A multiple myeloma patient experienced complete remission after receiving a personalized cellular therapy called CTL019, which targets cancerous white blood cells. The treatment was combined with chemotherapy and an autologous stem cell transplant, and the patient remains in remission over 12 months after infusion.
Researchers will investigate three projects: one on menopausal symptoms, another on biological activity of botanicals, and a third on interactions with prescription drugs. The goal is to determine the safety and efficacy of botanical dietary supplements as alternatives to hormone therapy.
A study by University of Texas at El Paso researchers found that 61% of kissing bugs in west Texas are infected with the Trypanosoma cruzi parasite, which causes Chagas disease. The disease can lead to life-threatening symptoms like heart rhythm abnormalities and difficult eating or passing stool.
A study published in JAMA Surgery found that postoperative delirium significantly increases adverse outcomes in older adults, including prolonged hospital stays and institutional discharge. Delirium alone exerts the highest risk of adverse outcomes at the population level compared to other major surgical complications.
Researchers have discovered that the dengue virus NS1 protein acts as a toxin, similar to bacterial cell wall products. This finding allows them to re-purpose existing drugs for a potential dengue treatment.
A Stanford-led study finds that pipeline replacement programs can significantly reduce natural gas leaks, with cities like Durham and Cincinnati showing a 90% decrease. This improvement is attributed to public-private partnerships, which have upgraded the city's infrastructure.
Researchers found diminished interaction among cytokines in people who later developed tumors five years before diagnosis. This suggests the tumor is suppressing local immune activation, allowing it to grow.
A major European study has identified key characteristics of severe asthma, which will help develop new treatments. Patients with severe asthma experience daily symptoms despite high doses of treatment and are more likely to be hospitalized.
New research suggests offering financial incentives for farming industries to mitigate environmental impact has a positive effect on greenhouse gas reduction and increased biodiversity. However, the study finds that current agriculture funding models are 'perverse subsidies,' promoting negative actions in both the long and short term.
Researchers analyzed public reaction to Sherman's remarks, finding that professional media defended him while most Twitter commenters denounced his comments using negative racial connotations. The study highlights the need for awareness of stereotypes to prevent harmful responses.
A new study by Baylor University researchers reveals that taking mid-morning breaks is more beneficial than traditional afternoon breaks for boosting energy, concentration, and motivation. The research also suggests that preferred break activities, such as work-related tasks, are key to restful recovery and improved job satisfaction.
A new study by NYU Langone Health has found that the presence or absence of dueling toxins in Staphylococcus aureus bacteria explains why hospital-acquired MRSA is more deadly than community-acquired forms. The study reveals a key toxin that counteracts another, more deadly toxin, opening up possible new pathways for vaccine development.
NASA-NOAA satellites confirmed Tropical Storm Grace had weakened into an open wave of low pressure, with wind data from RapidScat confirming the degeneration. The remnants are moving westward near 18 mph and expected to produce gusty winds and showers over the Lesser Antilles.
The Harvard Review of Psychiatry presents a timely update on new trends and developments in geriatric psychiatry. The special issue discusses policy changes, new diagnostic classifications, and research driving change in mental health care for older adults.
A UTSA computer science professor has received a Department of Army grant to create an image searching algorithm for combing through large amounts of surveillance videos. The goal is to identify individuals more quickly, especially in crowded and hectic situations like the Boston Marathon bombing.
Research found a strong association between low resting heart rate and an increased risk of violent criminality in men. Men with the lowest resting heart rates were more likely to be convicted of violent crimes, with a 39% higher chance compared to those with the highest rates.
A Pitt researcher used gene regulatory networks to uncover the origins of a recently evolved structure in male fruit flies, finding that it was created by reusing existing networks during development. This discovery sheds light on how complex animal forms arose and challenges the idea that new structures must be encoded by new genes.
Children's Cancer Institute Australia has been awarded close to $2 million to test new drugs in preclinical models of acute lymphoblastic leukaemia (ALL) under the Pediatric Preclinical Testing Consortium (PPTC). The PPTC will facilitate the acceleration of effective drugs into clinical trials.
A new study reveals countries with higher per-capita CO2 emissions, like the US and Russia, have accumulated large carbon debts. India is the largest creditor, while Brazil and Indonesia switch from being creditors to debtors due to deforestation and agriculture.
A new study of DCD liver transplantations found no significant correlation between donor age and organ survival. The results suggest that stringent donor and recipient selection can help expand the donor pool for life-saving liver transplantation, making aged DCD organs more viable.
Researchers found nearly 10 times more faint, early galaxies than previously detected in deep Hubble surveys. They used a new statistical method to parse out signals from noise in the images.
Tropical Storm Fred formed in the Eastern Atlantic and was tracked by NASA's Global Hawk. The storm weakened quickly under adverse atmospheric conditions, eventually losing its tropical cyclone status.
Researchers at the University of Pittsburgh have developed a new method for identifying pathogens using spectroscopy and protein hydrogels. This technique allows for rapid detection and identification of specific pathogens, enabling targeted antibiotic treatment and reducing the risk of misdiagnosis. The broader implications of this wo...
A new study published in Marine and Petroleum Geology has established a national baseline for earthquakes caused by human activity in the UK. Since 1999, an average of at least three onshore earthquakes per year with local magnitude greater than or equal to 1.5 have been linked to anthropogenic activities.
The American Academy of Otolaryngology will feature over 380 oral and poster presentations on various otolaryngic topics. Key findings include research on depression after hearing loss treatment and the correlation between pediatric sleep endoscopy and polysomnography.
Researchers identify two gold belts in the NCC, with gold mineralization linked to mantle-derived melts and fluids. The discovery of decratonic gold deposits has significant implications for understanding gold formation and exploring new large gold concentrations.
A nationwide study found that e-cigarette users are more likely to start smoking traditional cigarettes within a year compared to non-users. The study suggests that e-cigarettes deliver nicotine slowly, mimicking the act of smoking and making it easier for young people to transition to traditional cigarettes.
A new review presents a patient-specific plan to predict blood loss and address it, highlighting the commonality of anemia in surgical practice. The approach relies on detecting and treating anemia before surgery, reducing blood loss during surgery, and optimizing management after surgery.
Researchers examine differences between Southern California's summer and Santa Ana fires, which exhibit split personalities due to climate-driven conditions. Climate change increases the risk of both fire types, with non-Santa-Ana summer fires becoming more prevalent.
Researchers analyzed data from Australia's 2006-2007 wildfires and found exposure to wildfire smoke was associated with increased hospital emergency department visits for asthma. Fine particulates in wildfire smoke are easily inhaled and remain deep in the lungs, causing harmful health effects.
Forensic examiners can use blood or teeth samples to estimate an individual's age with great accuracy, helping track down criminals or identify human remains. Researchers at KU Leuven developed a test based on four age-associated DNA methylation markers, achieving margins of error of 3.75 years for blood and 4.86 years for teeth.
Researchers at UC San Francisco show that early humans' tool use led to changes in their shoulders, which helped the emergence of human-specific traits like high-speed throwing. The study's findings suggest that the common ancestor of modern humans and African apes looked more like a chimp or gorilla.
A study by UC San Francisco researchers found that privately insured pregnant women with 24-hour OB coverage and midwife care had lower C-section rates compared to those with traditional care. The study, which tracked data from 2011-2014, showed a significant decrease in C-sections among these patients.
A new study from NIMBioS reveals that contact rates and competition play crucial roles in determining the risk of parasitic disease outbreaks in animal communities. The research found that high contact rates and strong competition can amplify parasite fitness, increasing the likelihood of disease transmission.
A Tel Aviv University study found that even benign forms of incivility can impede medical personnel's ability to perform under pressure. Rudeness is linked to poorer diagnostic and procedural performance, as well as reduced information-sharing among medical staff.
A Kaiser Permanente study found that introducing electronic order entry and care-decision support in emergency departments led to a significant increase in the timely administration of clot-dissolving treatments for patients with acute ischemic stroke. The technology helped minimize errors while improving patient outcomes.
Researchers at UW's I-LABS study body maps in infant brain, finding they develop early and relate to social connections and imitation. The findings shed light on how infants build sense of self and connect with others.
Women with arthritis face a 87% higher risk of multidimensional poverty compared to nonarthritic females. Arthritis also affects men, increasing their poverty risk by 22% and 29% for multidimensional poverty, respectively.
A new Canadian-developed rule will help emergency department physicians determine when to use radiography in young children with minor head injuries. The rule identifies children under 2 months old or those with parietal or occipital swelling as high-risk, warranting a skull radiograph.
Scientists have successfully reversed an animal's behavior by altering a single synapse in its neural network. This groundbreaking study provides new insights into the stability of neural circuits and their role in controlling behavior.
The UK's largest breast cancer physiotherapy trial, PROSPER, will investigate the impact of physiotherapy on women after breast cancer surgery. The study aims to inform national guidelines and improve treatment outcomes for women experiencing shoulder problems and chronic pain after their treatment.
Researchers have found three new drug-like compounds that target a protein responsible for chemotherapy resistance in cancers, offering hope for improved treatment options. The compounds have shown promise in re-sensitizing resistant cancer cells to chemotherapy, improving the odds of survival for prostate cancer patients.
Researchers have created a new method for controlling gene activation, allowing for precise regulation of gene expression in cells. The method employs CRISPR technology combined with chemical compounds to activate specific genes without altering the genome.
Researchers from various disciplines set eight research axes to improve nutrition science, including sustainability, data analysis, and human behavior. The initiative aims to bring together experts to tackle key challenges in the field.
A recent Mayo Clinic study found that the number of new thyroid cancer cases is doubling, driven by the detection of previously undiagnosed low-risk tumors. These silent cancers often require unnecessary treatments, leading to financial and physical hardship for patients.
The researchers used broad ion beams to create nanostructured arrays on a gallium arsenide wafer, resulting in well-defined structures reminiscent of sand dunes. The process involves heating the sample during ion bombardment and compensating for missing atom bonds by forming pairs of gallium atoms.
Scientists explore reviving extinct Mediterranean forests through minimal human disturbance and restoration of native vegetation. They also investigate the impact of ocean noise pollution on undersea animals and propose internationally binding commitments to monitor and limit noise.
Researchers from Queen Mary University of London found declining numbers of Bovine TB infections in Scotland and Wales, while England's approach is unlikely to succeed. More frequent testing led to effective control of the disease, with a significant decline in infections.
Tropical Storm Etau formed near Iwo To, Japan on September 7 and was approaching Japan by September 8. The storm made landfall near Kyoto, Japan late on September 8/early September 9 and is forecast to dissipate due to land interaction.
Researchers at Northwestern University have developed a solution to create stable carbon nanotube-based integrated circuits using newly designed encapsulation layers. These layers protect the sensitive devices from environmental degradation, enabling reliable operation for years or even decades.
Tropical storm Grace has weakened to a depression in the Eastern Atlantic Ocean after just three days of formation. NASA's GPM satellite found only scattered areas of light rain in the system.
Researchers develop a new theory that describes how a knot's topology determines its mechanical forces, providing guidelines for choosing certain knot configurations. The theory accurately predicts the force needed to close a knot, given its topology and strand properties.
A study of over 1 million Medicare recipients found that flu vaccines with a high match rate to the prevalent strain reduced pneumonia hospitalizations by 4.2% and deaths by 2.0%. The study estimated lives saved and prevented hospitalizations annually in long-stay nursing home residents.
Scientists have elucidated a molecular mechanism that contributes to the 'cocktail effect' of endocrine disruptors when combined. The study shows that certain compounds bind cooperatively to a receptor in the cell nucleus, inducing a toxic effect at lower concentrations than individual molecules.
Researchers have expanded their search radius for dark matter particles using the CRESST experiment, which can now detect particles with masses below 10 GeV/c^2, including those comparable to a proton. The new detectors are being equipped and will begin measuring in late 2015.
Ozone concentrations commonly near urban areas can strongly inhibit bees' attraction to flowers due to fast scent degradation. The loss of scent signals affects the successful pollination of most insect-pollinated plants.
Child trafficking survivors experience poor mental health, self-harm, and suicide attempts, with 56% screening positive for depression and 15.8% reporting suicidal thoughts in the past month.
A study published in the Journal of Public Economics found that Prize Linked Savings (PLS) products, which combine savings with the possibility of winning large cash prizes, are more effective at inducing savings than standard interest-bearing accounts. This is particularly true for lower-income and less-educated individuals who are al...
Tropical Storm Jimena is being pushed west by strong vertical wind shear, affecting cloud top temperatures and thunderstorms. Forecasters expect the storm to gradually weaken over the next five days.
Researchers found that nearly 50% of Asian Americans with diabetes remain undiagnosed, with the highest prevalence in Hispanic Americans at nearly 23%. The study highlights the need for increased education and testing efforts among this population.