A phase I study of LOXO-101 demonstrated efficacy in reducing tumors in six patients with TRK fusion-positive cancers, including sarcoma, thyroid, and non-small cell lung. The study showed significant tumor regression in all six patients, with one patient experiencing a 17% tumor reduction.
Researchers at the University of Bath have developed a miniature fuel cell that can generate electricity from urine, offering an affordable and carbon-neutral way to produce power. The device has the potential to provide much-needed electricity to remote areas at low cost.
Professor Serge Ferrari has been recognized with the International Osteoporosis Foundation's 2016 Olof Johnell Science Award for his significant work in bone health, genetics of osteoporosis, and bone remodeling. He is a leading thought leader in the field, known for translating new research findings into improved patient care.
A new study found that the risk of a second major osteoporotic fracture increases by 4% for each year of age and is 41% higher in women than men. The risk of subsequent fractures decreases over time, but remains elevated throughout follow-up.
The IOF-ESCEO 2016 Pierre Meunier Young Scientist Awards were presented to Professors Elaine Dennison and Olivier Bruyère for their exceptional research on musculoskeletal ageing, osteoporosis, and osteoarthritis. The awards recognize their potential to become key opinion leaders in the field.
Researchers identified mechanisms that allow TRK-fusion lung cancer cells to evade targeted therapies. Specific genetic changes, including amino acid positions in TRK fusion genes, confer resistance to LOXO-101. This study's findings may have implications for other kinase-driven cancers treated with tyrosine kinase inhibitors.
Dr. Elias Hanna Saba, Chief Executive Director of the Palestinian Osteoporosis Prevention Society, was awarded the International Osteoporosis Foundation's Committee of National Societies Medal for his over 26 years of experience in bone and muscle health and patient education. The medal recognizes his dedication to expanding IOF's mess...
Professor Eugene McCloskey was recognized for his significant advancements in vertebral fracture definition, osteoporosis epidemiology, and non-invasive assessments of bone strength. He has contributed to the development of the FRAX tool and published over 250 peer-reviewed publications.
The International Cancer Genome Consortium (ICGC) has launched ICGCmed, a platform that links genomic data with clinical information to guide personalized cancer treatment. The initiative aims to accelerate the movement of genomic discoveries into the clinic.
The partnership will enable pharmaceutical companies to identify compounds most likely to succeed in human clinical trials, shortening the timeline to drug approval. Advanced lipidomic profiling analysis on tissues such as the liver will be made available, enhancing the depth and quality of scientific data.
Researchers at Ohio State University found that SPF30 sunscreens delayed melanoma onset in a mouse model by 80% when applied prior to UVB light exposure. The study suggests the potential of these sunscreens as effective melanoma-preventing agents.
Researchers developed a method to isolate circulating tumor cells from blood samples using gas microbubbles. The technique successfully isolated up to 80% of cancer cells in some cases, offering a rapid and inexpensive way to analyze these rare and fragile cells.
A study by UK and Swedish researchers found that male Swedish farmers have a significantly lower risk of hip fracture, possibly due to their high levels of physical activity. The researchers analyzed data from Sweden's national registry and found that farming was associated with a 39% lower risk of hip fracture.
The IOF President's Award was presented to eight leading regional osteoporosis experts and advocates for their contributions to global osteoporosis awareness and education. The recipients were recognized for their outstanding work in the field, including Dr Ambrish Mithal, Prof Patricia Clark, and Prof Jorge Cannata Andia.
A new study presents data demonstrating that personalized direct-acting antiviral treatment can eradicate the hepatitis C virus from the body in patients who had previously failed treatment. The study identified effective re-treatment combinations for genotype 1 and 3, achieving SVR12 rates of 90% and 100%, respectively.
A Phase 1 study found that NVR 3-778, a first-in-class HBV capsid assembly inhibitor, is well-tolerated when combined with pegylated interferon. The treatment reduced levels of hepatitis B more than NVR 3-778 alone, with the largest reduction seen in the combination group.
A recent study reveals that sarcopenia is expected to significantly increase in Europe, affecting up to 19 million seniors. The prevalence of sarcopenia will rise from 11.1% in 2016 to 12.9% by 2045, with women accounting for a majority of cases.
Scientists have created T cells that can recognize and destroy cancer cells in pancreatic tumors. The engineered cells were able to attack tumor cells for up to 10 days without harming healthy tissues.
Research shows that patients with total knee replacement due to primary osteoarthritis have a low risk of hip and vertebral fractures before and after surgery. However, the risk increases by 19% for vertebral fracture and 4% for hip fracture in the years following surgery.
A UK study found no link between calcium supplementation, with or without vitamin D, and hospital admissions or mortality due to cardiovascular events. The analysis of the UK Biobank dataset showed that calcium supplementation did not increase the risk of future cardiac events.
A recent study by Dr. Barbro Kjellström found that heart attack patients are more likely to be depressed, with 14% experiencing symptoms compared to 7% of control group members. However, antidepressants were prescribed less frequently among heart attack patients with depression, at just 16%, compared to 42% of control group members.
A new study presents Norursodeoxycholic acid as a viable treatment option for patients with primary sclerosing cholangitis, a rare condition characterized by inflammation and scarring in the bile ducts. The treatment significantly reduced levels of serum alkaline phosphatase and had similar rates of adverse events compared to placebo.
A new study finds that generic direct-acting antiviral treatment for Hepatitis C can deliver high sustained virologic response rates comparable to branded treatments, but at a significantly lower price. The results suggest that generic DAAs could support access to treatment in many countries where it is currently unaffordable.
A new study reveals high levels of hepatitis B markers among unvaccinated refugee populations in northern Germany, highlighting a significant public health concern. The research found that nearly one million asylum applications were lodged in Germany last year, with many coming from unstable states where health systems have broken down.
A pilot study found that a direct-acting antiviral treatment over six weeks can effectively cure acute hepatitis C in patients. The treatment resulted in undetectable HCV levels and sustained virologic response after a 12-week follow-up, with side effects including fatigue.
A new study published at The International Liver Congress 2016 found that the diabetes drug sitagliptin was no more effective than placebo in reducing non-alcoholic fatty liver disease. However, researchers demonstrated that non-invasive imaging techniques based on MRI were useful for measuring changes in liver fat and fibrosis.
A new study has demonstrated the efficacy of all-oral treatment regimens in adolescents with hepatitis C virus. The study found that 97% of patients achieved sustained virologic response rates after 12 weeks of treatment, suggesting a promising treatment option for this patient group.
ABT-493 and ABT-530 achieved 100% sustained virologic response (SVR12) in cirrhotic patients, while non-cirrhotic patients showed a 97% SVR12 rate after eight weeks. This treatment offers hope for genotype 3 patients with heavily scarred livers.
A new study demonstrates that a build-up of fat around the waist can cause more serious complications than obesity in the development of non-alcoholic fatty liver disease (NAFLD). Non-obese patients with a large waist circumference are at risk of NAFLD complications, according to the research. The study highlights the need for addition...
Ganguly's research aims to reduce energy consumption in data centers using wireless frequencies, potentially saving 10 times the current energy usage. The project could lead to a more sustainable computing infrastructure by reducing power consumption and prolonging computer lifespan.
Patients on warfarin have poor knowledge about diet and drug interactions, which can lead to fatal side effects. Experts recommend consistent monitoring and education to improve patient outcomes.
A 71-year-old HIV-positive man was diagnosed with Alzheimer's disease through a PET scan showing amyloid deposition in the brain. This finding suggests that some older HIV-positive patients may be misdiagnosed with HIV-associated neurocognitive disorders and highlights the need for accurate diagnosis to guide treatment.
Researchers at Columbia University have developed the first on-chip RF circulator that doubles WiFi speeds with a single antenna, transforming telecommunications. The technology enables full-duplex communications, where transmitter and receiver operate simultaneously, doubling network capacity.
Researchers confirmed plasma genotyping's benefit in predicting treatment benefit for NSCLC patients, particularly those with higher tumor burden and younger age. However, tissue biopsies remain the gold standard due to low sensitivity of plasma tests, which may not fully replace them.
A new study demonstrates that antiviral therapy for immune tolerant Hepatitis B patients prolongs overall survival and reduces the risk of developing liver cancer (HCC) and scarring of the liver (cirrhosis). Nucleos(t)ide analogue treatment significantly lowers HCC and cirrhosis risks.
A new study from Mayo Clinic found that patients with high and low levels of donor-specific alloantibodies who received simultaneous liver-kidney transplants showed a lower incidence of cellular and antibody-mediated rejection, chronic injury to the kidney, and better overall kidney function compared to those who received a kidney tran...
A new tool has shown that evolutionary history plays a significant role in the activity of bacteria in soil communities. The study found that related bacteria exhibit similar growth rates and carbon use patterns, contradicting the idea of functional redundancy.
A new algorithm designed for End-Stage Liver Disease (ESLD) accurately predicted death in 96% of patients and determined which patients would benefit from intensive care unit treatment. The algorithm combines pre-morbid liver function and Acute-on-Chronic Liver Failure grade to make predictions.
Researchers found that polyandry in house mice does not enhance immune resistance against Salmonella infection. However, male mice showed surprising resistance to the disease, with lower bacterial loads compared to females.
A new study found a potential link between long-term oral nucleos(t)ide analogue treatment for hepatitis B and an increased risk of colorectal and cervical cancer. Regular screening is recommended to prevent these cancers in patients receiving such treatment. The study analyzed data from 45,299 patients with chronic HBV infection.
A preliminary clinical trial found that an experimental antibody treatment decreased the number of cancer stem cells driving tumor growth in nearly all patients with multiple myeloma. The treatment was tested in 15 newly diagnosed patients and showed promising results, with no serious adverse side effects.
Researchers created an efficient diode-pumped eye-safe laser using GdAl3 single crystals co-doped with Er and Yb. The laser emits safe wavelengths for human eyes and has advantages in telecoms due to low atmospheric losses.
Researchers at the University of Helsinki found that the modified Rankin Scale is poorly suited to evaluating neurosurgical treatment results. A one-year follow-up study revealed that 24% of patients with no complications showed decreased function on the scale, while 28% with complications received identical or better scores.
Researchers found that pollutants in seafood, including DDT and flame retardants, can interfere with the body's P-gp protein, which protects against foreign chemicals. The study suggests a risk assessment for protecting human health when eating contaminated seafood.
Scientists used NASA satellite data to study cloud cover, finding it helps identify the size and location of important animal and plant habitats. The study found that variations in cloud cover sharply delineate the boundaries of ecological biomes relevant to many unique species.
Record Balkan floods of 2014 were likely caused by the temporary slowdown of giant airstreams and planetary wave resonance. The study found that extreme rainfall events are strongly increasing in the region, even more than globally observed.
Researchers at MD Anderson Cancer Center reported encouraging correlations between immunologic biomarkers and responses to treatment with nivolumab in the first-ever phase II clinical trial for metastatic squamous cell carcinoma of the anal canal. Five patients treated with nivolumab experienced significant tumor size reductions.
A global study reveals that despite closing the education gap with men, women still face significant barriers to accessing quality jobs and government representation. Women have reached 91% of men's education levels but only 70% of their employment rate and 25% of political representation.
Researchers at UT Southwestern Medical Center identified molecular ties between cancer cell growth and heart cell enlargement, potentially leading to repurposed cancer treatments for heart disease. The study found that inhibiting enzymes called HDACs can blunt excess heart muscle cell growth and slow the spread of cancer.
University of Wisconsin-Madison engineers developed a biologically inspired artificial eye that can see in the dark using a lobster-inspired fish-eye design. The system improves image-taking through lenses rather than sensor components, resulting in fourfold sensitivity improvement.
The World Health Organization (WHO) commended innovative hepatitis testing projects from five countries at The International Liver Congress. These projects showcased new testing models for hepatitis in primary care, community settings, and prisons, highlighting the need to scale up hepatitis testing globally.
A Massachusetts General Hospital study confirms the safety of allergy immunotherapy with no evidence of infections related to administration. The study analyzed 10 years of data from over 135,000 patients and found no soft-tissue or systemic infections attributed to AIT.
Steve Elgar, a physical oceanographer at Woods Hole Oceanographic Institution, has been awarded a National Security Science and Engineering Faculty Fellowship to study surf zone processes. His research aims to develop numerical models that simulate wave dynamics and predict coastal flooding, beach erosion, and rip currents.
The American College of Cardiology published a consensus statement recommending pre-participation screenings for college athletes and establishing emergency action plans for responding to sudden cardiac arrests. The plan should include training responders, emergency communications systems, and protocols for automated external defibrill...
Scientists at Université de Genève successfully manipulate the magnetic properties of LaNiO3 and LaMnO3 oxides to create tailored materials. By controlling the interactions between these materials, they can now develop artificial structures with specific magnetic properties.
A new study reveals that women with epilepsy have a comparable likelihood of achieving pregnancy and similar time taken to get pregnant as healthy women. The study, which followed over 200 women with epilepsy and healthy controls, found no significant differences in pregnancy outcomes or fertility rates.
A new study published by the University of Sussex suggests that the world could transition away from fossil fuels in just a decade. Professor Benjamin Sovacool's analysis of past energy transitions highlights the potential for accelerated change driven by technological innovation, policy intervention, and shifting consumer behavior.
Researchers will report on newly identified gene variants that impact breast cancer risk in childhood cancer survivors treated with radiation therapy. A novel analytical approach also detected pathogenic germline mutations predisposing carriers to develop cancer.
Researchers create single-particle engine that can store and generate energy, operating at 0.3% efficiency with a power output of 10^-22 watts. The device has potential applications in quantum thermodynamics and nano engineering.
Collaborative research found that standardizing care policies for infants born with NAS reduced length of treatment by one day and length of hospitalization by two days. Simple strategies such as swaddling, soothing, and skin-to-skin contact were implemented to prevent escalation of withdrawal symptoms.