Researchers discovered a new way to kill rapidly multiplying cancer cells using necroptosis, an alternative form of cell death. This approach may lead to more effective treatments for patients with acute myeloid leukaemia (AML) who have resisted traditional therapies.
Astronomers at Queen's University Belfast will lead the UK's search for distant supernovae, asteroids, and comets. The LSST telescope will generate a massive scientific dataset of billions of galaxies, stars, and solar system objects, providing insights into the origin of chemical elements and the size and geometry of the Universe.
A new study finds that 81.75% of transsexual individuals experience physical aggression, while 31.16% face discrimination in the workplace, contributing to mental health concerns like depression and social anxiety.
A new species of horned dinosaur, Spiclypeus shipporum, has been identified in Montana, featuring sideways-protruding horns and unique bony spikes. The fossil discovery provides insights into the Late Cretaceous period's dinosaur diversity and highlights the importance of dietary specializations.
A new gene therapy has been developed to repair lungs damaged by chronic allergic asthma, reducing inflammation and improving airway structure and function. The study used a novel biodegradable platform to deliver the thymulin gene therapy, showing effective results in mice with experimental asthma.
A new study predicts that Totten Glacier in Antarctica may cross a critical threshold within the next century, triggering an irreversible period of rapid retreat and contributing up to 2.9m to global sea-level rise. The glacier's instability is linked to its geology, which will become unstable if it retreats another 100-150km.
A new study from the US Department of Energy's Lawrence Berkeley National Laboratory estimates that solar power could deliver $400 billion in environmental and public health benefits by 2050. The study finds that a high-penetration solar scenario would result in significant greenhouse-gas emissions reductions, air-pollution health and ...
A study of 417,494 older adults with COPD, asthma, or both found a significant increase in nontuberculous mycobacteria pulmonary disease among current and former inhaled corticosteroid users. Researchers identified fluticasone as a potential contributor to the increased risk.
Researchers discovered that HIV controllers' CD4+ T cells express specific T cell receptors targeting the HIV capsid protein, enabling sensitive detection and control of viral replication. These findings offer potential for developing immunotherapy strategies to restore antiviral responses in patients with HIV.
Researchers have developed a new computing technique that can analyze large amounts of genomic information, which could lead to better understanding of diseases and environmental issues. The approach, called GISMO, uses Gibbs sampling to find biological signals in the data, improving upon conventional sequence alignment programs.
Scientists have developed a new type of graphene-based transistor that enables record low power consumption and high clock speeds. The device uses bilayer graphene, which exhibits a unique electronic structure allowing for efficient tunneling switches.
Researchers at ANU tested breeding habits of fish to disprove theory that larger genitals make males more attractive or successful in fathering offspring. They found females don't find bigger genitals more attractive, contradicting previous studies and human research.
A recent Iowa State University study found no evidence that grit improves performance, contradicting popular views on the trait. The research analyzed over 67,000 people and concluded that grit is not a unique predictor of success.
Researchers analyze high-risk individuals and track their HIV status to understand the evolution of symptoms and signs during acute infection. The study reveals a correlation between peak viremia and set-point viremia, establishing a critical window for intervention strategies.
Critically ill MERS patients exhibit more severe disease and higher mortality than non-MERS patients with SARI. The study, conducted at 14 hospitals in Saudi Arabia, highlights the need for improved diagnostic tools to combat this deadly virus.
The study, led by IAC researcher Enric Pallé, has updated observations of the Earth's albedo from 2007 to 2014, showing monthly and annual variations but no long-term trend. The results coincide with a stabilization in the planet's mean temperature.
Researchers at the University of Zurich have discovered a new way to kill off resistant leukemia cells via necroptosis, a cell death program that can bypass traditional apoptosis. SMAC mimetics, which activate necroptosis, showed promise in killing leukemia cells in 33% of patient samples tested.
A recent study by McGill University researchers found that users tend to follow those with more connections than themselves, resulting in a phenomenon known as the Generalized Friendship Paradox. This paradox suggests that even active and influential users experience it, with up to 90% of users experiencing this effect.
Scientists detect and quantify metastability induced by disorder in granular materials for the first time. The team uses a parameter from liquid crystal physics to measure force chain orientation, confirming the relationship between disorder and metastable energy states.
The EVE sounding rocket will provide under-flight calibration for the SDO EVE spectrometers, supporting the calibration of other solar soft X-ray and extreme ultraviolet spectrometers. This mission aims to gather data for a tune-up of satellite instruments, helping scientists understand degradation trends.
Research from North Carolina State University finds that bees in cities rely on flowers for nectar, not processed sugars. Domesticated and feral bee populations show varying levels of sugar consumption.
A highly effective antidote to opioid overdoses, naloxone, is becoming more accessible to patients and bystanders. New intranasal spray and autoinjector devices have been developed to address issues with getting the drug to those in need.
Researchers have developed a soft actuator that allows robots to move freely without harming humans. The actuator uses hyperelastic membranes and electric fields to control movement, enabling robots to give way in case of doubt, making them suitable for applications where human safety is a concern.
Researchers demonstrate that rotational motion in the universe follows general relativity principles, connecting it to dark energy content and inertial dragging. The study yields a prediction that 73.7% of the present content of the universe is in the form of dark energy.
Researchers at George Mason University have successfully developed an early-detection urine test for Lyme disease that accurately identifies the bacteria protein, even in patients with active cases. The test has shown promise for diagnosing other diseases, including Ebola, malaria, and tuberculosis.
Researchers discovered a crucial connection between protein structures and molecular functions by analyzing ancient genetic sequences. They found that tiny gene segments determine the formation of active sites in proteins, enabling them to perform specific functions.
A new study suggests that student loan debt compromises young people's ability to accumulate wealth after college, particularly for black young adults. The researchers found that those with outstanding balances on their student loans when they graduated or dropped out of college had lower net worth, fewer financial and nonfinancial ass...
A new study suggests that conventional repeated radiation treatments for brain tumors may kill important support cells and cause more damage than single dose radiation therapy. This can lead to cognitive problems in patients after treatment.
The study found that emergency medicine residents carry an average of $212,000 in educational debt, surpassing the national average mortgage of $168,000. This debt significantly impacts their career decisions and overall financial well-being.
Researchers design a perovskite nanoparticle that changes color when interacting with ions and small molecules during chemical reactions. This allows for qualitative monitoring of reactions with the naked eye and quantitative analysis with simple instrumentation.
An international team of astronomers has detected icy comets and carbon monoxide gas around a nearby sun-like star using ALMA. The findings provide early insights into the properties of comet clouds in stellar systems just after their birth.
Researchers designed a novel mTOR inhibitor, Rapalink, to combat drug-resistant tumors. In animal experiments, Rapalink reduced the size of tumors resistant to earlier-generation inhibitors.
A novel study reveals a method for controlling hot molecule reactions using precise temperature modulation and degree of bending. The researchers found that resonant energy positions decrease as molecular bending increases, affecting interaction likelihood with electrons.
A study published in Neurology found that pregabalin, commonly used to treat pain and anxiety, is associated with a higher risk of major birth defects. Women taking pregabalin during pregnancy were three times more likely to have a child born with a major defect compared to those who did not take the drug.
A new study suggests that the Riasi fault in Indian Kashmir has been building up pressure for thousands of years, potentially leading to a magnitude 8.0 or greater earthquake. The fault's lack of recent seismic activity increases the likelihood of a major event, posing a significant threat to millions of people in the region.
A third of global burden of disease for mental disorders occurs in India and China, with significant treatment gaps. Community engagement, traditional medicine practitioners, and increased support are key to bridging this gap.
A new species of horned dinosaur, Spiclypeus shipporum, has been identified with a unique 'spiked shield' on its head frill. The dinosaur lived around 76 million years ago and showed signs of arthritis and bone infection.
Children with sickle cell disease show significant improvement in lung function after receiving hydroxyurea treatment. The study found a reduction of over one-third in the annual pulmonary function decline, indicating potential benefits for patients.
The next WHO director general must establish a well-coordinated system for preventing and responding to outbreaks, strengthen accountability mechanisms, and engage private sector foundations during public health emergencies. This is according to experts' analysis of key questions for prospective candidates.
The Bell Museum has launched the Minnesota Biodiversity Atlas, providing public access to hundreds of thousands of plant and animal specimens. The Atlas serves critical needs like guiding field surveys, conservation planning, and enabling research on biodiversity in Minnesota.
A study published in Frontiers in Microbiology found that captive giant pandas experience gastrointestinal problems when switching from bamboo stalks to leaves, leading to reproductive issues. The researchers analyzed the bacteria in the pandas' poop and discovered a unique population of microbes associated with digestive dysfunction.
A new study by the University of Illinois reveals that Palmer amaranth populations are resistant to PPO-inhibiting herbicides due to a genetic mutation involving the deletion of three nucleotides. This mutation is expected to spread rapidly, making it essential for farmers to switch to alternative herbicides.
A novel laboratory blood test has shown promise in identifying HELLP syndrome, a life-threatening condition affecting 1% of pregnant women. The test measures levels of components of serum and may help reduce pre-term deliveries and complications for mothers and babies.
A new study published in JAMA Psychiatry found that nearly 70% of young adults with ADHD did not meet criteria for the disorder in childhood, suggesting that adult-onset ADHD may have different causes. Adults with late-onset ADHD had high levels of symptoms and impairment, as well as other mental health disorders.
Two new studies from JAMA Psychiatry explore the causes and developmental patterns of ADHD in young adulthood. They found that many individuals with ADHD at age 18 did not have a childhood diagnosis, and those with 'late-onset' ADHD showed fewer externalizing problems but comparable symptoms to those with persistent ADHD. The findings ...
A team of researchers has found that voltage-gated calcium channels open in unison to allow calcium ions into and activate excitable cells like neurons and muscle cells. This cooperative behavior could lead to improved therapies targeting aberrant calcium channels in malfunctioning cells.
EPFL scientists have described the atomic-level mechanism of bacteriophage infection using state-of-the-art tools. The breakthrough reveals how the baseplate coordinates attachment and contraction of the viral tail, shedding light on a complex process that has major implications for medicine and research.
Researchers have found direct evidence of past changes in the Totten Glacier's glacial history, revealing unstable zones prone to rapid collapse. This study sheds light on the region's vulnerabilities and warns of potential catastrophic consequences for sea level rise.
A study published in JAMA Cardiology found that women with atrial fibrillation (AF) exhibit more symptoms, functional impairment, and poorer quality of life compared to men. However, women also demonstrated a higher risk-adjusted survival rate and lower cardiovascular death rate despite their AF-related challenges.
Researchers used GIS tools to identify high-risk poaching areas and proposed drone surveillance for more efficient conservation efforts. The study found that open savannah areas with roads and water features are hotspots for poaching.
A study found that teenagers who multitask between media while studying perform worse academically, having lower working memory and being more impulsive
A simple paper sheet can remove resistant viruses from water, improving access to safe drinking water for millions. The mille-feuille filter uses cellulose nanofibers and has a unique layered internal architecture.
A new RAND Corporation study reveals that neighborhood parks in the US are underutilized by adults, seniors, and younger females, with those aged 65+ using walking loops as a primary source of physical activity. The study also highlights a gender gap in park use among children and teens, with females representing only 40% of observed y...
A recent study found that broad-spectrum antibiotics can raise the risk of complications from stem cell transplantation, including graft-versus-host disease. The study suggests that selecting antibiotics that spare
A new study shows success with a combination therapy of the sugar 2-Deoxy-D-glucose (2-DG) and fenofibrate, which selectively starves slow-growing cancer cells while sparing normal cells. This approach eliminates toxic chemotherapy side effects, paving the way for non-toxic treatments for various cancers.
Researchers found that hornbills' beaks account for up to 20% of their non-evaporative heat loss, helping conserve water in hot desert environments. This unique adaptation may provide an advantage over panting, a method used by birds to cool off.
Assoc Prof Lim Soon Thye has received a S$2.5 million Tanoto Foundation Professorship to advance research on Non-Hodgkin's Lymphoma, a cancer prevalent in Asia with limited treatment options. The funding will focus on improving diagnostic and clinical outcomes for patients.
Researchers at Rutgers University and Dartmouth College find that oral drug deferiprone kills HIV-infected cells in lab cultures and suppresses the virus in patients in a limited clinical trial. The treatment approach has potential as a new strategy for destroying the DNA harbored in HIV-infected cells.
The SPB is testing and validating its technology for long-duration flights at mid-latitudes, with the goal of 100+ days. The balloon is carrying a gamma-ray telescope and infrasound instrument to study galactic positrons and black holes.
Researchers have discovered a carbon coating that can prolong the life of wind turbine components, reducing micropitting and associated failures. The 'diamond-like' coating, named N3FC, has proven its worth through over 100 million testing cycles with no appreciable wear.