Researchers at UMass Medical School have discovered two host cell membrane proteins, SERINC5 and SERINC3, that greatly reduce the virulence of HIV-1 by blocking its ability to infect new cells. This breakthrough offers a promising new anti-retroviral strategy for treating HIV-1 and similar viruses.
A team from Penn Dental Medicine successfully produced a shelf-stable, low-cost drug using freeze-dried lettuce leaves, which promotes tolerance to clotting factors for hemophilia patients. The study confirms the viability of plant-based biopharmaceutical production on a commercial scale.
The BGU project Boomerang is a modular system that recognizes cancer cells at a high level of specificity and can cause disruption of genes essential for cancer survival or activate suicide genes. It has many applications in personalized medicine, paving the way to change the approach to cancer treatments.
Hurricane Joaquin strengthened into a hurricane after NASA satellites gathered data on its heavy rainfall and cloud height. The Global Precipitation Measurement satellite captured images of the storm's intense rain and convective towers, indicating its potential for intensification.
A new study found that local estrogens, such as vaginal tablets, may be more effective than cream in treating genitourinary symptoms of menopause. Women who took tablets were more likely to adhere to treatment guidelines and show improved results.
A new study suggests that early initiation of menopausal hormone therapy within five years of menopause onset reduces the risk of future coronary heart disease. Conversely, late initiation is associated with an increased risk of incident coronary heart disease.
Typhoon Dujuan brought extreme rainfall to Taiwan, with heaviest totals over 275 mm along the coast south of landfall. The typhoon caused hundreds of injuries and at least three deaths in Taiwan.
Researchers discovered a technique to renature denatured proteins, restoring their original spatial structure and increasing activity by 180%. This method uses nanoparticles to bind to protein molecules, preventing aggregation and reactivating the active center.
Scientists have discovered a previously unknown process of warm Gulf Stream water and continental shelf exchange. Researchers also explored the effects of Saturn's magnetospheric dynamics on Titan's ionosphere.
Infants under stress exhibit less flexible behavior when presented with new situations, unlike adults who also show reduced flexibility due to stress. This study suggests that repeated exposure to stress in infancy may hinder knowledge acquisition and have lasting effects on cognitive development.
A new University of Waterloo study found that Canadian women's magazines often prioritize a tanned appearance over skin cancer prevention messages. The research examined coverage of skin cancer and tanning in six popular women's magazines from 2000 to 2012, revealing limited information on risk factors and early detection.
Researchers are investigating two new avenues for detection and treatment of advanced prostate cancer, focusing on biochemical reactions downstream of the androgen receptor. By targeting the metabolism of cancer cells, they aim to bypass ineffective drugs and develop new therapies.
Scientists have developed a new hydrogel coating that can neutralize both mustard gas and nerve agent VX in under 20 minutes. This breakthrough could lead to the creation of protective clothing and paints that safeguard against chemical warfare agents.
Researchers identified abnormal miRNA levels in patients with myeloma, detectable in peripheral blood, suggesting a potential biomarker for disease progression. Analysis revealed unique miRNA signatures indicative of myeloma, including the let-7 family members.
Griffith University researchers have discovered a thousand-fold fluorescence enhancement in an all-polymer thin film due to a novel multi-layer Colloidal Photonic Crystal (CPhC) structure. This breakthrough has significant implications for ultra-sensitive sensing, energy efficiency and lighting devices.
Analysis reveals that public charging infrastructure is not needed everywhere, with homes, workplaces, and 'hot spots' sufficient for adoption. Drivers tend to favor a few public stations when away from home, with workplace charging enabling significant electric range extension.
A team of geologists from GEOMAR and Spanish institutions presented an explanation for the smaller-than-expected 2014 Iquique earthquake. Seamounts in the region, which subduct under the South American plate, actively deformed the interface and reduced stress buildup, resulting in a smaller earthquake.
A cognitive-behavioral prevention program for depression among at-risk youth showed benefit over 6 years after implementation, reducing depression incidence and promoting competence. The program's effects were seen in youths whose index parent was not depressed at enrollment.
Researchers detected an average of 104-105 viable microbial aerosol particles per cubic meter in the air, with Bacillus dominating the bacterial community. The team found striking differences in size distribution patterns across different climate zones, which may serve as a fingerprint for a particular region.
A University of Texas at Arlington professor will analyze complex data using imaging genomics to identify biomarkers predicting Alzheimer's disease risk. He aims to develop advanced algorithms to study the brain, incorporating biological knowledge into data sets.
New research suggests that individuals who demonstrate a strong brain response to sham treatment are more likely to experience symptom relief when receiving actual depression medication. This finding could lead to the development of new treatments and biomarkers for treatment response in depression.
Researchers discovered a method to reprogram fibroblasts, healthy tissue around tumors, to trap and contain cancer cells. This approach reduces the movement of cancer cells away from the tumor, showing promise in preventing tumor spread. The study has potential for various cancer types and could lead to better ways to control the disease.
A new class of antidepressants has been found to work by targeting the brain's ability to respond to glutamate. The experimental therapies have been shown to produce an antidepressant effect in mice by altering brain signaling in particular neurons.
Researchers at KIT have developed an invisibility cloak that guides sunlight around contact fingers on solar cells, reducing optical losses and increasing efficiency. By applying a special coating onto the solar cell, the cloaking effect can be achieved, potentially leading to up to 10% increase in efficiency.
Researchers at OSU create a new approach to treat eczema and inflammatory skin disorders by identifying specific lipid deficiencies in each person. This system uses advanced science and mass spectrometry to develop personalized treatments.
Postmenopausal women with vulvar and vaginal atrophy often suffer from dyspareunia despite recognizing its physical, emotional, and psychological consequences. Women are not educated about treatment options or the underlying clinical cause of VVA.
A new study found that 87% of Millennials use paid content for entertainment or news, with popular services including movies and TV, music, and Facebook. Socioeconomic differences were not a major indicator of paid content usage.
Scientists used computer simulation to discover that asteroids can deliver more water to the lunar surface than the cumulative fall of comets over a billion year period. The study found that asteroids contain a significant proportion of water, effectively protected in their crystal lattice of minerals, and can release it when heated.
A team of scientists has created the most extensive catalogue of structural variations in human genomes, revealing over 200 missing genes and demonstrating that these changes are common risk factors for disease. The study's findings will help guide future research on genetics, evolution, and disease diagnosis.
Researchers found that mixtures of cereal rye and hairy vetch can effectively control weeds and conserve soil moisture. Adding poultry litter increased decomposition and nitrogen release when the cover crop contained at least 50% cereal rye.
Researchers found that environmental and social factors shape participants' use of SOV vs SVO syntax when communicating events, with iconicity playing a key role. The study also showed that adapting to interlocutors' lead and frequent event types influence syntactic patterns.
Researchers have developed a model to predict the risk of waterborne diseases in flooding rivers, which can affect millions of people worldwide. The study's findings highlight the importance of understanding the complex interactions between environmental and human factors in shaping disease dynamics.
A national survey reveals that nearly a third of US women taking hormones at menopause are using unapproved and untested compounded hormones. The study found four cases of endometrial cancer among these users, highlighting the risks associated with these therapies.
A study published in the New England Journal of Medicine found that reducing nicotine content in cigarettes can significantly reduce cigarette use and dependence. Researchers discovered that participants who smoked low-nicotine cigarettes showed lower smoking levels and reduced exposure to nicotine.
A new study led by UCSF scientist Neal Benowitz found that reducing nicotine levels in cigarettes can substantially decrease tobacco dependence without increasing inhalation. Smokers who reduced cigarette intake reported attempts to quit twice as often and had lower cravings compared to those smoking regular cigarettes.
A study found that training patients with melanoma and their partners on skin examinations increased patient self-efficacy in performing self-examinations. The intervention showed the greatest benefit for pairs with low relationship quality and limited time together.
A national nitrogen budget for Denmark shows significant reductions in nitrogen emissions from agriculture, but other sectors like energy production and transport remain major contributors. New initiatives, such as organic farming expansion and electric vehicles, aim to further reduce nitrogen losses.
A new study found that people with Parkinson's disease psychosis who took antipsychotic medication were four times more likely to die than those who didn't. The treatment also led to serious health issues such as cognitive decline and worsening of Parkinson's symptoms.
Researchers at the University of Eastern Finland have found that barley straw can be effectively fermented into biobutanol, a potential alternative to ethanol. The study established optimal pre-treatment conditions for turning straw lignocellulose and barley starch into fermentable sugars that can be used in biobutanol production.
Researchers discovered that genetic background affects mutations in lymphoma tumors across different dog breeds. The study identifies breed-specific genes and molecular subtypes, offering a unique model for understanding how genetics influence cancer development.
The BMJ expert advocates for hospital e-cigarette access to aid smoking cessation, reduce passive smoking risks, and promote healthier alternatives. The policy ban on e-cigarettes may harm patients' health, particularly during nicotine withdrawal.
Berkeley Lab's report reveals a 70% decline in PPA prices since 2009, making solar increasingly cost-competitive for utilities. Installed project costs have fallen by over 50%, with median up-front costs dropping from $6.3/W to $3.1/W.
The Feed the Future program aims to address declining coffee production in Rwanda by promoting research, farmer capacity building, and policy engagement. MSU will inform coffee sector stakeholders of effective practices for controlling pests and establish a policy environment that encourages producers to invest in sustainable practices.
A multicenter clinical trial led by Mount Sinai researchers found that brodalumab achieved a 100 percent reduction in psoriasis symptoms, exceeding the results of ustekinumab. The study demonstrated that targeting the IL-17 receptor is highly effective in treating moderate to severe plaque psoriasis.
A new study published by Mayo Clinic reveals a significant link between recent abuse and menopause-related symptoms. Verbal and emotional abuse were found to have the most impact on women's experiences, while physical and sexual abuse also played a role in increased symptom severity.
A study published in JAMA Dermatology found that psoriasis is associated with a higher risk of major depression, regardless of severity. Patients with psoriasis reported daily functional impairment more frequently than those without the condition.
Scientists at the NIH discovered a link between human endogenous retroviral genes and ALS, suggesting that reactivated viral genes may destroy neurons. Activation of HERV-K genes may be controlled by TDP-43, a gene-regulating protein linked to ALS.
The Ocean Conservancy's report outlines specific land-based solutions for reducing ocean plastic waste, including a four-point plan to cut leakage by 45% in 10 years. The report estimates a total cost of $5 billion and significant returns to the global economy.
A six-week clinical trial found that reduced-nicotine cigarettes decreased nicotine exposure and dependence, as well as the number of cigarettes smoked per day. The study suggests potential benefits for smoking cessation and reducing tobacco-related harm.
A 2009 mandate reduced time between critical injury and definitive care, resulting in improved survival rates. Decreasing transport time and increasing prehospital helicopter transport within 60 minutes or less led to a lower percentage killed in action.
A UK university team has received funding to develop a training program for Sierra Leonean health workers to combat viral hemorrhagic fever. The program will use immersive technology to educate community health workers and healthcare professionals on infection prevention control.
Researchers at NYU Langone Health found that GANT61 increases myelin production by 50% and recruits neural stem cells to repair damaged areas of the brain. The treatment also improves symptoms in mice with multiple sclerosis, including paralysis and leg weakness.
Scientists have discovered a previously unknown process where warm Gulf Stream water and colder waters of the continental shelf exchange, influencing shelf circulation, biogeochemistry, and fisheries. The discovery provides new insights into the complex interactions between these two water masses.
A recent study published in Alcoholism: Clinical and Experimental Research reveals that adults with a history of problem drinking who continue smoking are at a greater risk of relapsing to alcohol dependence. Quitting cigarettes is crucial for maintaining sobriety, according to the researchers.
An international team of researchers reviewed theoretical ideas on quantum teleportation, concluding a hybridisation of protocols is the most fruitful approach. This could lead to more efficient and reliable teleportation systems for quantum computing, communication, and network development.
Researchers have uncovered a significant relationship between a chemical transmitting brain signals and genetic mutations in individuals with autism spectrum disorder. Targeting a specific serotonin receptor, 5-HT2cR, can reverse social deficits in mouse models of the autism risk gene Pten.
Researchers at RIKEN Brain Science Institute found that two forebrain regions determine whether males exhibit paternal or infanticidal behavior. Activity patterns in these regions were associated with paternal behavior and inhibited infanticide.
Researchers have developed a technique to coat anticancer drugs in membranes made from a patient's own platelets, allowing the drugs to target both primary tumors and circulating tumor cells. This method can prolong drug circulation time up to 30 hours, increasing effectiveness.
Researchers found a 5% improvement in peer review report quality when articles underwent open peer review compared to single-blind models. Author-suggested reviewers also tended to recommend acceptance more often than non-author suggested reviewers.
A study analyzing fossil brachiopod shells from West Virginia and Ohio found minimal seasonal variation in temperature and rainfall during the latest Pennsylvanian (~300 million years ago). The findings may help resolve a paleoclimate debate about monsoonality and sea level, providing insights into ancient mega-continent climates.