Lauren Sciences will use the grant to customize LAUR-301 with neurotrophic factor and deliver it to disease sites in central nervous system ALS mice. The company aims for LAUR-301 to enter human clinical trials and become a transformative V-Smart TM Nanomedicine for treating ALS.
New technology allows for detailed analysis of prostate shape changes after treatment, potentially providing prognostic information and early biomarkers. The study, published in PLOS ONE, involves eight patients and plans to expand to 40 more, tracking long-term outcomes.
A study found polar bears are swimming more due to reduced summer sea ice, with adult females covering distances of up to 249 miles in search of food. Climate change is linked to the increased swimming behavior, which may have serious implications for polar bear populations.
A data sharing pilot project will report and reflect on data policy challenges in development research. The project, which involves 8 case studies, aims to develop a model open research data policy and implementation guidelines for funders.
Researchers examined Nike and Adidas' strategies to improve environmental impacts and working conditions from 1995 to 2012. Both companies ultimately adopted sustainability as a core business strategy, but took different approaches to get there.
A study published in Human Reproduction found that women with BRCA1 gene mutations have lower levels of anti-Müllerian hormone, indicating reduced ovarian reserves. This may impact fertility and suggest a need for earlier pregnancy planning.
Researchers at Baylor College of Medicine developed a new class of small molecule drug SI-2 that accelerates the destruction of cancer signaling molecule SRC-3, leading to slower cell proliferation and migration. The study suggests SI-2 has potential for improving cancer treatment with low toxicity to normal cells and animals.
A new machine learning algorithm can identify human facial expressions based on neural activity, with a 60% success rate. The area of the brain responsible for this task is the posterior superior temporal sulcus (pSTS), which activates when looking at images of different facial expressions.
A phase III trial found that patients taking nivolumab were more than twice as likely to be alive after one year compared to those treated with chemotherapy. Median survival for nivolumab was 7.5 months, significantly longer than 5.1 months for chemotherapy.
A new study identifies several risk factors for pre-eclampsia, including having had pre-eclampsia in a previous pregnancy or chronic hypertension prior to the current pregnancy. The researchers developed a tool using routinely collected clinical information to distinguish women who are unlikely to benefit from aspirin therapy.
Researchers at Cincinnati Children's Hospital Medical Center propose a new drug to treat life-threatening lung damage caused by infections, cancer treatments, and premature birth. The treatment targets FOXF1, a transcription factor that promotes recovery from acute lung injury.
The new study found that higher levels of antibody against neuraminidase protein were better predictors of protection against flu infection and its side effects. Participants with high levels of HA antibodies experienced lower incidence of mild-to-moderate influenza, but not necessarily less severe symptoms.
Research found that TNF-alpha induces immune surveillance cells called M cells, which promote the body's ability to regulate and suppress inflammatory responses. This discovery could lead to more targeted drug therapies for treating IBD and other autoimmune diseases.
Researchers at Kyung Hee University propose a model to recycle lithium ion batteries into energy storage units for solar-powered LED lamps, reducing e-waste and providing job opportunities. The system can light up a room for about five hours each day, lasting approximately three years without maintenance.
A study published in Trends in Cognitive Sciences suggests that our visual perception may be limited to the 'big picture', capturing details but not specifics. This challenge to the notion of rich visual experience highlights the complexities of consciousness and perception.
Researchers have designed heterocycle-based luminogens with aggregation-induced emission characteristics, offering improved electron transport and tunable energy gaps. These materials exhibit superior performance in optoelectronic devices, chemo- and bio-sensors, and bioimaging applications.
Scientists have developed new methods to monitor endogenous oxidants, which are essential chemical messengers that help maintain organism function. The methods involve genetically encoded probes that can detect specific oxidants in real-time and down to single-cell levels.
A new study from Indiana University reveals that nearly half of all long-stay nursing home residents are sent to the Emergency Department over a year, despite their cognitive status. The study's findings highlight the need for strategies to avoid unnecessary transfers and deliver patient-centered care in long-term care facilities.
Research finds harsh parenting increases risk of poor physical health and obesity, while a warm coparent can partially mitigate this risk. However, the effect on body mass index is counterintuitive, as increased warmth from the other parent increases the health risk.
A systematic review found that parents generally provide the most accurate estimates of their children's body weight in emergency departments. Length-based methods, such as the Broselow Tape, were the next most accurate, but still had limitations.
Despite concerns, leading eye specialists find no evidence to suggest lasers pointed at airplane cockpits damage pilots' eyesight. However, the dazzle and distraction from such incidents could prove disastrous during critical moments like landing.
A multidisciplinary team led by USC Viterbi Professor Maryam Shanechi aims to develop brain-machine interfaces enhancing human decision making through multimodal data modeling and multi-sensory processing.
Ecohydrologist Lixin Wang investigates the impact of non-rainfall water sources on drylands, focusing on fog and dew. He aims to better understand ecosystem functions and interactions with limited knowledge of these sources in dryland environments.
A 20-month-old girl's tumor regression shows promising evidence of the potential for LOXO-101 to provide significant benefit for pediatric patients with NTRK gene fusions. The patient achieved a 90% reduction in tumor size after receiving an experimental treatment.
Scientists observed a current sheet during a December 2013 solar flare, confirming the role of magnetic reconnection in solar flares. The detailed measurements from three NASA missions provide unprecedented insight into the complex physics behind solar eruptions.
A new University of Washington study shows that bulkheads and seawalls along Puget Sound's shores have a cumulative impact on the ecosystem, shrinking beaches and reducing habitat for invertebrates and fish. The study provides crucial information for improving management approaches to shorelines.
A phase 2 clinical trial of pembrolizumab as a first-line systemic therapy for advanced Merkel cell carcinoma found that the treatment produced an objective response rate of 56% and sustained responses in 86% of patients. The study suggests that immunotherapy may be a promising approach for this aggressive type of skin cancer.
Researchers found that neural stem cell transplantation increased M2 microglial proteins, contributing to anti-inflammatory effects and reducing axonal injury. The study suggests a potential therapeutic strategy for treating traumatic brain injury.
Patients treated with stent retrievers within 2.5 hours of symptom onset had a 91% chance of functional independence, compared to 81% for those treated between 2.5-3.5 hours. Inter-facility transfer times can significantly delay treatment.
The pandemic E. coli strain H30 causes persistent and deadly infections, often undetected until severe complications arise. Researchers found that patients with underlying conditions and those in healthcare facilities are at higher risk for infection.
Researchers at Drexel University have discovered that the pre-Bötzinger complex in the brainstem generates the breathing rhythm through mixed-mode oscillations. This finding challenges previous theories and may impact how scientists research and clinicians treat respiratory disorders.
A new study by Kathleen Brewer-Smyth of the University of Delaware's College of Health Sciences found that female inmates with an incarcerated adult family member during childhood were more than twice as likely to have neurological abnormalities as adults. The implications are significant internationally, particularly in light of a Wor...
A study published in PLOS Medicine found that low body mass index increases risk of mortality after acute myocardial infarction, even after controlling for other health factors. The researchers analyzed data from 57,574 elderly patients and found underweight patients had a 13-26% higher risk of death compared to normal weight patients.
Researchers at MIT have successfully created simple electrical heating devices using coal, showcasing its potential for various high-tech uses. The team characterized the chemical, electrical, and optical properties of four different types of coal, revealing a range of conductivities that can be tailored to specific applications.
A Mayo-led study found that aspirin use is associated with a significantly reduced risk of developing bile duct cancer. The study showed that individuals who took aspirin had a more than two-and-a-half to three-and-a-half-fold lesser chance of developing the disease compared to those who did not take aspirin.
A multicomponent intervention to reduce sitting time has shown potential health benefits, including a 0.61 percentage point reduction in body fat percentage after just one month.
The EDGE project, funded by HORIZON 2020, trains 15 Ph.D. students from 5 European countries in virology and immunology to tackle herpes virus challenges.
A rare South African plant, Mrs Barber's Beauty, was rediscovered in the Great Winterberg mountains after 147 years. The plant is now recognized as Critically Endangered due to limited ecological conditions.
Aerosol jet printing uses a carrier gas and printer heads to deposit metal particles, promising to slash manufacturing time for circuit boards from a month to a day. The technique can print around bends, on spheres or flat surfaces, making it ideal for detector assemblies with many tiny components.
Indoor air pollution from smoke, building materials, and spores kills millions each year. The research aims to combat air quality issues with smart city technologies and real-time data monitoring. Dr. Prashant Kumar explains the need for better indoor pollution monitoring to protect human health.
Researchers found striking similarities between the genetic mechanism used in human limb development and that of skate embryos' gill arches. The study suggests that limbs may have evolved from sharks' gills via a critical gene called Sonic hedgehog, supporting a century-old theory.
This year's top winners include a study on benign disorders simulating thoracic malignancies and a thorough understanding of ankle nerves for nerve entrapment evaluation. B-flow imaging is also highlighted as a promising method to complement color Doppler ultrasound.
The adAPT trial is a clinical study evaluating the effectiveness of metformin in preventing type 1 diabetes. Researchers aim to identify children at high risk and examine the impact of administering metformin on beta cell stress.
An immunization regimen using two Ebola vaccine candidates was found to be safe and well-tolerated, inducing an immune response in healthy adult volunteers. The study's results suggest that the vaccines could provide durable protection against Ebola, which is essential for areas with intermittent outbreaks.
A survey of 185 professionals found only 11% felt their academic training provided necessary natural history exposure. Experts now advocate for citizen science to keep natural history relevant and empower public participation in environmental conservation.
A study found that math scores drop 5% in the first year of a budget cycle when tax-compression rules are triggered, disrupting planning and teacher assignments. School districts face uncertainty until state budgets are finalized, affecting resource allocations.
Researchers at WSU have developed a method to improve the performance of conductive plastic, which can be used in devices that interface with the human body. The material is biocompatible and can detect faint signals from neurons, enabling medical breakthroughs such as limb reanimation.
Researchers at Toyohashi University of Technology developed nano-magnetic pixels for wide-view 3D holographic displays. These displays can reconstruct realistic 3D images with a viewing angle over 30°, eliminating the need for special glasses.
Researchers analyzed astronaut quotes to understand the 'overview effect,' a sense of unity, vastness, and connectedness. They aim to induce similar feelings through virtual reality and create recommendations for maintaining astronaut well-being in extended space missions.
Breast milk plays a crucial role in shaping the infant's immune system and gut microbiome by favoring the colonization of specific bacterial groups. After one month, breast milk composition transitions to support infant growth with increased fat and nutrients.
A study published in JAMA found that pembrolizumab, an antibody against PD-1, was associated with a 33% objective response rate and 23-month median overall survival in patients with advanced melanoma. The treatment also showed improved progression-free survival rates of 35% at 12 months and 52% at 12 months
Researchers developed a paper-based biosensor to detect water toxicity, measuring color changes caused by bacteria metabolism. The technique is quick, simple, and inexpensive, suitable for use in developing countries or economically restricted areas.
A study published in Addiction found that almost half of all drinking occasions in the UK involve moderate, relaxed drinking at home. Meanwhile, groups of friends often move between home and pub drinking, consuming high amounts of alcohol. The research reveals a complex picture of British drinking culture, challenging common stereotypes.
The Australian Institute for Nanoscale Science and Technology (AINST) has been officially opened, featuring a $150m Sydney Nanoscience Hub. The facility is expected to deliver real-world solutions in areas such as energy, health, and security.
A multi-institution team is using the Titan supercomputer to study actinide chemistry and design methods for separating radioactive compounds from their inert counterparts. The team aims to develop a broad understanding of actinide science to safely store spent nuclear fuel and remediate contamination.
A phase II clinical trial showed that watercress extract significantly inhibits the activation of tobacco-derived carcinogens in cigarette smokers, with a stronger effect in those lacking certain genes involved in processing carcinogens. The extract also detoxifies environmental carcinogens and toxicants found in cigarette smoke.
Ring-tailed lemurs combine wrist and chest secretions to create more complex scents, increasing the amount of information conveyed by a single dab. This mixture may also lock in fleeting aromas and boost their staying power.
A recent multi-centre study found that breast cancer patients undergoing treatment with trastuzumab-containing regimens are at significant risk of heart damage, regardless of age. The study suggests that younger patients should also be equally monitored for heart damage.
A team of researchers from Karlsruhe Institute of Technology (KIT) has developed a compact, miniaturized switching element that converts electric signals into clearly defined optical signals. The innovation uses integrated carbon nanotubes and nanostructured waveguides to generate narrow-band light in the desired color on the chip.
A leading scientist at Florida Atlantic University has received a $540,250 NIH grant to continue his research on collagen-based diseases. He aims to develop models to study the degradation of collagen in various conditions such as multiple sclerosis, cancer, and sepsis.