Researchers found that high cholesterol in young adults between 35-55 years increases heart disease risk by 39% each decade, even among those with normal blood pressure and weight. The study suggests that healthy individuals in this age group should consider cholesterol control earlier.
A large study found that younger adults with isolated systolic hypertension have a significantly higher risk of cardiovascular disease and coronary heart disease. Women in this age group are particularly at risk, with a 55% increase in cardiovascular death compared to their male counterparts.
Phospholipase A2 (PLA2) enzymes play a role in inflammatory diseases. Researchers created 3D models that show how PLA2 enzymes extract substrates from cell membranes, triggering inflammation. These models could help design and develop specific PLA2 inhibitor drugs.
Researchers at Gladstone Institutes discovered a new memory regulator in astrocytes, which improved memory in healthy mice and prevented impairments in Alzheimer's disease models. The study suggests that targeting A2A adenosine receptors may offer a potential treatment for improving memory.
Defective cilia can lead to diseases such as blindness, infertility, and obesity. UGA researchers have made a breakthrough by imaging and measuring tubulin transport in cilia, revealing the mechanism behind their assembly.
Researchers have reconstructed the development of winter temperatures in Russia's Lena River Delta, revealing a clear trend: warming winters over the past 7,000 years. The study used oxygen isotope analysis on ice wedges to access temperature information stored in the ice and compile it into a climate curve.
A recent study published in PEDIATRICS found that morphine administered for post-operative pain in children who have undergone tonsillectomy with or without adenoidectomy can cause significant respiratory problems and potentially fatal breathing disruptions. In contrast, ibuprofen was shown to be a safe and effective alternative.
A team of researchers has created a method to change graphene's electron density without physical alteration, enabling dynamic reconfiguring of circuit elements. This technique uses oxides to tune the amount of electrons in graphene, potentially revolutionizing semiconductor devices and optoelectronics.
Researchers at the University of Kentucky's Markey Cancer Center have identified pyruvate carboxylase as a key enzyme in lung cancer cell growth and survival. The study suggests that inhibiting this enzyme could lead to novel drug development for treating lung cancer, offering new hope for improving current treatment options.
The study found that well-established rules for getting good sleep, such as limited caffeine and a regular bedtime, led to sufficient sleep quantity and adequate sleep quality. Reducing the encroachment of technology into sleep time is crucial to support well-known sleep hygiene principles.
A team of researchers discovered that negatively charged molecules in biological scaffolds act like an 'ion sponge,' capturing calcium ions to guide crystallization. This new understanding may aid in developing advanced materials for energy and environmental applications.
A new study reveals that top firms behind most of the innovation in market infrastructure are a mix of 'new entrant' and 'incumbent' firms. Software companies and smaller brokerage firms have invested heavily in technology to stay competitive.
Researchers successfully mutated the thyroid hormone receptor in tadpoles, disrupting hind limb development and providing insight into the importance of hormones in early development. The study also has potential applications in understanding human developmental disorders such as cretinism.
A new kindergarten curriculum developed by the University of Wisconsin-Madison has been shown to improve preschoolers' academic performance and social skills. The curriculum focuses on promoting kindness, compassion, and self-regulation skills in young children.
A study found that giving employees more control over their work schedules can improve sleep quantity and quality, reducing the risk of chronic disease and early mortality. Participants experienced an average gain of nearly an hour of sleep per week compared to those without flexible scheduling.
Researchers found that hemin treatment suppresses hypertriglyceridemia and hypercholesterolemia while reducing pericardial adiposity. Hemin also attenuates adipocyte inflammation and oxidative insults, promoting regeneration of proteins such as beta-catenin and Oct3/4.
Researchers have identified widespread incorporation of ribonucleotides in genomic DNA, with hotspots found in nuclear and mitochondrial DNA. The Ribose-seq technique allows for the precise location of ribonucleotides, which can affect genome stability and function.
A study found that Medicaid copayments for nonurgent emergency room visits had little impact on usage rates, with no significant difference in states with and without copayments. The researchers suggest that lack of access to primary care physicians may be a reason why patients continue to seek ER care.
A team of scientists has identified a brain circuit in mice that regulates thirst, with two distinct cell types working together to maintain fluid balance. The study found that activating one set of cells triggers drinking behavior, while silencing the other population suppresses thirst.
Researchers at CNIO have discovered a new way to produce platelets artificially, reprogramming megakaryocytes to increase in size. This breakthrough could lead to the development of new treatments for thrombocytopenia and cancer by targeting specific proteins involved in cell growth.
A recent study published in JAMA Internal Medicine found that low-risk patients presenting to the emergency department (ED) with chest pain did not experience a significant increase in heart attack risk regardless of the initial diagnostic testing strategy. The researchers analyzed data from over 421,000 ED visits and concluded that ce...
A recent brain study has confirmed significant differences in play behavior, brain activation patterns, and stress levels between children with autism spectrum disorder (ASD) and typically developing children. The research suggests that some children with autism may experience social engagement as stressful or aversive.
Researchers at Penn Dental Medicine have identified Foxo1 as a critical molecule that impairs wound healing in diabetics. The study found that deleting Foxo1 in keratinocytes improved wound healing in diabetic mice, suggesting a potential target for therapies to boost healing.
Researchers found that reclaimed oil and gas well pads in Colorado lack the patchy soil patterns that support sagebrush recovery. This uniformity can make it harder to reestablish big sagebrush, a critical component for diverse wildlife species.
Researchers have found that cooperation between cancer cells leads to the evolution of resistance and relapses after therapy. A new treatment approach involves genetically modifying cancer cells to remove growth factor-producing genes, potentially eliminating tumor heterogeneity.
Research finds accumulated brain damage linked to memory deficits and mood regulation in former NFL players, supporting calls for improved athlete protection from concussion. PET scans show concentrated zones of high translocator protein levels, indicating brain injury and potential long-term neurological risk.
Researchers at the University of Liverpool have successfully controlled a material's structure to generate both magnetisation and electrical polarisation, two contradictory properties. This breakthrough has significant implications for low-energy information technology applications, such as efficient information storage and logic devices.
Researchers have identified a specific population of stem cells in the skin that exclusively generate and maintain Merkel cells, crucial for touch sensation. Removing these cells led to a permanent reduction in Merkel cells, highlighting their unique role.
The CUDC-101 clinical trial, conducted at the University of Colorado Cancer Center, demonstrated activity against key drivers of head and neck cancer. In the study, patients with medium- to high-risk head and neck cancer showed significant results after treatment with CUDC-101 combined with radiation and chemotherapy.
A new study finds that pollinator declines could lead to severe nutritional deficiencies in some populations, particularly vitamin A deficiencies. The research examines the connection between crop-pollinating animals and human nutritional health, revealing alarming effects in certain countries.
A swarm of microprobes with different sensors could be sent to Jupiter, collecting data as they fall and transmitting it before burning up. This mission concept aims to study the planet's atmosphere and shed light on its composition, solar nebula formation, and impact history.
A study by UVM's Carmen Petrick Smith found that elementary school students who performed body-based tasks while interacting with a Kinect program showed significant gains in understanding angles and angle measurements. The movement-based lessons were more effective than traditional static representations.
Scientists have discovered a novel mechanism that helps cells respond to oxidative stress, a major cause of Parkinson's and Alzheimer's diseases. The new mechanism involves a protein modification called ubiquitination, which stabilizes ribosome function and promotes protein synthesis.
A Tel Aviv University study prioritizes reasons for forecast failures across different regions, identifying man-made and natural factors such as land-use changes, topography, particles in the atmosphere, and population density. The researchers found unique factors affecting forecasts in various regions, including Europe, North Africa, ...
A new report published in Sleep Health found that reducing work-family conflicts in the workplace can lead to better sleep outcomes. Workers who participated in an intervention aimed at reducing conflict slept an hour more each week and reported greater sleep sufficiency compared to those who did not participate.
Laurie Sanders, a Pitt assistant professor of neurology, will receive the William N. & Bernice E. Bumpus Foundation Innovation Award. The award supports her research on unrepaired mtDNA damage and its role in Parkinson's disease development.
Researchers discovered that babies born with smaller kidneys are more likely to develop chronic kidney disease and high blood pressure as adults. The study found enhanced nerve activity and an inability to respond to nitric oxide promote kidney injury.
A new study by Kansas State University veterinary diagnosticians found that a rabies booster can protect pets with out-of-date vaccinations from developing the fatal disease. The finding gives pet owners and veterinarians new options when faced with quarantining or euthanizing a pet exposed to the rabies virus.
Researchers at the Max Planck Institute discovered that removing water from collagen fibers dramatically increases their tensile forces, generating up to 300 times more force than human muscles. This finding suggests a more active role for collagen in living organisms and opens new possibilities for developing novel materials.
Researchers at Columbia University Irving Medical Center have identified the brain's on-off switch for thirst, revealing two types of neurons that drive and suppress the sensation. The study uses optogenetics to activate specific neuron populations in the subfornical organ, leading to increased drinking behavior in mice.
Researchers developed a novel laboratory model to test factors improving MSC binding to defective cartilage. Integrins were found essential for effective MSC attachment and therapy efficacy in osteoarthritis repair.
A Finnish study found that travelers who used antibiotics to treat diarrhea were more likely to carry drug-resistant intestinal bacteria, such as ESBL, upon return. Carriers can spread the bacteria to others, even without symptoms.
A team of chemists at Nagoya University has synthesized novel transition metal-complexed cycloparaphenylenes that enable selective monofunctionalization of CPPs. The discovery opens doors to the construction of unprecedented nanocarbons, including carbon nanotubes with new properties.
A new Canadian guideline recommends measuring body mass index at primary health care visits to prevent and manage obesity. Structured behavioral interventions, including counseling, education, and environmental modifications, can help individuals lose weight, particularly those at high risk of diabetes.
A study of abandoned Romanian children reveals significant associations between childhood neglect and altered white matter in the brain. Early intervention into foster care promoted more normal development in previously neglected children.
Joshua Plotkin, a young professor at Penn, has won the prestigious prize for his innovative theoretical work in mathematical biology. His research on the evolution of influenza virus has significant implications for public health and vaccine design.
A new study seeks to improve the health of sedentary people at risk for diabetes and heart disease by decreasing their sitting time. The program will test whether reducing sedentary behavior is as effective as increasing physical activity in improving overall health.
Researchers found that prescriptions for quinine and Google searches for leg cramps peak during the summer months. This seasonality could lead to a 'quinine holiday' during colder months for patients taking the medication.
Researchers at the University of Copenhagen have discovered that Ras protein misregulation is linked to cell shape. By targeting changes in membrane curvature, they hope to develop new ways to diagnose and treat cancers.
Cardiothoracic surgeons are stepping back as vascular specialists play a larger role in managing patients with Type B aortic dissections. Advances in minimally invasive endovascular surgery have driven this shift.
A new study reveals that over half of ICU patients using ventilators can communicate, challenging common assumptions about their ability to participate in care. Establishing lines of communication is crucial for accurate symptom assessment and management, leading to a better patient experience.
A study by University of Illinois researcher Brittany Duff found that people's processing styles and moods can impact their ability to recognize ads while multitasking. Analytic processors tend to focus on specific items, while holistic processors take in everything at once.
Researchers discovered that EBV microRNAs block a key component of the human immune system called interferon response. This finding explains why some cancer therapies fail in certain cases and may lead to new treatments for viral cancers.
A study isolated the domain IV paddle of scorpion venom and found it remained sensitive to scorpion venom even when bound to a chip. This breakthrough could lead to faster identification of drugs that target this region, modifying sodium channel activity in beneficial ways.
A large study links taking commonly used medications with anticholinergic effects to a significantly increased risk of developing dementia and Alzheimer's disease. People taking certain medications at high doses or for longer periods are estimated to be at greater risk for developing dementia.
A new study found that oatmeal breakfast resulted in greater fullness and lower calorie intake at lunch compared to sugared corn flakes or water. The study suggested that the satiety effect of oatmeal may be due to its slower gastric emptying, which was more pronounced in overweight subjects.
Researchers investigated 56,000 participants and found daily drinking significantly increases the risk of alcoholic cirrhosis. Recent alcohol consumption, not lifetime consumption, is the strongest predictor of this condition.
A strong nor'easter is developing in the Atlantic Ocean and will bring snowfall of 1-3 feet or more to parts of the Northeast. The storm system was captured in a NASA movie of NOAA's GOES-East satellite imagery, showing its progression from January 24 through 26.
The American College of Physicians marks its centennial year with a focus on the role of internal medicine in healthcare systems, professional satisfaction, and cost control. The journal also explores the challenges of sharing clinical trial data, highlighting the need for a consistent approach to balance benefits and risks.
Researchers found that anti-TB granulomas have abnormal blood vessel networks, similar to solid tumors, which limit drug penetration. Treating these vessels with bevacizumab improved drug delivery and reduced oxygen-starved cells.