Researchers at Purdue University have discovered a link between cholesterol metabolism and pancreatic cancer spread, pointing to potential new treatment using drugs for atherosclerosis. Controlling cholesterol metabolism reduces tumor growth and metastasis in mice.
A team of researchers has successfully imaged all steps in a complex organic reaction, revealing the mechanisms behind it. The study used atomic force microscopy to visualize the bond configuration of reactants, intermediates, and products, providing new insights into the stabilization of intermediates.
The Department of Energy has selected 49 scientists from across the US to receive significant funding for research under its Early Career Research Program. Researchers will receive up to $500,000 per year for five years to support their formative work.
George E. Fox, University of Houston professor and renowned biologist, has been awarded the university's highest faculty honor, the Esther Farfel Award. His groundbreaking research, including the discovery of the Archaea domain, has earned him recognition as one of the most meritorious scientists alive today.
Scientists have found that pieces of the underside of the North American Plate are peeling off, sinking into the mantle, and causing earthquakes in the southeastern US. This process is likely to produce more earthquakes in the future due to unbalanced stresses in the plate.
Researchers identified factors that make some species more resilient to extinction, including color variation, live birth, and low-latitude habitats. These species are more likely to adapt to future climate changes, helping conservationists predict which species are most at risk.
New research suggests that heat-based exercise is a more efficient means of improving altitude tolerance than normobaric altitude training. Heat-based training reduced physical strain and improved time-trial performance in cyclists, with similar effects on blood cells as low-oxygen training.
The Gutenberg Research College has appointed Professor Klaus Müllen as a new fellow, while presenting Dr. Vishva Dixit with the Gutenberg Research Award 2016 for his groundbreaking research in apoptosis and inflammation.
Dr. Steve Granick, a renowned expert in colloids and polymers, has been selected for membership in the American Academy of Arts and Sciences. He is one of 176 new fellows and 37 foreign honorary members to be formally inducted on October 8, 2016.
Scientists at UC San Diego have developed a new tool that allows them to visualize nanoscale mixing processes occurring in liquids. This technique enables researchers to study chemical interactions and kinetics, previously impossible with traditional methods.
Researchers at PPPL discovered that the bootstrap current is mostly carried by magnetically trapped electrons, contradicting previous understanding. This finding provides a new explanation for the large size of the bootstrap current at the tokamak edge.
A phase I trial of the rVSV-ZEBOV vaccine in Africa and Europe has shown promising results, with antibodies detectable after six months. The vaccine stimulates a strong immune response and appears to control virus replication.
Outpatient oral antibiotic prescriptions were estimated to be 30% inappropriate in the US, with an annual impact of 34 million unnecessary prescriptions. A 15% reduction in overall antibiotic use is necessary to meet the White House National Action Plan goal by 2020.
Alan R. Palmer has received the William and Christine Hartmann Prize in Auditory Neuroscience from the Acoustical Society of America, recognizing his work on understanding the mechanisms behind sound perception and brain activity.
Researchers plan to use stored tissue samples, cell lines, and sperm to develop stem cell technologies and create viable northern white rhinoceros populations. The ultimate goal is to establish self-sustaining populations in several decades.
Researchers from the University of Leeds found that human steering in a driving simulator is influenced by visual speed signals, not just road edges. The study's findings suggest that our brains process information from across the whole visual scene to guide steering, similar to how insects choose their flight paths.
The CSU students were recognized for their research and community service in the environment and tribal public policy categories. They will participate in a Scholar Orientation and receive up to $7,000 in scholarships to support their junior or senior year.
The European Association of Cardiovascular Imaging has released new guidelines for the imaging assessment of prosthetic heart valves. The guidelines provide recommendations for a multimodality approach to diagnose and manage complications, including echocardiography as the first-line imaging modality. The study aims to improve assessme...
Researchers at Umea University and Swedish Defence Research Agency develop a three-dimensional structure of the HI-6 nerve agent antidote, revealing its binding mechanism to acetylcholinesterase. The breakthrough provides new insights into designing effective antidotes against sarin and other nerve agents.
The study found that sharing sanitation facilities with one or two households was associated with an increased risk of diarrhea in young children. Private household sanitation facilities were not found to be associated with this risk at all sites, suggesting a global health priority for access to these facilities.
Researchers at Arizona State University found that a particular type of cyanobacteria can bore into and live within solid carbonates, hastening coral reef erosion. The microbe orchestrate cell-to-cell calcium transport, developing specialized cells to store and regulate calcium levels.
New research by astronomers at the Harvard-Smithsonian Center for Astrophysics examines scenarios for Planet Nine's formation and finds most have low probabilities. The simplest solution suggests the solar system created an extra gas giant, boosting Planet Nine into its wider orbit over time.
The study found that Latinos diagnosed with bilateral AMD and large drusen had a substantially lower health-related quality of life compared to those with single-eye lesions. The research also indicates an earlier decline in quality of life due to early-stage AMD, highlighting the need for earlier stage interventions.
A new study found that more than 1,000 sperm whales have a mitochondrial DNA profile from a single 'Eve' ancestor tens of thousands of years ago. The females in this ancestral lineage are responsible for shaping the global population structure, showing strong fidelity to local areas.
Researchers found that yoga and aquatic exercise significantly improved symptoms of multiple sclerosis, including reduced fatigue, depression, and paresthesia. The study, involving 54 women with MS, showed a significant reduction in moderate to severe depression in those who exercised three times a week.
Researchers obtained images of the NMDA receptor in active, non-active, and inhibited states using x-ray crystallography and single-particle electron cryomicroscopy. The study reveals the complex movements of the receptor's subdomains during activation and provides insights into designing novel therapeutic compounds.
A Stanford University School of Medicine study found that $1.4 billion in HIV prevention programs promoting sexual abstinence and marital fidelity had no impact on changing individual behavior or reducing HIV risk. The researchers suggest reallocating funding to effective HIV prevention methods, as the remaining $50 million in annual f...
Scientists discovered that up to 60% of airborne particles after a rainstorm come from the soil, releasing organic matter into the atmosphere. This finding has significant implications for understanding the planet's climate and will be integrated into atmospheric models.
A study of 257 female inmates in Rhode Island found that 68 had engaged in sex exchange, which was associated with higher risks of physical abuse, injection drug use, and multiple STIs. Assessing a lifetime history of sex exchange could help identify women at risk for these problems.
MicroRNAs play a crucial role in controlling fertility and puberty by regulating the expression of gonadoliberin or GnRH, a neurohormone that stimulates sexual maturation. Failure to produce microRNAs leads to infertility and sterility in adults.
Researchers have developed nanoparticles that deliver antiobesity drugs directly to fat tissue, transforming white adipose tissue into brown and stimulating angiogenesis. The treatment resulted in a 10% weight loss in mice without adverse side effects.
Despite federal legislation, Yale researchers found that shortages for acute-care drugs used to treat critically ill patients have increased since the passage of FDASIA. The median duration of these shortages was approximately eight months, posing risks of medical error and reduced effectiveness.
Researchers have sequenced the mitochondrial genome of the Hispaniolan solenodon, revealing that it diverged from other living mammals 78 million years ago. The venomous mammal survived asteroid impact and human colonization, but is now threatened by habitat loss and introduced predators.
A new study published in CMAJ found that the UK Health Check program had a modest impact on reducing cardiovascular disease risk factors, with limited success in meeting national and international targets. The program resulted in increased diagnoses of vascular diseases such as hypertension and type 2 diabetes among participants.
A new study by Spanish National Research Council (CSIC) reveals that the 3-nitrooxypropanol compound reduces methane production in ruminants without harming their health. This finding opens up possibilities to decrease global temperatures and increase efficiency of ruminant production systems.
The study uncovered five new genes associated with breast cancer and 13 new mutational signatures that influence tumour development. The analysis revealed the genetic variations in breast cancers and their distribution across the genome.
The researchers developed a new method to increase the aggressive intensity of cavitation without increasing power. By controlling pressure at the bubble collapse region, they were able to enhance cavitation efficiency by a factor of about 100.
A recent NIH-funded study found that half of patients with age-related macular degeneration (AMD) maintained 20/40 vision or better after five years of anti-VEGF drug treatment. The study also showed that the two most commonly used drugs, Avastin and Lucentis, were equally effective in preserving visual acuity.
A new study from Harvard Medical School found that corporate churning in nursing homes is linked to lower quality of care. The research, led by David Grabowski, measured the impact of ownership changes on nursing home quality and found that transactions were often associated with existing quality problems.
The US lead poisoning crisis worsens as unknown communities are left exposed to tainted water. Inadequate funding may not alleviate damage done in the past.
Algae farming is sensitive to fertilizer costs, with ammonia and carbon dioxide being major concerns. Approaches like increasing surface area, partial pressure, and contact time can improve nutrient utilization efficiency for CO2. Dosing ammonia at a controlled rate can minimize its volatility and toxicity.
A recent study found that hydropeaking, or the daily raising and lowering of river flows, has a devastating impact on aquatic insect abundance. The researchers discovered a clear correlation between hydropeaking and the number of insect species present, with certain insects being nearly absent in areas where they should have been present.
A study published in Journal of Public Health Management and Practice found that veterans are more likely to report delays in seeking necessary healthcare compared to the US general population. The study suggests that access problems within the VA system may be creating disparities in care for this vulnerable population.
Researchers at Northwestern University have stabilized exfoliated black phosphorus by covalently bonding a single-molecule-thick layer onto its surface. This enhances electronic properties and prevents degradation in open air, making it suitable for applications such as sensors, transistors, and optoelectronics.
A new study by the USGS reveals that hydropeaking, a widespread practice in hydroelectric dam operations, can disrupt river food webs and harm aquatic insects. Alternative hydropower practices, such as leaving river levels low and stable during periods of minimal power production, may help mitigate these negative effects.
Researchers studied skeletons from London's St. Mary Spital cemetery, finding that stress markers like LEH were correlated with famine deaths. However, periosteal lesions on shin bones were found to be associated with normal, non-famine related deaths, contradicting previous assumptions about their significance.
Scientists have developed a new method to image magnetic fields on the nanometer scale at temperatures close to absolute zero. They used quantum sensors in diamond-based microscopes to achieve unrivalled precision in measuring magnetic fields in superconductors.
Scientists have discovered that silencing the molecular alarm, HIF-1α, reduces heterotopic ossification and disability in a rare bone disorder. By targeting this protein, researchers hope to develop more effective treatments for FOP and related disorders of heterotopic ossification.
A new study published in Hypertension found that arterial stiffening can be detected in early adulthood, particularly in ethnic minority groups, and is associated with physical inactivity, stress from racism, and high blood pressure. Regular physical activity was linked to lower arterial stiffness, emphasizing the importance of exercis...
A team of researchers at ICIQ has designed and synthesized highly selective and effective Englerin analogues that inhibit the growth of renal cancer cells. The analogues were developed using gold catalysis and exhibited potent anti-cancer activity in cell lines, offering a promising treatment option for patients with kidney cancer.
A McMaster University research team is examining how environmental factors, such as agricultural practices and toxicants, affect brown adipose tissue activity in individuals with obesity or type-2 diabetes. The studies aim to develop new strategies to enhance BAT activity for treating and preventing these diseases.
Researchers found that the CB2 receptor regulates nerve cell activity in the hippocampus, adjusting communication processes. The discovery could lead to novel medications for schizophrenia, depression, and Alzheimer's disease.
A study by the University of Toronto's Rotman School of Management found that having a first-class cabin increases air rage incidents nearly four times more than a nine-hour flight delay. Economy passengers who pass through first class are also more likely to exhibit bad behavior.
A new study found that drinking water from private wells, especially those established before the 1950s, may contribute to elevated bladder cancer risk in Maine, New Hampshire, and Vermont. The researchers estimated that increasing cumulative arsenic exposure was associated with an increased risk of bladder cancer.
A study of 36 women found nearly all carried cancer-associated gene mutations, suggesting high accuracy and sensitivity for detecting ovarian cancer. Duplex sequencing technology can identify low-frequency cancer-like mutations, potentially leading to early detection and treatment.
Researchers discover microbes creating tubular microtunnels in basaltic volcanic glass on Earth, expanding our understanding of subsurface microbial activity. This finding also suggests that similar features may exist on Mars, potentially near the surface, which could aid future Mars missions.
Experts weigh the benefits of expanding buprenorphine prescribing, citing its effectiveness in reducing opioid mortality rates, but also raising concerns about misuse and diversion. Proposed strategies aim to ensure safe and effective use while promoting quality care.
A new study suggests children with ADHD follow fewer healthy lifestyle behaviors than non-ADHD youth. Children with ADHD were more likely to consume artificially sweetened juice, have excessive screen time, and engage in less physical activity.
A Kaiser Permanente study found that a widely recommended cardiovascular risk calculator overestimates the actual five-year risk of heart attacks and ischemic strokes. The study suggests that individuals may be over-treated due to the inaccuracies.
Research reveals that tropical cyclones in the southeastern United States increase forest photosynthesis and growth, capturing significant amounts of carbon from the atmosphere. This effect significantly exceeds carbon emissions from American vehicles each year.