Young men with HIV who have sex with men are more likely to report condomless anal sex, particularly with a partner not infected with HIV. Behavioral approaches to improve engagement in care and medication adherence may need to occur in concert with interventions to reduce risky sexual behaviors.
Researchers have identified four potential treatment opportunities for acute myeloid leukemia, including compounds targeting metabolism, internal communications, and protein transport. These findings represent significant progress in seeking out new ways to approach an intractable cancer.
Researchers have uncovered the atomic-level structure of the bluetongue virus, providing a detailed understanding of its mechanism of entry into host cells. This breakthrough could lead to the development of more effective vaccines and treatments against this devastating disease.
A recent study published in Nature Genetics reveals that Short Tandem Repeats (STRs) regulate gene expression and modulate disease traits. STRs, previously thought to be neutral or 'junk' DNA, were found to act like springs or knobs that fine-tune nearby gene expression.
Researchers at Toyohashi University of Technology have developed a novel gene-transfection method that uses electrostatic manipulation in water-in-oil droplets. This technique increases transfection efficiency and cell viability compared to traditional methods, offering promising applications in regenerative medicine and gene therapy.
Researchers found that including plants' acclimation to changes in temperature improves climate model accuracy, especially for tropical forests. Adding formulas for acclimation increases carbon exchange simulations by 36%, leading to a better understanding of how regions will respond to warmer temperatures.
A study found that breast cancer survivors with therapy-related leukemia often have inherited cancer susceptibility and gene mutations. Researchers suggest a long-term follow-up study to understand the impact of these genes on leukemia risk, enabling personalized conversations about treatment benefits and risks.
Researchers have achieved unprecedented response rates of up to 93% and durable remissions of over two years in children with relapsed/refractory acute lymphoblastic leukemia. Similarly, patients with non-Hodgkin lymphoma responded well to personalized cellular therapy, with complete remissions seen in 14 patients.
Researchers at Dana-Farber Cancer Institute have conducted three studies demonstrating the effectiveness of new drug combinations in treating relapsed or treatment-resistant multiple myeloma. The trials showed impressive partial and complete remissions, as well as increased duration of remissions with tolerable side effects.
Researchers identified a nuclear receptor protein called RXRgamma, which promotes OPC differentiation and remyelination. A vitamin D-activating drug may enhance remyelination in MS patients by controlling myelin sheath regeneration.
A University of Eastern Finland study found that small gallstones are often caused by idiopathic pancreatitis and can be prevented by laparoscopic gallbladder removal surgery. Statin use was also associated with an increased risk of acute pancreatitis, especially during the first year of use.
A recent study from Australia found that urban environments contain disproportionately more threatened protected species in a given area than non-urban environments. Cities consistently supported a greater number of protected species than other areas, showcasing the importance of cities in tackling biodiversity loss.
Experts presented research on the complex relationship between diabetes and bone, highlighting increased risk of fragility fractures in people with type 2 diabetes. The studies found that diabetic patients may experience higher BMD but lower bone microstructure quality, leading to an increased risk of wrist fracture.
A recent survey by Drexel University researchers found that there is a lack of understanding about the costs and benefits of improving indoor air quality, even among building owners and designers. The study suggests that increasing ventilation and using better air filters can significantly improve health and productivity, but many peop...
A Stanford study found that infertile men have a higher risk of developing heart disease, diabetes, and other health problems. The research suggests that male infertility is associated with increased rates of mortality and general health issues, even after adjusting for obesity and smoking.
Young adults born preterm have a 40% increased risk of premature death compared with people born at term. Regular measurement of blood pressure and pulmonary function testing are recommended to help manage risks associated with preterm birth.
A new study found that a brief dissonance-based eating disorder prevention program alters how young women's brains respond to images of thin supermodels. The program reduces pursuit of unrealistic beauty standards and changes brain responsivity to normal-weight women, suggesting a shift in valuation towards healthy weight.
A study of medical records found that men taking androgen deprivation therapy for prostate cancer were almost twice as likely to be diagnosed with Alzheimer's disease as those who didn't undergo the therapy. The longer duration of ADT, the greater the risk of Alzheimer's disease.
Scientists have reevaluated the emergence of early dinosaur relatives and their connection to the first dinosaurs. The new findings suggest a shorter time gap between the two, dating back around 234-236 million years, contradicting previous estimates.
Brian Litt, M.D., receives the American Epilepsy Society's Research Recognition Award for Clinical Science for his pioneering work in neuroengineering and translational neuroengineering. His research focuses on developing new diagnostic and therapeutic technologies to improve epilepsy treatment outcomes.
A recent study published in Cancer Research reveals that obesity contributes to metastasis in ovarian cancer patients. Researchers from the University of Notre Dame found that tumor cells are better able to metastasize when grown in a high-fat environment, suggesting potential targets for dietary and therapeutic interventions.
Researchers have developed personal monitoring devices that can track seizure activity in the home environment, providing advance warning before seizures strike. These devices use biometric recording technology and can operate for seven days on a single charge, revolutionizing epilepsy therapy.
Research studies presented at the IOF regional meeting found significantly low levels of vitamin D in different population groups across the Middle East. The studies revealed high prevalence of vitamin D deficiency, affecting all age groups, sexes and local/non-local populations.
Researchers have found that continuous intravenous infusions may not be appropriate for all patients with drug-resistant status epilepticus, while a sedative called ketamine is increasingly used as a treatment option. The duration of status epilepticus in children depends on factors such as the length of time between seizure onset and ...
Professor Federico Rosei of INRS Énergie Matériaux Télécommunications Research Centre has received the 2016 John C. Polanyi Award from the Canadian Society for Chemistry. He is known for his research on nanostructured materials and has earned several national and international awards.
A new model has been developed to track animal movements using solar geolocators, providing more precise locations and behavioral data for migratory species. The FLightR R package enables accurate estimates of migration routes with increased precision than traditional methods.
A team of researchers discovered non-coding RNA molecules in cancer cells that stimulate an immune response by mimicking pathogens. The findings suggest these molecules may play a significant role in mediating immune responses against cancer.
Researchers identify NEK7 enzyme's switch-like activity in immunity, leading to potential new treatments for metabolic disorders and inflammatory conditions. The study provides insights into the inflammasome pathway and its connection to cancer.
The Rice researchers used experiments and simulations to study the stiffness of joined nanotubes and found that some types are tougher than others, with all having potential uses in macroscale structures. The team discovered that the X's were the stiffest and most able to bounce back to nearly their original shapes.
The study describes for the first time the developmental processes that differentiate Neanderthal facial skeletons from those of modern humans. The researchers found that Neanderthals' faces grow with extensive deposits by osteoblasts without a compensatory resorption, leading to a prognathic maxilla.
Researchers create spatiotemporal genomic analysis (SAGA) technique to study differences in cellular behavior, including cell migration and response to chemotherapy. This approach may lead to new treatments that hamper metastasis.
Researchers at the University of Warwick discovered that sperm tails rotate in a counter-clockwise motion to move through fluids. Approximately 50% of observed sperm moved to the right by distorting their bodies to counteract the left-turning force, suggesting two distinct physiologically subpopulations
Scientists have detected spin currents on a topological insulator at room temperature for the first time, enabling dissipationless spin currents. The breakthrough uses ferromagnetic tunnel contacts to measure the spin polarization of electrons on the surface.
A study published in Health Affairs found that the most crowded US hospital emergency departments did not adopt effective interventions to improve flow, leading to worse patient care and outcomes. Despite increased adoption of strategies to reduce crowding over four years, many hospitals still failed to implement proven interventions.
Researchers at the University of Missouri-Columbia found that TigerPlace residents who used sensor technology and onsite care coordination stayed in their apartments for an average of 4.3 years, nearly double the national median of 1.8 years.
Once-weekly GLP-1RAs lack clear-cut benefits and harms, making it challenging to choose the most suitable medication. The medications share similar outcomes for blood pressure and lipids but have differences in terms of HbA1c reduction and body weight, as well as risk of nausea and heart rate increase.
A new mobile biochip device, the HemeChip, can rapidly screen for sickle cell disease with just a few drops of blood, providing an easy-to-use and cost-effective tool for equitable diagnosis. This technology has the potential to make a huge difference in developing nations worldwide by enabling early treatment.
A UK-based research team aims to produce a yeast-derived substitute for palm oil using sustainably-sourced waste feedstocks, potentially mitigating environmental issues associated with palm oil production. The £4.4m grant-funded project will develop a novel yeast and apply innovative methods of depolymerizing waste materials.
Researchers harness molecular machinery of living systems to power integrated circuit from ATP, enabling new artificial systems with both biological and solid-state components. The system produces an electrical potential harvested by the IC in the presence of ATP.
Researchers at TUM developed a new method to produce extremely thin and robust, yet highly porous semiconductor layers using nanostructured germanium. These layers can be custom tailored with organic polymers to create hybrid materials suitable for small solar cells or batteries.
New research published in CMAJ found that older men taking alpha-blockers for prostate issues are at higher risk of ischemic stroke during the initiation phase. The study suggests caution when prescribing alpha-blockers to patients not already on other blood pressure medications.
A new study by Johns Hopkins Bloomberg School of Public Health researchers found that over 112,000 people exiting prison or jail got health care coverage through Medicaid in a single year. The programs that helped with enrollment primarily targeted low-income men, and the number of new enrollees likely far exceeds this total.
Researchers have developed a novel method to reposition an FDA-approved anti-cancer compound for targeting liver cancer tumors. The 'triple attack' technique uses nanobubbles filled with the drug to specifically target cancer cells, minimizing harm to healthy tissue.
Researchers use high-energy synchrotron X-rays to analyze cast iron structure, revealing insights into its mechanical and thermal properties. This technology enables the development of high-performance materials for fuel-efficient engines and engine parts.
A phase I/II clinical trial found that acalabrutinib promotes high response rates and durable results in patients with relapsed chronic lymphocytic leukemia while producing minimal side effects. The drug's selective blockade of the BTK pathway may offer improved tolerability compared to other treatments.
Researchers found support for Chomsky's decades-old theory that we possess an 'internal grammar' to comprehend nonsensical phrases. The study used magnetoencephalography and electrocorticography to isolate brain activity while subjects listened to linguistically manipulated sequences.
German cockroaches' gut bacteria produce pheromones that attract other roaches, promoting aggregation. The compounds are essential for nymphs to determine a safe place.
A £5.5m research project aims to tackle air pollution in Beijing, which poses a serious threat to human health, particularly among China's 500 million urban residents. The five four-year projects will investigate the concentrations and sources of urban air pollution, its effects on health, and potential solutions.
Midostaurin has been shown to improve the five-year survival rate of patients with high-risk acute myeloid leukemia (AML) who carry the FLT-3 gene mutation. The clinical trial found that midostaurin added to standard chemotherapy reduced the risk of death by 23% compared to placebo, resulting in a 50.9% five-year survival rate.
Researchers at Umea University discovered unique muscle fibers in the soft palate of humans, found in greater numbers in snorers and sleep apnea patients. These fibers have a distinct molecular build-up and are absent or modified in some key proteins.
A clinical trial showed midostaurin, a multi-kinase inhibitor, improved the five-year survival rate of patients with high-risk acute myeloid leukemia (AML) who carry the FLT-3 gene mutation. The treatment resulted in a 50.9% survival rate compared to 43.9% for those without the mutation.
Researchers have developed an innovative approach to treat drug addiction using RVG-exosome delivered RNAi against the opioid receptor mu (MOR). This method successfully down-regulates MOR in mouse brain and rescues opioid relapse. The study demonstrates the potential of this therapy for treating CNS diseases.
Researchers developed a simple method to track and predict viral evolution based on whole-genome sequences of influenza viruses. By identifying genetic variants that change the structure of influenza proteins, they found that many strains used in vaccines during previous seasons lacked these markers.
Researchers found that men use cardinal directions more efficiently and the hippocampus less than women, while women rely on local memory. Administering testosterone improved women's navigation skills, but not their performance.
A Phase I study combining natural killer cells with high-dose chemotherapy and stem cell transplantation showed promising results in treating multiple myeloma. The treatment resulted in no toxicity or graft-versus-host disease, offering a potential new approach for patients.
A new antivirus add-on can scan across computer networks and trap malicious activity missed by system firewalls, offering improved protection against malware. The system adds little computing overhead and can block malware before it causes harm or spreads to other machines.
Researchers at SLU are developing a biomarker to help diagnose sepsis early and improve treatment outcomes. Chlorinated lipids may hold the key to this discovery, as they appear under conditions of inflammation.
Researchers found that physical activity enhances neuroplasticity in the visual cortex of adult humans, paving the way for non-invasive therapeutic strategies. The study suggests exercise plays a crucial role in brain health and recovery, particularly for individuals with conditions like amblyopia.
A new study identifies brain processes in mice that may help explain how weak sensory inputs are interpreted differently in the same brain. Activity in higher-level perception areas of the brain is shaped by lower-level sensory input, adding a cellular layer to our understanding of perception.
Researchers found a 15-20% reduction in hospitalization risk for heart failure or death among patients with cardiac resynchronization therapy compared to those with implantable cardioverter defibrillators. The treatment is associated with improved outcomes, but further studies are needed.