Scientists have developed a new technique to genetically engineer cells by inserting large DNA sequences at specific genomic sites. This method may be useful for producing high levels of proteins in mammalian cells.
A team from Duke University has developed a new method to measure the aging process in young adults, finding that signs of aging can appear as early as age 26. The study used 18 biological measures to determine an individual's pace of aging, with some participants aging at rates of three years per year.
Researchers exploring strategies in biology to create different mechanical properties, such as draglines and pheromonal trails, reveal principles that inform new material designs. By understanding nanoconfinement and the role of mechanics in biological systems, scientists can speed up discovery and develop innovative materials.
Researchers have discovered thousands of new peptide toxins in the venom of a single type of Queensland cone snail, opening up promising leads for new pain and cancer treatments. The study's innovative method allows for deeper analysis of venom toxins than ever before.
Scientists at UC Davis have identified endoplasmic reticulum stress as the significant driver of neuropathic pain. The discovery opens new avenues for treating chronic pain from various conditions, such as diabetes and multiple sclerosis.
Typhoon Nangka's infrared data showed cold cloud top temperatures indicating strong thunderstorms and a good circulation. The storm intensified from a tropical storm to a typhoon after NASA's Aqua satellite passed overhead on July 6.
Faith-based organisations have played critical roles in delivering education, health, and social services, particularly in hard-to-reach areas. Religious leaders provide a much-needed complement to public health messages, inspiring congregations to adopt healthy behaviours.
Researchers found key differences between people receiving hospice care in ALFs versus those cared for at home. People in ALFs were more likely to be older and female, and received help from the hospice team earlier, leading to a higher quality of life before death.
Researchers at Rice University are developing gas-releasing microbial sensors to study microbe-driven processes that regulate Earth's environment. The sensors will allow researchers to test hypotheses about how microbes control environmental processes and build model ecosystems in the lab.
Researchers found that intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events triggered by cellular senescence, providing proof-of-principal for a new treatment paradigm. The study shows that once disrupted, it takes time for the inflammatory loop to reestablish, offering hope for a safer and more effe...
Researchers used OCT to study brain vascular imaging during real-time experimental stroke, revealing high-resolution images of in vivo vascular networks and biologically initiated rescue mechanisms. This could provide guidance for clinicians treating stroke patients.
Researchers discovered that dengue virus adapts by interacting with host RNA and proteins, allowing it to bypass the immune response. This finding explains the 1994 Puerto Rico epidemic and may help predict future outbreaks.
A new study reveals that almost one in four psychiatric patients in Ontario hospitals are restrained using control interventions. This can damage therapeutic relationships and stigmatize patients, with health-care providers administering medication to manage dangerous situations.
Ticks carrying Lyme disease are increasingly found in new areas of the US, with a study suggesting southern ticks migrated northwards. Understanding these movements is crucial to identifying factors driving population shifts and reducing public health risks.
A study of 1159 males who illicitly used amphetamines found that half reported no impact on sexual functions, while the other half experienced reduced erectile rigidity, enhanced orgasmic intensity, and delayed ejaculation. Amphetamine users were also twice as likely to experience erectile dysfunction compared to matched controls.
Research published in BMJ Quality & Safety found a heightened risk of death after hospital admission at weekends in several developed countries. Patients admitted for planned surgery were more likely to die within 30 days, with a 'Friday effect' observed in Dutch hospitals.
A team of Pitt scientists has developed consensus guidelines for thyroid cancer molecular testing to help clinicians make informed decisions about diagnosing the condition. The new guidelines incorporate newly available tests that better incorporate personalized medicine into diagnosing thyroid cancer.
Children with long QT syndrome who take ADHD medications are at increased risk of experiencing heart-related problems, including syncope. Researchers call for cautious prescribing and close follow-up to mitigate this risk.
A rollator improves walking distance and time for patients with COPD, while a draisine has detrimental effects. Researchers found that unaided walking resulted in the longest distance walked by COPD patients.
A new ASU project will leverage social media to monitor and analyze conversations to determine significant dangers. The goal is to develop a logic-based framework to understand extremist mindset and motivations, supporting counter-messaging strategies.
Researchers at KU Leuven have developed a method to produce bioplastics, such as polylactic acid (PLA), more efficiently and with less waste. This breakthrough could lead to cheaper and more sustainable production of biodegradable plastics.
Researchers developed a lightweight system to produce therapeutic nitric oxide from the air using an electric spark, overcoming size and cost limitations of existing equipment. The device shows promise for treating conditions like pulmonary hypertension, chronic lung diseases, and certain types of heart failure.
A new RAND Corporation study found that adolescents who saw medical marijuana ads were twice as likely to use the substance or report plans to use it in the future. The study suggests a need to revise prevention programming for youth as legalization and visibility surrounding marijuana change.
Researchers found that an extra set of guanines in our DNA may function like a spare tire to repair damage and prevent cancer. This 'factory-installed safety feature' could be a key to understanding why some people don't develop cancer despite high levels of oxidative stress
A new study reveals how synchronized gene activation is achieved in developing neurons through a TTP/miR-9 regulatory pair, which limits messenger destabilization and ensures coordinated accumulation of neuronal proteins.
Ezrin regulates osteosarcoma's spread by acting as an air traffic controller, coordinating multiple functions within cancer cells and allowing them to survive stress conditions. Researchers have developed molecules that block ezrin's function, preventing osteosarcoma spread in mouse models.
The updated ecoprofile data assesses energy, water, and resource usage, as well as air and water emissions and solid waste. Ingeo biopolymers replace petroleum-derived materials in various products, offering positive lifecycle benefits.
A study examines the effect of DEHHP on PVC flexibility, revealing molecular-level interaction between hydrogen bonds and improving polymer-solvent interactions. The research shows that temperature and concentration affect the strength of these interactions.
New research reconstructs beetle family tree, showing diversification over nearly 300 million years. The success of beetles attributed to low extinction rates and interactions with plants, fungi, and microorganisms.
Research suggests differences in oil-secreting glands and dermis thickness contribute to wrinkle formation. The study, published in Clinical Anatomy, found shallower wrinkles on the forehead compared to the outer eye area.
Biologists from Penn University analyzed genetic data to track blacklegged tick migrations. The study reveals that ticks moved into new areas through short-distance local moves, shedding light on patterns of disease spread and controlling strategies.
Researchers at UCSF found that frequent premature ventricular contractions (PVCs) are associated with heart failure incidents and increased mortality. PVCs can be prevented through medical or ablation therapy, suggesting they may be a modifiable risk factor for congestive heart failure and death.
A recent Arctic tundra study found that climate warming is driving dramatic changes in the region's vegetation, with shrubs growing more in warmer temperatures. This increase in shrub growth can lead to more warming in tundra ecosystems and globally.
The project aims to improve food environments and increase physical activity in southwest Atlanta's target neighborhoods. Over three years, it will work to increase healthy food access for at least 75% of the communities.
A newly discovered human protein called intelectin has the ability to selectively identify and distinguish between human cells and those of disease-causing microbes. This discovery could lead to the development of new antibiotics and strategies to combat infectious diseases.
Typhoon Chan-Hom strengthened over three days, peaking as a Category 4 typhoon with maximum sustained winds nearing 130 knots. The storm is forecast to pass between Ishigakjima and Kadena islands on July 9 before making landfall in eastern China.
Researchers discovered a link between autoimmune diseases and Long QT syndrome, a potentially life-threatening heart condition. Screening and counseling are now recommended for patients with certain medications or abnormal electrolytes.
A new study reveals that older patients with traumatic spinal cord injuries are less likely to receive surgery and experience longer wait times for treatment. The delay in diagnosis and treatment may be due to age-related biases or delayed recognition of less severe injuries.
Researchers found an enzyme called LSD1 turns off genes required to maintain cancer stem cell properties in glioblastoma. Drugs modifying LSD1 levels could provide a new approach to treating the disease.
A new study published in Nature Climate Change suggests that climate change will not lead to widespread interbreeding among closely related species. Only about 6 percent of species with non-overlapping ranges are likely to come into contact by the end of this century.
A recent study found that approximately 1 in 6 aging individuals would be reclassified as having 'at goal' blood pressure under the new guidelines, despite frequent use of antihypertensive medications. The study suggests that less stringent blood pressure goals may increase the risk for heart attacks and strokes among older adults.
Researchers at Cedars-Sinai Medical Center tested two methods to preserve cognition in laboratory mice with Alzheimer's disease. Immune cells from bone marrow and a drug for multiple sclerosis were found to travel into the brain, resisting abnormalities associated with the condition. The study showed measurable benefits in mice.
A new study reveals that smooth muscle cells play a more complex role in the formation and stability of atherosclerotic plaques than previously thought. The researchers found that 82% of smooth muscle cells within advanced lesions cannot be identified using traditional methods, leading to confusion about cell identity.
A recent study from Michigan State University found that perennial biofuel crops use a comparable amount of water as traditional corn crops in the Midwest. This discovery has significant implications for cellulosic biofuel production and understanding the impact of climate change on water balances.
Rice University's HERC will explore new areas of education research in HISD, linking data with other sectors like early childcare and the workforce. The funding supports HERC's connection between research and policy/practice to improve educational services.
A previously unknown leafhopper species has been found in the New Jersey Pine Barrens, threatening a listed threatened pinebarren smokegrass species. This discovery highlights the impact of climate change and human activities on ecosystems.
A blood-borne molecule called beta-2 microglobulin increases with age and blocks brain cell regeneration, leading to cognitive decline. Administering the molecule to young mice reverses this effect, suggesting a potential therapeutic target for age-related cognitive diseases.
Researchers found that coronary artery calcification scans can accurately predict all-cause mortality up to 15 years in asymptomatic patients. The study's findings suggest that CAC scanning could help physicians identify patients at risk for early death and advise them to adopt healthier lifestyles.
A new study found that over 750 popular music songs reference weather, with a range of emotions conveyed through multiple weather types in some songs. Popular artists like Bob Dylan, John Lennon, and Paul McCartney have written or sung about weather-related topics.
A study by Leuphana University and George Mason University found that preschoolers with a good understanding of their emotions experienced fewer attention problems. The research suggests that emotion knowledge is a key factor in the development of attention skills, alongside executive functions.
A new investigational vaccine designed to protect against West Nile Virus infection is being tested in a Phase 1 clinical trial. The vaccine was developed with a novel, hydrogen peroxide-based process that renders the virus inactive while maintaining key immune-system triggering surface structures.
Researchers at UC Santa Cruz have determined the molecular mechanism involved in light-induced activation of Channelrhodopsin-2, a widely used protein in optogenetics. The discovery provides insights into creating tailor-made proteins optimized for use in optogenetics experiments.
The latest Ebola outbreak is the largest, most sustained, and most widespread to date, with several potential treatments undergoing clinical trials. Dr. Ali Mirazimi notes that emerging infectious diseases will continue to challenge global health.
A meta-analysis found that cognitive behavioral therapy for insomnia was associated with reduced insomnia symptoms and sleep disturbances in individuals with coexisting psychiatric and medical conditions. Patients who received cognitive behavioral therapy had twice the percentage of remission from insomnia compared to control groups.
A new smartphone app, Alcohol Tracker, warns users if they exceed recommended daily/weekly alcohol units. The app provides built-in psychological therapies and helpline links to help users manage their drinking.
Researchers found that recent years have seen three of the stormiest seasons on record, with the summer of 2012 being the 'stormiest' since at least 1871. A 142-year climate data study confirms a strong relationship between seasonal precipitation totals and cyclone frequency in the region.
Researchers have created and controlled surface plasmon wakes of light-like waves on a metallic surface, demonstrating a new technology with potential applications in nanotechnology and optics. The discovery uses a faster-than-light running wave of charge along a metamaterial to create and steer the wakes.
Dr. J. Richard Steadman, a renowned US ski team doctor and orthopaedic surgeon, has been inducted into the American Orthopaedic Society for Sports Medicine's (AOSSM) Hall of Fame. He is recognized for his contributions to sports medicine, including developing the microfracture technique for treating chondral defects of the knee.
Researchers create large-scale simulation of 275,000 atoms to study iron-nickel alloys' structure changes with temperature. They find that transitions occur in both orderly and disorderly ways, depending on heating or cooling, respectively.
Researchers at the University of Hawai'i Cancer Center found that aspirin can inhibit the growth of mesothelioma by blocking HMGB1. This could lead to improved survival rates for patients with this aggressive cancer, which kills around 3,200 people annually.
Researchers have found a potential treatment option for children with Ewing's sarcoma by combining two active ingredients, Olaparib and Trabectedin, which achieves complete remission in all cases. The combination enhances the sensitivity of cancer cells to these drugs, increasing its effect.
New grant funds development of efficient genomic data compression software to handle large volumes of genomic data, addressing challenges in data storage and transfer. The project aims to identify commonalities in compression strategies across different types of genomic data.
The Bcl-Rambo protein is involved in safely clearing damaged mitochondria from cells, a process called mitophagy. Controlled regulation of this protein may help limit the development of heart failure. Further research is needed to develop methods to control its activity.
Researchers discovered that protein p53 monitors centriole numbers to prevent potentially disastrous cell divisions. Without centrioles, cells are unable to divide due to the presence of p53, which acts as a backup to prevent abnormal cells from forming.
A study found that increased screening mammography was associated with more diagnoses of small breast cancers, but not significant changes in mortality or larger cancer incidence, suggesting overdiagnosis
Researchers have developed a highly sensitive test to detect infectious diseases like hepatitis C and superbugs. The new method can pick up tiny traces of metabolites, proteins or DNA fragments, making it 10,000 times more sensitive than other detection systems.
Scientists at UT Arlington and UNTHSC are building a prototype shunt flow monitoring system that can deliver on-demand and continuous readings of hydrocephalus. This could lead to better treatment, especially in infants and children who account for most shunt operations.
A new study from Lawrence Berkeley National Laboratory found that autonomous taxis could significantly reduce per-mile greenhouse gas emissions, with savings ranging from 63-82% compared to hybrid vehicles and 90% compared to gasoline-powered cars. The use of right-sizing, where the size of the taxi is tailored to each trip's occupancy...
Scientists at the Max Planck Institute for Polymer Research discovered the fundamental parameters of Mott conduction, a key effect in magnetic memories and technologies. They found that traditional measurements underestimated the spin-asymmetry in electron scattering, which is responsible for magnetic sensor operation.
A new USC-led study found that heart disease is the main reason for the disparity in life expectancies between men and women, with female death rates decreasing 70% faster than male death rates after 1880. The study suggests that biological differences may be at play, with potential factors including diet, exercise, and genetics.
The American Orthopaedic Society for Sports Medicine (AOSSM) presents ten research awards and seven grants to recognize outstanding research initiatives. This year's award recipients include Thomas Kremen, Clare L. Ardern, Blaine A. Christiansen, Alexander Scott, and several others for their innovative projects on stem cell use, osteoa...
A Temple-led research team has discovered that bacterial biofilms found in the gut can provoke the onset of systemic lupus erythematosus (SLE) in lupus-prone mice. The researchers found that curli amyloid and DNA complexes in biofilms lead to inflammation, self-attacking antibodies, and autoimmune disease symptoms.
Researchers found that electron-phonon interaction is suppressed in 2D materials due to dimensional effects, leading to increased conduction. The discovery has potential applications in the creation of future flat and flexible electronic devices.
A new Northwestern Medicine research center will investigate the potential heart damage caused by excess dietary phosphate, particularly in African Americans. The goal is to find new ways to prevent and treat heart failure and build evidence for regulating phosphate in the food supply.
Researchers found that dental pulp stem cells can regenerate myelinated axons in laboratory rats with sciatic nerve defects, outperforming autologous nerve grafts. The study suggests that MDPSCs contribute to peripheral nerve regeneration through the secretion of neurotrophic and angiogenic factors.
Gerhard M. Sessler, a renowned expert in acoustics, received the 2015 Gold Medal of the Acoustical Society of America for his groundbreaking work on electret and silicon-based microphones. His inventions have led to the development of highly sensitive and cost-effective microphones that dominate global production.
Researchers at UNC School of Medicine have discovered two biomarkers - oxidized LDL cholesterol and fructosamine - that are strongly correlated with the development of severe coronary disease in females. Elevated levels of these biomarkers were found to be a strong predictor of severe heart disease, particularly in women.
Researchers discovered a new category of tRNA fragments that depend on individual characteristics, including race, gender, and population. The analysis also found that tRNA fragments have regulatory roles in cellular processes and differ between tissues, disease subtypes, and individuals.
A review of 34 countries' policies on children's exposure to radio frequency electromagnetic fields (RF-EMF) from technology found varying degrees of advice. Dr. Mary Redmayne recommends minimizing exposure by turning off devices at night, using flight mode, and storing them 20cm away from the body.
A study of nearly 18,000 women in the UK, Ireland, Australia, and New Zealand found that 20-80% drank during pregnancy, with higher rates among smokers. The prevalence of binge drinking was also common, particularly before pregnancy. Factors associated with lower risk included age, ethnicity, education level, and body weight.
Tropical Storm Linfa weakened due to wind shear after moving over land, with a elongated shape and deep convection in the southwest quadrant. The storm is forecast to strengthen before dissipating in the Taiwan Strait on July 10.
Researchers found that very small brain lesions noted on imaging are associated with a heightened risk of stroke and death. The discovery may help physicians identify people at risk for stroke before they have symptoms, even in middle age.
Researchers found large-amplitude slow-delta waves in patients receiving nitrous oxide, twice as powerful as those seen in deep sleep. The discovery could lead to better anesthetic dosing decisions and alleviate concerns about awareness under anesthesia.
A new study proposes a novel nanotechnology-based strategy to enhance water diffusion through sanitation filters using phonon oscillations, resulting in three times the efficiency of water transport. Crowdsourced computing played a crucial role in this project, with over 150,000 volunteers contributing their computing power.
Changes in key biomarkers of Alzheimer's disease during midlife may help identify those who will develop dementia years later. The study found that drops in amyloid beta 42 levels among cognitively normal participants are linked to the appearance of plaques in brain scans years later.
A study published in Annals of Internal Medicine found that even very small brain lesions (less than 3 mm) detected by MRI triples the risk for stroke and death in asymptomatic patients. Having both small and larger lesions increases the risk to eight-fold, highlighting the importance of considering all lesion sizes in clinical practice.
Results from the EORTC trial 62072 show pazopanib improves progression-free survival in soft tissue sarcoma patients without affecting their health-related quality of life. The study provides valuable data on treatment outcomes and cost effectiveness for this patient population.
Research shows older patients with spinal cord injuries have more severe lag times between injury and surgery, with a significant delay in treating those over 70 years old compared to younger patients. This can lead to less severe injuries and better outcomes for these patients.
Researchers have discovered a stress pathway in immune cells that play a role in certain forms of asthma. The IRE1α/XBP1 pathway helps eosinophils, a type of immune cell implicated in asthma, develop and survive. This finding suggests a potential new therapeutic target for treating asthma.
A new study published in PNAS found that anxious parents are more likely to have anxious offspring, and that an over-active brain circuit may set the stage for developing anxiety and depressive disorders. The research identified three brain regions responsible for passing anxiety from generation to generation.
A survey of physicians and advanced practice clinicians found that many report working while sick due to fear of letting colleagues down and staffing concerns. The study highlights the complex social and logistic factors driving this behavior and emphasizes the need for systems support to prioritize patient safety.
Researchers discovered that Schwann cells digest damaged myelin internally through autophagy, clearing 40-50% of the myelin within 5-7 days. This mechanism enables significant nerve repair in the peripheral nervous system, contrasting with the CNS where oligodendrocytes fail to clear myelin.
A UCLA review of common practices in prostate cancer has found that monitoring men with very low- and low-risk prostate cancers using watchful waiting or active surveillance is an effective approach for many patients. This approach could spare them the debilitating side effects of aggressive treatments, which are often used unnecessari...
A retrospective study found that women with epilepsy have an increased risk of maternal death and adverse outcomes during delivery. The authors identified 80 deaths per 100,000 pregnancies among women with epilepsy, compared to 6 deaths per 100,000 pregnancies without epilepsy.
A natural-color satellite image taken on July 05, 2015, shows the impact of Canadian wildfires on the 2015 FIFA Women's World Cup Finals in Vancouver. The smoke from three wildfires in the Boulder Creek Wildfire complex grew rapidly, blanketing the stadium and surrounding areas.
Johns Hopkins scientists discovered that blocking calcium from entering mitochondria in heart cells didn't prevent cell death after heart attacks, but rather activated alternative pathways. The study's findings challenge the long-standing theory of using calcium channel blockage to prevent heart attack damage.
CAM research provides a roadmap for increasing agricultural production by developing water-efficient crops and improving existing non-CAM crops. The emerging discipline has tremendous potential for applications, attracting growing interest from academia and industry.
Research in Japan reveals worsening cardiovascular risk factors, including hypertension and high cholesterol, despite global declines in the US. Improved data collection and clinical trials are crucial to developing new treatments and improving patient outcomes worldwide.
Researchers developed a non-invasive technique using Raman spectroscopy to detect various forms of skin cancer. Malignant melanoma can be detected with an accuracy of 91%, while non-melanoma skin cancers are accurately identified between 73% and 85%.