved both sprint performance and decision-making during prolonged intermittent exercise. The study showed a 3.5% increase in sprint performance and a 3% improvement in decision speed for athletes consuming the nitrate-rich version.
Research suggests that online campaigns need to be surprising to motivate public response, with distrust in sources and bias against non-news sources hindering engagement. Unfamiliarity with organisations also plays a key role.
Researchers at UMass Amherst propose a multivariate simulation approach to assess climate-land use effects on watersheds. The study recommends increased green infrastructure and best management practices to enhance watershed resilience.
New research from Monash University finds that Australian children and adolescents receive millions of exposures to alcohol advertising during daytime TV viewing of AFL, NRL, and Cricket. The study suggests removing a clause allowing alcohol advertising during daytime in sport could halve children's exposure.
Researchers found that artificial breeding created extreme wing shape and size relationships in fruit flies, but natural selection corrected these changes within just 15 generations. This study suggests that evolution is constrained by fundamental biological processes, such as developmental links between traits.
Researchers have identified a potential new way to predict which patients with head and neck cancer may benefit most from chemotherapy. The use of dynamic contrast-enhanced MRI scans has shown that tumour blood flow can predict response to treatment, with patients having high blood flow more likely to respond.
Tropical Depression 9 is battling strong vertical wind shear and dry air, leading to its weakening. The depression is expected to degenerate into a remnant low pressure area in 24 hours or less due to persistent environmental conditions.
A recent study by Dr. Sylvie Belleville and her team has identified typical patterns of brain progression towards Alzheimer's disease, revealing a complex path characterized by periods of stability followed by accelerated decline. The study suggests that rapid memory decline is a key indicator of risk, allowing for earlier treatment.
People fed β-glucan-enriched pasta for two months showed increased populations of beneficial Lactobacilli and reduced LDL cholesterol. The study also found an increase in certain short-chain fatty acids with anti-inflammatory activity.
UAB researchers discovered a triple mechanism that stops chromosome separation in response to DNA injuries, preventing cancerous transformation. The three control pathways, mediated by genes Wee1, Pds1/securina and Rad53/Chk2, must be eliminated simultaneously for damaged chromosomes to be segregated.
Scientists have found that local structures in liquid water persist for longer than a picosecond, contradicting the general perception of water as a solvent. This discovery was made using ultrafast vibrational spectroscopies and has significant implications for understanding chemical and biological reactions on Earth.
A new study suggests that in-hospital nocturnal dialysis may be beneficial for patients' hearts as well as their kidneys. The procedure was found to reduce left ventricular mass by a significant margin after one year, which is associated with a lower risk of cardiovascular diseases such as heart failure, heart attack, and stroke.
The 'Tree of Life' for 2.3 million species has been released, depicting relationships among living things over time. The collaborative effort combines smaller trees from various sources, with the goal of creating a comprehensive and editable online resource.
Researchers at Thomas Jefferson University found that patients with metastatic cancer are at high risk of venous thromboembolism after surgery, and a personalized approach to anticoagulation therapy is needed. The study suggests that the primary type of cancer may play a role in determining the risk for blood clots.
Researchers at Michigan State University found that Chinese farmers are adapting to shrinking domestic soybean fields by planting more profitable crops like corn, but this shift has environmental implications. Meanwhile, pockets of resilience in soybean cultivation suggest potential solutions for China's burgeoning food demand.
Researchers found early ultrasound signs of water absorption changes in cervix before delivery, indicating potential preterm birth risk. Current cervical length measurement methods are limited in their usefulness.
Involving parents in the treatment of adolescents with bulimia nervosa is more effective than treating the patient individually. Family-based therapy achieved higher abstinence rates from bingeing and purging compared to cognitive behavioral therapy, according to a randomized clinical trial.
A new study published in PLOS ONE found that higher doses of hydrocortisone are not associated with brain injury or neurodevelopmental impairments in extremely low birthweight infants. However, the study suggests that lower doses of hydrocortisone may improve cognitive outcomes.
The study aims to develop machine learning models that mimic the toddlers' ability to recognize objects, leveraging 500 hours of video and 54 million images from over 100 children. The research could lead to more sophisticated digital object-recognition technology.
The European Commission Joint Research Centre has found that the uncertainty in solar photovoltaic power measurements can be reduced by more than half, allowing for tighter margins and increased accuracy. This breakthrough could lead to cheaper and faster calibration of secondary reference devices, benefiting both industry and research.
Researchers at Caltech found that ocean microbes can consume large amounts of methane using electrons to share energy over long distances. The microbes use a symbiotic relationship to break down methane, which could help mitigate climate change.
A first draft of the 'tree of life' for 2.3 million named species has been released, combining existing branches into a single diagram. The digital resource was created by compiling thousands of smaller chunks and requires software tools to analyze and update.
Researchers are working to design recommendations for scientists and government organizations to work ethically with indigenous peoples. The project aims to improve collaboration between Native American tribes and climate scientists to better plan for climate change.
A study published by the Institute of Food Technologists found that a bean-based meal provided a similar feeling of fullness compared to a beef-based meal. The researchers discovered that plant-based proteins with high fiber content may offer similar appetite regulation as animal protein.