A new study led by William Kerr of SUNY Upstate Medical University found that SHIP1 inhibition improved metabolic phenotypes in mice fed a high-fat diet. The results showed that SHIP1 inhibition prevented excess weight gain, improved blood sugar control, and reduced inflammation in adipose tissue.
Researchers at MIT develop a method to stack hundreds of nanoscale layers, producing strong and conductive composites. The technique, inspired by pastry-making, enables the creation of materials with tailored properties for various applications.
A study confirms a rare case of mutualism between humans and a wild animal, the Yao tribe's use of a distinct call to attract a bird species as a honeyguide resulting in 75% successful discovery of beehives. Researchers found that the 'brrr-hm' call increased the probability of being guided by a honeyguide from 33% to 66%.
People who have recently attempted to quit smoking are more likely to try to drink less alcohol. They report lower levels of alcohol consumption and are less likely to binge drink compared to other smokers. This finding goes against the common assumption that quitters tend to increase their drinking.
A new study identifies nearly 1.37 billion hectares of land globally suitable for oil palm cultivation, while avoiding protected forests and high-biodiversity areas. The resulting map includes 19.3 million hectares of land that could be available for future production, slightly more than the current extent of palm oil production.
Researchers designed an engineered protein to repress a specific cancer-promoting message within cells, paving the way for precise treatments with fewer side effects. The protein, Rbfox2, was modified to bind to microRNA miR-21, which is present in high levels in many tumors.
Researchers found that each 1% decrease in trauma center volume is linked to a two-fold worsening in patient survival odds. The study suggests that unnecessary trauma centers can have a significant negative impact on patient outcomes.
Researchers found that lateral groundwater flow uniquely affects plant transpiration, making it up to 30 times greater than evaporation from shallow soil. Including this process in earth system models is crucial as changes in the water table become more common.
A new review of epidemiological evidence reveals a causal link between alcohol and cancer at seven sites: oropharynx, larynx, oesophagus, liver, colon, rectum, and female breast. The strongest evidence comes from meta-analyses and dose-response relationships.
A new study discovered 172 novel cancer gene-drug combinations that selectively kill cancer cells without harming healthy cells. This breakthrough expands the number of actionable mutations and provides a promising approach to personalized cancer therapy.
Researchers have identified molecular pathways required for the development of mucormycosis, a fatal infection in patients with weakened immune systems. The study provides new insights into the evolution of Mucorales fungi and offers potential therapeutic targets.
The Large Underground Xenon (LUX) experiment has completed its search for dark matter with sensitivity far exceeding expectations, but yielded no trace of a dark matter particle. This result eliminates many potential models for dark matter particles, offering critical guidance for the next generation of dark matter experiments.
Researchers studied the effects of different spin types on cricket ball trajectory. They found that adding top-spin to a delivery can reduce pitch length by up to 25cm, while introducing side-spin can produce significant drift. The study aims to help newcomers master spin-bowling and potentially benefit tennis players.
A multi-university research team found that researchers and practitioners share common interests in reducing pay inequality, improving employee morale, and leveraging technological innovation. The study suggests four steps for business schools to improve collaboration: promoting research findings, creating a new journal focused on prac...
Researchers at UT Southwestern Medical Center have identified a new route of entry for the tuberculosis bacteria, suggesting an alternative to traditional inhalation-based transmission. This finding opens up potential avenues for developing new therapies to prevent or treat tuberculosis infection.
Researchers found that long-term antibiotic treatment decreased levels of amyloid plaques and activated inflammatory microglial cells in mice brains, while altering the gut microbiome. The study suggests a link between the gut microbiome's composition and immune system activity impacting Alzheimer's disease progression.
A new species of scorpionfish, Scorpaenodes barrybrowni, has been discovered in the Caribbean by a team of scientists using a manned submersible. The fish is found at depths between 95m and 160m, making it the deepest-living member of its genus in the western Atlantic Ocean.
A recent study published in PLOS Biology suggests that larger brains are more susceptible to mental illnesses such as schizophrenia and Alzheimer's disease due to weaker long-distance connections. The researchers found that the global architecture of cortical networks in primates and rodents follows common principles, with primate brai...
Researchers at Colorado School of Mines have developed a unique model that integrates processes not often captured in existing water models, including lateral groundwater flow. The study found a significant increase in water supply from transpiration when including lateral groundwater flow, paving the way for better global water models.
A new Stanford-led analysis reveals that introducing snail-eating prawns to local water sources is the most effective way to reduce schistosomiasis prevalence, outperforming drug-only treatment by over 90%. This approach has consistently proven effective in controlling the disease globally.
A study of 869 Tsimane women over 12 years found that high birthrates do not significantly impact maternal health, contrary to expectations. Despite a harsh environment with limited nutrition and high parasite exposure, women experience minimal health costs from their intense reproductive effort.
Researchers will investigate how vasopressin and serotonin act on the brain to alter responsivity to social stress in males and females. The project aims to define the basic brain mechanisms involved in regulating social behavior, with potential translational impacts for psychiatric disorders like PTSD.
University of Adelaide physicists discovered the timing of electronic orders on the stock market follows a Weibull distribution similar to light bulb lifetimes, showing rational behavior when intervals exceed 10 milliseconds. The finding could help predict dramatic movements and detect irregularities in market abuse.
Researchers are working to identify demographic and clinical factors that distinguish individuals under 50 with colon cancer from those without the disease. The study aims to develop a risk-based screening system, potentially including blood stool tests or other less invasive tests for high-risk groups.
A study examined regional radiotherapy practice patterns for ductal carcinoma in situ (DCIS) and their effect on mastectomy use. Women living in areas with high radiotherapy rates were more likely to undergo mastectomy despite being eligible for breast-conserving surgery.
Researchers at the University of North Carolina and partner institutions have made significant strides in understanding HIV latency, a key obstacle to eradicating the virus. The team has developed effective strategies, including histone deacetylase inhibitors, to reverse latency and boost the immune system.
Researchers have successfully demonstrated self-organizing pattern formation in active materials at microscale by modifying one parameter. The study uses Janus colloids to experimentally test collective, dynamic behavior, creating swarms, chains, clusters, and isotropic gases.
Researchers at St. Michael's Hospital discovered brain shrinkage, reduced blood flow, and white matter damage in college athletes with a history of concussion. These findings suggest that even young, healthy adults may be affected by repeated head injuries.
Researchers aim to develop a multi-layered defense strategy targeting mucosal barriers, blood, and tissues. The goal is to induce host defenses against HIV simultaneously at multiple levels.
Using genomic data from three lizard species, City College of New York-led researchers gained insights on the impact of climate change on animal populations in South American forests. The findings improve ways to model biodiversity distribution in the past and future.
A new study has revealed that lichens form a complex symbiotic relationship involving three species, including yeast and fungi, which produces the toxic substance vulpinic acid. The research found that the yeast cells are vital to the lichen's health and may play a crucial role in its shape.
An international team predicts several new types of quantum particles in materials, distinguished by intrinsic properties such as responses to magnetic and electric fields. The researchers propose that these fermions can appear in the bulk of materials, enabling a more systematic way to determine whether a system is a protected metal.
Research reveals that humans use special calls to recruit wild birds, while honeyguides actively recruit appropriate human partners. This unique collaboration allows both species to access valuable resources.
Researchers developed an analog of an investigational drug that binds to portions of the androgen receptor common to full-length and variant forms. This compound specifically detected prostate cancer cells expressing androgen receptor in a mouse model using SPECT/CT imaging.
Researchers at Hokkaido University have discovered a key to understanding molecular evolution in space by revealing the temperature-dependent energy-state conversion of molecular hydrogen on ice surfaces. This finding challenges existing theories and opens new horizons for studying molecular formation and evolution.
NASA's Aqua satellite detected coldest cloud top temperatures between minus 60 and 70 degrees Fahrenheit, indicating strong storms remained north of Tropical Storm Darby's center. The storms are expected to generate heavy rainfall due to their high altitude in the troposphere.
Researchers have developed a new method to analyze scrambled cancer genomes, allowing for the simultaneous identification of two types of genetic changes and their connections. This tool, called Weaver, may help identify characteristics that distinguish cancers and inform personalized treatments.
Research by Michigan State University scholars found that high-status individuals who don't feel they deserve their position are more generous. Generosity can alleviate feelings of inequity and promote a sense of fairness.
Researchers found direct evidence that Aedes aegypti mosquitoes transmit Zika virus, helping control efforts. The study identified Zika virus in several samples of A. aegypti but not in other mosquito species.
Researchers created ten large, two-component protein complexes with icosahedral symmetry, capable of encapsulating materials and self-assembling at the atomic level. The structures can be genetically modified to serve as biomolecular machines for drug delivery, vaccines, and bioenergy applications.
Drs. Henry Boom and Moses Joloba at Case Western Reserve University and Makerere University, respectively, have received a $1.5 million five-year grant to strengthen Ugandan biomedical research capacity. The program aims to provide PhD-level training in microbiology and immunology to talented young Ugandan scientists.
A new Stanford study reveals that managed aquifer recharge (MAR) is an effective and affordable way to balance local groundwater decisions with regional and statewide management. The median cost of MAR projects is $410 per acre-foot, compared to $2,100 for surface water projects.
Airbags and seat belts significantly reduce the likelihood of facial fractures in motor vehicle collisions. The study found that using an airbag alone reduced the risk by 18%, a seat belt by 43%, and combining both devices by 53%. Facial fractures were more common among young males who used alcohol during the collision.
Researchers at the University of Southampton have found a potential method for preventing asthma by targeting the ADAM33 gene, which is associated with airway remodelling and inflammation. Stopping the rogue gene can significantly reduce asthma symptoms in mice, suggesting a new approach to disease modification therapy.
Sorafenib treatment reduces immune-suppressive phenotypes in HCC patients, including decreased PD-1 expression and lower regulatory T cells. These responses correlate with increased overall survival.
Researchers at the Weizmann Institute of Science identified a stress mechanism that regulates social behavior in mice, determining their willingness to form new relationships. The findings suggest that similar mechanisms may operate in humans, potentially informing treatments for social anxiety and other disorders.
A study by Dr. Kalipada Pahan found that cinnamon improves learning in poor mice by increasing sodium benzoate, a chemical produced as cinnamon breaks down in the body. The effect appears to be due mainly to sodium benzoate's ability to stimulate hippocampal plasticity and enhance the structural integrity of brain cells.
Scientists have discovered a mathematical resemblance between swarm dynamics and gravitational interactions in midge swarms. The team proposes an 'adaptive gravity' model that explains how swarming insects maintain cohesion despite the dominant interaction being long-range.
The Hubble Space Telescope has explored the farthest objects in the universe, unveiling a warping-of-space phenomenon predicted by Einstein. The telescope has magnified images of galaxies much farther away, allowing astronomers to study the early universe and understand dark matter.
Naturally occurring carbon dioxide concentrations allowed for a relatively slow onset of climate change effects. Scientists have a longer window to understand and mitigate human-induced climate change.
A study published in PLOS NTDs found that 19 programs using widespread snail control reduced schistosomiasis prevalence by over 90%, while 29 with little or no snail control achieved less than 40% reduction. Ecological, economic, and political factors also contributed to successful elimination.
The Damon Runyon-Sohn Pediatric Cancer Research Fellowship Award provides funding to promising young scientists working on high-impact translational research. The award supports research into childhood and adolescent cancers, which often receive limited funding compared to adult cancer research.
The researchers will examine rapid solidification processes in aluminum alloys associated with laser or electron beam processing technologies. They hope to discover the mechanisms of how alloy microstructures evolve during solidification after laser melting, validating computer models and optimizing manufacturing processes.
Researchers developed a perceptual model to predict the perceived softness and stiffness of nonlinear elastic objects, replicating an object's feel despite material differences. The model was validated through experiments and shown to accurately predict how people perceive the softness of various materials.
A new web-based data facility has been launched to aid the creation and implementation of patient-centered care policy. The Measure for Person Centred Coordinated Care (P3C) provides a compendium of measures for person centred care, making it easier to source information for commissioners and researchers.
Researchers at UC Davis used DREADDs technology to temporarily turn off the amygdala, a key region for emotions, and found changes in activity across the entire brain. This study suggests that altered brain connectivity may be used to determine pathology sites in complex disorders like schizophrenia and autism.
Researchers are developing new simulation techniques to improve the accuracy of heavy ion cancer therapies. The project aims to develop a real-time dose monitoring technique to minimize exposure of healthy tissues. This collaboration reflects UTA's focus on data-driven discovery and health, with potential implications for patient care.
Researchers at MIT have programmed cells to remember and respond to a series of events, including substances commonly used in lab experiments. This approach enables the creation of environmental sensors that store complex histories and biological state machines with different behaviors.
The American Society for Radiation Oncology has updated its treatment standard for rectal cancer, recommending a more customized approach that may reduce treatment side effects. The new guideline suggests alternatives to the traditional tri-modal approach, including short-course radiation therapy and non-operative management.
Researchers found that combining antiretroviral therapy with an immune-enhancing treatment can destabilize viral reservoirs in macaques infected with simian immunodeficiency virus. The treatment, which targets PD-1, boosted anti-viral CD8+ cells and reduced SIV levels in infected monkeys.