Researchers warn that thiazide diuretics may cause low blood pressure in congestive heart failure patients, leading to dizziness and reduced blood flow to the brain and kidneys. The study suggests that these patients should exercise caution when taking thiazides or consider alternative medications.
A new study comparing kidney transplantation and home hemodialysis found that transplant recipients outlived their hemodialysis counterparts by 4 times over 5 years. Elderly patients on hemodialysis had nearly a 5 times higher risk of dying compared to those with transplants, highlighting racial disparities in mortality rates.
Researchers created a synthetic model of E. coli's outer membrane, providing unprecedented access to its structure and dynamics. The model was used to test how antibiotic molecules can cross the critical barrier, which is highly impermeable to incoming molecules.
The new atlas uses tree rings to map severe droughts and wet periods across Europe, parts of North Africa, and the Middle East over 2,000 years. It fills a major geographic gap in climate data, helping scientists pinpoint causes of drought and extreme rainfall.
A new study by Emilio Ferrara and Zeyao Yang found that positive emotions spread virally through Twitter feeds, with about 20% of users deemed highly susceptible to 'emotional contagion'. These users were four times more likely to produce positive tweets than negative ones.
A study published in PLOS ONE found that a small dose of dexrazoxane protected ovarian function and fertility in mice after chemotherapy. The treatment also increased survival rates and reduced toxicity, providing new hope for young cancer patients.
A recent study by Professor John Turri and Wesley Buckwalter found that people attribute moral obligations to those unable to fulfill them, regardless of ability. In experiments, participants judged a lifeguard obligated to save both drowning swimmers despite physical limitations.
Researchers developed a computerized tool to guide stakeholders in recovering large-scale infrastructure systems after disasters. The tool, based on network science, identifies the order in which stations need to be restored, considering factors like centrality measures and station importance.
The Integrated Mathematical Oncology Department at Moffitt Cancer Center has been awarded a $10.4 million grant from the National Cancer Institute to develop new strategies to prevent and treat cancer by exploiting Charles Darwin's concept of natural selection.
Researchers at MIT have developed techniques to amplify minute motions in digital video, as well as smooth out small variations in digital images. The techniques can produce more polished images for graphic-design projects, while also disclosing structural defects and camouflaged objects.
Researchers have found that monitoring farmland biodiversity across Europe can be done at a modest share of the Common Agricultural Policy budget, with costs ranging from 0.01% to 2.48% of the total budget.
A study published in Nature Communications has identified seven genetic risk loci for atopic dermatitis and asthma, suggesting a link between the two conditions. The research found that regions determining atopic dermatitis risk also influence the development of asthma and other allergies, known as the atopic march.
Research at Lund University reveals that mucus in the saliva stimulates white blood cells to form effective nets of DNA and proteins, capturing and killing bacteria. Patients with aphthous stomatitis and Behçet's disease often lack saliva with this property, highlighting a potential link between mucus and these diseases.
A new study published in the American Journal of Psychiatry found that patients with treatment-resistant schizophrenia who switch to clozapine have better outcomes, including fewer hospitalizations and longer medication adherence. The findings provide important guidance for clinicians caring for this vulnerable population.
Researchers used genetically-modified mice to study hereditary deafness caused by mitochondrial dysfunction. Reducing enzyme activity in mice showed promise for preventing or delaying deafness, according to new research.
Scientists at Case Western Reserve University School of Medicine have discovered a repair and renewal mechanism in protein movement within hair cells of the inner ear. The study found that constant movement and replacement of proteins serve a maintenance and even repair function, potentially reversing hearing loss.
Samumed's Phase II clinical trial aims to evaluate the safety, tolerability, and efficacy of SM04690 in treating moderately to severely symptomatic OA patients. The trial will assess changes in WOMAC pain and function subscores at Week 13.
A study published in Molecular Systems Biology reveals that gut microbiota regulates glutathione and amino acid metabolism in mice, which may contribute to the development of obesity, type 2 diabetes, and other diseases. The research also highlights the potential for probiotics to deliver beneficial bacteria to the gut and prevent meta...
Researchers recreated conditions inside brown dwarfs using a powerful laser, shedding light on their formation and properties. The findings pave the way for further understanding of these mysterious celestial objects, which are difficult to spot due to their small size and cool temperatures.
A Massachusetts General Hospital-developed system using diffusion MRI improved patient selection for endovascular treatment, leading to a greater percentage of screened patients receiving treatment. The system's precision resulted in similar outcomes to recent clinical trials and significantly increased the number of treated patients.
A new molecular pathway involved in heart attacks and death from heart disease has been identified by a Duke University research team. They found that stress on the endoplasmic reticulum organelle is associated with risk of future heart events and can be detected in bits of molecular detritus circulating in the blood.
A rapid-detection Ebola test developed by Dr. Manfred Weidmann has been deployed in Senegal and Guinea, performing exceptionally well under field conditions. The test uses a method called recombinase polymerase amplification and can be stored at room temperature, operated by local teams without the need for confirmatory tests.
A new study reveals that hepcidin, a protein regulating iron absorption, can inhibit the body's ability to absorb iron supplements in quantities necessary and desirable. The researchers suggest waiting longer between doses may improve iron absorption efficiency and reduce side effects.
A study found that adults who received kidneys from deceased pediatric donors aged 0 to 5 years experienced no surgical complications, organ failure, or rejection. The results showed excellent outcomes with no adverse effects from younger donor age or low weight.
BitDrones allows users to explore virtual 3D information by interacting with physical self-levitating building blocks, enabling a 'Real Reality' interface. The system has numerous applications, including real-reality 3D modeling, gaming, and medical imaging.
Researchers have developed a new way to detect chemical damage to DNA that can lead to genetic mutations and diseases. The method combines existing techniques to mark and copy DNA damage sites, preserving information on the location and type of damage.
A new school safety project, Project SOAR, aims to use mobile apps and high school youths to prevent violence by promoting student involvement and restorative justice. The $1.6 million project will utilize technology-based tools and involve students in developing a school safety framework.
A study by Rice University and Penn State University researchers found that cancer survivors are less likely to receive callbacks from retail employers compared to those who did not disclose their health history. Applicants disclosing a cancer history received fewer callbacks, highlighting subtle biases in hiring practices.
A study published in ZooKeys found that smaller stonefly species were more capable of recolonizing Isle Royale Island due to their better flight abilities. In contrast, larger stoneflies struggled to cross the lake despite being well-suited for aquatic environments.
A new hybrid optical microscope/mass spectrometry-based imaging system developed at ORNL provides sub-micron resolution for chemical analysis and differentiates between polymers and cells. The technology enhances understanding of material interactions, drug transport, disease progression, and response to treatment.
Berkeley Lab scientists discovered specific amino acid arrangements in FG Nups proteins enable efficient transport of molecular cargo into and out of the nucleus. These findings have implications for understanding diseases like cancer and infectious disorders.
A new report by Plymouth University finds that ocean acidification is benefiting invasive species such as algae and jellyfish, which can cause toxic blooms and harm native herbivores. As CO2 levels rise, these organisms are becoming more resilient and spreading to new areas.
A team of top researchers will focus on reprogramming pancreatic tumor biology using cutting-edge technology and developing new SE-targeted drugs. The goal is to dial up sensitivity to chemotherapy and push tumors into lasting remission.
A study found that three commonly used kidney function equations yield discordant results for transplant waitlist qualification, potentially leading to significant differences in qualification time and disadvantage patients. The Cockroft-Gault equation most often disadvantaged patients compared to the MDRD and CKD-EPI equations.
Tropical Cyclone Megh is intensifying as it approaches Socotra Island, Yemen, with forecasters predicting hurricane-strength winds before landfall. The storm's trajectory may be impacted by cooler waters and increasing wind shear in the Gulf of Aden.
A Newcastle University study found that stressed baby starlings grow into fat and greedy adults, changing their eating behavior as a result. The research showed that chicks that faced greater competition for food as juveniles tend to overeat when presented with freely available food.
PharmaMar's novel Antibody-Drug Conjugate (ADC) MI130004 demonstrates potent anticancer activity against HER2-expressing breast, gastric, and ovarian cancers. The ADC impairs tubulin polymerization, causing mitotic failures and halting cell division in tumor cells.
Researchers at the University of Georgia have identified Tpl2 as a key regulator of immune signaling proteins called interferons, which play a large role in host defense against viral infections. The study found that Tpl2 promotes induction of antiviral genes and protects against influenza virus infection.
A study evaluating patients who purchased organs internationally found higher rates of hepatitis C, B, and cytomegalovirus, as well as increased risk of acute and recurrent rejections. Survival rates were also lower compared to living related donor transplants.
Studies reveal crucial role of histone chaperone protein in maintaining epigenetic landscape and genomic fidelity. Deletion of key protein leads to severe developmental defects, DNA damage, and compromised gene regulation.
Swift has detected over 1,000 gamma-ray bursts, providing valuable insights into extreme physical processes. The most distant GRB recorded by Swift is from over 12 billion years ago, offering new opportunities to investigate how these events are distributed across space and time.
A new analysis of the iPrEx trial suggests that PrEP is effective in preventing HIV infection among transgender women. However, lower drug levels and reduced adherence rates are observed due to socio-cultural factors, emphasizing the need for tailored delivery models.
Researchers at Washington University in St. Louis developed nanoparticles that increase the nutrient content and growth of tomato plants. The study found that treated plants produced nearly 82% more fruit than untreated ones, with higher antioxidant content.
A new study reveals racial disparities in living kidney donation rates and complications after donation. African Americans have the lowest rates of living donation, while also experiencing higher risks of complications, including gastrointestinal issues, bleeding, and respiratory problems. The findings suggest that socioeconomic factor...
Researchers have discovered a dying giant radio galaxy 9 billion light years away, offering insights into the properties of magnetic fields in the distant universe. The galaxy's radio lobes are fading due to energy loss through radio wave emission and inverse Compton scattering.
A University of Michigan Medical School team compared the cost-effectiveness of two anticoagulant drugs, dabigatran and warfarin, for preventing stroke in patients over age 65 with atrial fibrillation. They found that new drugs are more cost-effective for those with prescription coverage, but may not be worth it for those without cover...
A newly designed vital sign monitoring system reduces unnecessary alarms and increases patient safety in medical units. The system provides continuous monitoring of oxygen saturation, heart rate, blood pressure, and respiration rate, with 92% of nurses agreeing it is suitable.
A team of top researchers, led by TGen's Dr. Daniel D. Von Hoff, aims to develop therapies that greatly improve patient survival. They will focus on reprogramming the 'super enhancers' in cancer cells to stop tumor growth and offer novel treatments for patients with pancreatic cancer.
Scientists have characterized six major molecular subtypes of serotonergic neurons in mice, revealing distinct expression patterns of hundreds of genes. These subtypes modulate different behaviors and vary in developmental lineage, anatomical distribution, and electrical firing properties.
Researchers identified a key protein secreted by basal-like breast cancer cells that supports cancer stem cells. Disrupting this protein or its receptor leads to reduced CSCs and impaired tumor formation.
A group of undergraduate researchers experimentally investigated the Himalayan singing bowl and discovered how it produces 'chatter', a rapid knocking sound. The study found that the puja's motion excites the vibration of the bowl, causing a unique deflection shape.
Research finds that Hanoks' earthen walls, paper windows, and wooden floors create a resonance effect, amplifying sound clarity and reverberation time. The unique acoustics of these traditional Korean houses make them suitable for playing classic instruments like zithers.
Researchers found that adults over age 30 are not happier than they used to be, but teens and young adults are experiencing higher levels of happiness. The study, led by San Diego State University professor Jean M. Twenge, analyzed data from four nationally representative samples of Americans ages 13 to 96.
Researchers found that embedded clinical practice guidelines in patient electronic medical records during outpatient visits improved the use of severity measurement tools, referrals to rehabilitation programs, inhaler education, and vaccinations among stable COPD patients. The intervention also led to better quality of care measures.
Scientists have developed a technique using optogenetics to suppress nervous system activity in genetically-altered fruit fly embryos, showing promise in preventing the onset of epilepsy symptoms when treated early enough.
PTB researchers have developed a laser-based vector network analyzer (VNA) for precise and cost-effective high-frequency measurements. The new method enables frequency-resolved scattering parameter measurements on planar waveguides up to 500 GHz with a 500 MHz frequency spacing.
The project aims to enhance wheat crop yields by understanding the genetic basis of more efficient photosynthesis. By combining diverse expertise and next-generation DNA sequencing, researchers will identify key genes responsible for improved crop performance.
Physicists at JILA have created a denser quantum crystal by packing about five times more molecules into it, allowing for the study of correlations among molecule spins and entanglement. The crystal's high density enables scientists to investigate complex effects that may lead to new materials for electronics.
Scientists investigate butterfly mimetic communities in the Western Ghats of India and find that females are generally better mimics than males. The study's results challenge expectations and raise new questions about the evolution of mimicry and selective forces influencing butterfly wing patterns.
Researchers at Baylor College of Medicine discovered that estrogen receptor β promotes the growth of endometriosis by allowing abnormal cells to escape immune surveillance. Elevated levels of this protein were found in human tissues and studies in mice showed a similar effect, highlighting a new target for effective treatment.