Researchers have identified various miRNAs that can predict the response of metastatic renal cancer patients to anti-angiogenic agents. These biomarkers have been shown to be stable and detectable, allowing for personalized treatment. The study provides a promising tool for improving patient outcomes.
Two groundbreaking studies published in New England Journal of Medicine found that patients with specific subtypes of breast cancer responded better to neratinib and veliparib combinations before surgery. These findings have led to the fast-tracking of experimental drugs for large-scale phase 3 trials.
A University of Colorado Boulder study reveals that regular pedelec use improves cardiovascular health, boosts aerobic capacity, and regulates blood sugar control. By incorporating physical activity into daily commutes, riders can increase their fitness levels without requiring separate exercise sessions.
Athletes may experience long-term brain changes even after recovery from a concussion, according to new research. The study found alterations in brain white matter six months post-injury, with more severe symptoms at the time of the concussion being a predictor of these changes.
Scientists analyzed genetic mutations in patient tumors and cancer cell lines to predict which drugs will best fight various cancers. The study found that certain genetic mutations can signal whether cancer cells are sensitive or resistant to different compounds, depending on the type of tissue.
A new study reveals a significant gap between reported smoking during pregnancy and actual nicotine exposure, with 16.5% of women experiencing high-level nicotine exposure and 7.5% low-level exposure. The study highlights the importance of targeted public health efforts to decrease tobacco use among pregnant minority women.
Hurricane Blas continues to hold a Category 3 status with a large eye and powerful thunderstorms. The storm is expected to weaken over the next two days, potentially becoming a tropical storm by Friday night.
Researchers at Aarhus University discovered how simvastatin reduces inflammation in chronic diseases like rheumatoid arthritis and multiple sclerosis. The study found that simvastatin acts as a 'plug' in proteins retaining immune cells, reducing inflammation and improving symptoms.
A new study reveals that biofilm formation is a common feature of group A streptococcus necrotizing soft tissue infections, leading to higher bacterial loads, extensive inflammation, and more severe tissue damage. Biofilm should be considered as a complicating factor of NSTI.
A nationwide study by Michele Eliason and colleagues found that group intervention is effective in improving health behaviors among aging lesbian and bisexual women. The study, which involved over 375 participants, showed significant increases in physical activity and improvements in mental quality of life.
Researchers at Newcastle University have developed a genetic test to diagnose mitochondrial disorders, identifying six patients from four families affected by the disease. The test, which takes 2-3 days to produce results, has the potential to revolutionize diagnosis and treatment of this debilitating condition.
University of Illinois researchers have demonstrated doping-induced tunable wetting and adhesion of graphene, revealing its unique properties. The findings show that graphene can exhibit switchable hydrophobic and hydrophilic behavior, enabling the creation of reusable, self-cleaning sensors with potential energy savings.
A new study suggests that the weathering of rocks by early non-vascular plants, such as mosses and lichens, may have contributed to the cooling of the climate during the Late Ordovician period. This process, known as chemical weathering, can draw down atmospheric CO2, leading to global cooling.
A recent study reveals that a marine heatwave off the western coast of Australia has led to the dramatic loss of kelp forests, covering over 963 km2. The transition has resulted in a shift towards subtropical and tropical marine ecosystems, with significant changes in species composition.
Kiel researchers found that the stiffness of a male beetle's penis is crucial for successful mating, as the female's spiral-shaped reproductive organ makes penetration difficult. The study suggests that males with softer tips may have an advantage in mating.
Researchers caution against DIY tDCS use due to unpredictable effects and potential unintended consequences on brain function. The 'Open Letter' highlights concerns over frequency, cumulative dose, and individual variability in response to tDCS.
A national study developed by a University of Missouri researcher led to the creation of five pilot programs targeting lesbian and bisexual communities. The initiatives focused on lifestyle changes such as increased physical activity, healthier eating habits, and mindfulness-approach to improve overall health outcomes.
Researchers at The Wistar Institute have discovered a specific network of proteins present in the mitochondria of cancer cells that enables their ability to proliferate, migrate, and spread. By targeting this pathway, they believe it may be possible to develop new treatments for various types of tumors
Researchers analyzed animal and robot models to understand the evolution of the tail from water to land. They found that as surface slopes increased, tails became crucial for lateral movement, with significant benefits at steeper inclines.
The Cornell Lab of Ornithology has partnered with the Land Trust Alliance to launch the Land Trust Bird Conservation Initiative, aiming to improve bird conservation on private lands. The initiative provides technical support, workshops, and a Resources Directory to help land trusts enhance bird habitats.
Researchers from the University of Delaware have developed a new approach to detect hidden damage in structures, using carbon nanotube composites and electrical impedance tomography. The technique can monitor the health of structures and alert owners to potential problems, with major benefits including scalability and relatively low cost.
A look-back study suggests that a major operation to fuse the spines of children with rare, early-onset scoliosis can be eliminated in many cases. In the study, 26 out of 30 patients who opted out of the final fusion procedure had their spines stay straight over three to seven years of follow-up.
Researchers developed a theoretical framework to understand cooperation in competing populations, applying it to consensus votes and epidemic models. The model shows that long-range spatial correlations affect switching between cooperative and non-cooperative behavior.
Key findings highlight the need for national palliative care policies in African countries, where many lack such guidelines. The article discusses the evolution of palliative care policy on the continent, raising awareness and promoting education to address these challenges.
Researchers at CRG have discovered an active repression mechanism involving the progesterone receptor in hormone-dependent breast cancer cells, affecting 650 genes. The study identifies a protein FOXA1 that signals genes for repression by compacting chromatin and restricting gene access.
Researchers found that people who were easily bored tended to endorse more extreme political views. A second survey of 300 people also linked boredom with searching for meaning in life and political extremism.
The National Institutes of Health has selected Vanderbilt University Medical Center as the Data and Research Support Center for the Precision Medicine Initiative Cohort Program. The program aims to study genetic, environmental, and lifestyle factors affecting the health of a million or more people.
The grant will enable further development of SPEAKmore! and related mobile technologies for advanced speech and language training. The company aims to help individuals produce more complex sentences and generalize newly learned language concepts, improving their communication skills.
A recent study has discovered a strong link between genetic mutations and sensitivity to specific drugs in patient-derived cancer cell lines. The researchers found that these cell lines harbor most of the same genetic changes found in patients' tumors, making them useful models for identifying effective treatments.
Professor Falk's interdisciplinary research has led to breakthroughs in assistive technology and disease diagnosis. He will receive the award at Sigma Xi's annual meeting, discussing challenges posed by his work.
Researchers created super-sniffer mice using transgenic technology to study human odor receptors, which could lead to land mine detection and novel disease sensors. The mice were able to detect a specific odor two orders of magnitude lower than non-super sniffer mice.
A Michigan State University researcher is helping a farmers market and local food sources go mobile in Flint, providing healthier options to those most in need. The mobile market will offer fruits, veggies, meat, cheese, dairy, grains, and other foods, with community buy-in essential for its success.
The University of Illinois at Chicago is part of a national initiative to enroll 150,000 participants in the Precision Medicine Initiative Cohort Program. Participants will share health and lifestyle data to develop personalized prevention strategies and treatments.
A study found that a twice daily program of assisted range-of-motion exercises significantly improves bone strength in very low birth weight pre-term infants. This could lead to a reduced risk of osteopenia and future fractures.
A recent study by Avni Shah at the University of Toronto found that paying with cash increases feelings of connection and attachment to purchases, while credit cards may lead to a decrease in emotional attachment. This phenomenon is attributed to the 'pain of payment', which varies depending on the type of payment method used.
Research suggests that the location of ulnar collateral ligament (UCL) tears in MLB pitchers can predict non-operative treatment failures and guide surgical recommendations. Distal UCL tears are more likely to require surgery than proximal tears.
A study found that severe non-proliferative and proliferative diabetic retinopathy stages are associated with increased depressive symptoms in people with diabetes. Moderate or severe vision impairment, but not diabetic macular edema, contributed to the risk of depression.
Scientists at Vanderbilt University have developed monoclonal antibodies that effectively neutralize the H3N2 variant virus (H3N2v) in human subjects who received an experimental vaccine. These antibodies were able to neutralize H3N2 strains circulating between 1995 and 2005, but not currently circulating human H3N2 strains.
Research suggests that extra-coding RNAs play a critical role in regulating DNA methylation patterns in the adult brain, particularly in memory formation. By interacting with DNA methyltransferase enzymes, ecRNAs control the addition or removal of methyl groups at precise spots on chromosomal DNA.
The BMC Vital Village Network has received a $500,000 strategic planning grant to develop infrastructure supporting children entering kindergarten at a healthy weight. The project aims to promote healthy growth and development through a two-generation approach, involving community settings from preconception to age 5.
A new platform harnesses DNA as the engine of a microscopic nanomachine, detecting trace amounts of substances such as viruses, bacteria, and metals. The technology uses selectively triggered DNA molecules to create a signal, enabling ultra-sensitive detection and potential clinical testing.
Researchers at NYU Tandon School of Engineering have developed a technique called LAVA, which intentionally adds vulnerabilities to source code to test bug-finding tools. The results show that many popular bug finders detect only 2 percent of vulnerabilities, highlighting the need for improvement.
Scientists track brain-cell activity in mice to gain insight into how the brain creates a map to a destination. The study found that two sublayers of cells in the hippocampus process different types of learning, with one layer creating a stable internal map and the other layer updating it during navigation.
A study published by the University of Oxford found that man-made climate change was responsible for hundreds of deaths in two European cities during a 2003 heatwave. The research used computer simulations and health impact assessments to estimate the number of premature deaths attributed to climate change.
The Atmospheric Tomography (ATom) mission surveys the atmosphere over oceans for the first time, measuring pollutants and climate gases. The DC-8 aircraft will document interactions between air masses, understanding where pollutants originate and how quickly they react chemically.
A new study by Iowa State University researchers suggests that prolonged periods of food insecurity coupled with harsh parenting practices can lead to obesity in early adulthood among female adolescents. The study's findings indicate that females who experience food insecurity are more likely to be overweight or obese by age 23.
Astronomers have discovered a planet in a unique position between three stars, experiencing constant daylight or triple sunrises and sunsets. The planet, HD 131399Ab, is one of the youngest exoplanets discovered to date and has a wide orbit within a multi-star system.
A study reveals that rapid TB tests in West Africa have low accuracy due to the presence of other mycobacterial species like Mycobacterium africanum. The tests miss a substantial fraction of cases, leading to dire consequences for patients and TB control efforts.
A team of researchers used a custom-built robot, mathematical models, and studies of amphibious fish to explore the critical evolutionary leap from water to land. They found that stabilizing the body with a tail provided substantial benefits for early terrestrial vertebrates.
Researchers found that immune checkpoint blockade improved survival and promoted immune cell infiltration into tumors when combined with an antitumor vaccine. The study suggests PD-1 and PD-L1 may help tumors evade vaccines, supporting testing of therapeutic combinations in clinical trials.
Researchers found that sub-sensory vibratory noise delivered to the foot sole of older adults significantly augmented postural control complexity, leading to improved mobility and reduced TUG times. This study highlights the potential benefits of vibratory stimulation for enhancing physical function in older adults.
Researchers have discovered a new ferromagnetic superconductor, CsEuFe4As4, where both bulk superconductivity and full ferromagnetism are realized simultaneously. The material exhibits robust SC and FM, with the ferromagnetic ordering demonstrated by field-dependent magnetization.
Scientists have developed a new method that can accurately identify brain regions triggering seizures in people with epilepsy. The technique, using advanced mathematical modeling procedures, has shown promising results in predicting successful surgery outcomes.
A team of researchers from the Instituto de Astrofísica de Canarias has discovered a new gaseous component in a planetary nebula, which is helping to understand the chemical evolution of our Galaxy. The component, rich in heavy elements such as oxygen and carbon, was detected using the OSIRIS instrument on the Gran Telescopio CANARIAS.
Visits to emergency departments for hypertension increased by 64% between 2002 and 2012, despite a decline in hospitalizations. Aggressive home monitoring may be driving patients to ERs without other emergency conditions. Mortality rates were low, with less than 1% of patients dying within 90 days.
Researchers developed a system to predict storm damage by waves in the North Sea, focusing on densely populated areas. The model simulates waves and tidal currents, indicating interactions between waves from different directions play a fundamental role in wave climate.
Research finds The Blob had a stronger negative impact on marine productivity than El Niño off the West Coast, with ocean warming slowing nutrient flow and reducing ecosystem productivity. The study uses real-time data from autonomous gliders to assess the effects of major climate disruptions.
A large multicentre study found that freeze-all embryo protocols are associated with significantly improved IVF outcomes, particularly in women over 35. The study showed a 13% increase in ongoing pregnancy rates for these patients compared to traditional fresh embryo transfer methods.
Researchers have found evidence of water clouds in WISE 0855, a nearby brown dwarf that is the coldest known object outside of our solar system. The team used spectroscopic observations to study its composition and chemistry, revealing a spectrum dominated by water vapor and clouds.
A team of researchers at Nagoya Institute of Technology has developed a method to synthesize complex, versatile materials from starting materials with low reactivity. The synthesis uses the catalytic Mannich reaction to produce chiral imidazolines with high yield and stereoselectivity.