A new report by Eliezer Van Allen and colleagues found that melanoma patients who benefit from ipilimumab immunotherapy have unique tumor-produced antigens. The study suggests that predicting which patients will respond to the treatment may be challenging due to differences in molecular targets.
Oberdan is tracing the efforts of a group of intellectuals from diverse fields, including Moritz Schlick's Schlick Zirkel, who developed logical empiricism as a scientific philosophy. The research aims to provide insights into how scientists think about science and its implications for philosophical inquiry.
Recent advances in genetic testing are providing new insights into pediatric epilepsy, enabling timely diagnosis of potential genetic disorders. This can lead to optimized treatment and reduced costs for families, as well as reduced anxiety associated with unknown cause cases.
Researchers at Kansas State University have identified a key genetic link that enhances heterosis in sorghum, leading to improved plant height and potential increases in crop yield. The findings offer new insights into the complex genetic phenomena of heterosis and its impact on economically important traits.
A recent study by the Pew Research Center reveals significant differences in Americans' understanding of various science topics, with educational level being a major factor. Adults with higher education tend to perform better on science-related questions, while gender also plays a role, with men generally outperforming women.
The National Science Foundation has awarded $27.5 million in research grants to study ways to predict and respond to natural disasters. Researchers will focus on topics such as hurricane risk assessment, wildfire resilience and drought policy.
Researchers found a location-dependent pattern in cilia length that affects sensitivity to odors, with cells in the front of the nose having longer, more sensitive cilia. The discovery may shed light on disorders of the senses and has implications for understanding other sensory systems.
Poor diets, high systolic blood pressure, and smoking are top risk factors for global deaths, contributing to 30.8 million deaths in 2013. High blood pressure's impact on mortality has grown significantly, especially among men, while poor diet is the greatest cumulative impact on health.
Researchers develop cell-free protein synthesis platform to manufacture human phosphoproteins, enabling study of protein function and structure. The technology has the potential to pave the way for new drugs for diseases such as cancer and Alzheimer's.
Researchers found that stadium sponsors' stock returns are higher after home team wins, especially in post-season games. Unexpected game outcomes also lead to significant market reactions.
A team of scientists has uncovered over 1,500 hominin fossils in a cave complex in South Africa, representing the largest and most complete set found to date. The discovery adds a new branch to the human family tree, with the fossils suggesting that Homo naledi was deliberately depositing its dead in the cave.
Researchers at the University of Illinois found that smart watch motion sensors can be exploited by hackers to guess typed keystrokes. The 'MoLe' project reveals the potential for wearable devices to compromise user privacy.
Researchers have discovered that an anti-diabetic drug can 'suffocate' pancreatic cancer stem cells by preventing them from using oxygen for energy. This finding holds promise for developing new treatments that target these cancer stem cells and prevent recurrence after conventional treatment. Pancreatic cancer remains one of the most ...
Researchers found that people worldwide, including nomadic hunter-gatherers in Tanzania, group colors into categories similar to those used by other cultures. This study suggests a combination of nature and nurture influences color naming, revealing cultural universals despite dramatic diversity within each culture.
A study by the National Institute for Mathematical and Biological Synthesis found that monk parakeets develop an understanding of rank after about a week of interactions. They use social feedback to refine their behavior, avoiding fights with higher-ranked birds while targeting those closely matched in rank.
Researchers found that intoxication and distractions further impair driving abilities, even at low blood alcohol levels. The study suggests reducing the legal limit may not be enough to ensure safe driving.
Researchers have recalculated the frictional strength of subduction zone faults worldwide, revealing low stresses in these areas despite potential for large earthquakes. The study suggests that even weak faults can accumulate stress to produce significant quakes.
A new UNSW report shows that frozen embryo IVF cycles are just as successful as fresh embryo cycles, with a 23-27.5% birth rate. The report also found a significant increase in the use of frozen embryos and improvements in techniques such as vitrification and blastocyst culturing.
A 25-year analysis of global cause-of-death data reveals that dietary risks and high blood pressure have replaced child and maternal malnutrition as leading causes of death. The study highlights the importance of preventing avoidable risks like smoking, poor diet, and environmental hazards.
A Neolithic skeleton from Scotland reveals the earliest case of rickets in the UK, dating back over 3,000 years. The woman's diet and lifestyle suggest she suffered from Vitamin D deficiency due to lack of sunlight, highlighting unusual circumstances that led to her condition.
Researchers found that humans and chimpanzees express different levels of proteins controlling facial development, including PAX3 and PAX7 genes affecting snout length and skin pigmentation. They also identified species-biased enhancer regions contributing to craniofacial differences.
Homo naledi, discovered in South Africa, has a unique combination of derived cranial vault and hand morphology. Its age is unknown, but it may represent an intermediate between Australopithecus and Homo erectus.
Researchers found a distant galaxy cluster producing over 800 solar masses of new stars annually, significantly higher than our Milky Way. The discovery reveals a rare 'wet merger' event where a gas-rich spiral galaxy collides with the massive cluster's central galaxy.
A mathematical calculation platform predicts how patients respond to modified diets depending on their gut microbiome composition. The study reveals that individuals with low-diversity gut microbiomes experience improved blood chemistry when following a weight loss diet.
Researchers at Salk Institute discovered a single master gene, Sox10, that controls the formation of mobile cancer factories. High levels of Sox10 in breast cancer tissue enable these stem-like cells to rapidly produce variants that can survive and spread to other tissues.
Scientists at Goethe University Frankfurt have developed SLAP technology, a small labeling pair that achieves high sensitivity and efficiency in single-molecule localization microscopy. The approach avoids mislocalization artifacts caused by large detection markers, enabling precise analysis of protein clusters and oligomeric states.
A new Michigan State University study aims to identify early signs of Alzheimer's disease among Latinos and Hispanics, potentially delaying or preventing its onset. The $5.67 million grant will gather health data from nearly 7,000 middle-aged and older adults, with the goal of differentiating mild cognitive impairment from normal aging.
NASA's Aqua satellite captured an infrared image of Tropical Depression 8, revealing coldest cloud top temperatures near -63F/-53C. The depression is expected to strengthen and become a tropical storm later on September 9.
Researchers found a new biomarker in ceramides that may help diagnose and treat episodic migraine. Women with episodic migraine had lower levels of ceramides in their blood compared to those without headaches.
A neuroimaging study will use diffusion tensor imaging (DTI) to assess recovery after spinal cord injury (SCI), enabling medical professionals to predict motor recovery and provide more accurate prognoses. The study aims to improve rehabilitation outcomes for individuals with incomplete SCI.
A new study aims to illuminate the nationwide prevalence, frequency and scope of cyberbullying and electronic dating violence among youth. Researchers will survey a nationally-representative panel of teens aged 12-17 to collect data on contributing factors and negative outcomes.
A new study published in Patient Education and Counseling found that patients of minority race/ethnicity groups receive less information from their doctors about treatment rationale and scientific research. The study emphasizes the importance of consistent physician-patient communication to ensure equal care for all patients.
A University of Colorado Cancer Center study found that 41% of open lung cancer clinical trials excluded patients with previously treated CNS disease, while 26% allowed those with untreated CNS involvement. The study suggests that current practice may be based on habit rather than scientific rationale.
A University of Houston researcher is using brain activity tracking to study the connections between art and science, with a goal of improving creativity and understanding human emotion. The project involves artist Jo Ann Fleischhauer and uses advanced headset technology to track brain activity as she creates art.
The National Association of Science Writers announced the winners of its 2015 Science in Society Journalism Awards, recognizing outstanding reporting on science and society. Winners include Judy Foreman for her book A Nation in Pain: Healing Our Biggest Health Problem, and Erik Vance for his article Why Nothing Works.
Scientists have developed a technique to capture rapidly evolving intronic regions of the genome, increasing knowledge of evolution in difficult groups. The new method resolved evolutionary relationships between closely related Heuchera species, previously impossible to infer.
Researchers at Northwestern University found that discrimination during adolescence can have a lasting impact on cortisol levels, leading to flatter diurnal rhythms and increased risk of fatigue, mental health issues, and cardiovascular disease. The study suggests that cumulative experiences of discrimination, particularly during adole...
A caterpillar's feces induces corn plants to lower their defenses against insect predators, allowing the caterpillar to eat more and grow faster. This deception has likely evolved over thousands of years and may lead to the development of organic pesticides.
A new study reveals that women in social sciences receive slightly larger grants than men, with early career women being more successful. However, women overall receive only 41% of the £127 million allocated, largely due to the scarcity of female professors in senior positions.
A new enzyme-replacement therapy, Sebelipase Alfa, has been shown to effectively treat Lysosomal Acid Lipase Deficiency by reducing disease-related liver and blood cholesterol abnormalities. The therapy, which targets hepatocytes, resulted in lower cholesterol levels and reduced liver fat content in patients with the condition.
A study of over 4,000 European men found that those earning the majority of household income are most likely to want to work fewer hours. Men in partnerships and without children also desire shorter working weeks. The researchers suggest businesses should prioritize work-life balance for male breadwinners to reduce overwork.
Researchers found a significant increase in HCV infections among HIV-positive MSM, with the rate of new infections tripling between 1991 and 2010. The study also identified risk factors, including unprotected anal sex and sex while high on non-injected drugs.
The University of Maryland has received a $1.8 million grant from the National Institutes of Health to improve Bioconductor, an open-source data visualization software used in genomic marker identification for cancer and other diseases.
Researchers at UC Berkeley have identified nonstructural protein 1 (NS1) as a key culprit responsible for fluid loss and resulting shock in severe dengue virus infections. Blocking this protein in mice protected them from lethal effects, suggesting it could be a prime target for drugs and vaccines.
A recent study published in Nature Communications reveals that protein lamin A plays a crucial role in maintaining genomic structural stability by forming 'cross-links' that limit genetic material's freedom of movement within the nucleus. This creates a stable and linked polymeric structure promoting chromosomal integrity.
Smells trigger immediate emotional responses, and olfactory branding can supplant traditional marketing signals in settings like hotel lobbies. Over 41% of guests at ITC Sonar Luxury Hotels in Kolkata agreed that scent is a key factor in enjoying their stay.
A study of nearly 60,000 women who received synthetic vaginal mesh slings for stress urinary incontinence found a low risk of needing second surgery for mesh removal or revision. High-volume surgeons performed fewer complications, and multiple mesh-based procedures increased the risk of complications.
Research from Georgia Tech reveals that Twitter users adopt formal tone when using hashtags to reach a wider audience, while using @ symbols with smaller audiences or local language. The study shows geographical differentiation in online language, with regional lingo used in messages targeting specific cities.
Rice University researchers have developed a new technique to characterize the space within porous materials, allowing them to measure dimensions and dynamics at the nanoscale. This breakthrough could improve protein separation processes for the pharmaceutical industry.
Justin Ichida's lab will use cellular reprogramming to transform blood cells of ALS patients into motor nerve cells in a Petri dish. The goal is to rescue the cells by exposing them to normal levels of C9ORF72 protein and reveal its protective mechanism against ALS.
New insights into Mercury's movements and interactions with the solar system reveal its unique composition. Researchers reevaluate New Zealand's Alpine Fault after seismic data showed it becomes flatter at depth, providing new information for geological studies.
In a study published in PLOS ONE, researchers found that barbastelle bats emit two different types of weak echolocation signals alternately through their nose and mouth. These 'stealth echolocation' signals facilitate prey detection while minimizing environmental disturbance.
Researchers at Imperial College London have created a fluorescent molecule that can reveal the presence of quadruplexes in living cells. This breakthrough could be a game changer to accelerate research into these DNA structures and identify new compounds that can bind to them, potentially leading to new cancer treatments.
A team of researchers is using advanced computational models to better understand multiphase flows in porous media. They aim to improve carbon sequestration, mitigate climate change, and optimize energy extraction. By analyzing data from experiments and simulations, the team is developing a multiscale framework to model complex systems.
A new method of harvesting and growing lung stem cells has been developed by researchers at NC State University, which could provide an effective treatment for idiopathic pulmonary fibrosis (IPF). The study used a multicellular spheroid environment to enrich adult lung stem cells, which showed promise in mice trials with reduced inflam...
A Kansas State University research project will investigate the interaction between viruses and the immune system, focusing on poxviruses that could potentially become deadly diseases like smallpox. The study aims to predict future host ranges and develop new strategies for disease control.
Researchers found that when people took pride in an accomplishment, they were more likely to continue making disciplined choices throughout the day. However, when people considered a self-control goal before feeling proud, they were more likely to indulge in rewards and have less self-control.
A University of Cincinnati study found that black voters are more likely to support black Democratic candidates, but may consider voting for a Republican candidate if they know the candidate's party affiliation. The study suggests that building a Republican coalition with black voters is challenging due to ongoing racial and partisan t...
Researchers reveal that Saturn's F ring and its shepherd satellites, Prometheus and Pandora, formed from the collision of small satellites with a dense core. This study sheds light on the formation process of satellite systems in our solar system and beyond.
Researchers have found a new strategy to eliminate HIV by reactivating latent infected cells using a class of drugs called Smac mimetics. The approach, which has shown promising results in clinical trials for cancer, may lead to a safe and effective treatment to cure the virus.