Researchers successfully tested gene therapy combined with low-dose chemotherapy in five patients aged 7-24 with worsening immune systems due to SCID-X1. The therapy showed substantial improvements in immunity and clinical status, particularly in the first two patients who received treatment.
Scientists have found that maximum observed earthquake magnitudes on transform faults generally scale with offset across the faults, but for some earthquakes, a larger coseismic stress drop occurs. This study contributes to developing refined building codes and risk mitigation concepts along major transform faults.
Dr. Story Landis is honored with the AES's highest award for her exceptional service and contributions to epilepsy research. Her leadership at NINDS has supported $1.6 billion in annual research funding, driving progress in understanding synapse formation and neurological disorders.
Page B. Pennell, M.D., is recognized for her extensive service to the American Epilepsy Society (AES), including leadership roles on its Board of Directors and committees. She has made significant contributions to understanding and treating women with epilepsy through her research.
Studies investigate biological factors behind memory decline in people with epilepsy, particularly those with temporal lobe epilepsy. Loss of neurons from the hippocampus is a common cause of impaired memory. Researchers also explore effects of seizures on signaling pathways and brain activity.
Scientists create virtual tumors to test drug treatments, achieving an 85-86% correlation with lab results. The goal is a patient-specific workflow for early diagnosis and effective treatment identification.
Researchers at UT-Arlington developed a novel cancer cell detection method based on real-time cell behavior tracking, leveraging the unique dancing behavior of cancer cells on engineered surfaces. This technology has potential to serve as an additional modality for identifying tumor cells from blood samples or biopsy specimens.
A SWOG trial shows that adding bortezomib to lenalidomide and dexamethasone therapy in early treatment improves remission time and life expectancy for myeloma patients by about a year, compared to the standard two-drug regime.
Studies reveal that children with epilepsy show global differences in cognitive network development, but hubs of these networks are functionally similar to those of healthy peers. Graph analysis also suggests that neural networks linking cognitive skills are not well integrated in children with epilepsy.
Research from St. Jude Children's Research Hospital found genetic variations associated with an 8-to-15-fold increased risk for osteonecrosis in young ALL patients. These variants were more common in patients who developed osteonecrosis, particularly near the BMP7 gene important for bone development.
Chagas disease is a life-threatening illness caused by the protozoan Trypanosoma cruzi. In Spain, Latin American migrants are at high risk due to mother-to-child transmission, with an estimated 50,000-70,000 people infected. Screening is crucial to detect heart abnormalities early and prevent sudden cardiac death.
Two studies unveil neural networks that produce and propagate seizure activity, providing information to refine surgical interventions. A third study describes a device capable of detecting and diminishing seizure activity through brief electrical stimulation.