A recent study by Indiana University researchers found that an e-health and telehealth-based collaborative care intervention had a significant impact on patients with depression. The intervention resulted in a 43% reduction in depressive symptoms among participants, compared to only 17% in the usual primary care group.
A team of researchers led by Dr. William Gilhooly III found that viruses are infecting sulfur bacteria, altering their genetic code and influencing their behavior in oxygen-deficient lakes. This discovery opens up new avenues for understanding the impact of viral infections on bacterial ecosystems.
A team of IUPUI researchers has developed an AI-powered approach to classify insect species, tackling the challenge of discovering new species. The method uses deep hierarchical Bayesian learning to distinguish between known and unknown species, providing insight into their taxonomy and ecosystem impacts.
A review article breaks down dryland dynamics and discusses key drivers of shifts in vegetation, highlighting the importance of hydrological processes. The study suggests prioritizing holistic approaches to dryland management under increasing climate and anthropogenic pressures.
Researchers discovered significant lead pollution at Kincaid Mounds site due to galena processing and use by Native Americans. Sediment core samples revealed higher lead levels during the pre-Columbian period, tracing back to galena deposits in Missouri and the Upper Mississippi Valley.
IUPUI researchers used FRET sensors to monitor the force dynamics during cell movement, finding that cancer cells exhibit low tensions and slow mobility when interacting with bone cells. This study aims to provide clues for controlling cell migration and potentially stopping breast cancer spread.
A new study found that having Black female role models in STEM is crucial for black women college students to feel a sense of belonging. The research, led by Indiana University-Purdue University Indianapolis School of Science, also discovered that seeing a Black male scientist can signal more belonging, while high stigma consciousness ...
Researchers at IUPUI have developed a way to create more-mature models of the human retina using human stem cells and astrocytes. These findings will guide the development of a lab-grown model of glaucoma, enabling researchers to study the disease in greater detail.
Researchers are using lab-grown mini retinas to understand the connection between the eye and brain, with a focus on restoring vision in people with damaged retinal ganglion cells. The study found that a protein called Netrin-1 significantly increased axon outgrowth from these cells.
Researchers at IUPUI have spotted a new type of blow fly in Indiana, indicating shifting species populations due to climate change. The Lucilia cuprina fly was previously known to populate southern states but has now been found as far north as Michigan.
Researchers aim to uncover how altered signaling processes impact appetite regulation and obesity in mice, potentially leading to new therapeutic approaches for the condition. The grant could provide valuable insights into the complex communication pathways involved in brain obesity.
A new study by Indiana University found that online social forums for class networking improve physics students' success in calculus-based physics courses. The study analyzed data from a course where students participated in an online forum and found that those who were most central in the network achieved higher final grades.
IUPUI researchers identified a unique compound in the seed oil of the February orchid, which could lead to the development of environmentally friendly lubricants. The discovery provides clues as to what makes the seed oil a superior lubricant, demonstrating better friction and wear reduction.
The IUPUI 360 Dust Analysis project offers free testing of household dust contaminants, including lead and chromium, which can be tracked inside or blown in from outside. Participants receive detailed information about their dust and suggestions to mitigate any health risks.
Researchers have developed a method to simulate molecular motion using a photonic chip, allowing for the creation of virtual movies of molecular dynamics. This technology has the potential to improve the accuracy of molecular models and aid in the development of new pharmaceuticals.
A recent IUPUI study has made a groundbreaking discovery in understanding the role of blow flies in transmitting pathogens. Researchers found that analysis of blow fly digestive tracts can detect fecal metabolites, providing valuable insights into pathogen transmission and conservation.
A new tool can predict a person's eye, hair, and skin color from a small DNA sample, providing a physical description. The HIrisPlex-S system is capable of predicting all three pigment traits simultaneously using freely available webtool.
A new animal model study found that brief maternal deprivation in early life alters adult brain function and cognition, leading to memory impairment and decreased communication between brain regions. The findings suggest a potential link between early-life trauma and the development of schizophrenia.
Researchers have identified over 30 different subtypes of retinal ganglion cells, the neurons responsible for processing visual information. This comprehensive understanding will enable the development of more tailored drug development and treatment strategies for neurodegenerative vision disorders.
The study, led by George Mohler, found no statistically significant difference in arrest rates by ethnic group between predictive policing and standard patrol practices. The researchers also discovered that arrests were higher in algorithmically-selected areas but remained unchanged when adjusted for crime rates.
A multidisciplinary team at IUPUI is developing and testing compounds for potential treatment of hydrocephalus. They have identified a strong candidate compound that shows promise in preclinical evaluations.
IUPUI has received a $428,000 NSF grant to develop a novel educational program that enhances geosciences education and inspires students to address community problems. The program will engage undergraduates from underrepresented groups and provide opportunities for them to explore environmental justice through a themed learning community.
Researchers at IUPUI are developing a system to predict where and when social harm events like crime, traffic crashes, and medical emergencies will occur. The project aims to provide data-driven insights to stakeholders, enabling them to allocate resources effectively and improve community quality of life.
Researchers have identified a key protein, MgtE, that plays a crucial role in signaling bacteria to form clusters, or biofilms, in the lungs of cystic fibrosis patients. The study reveals how fluctuations in magnesium levels influence MgtE activity, providing new insights into the development of chronic pneumonia.
A new IUPUI study found that juveniles who perceive police injustice are more likely to engage in aggressive behavior, particularly those who justify immoral actions. Intervention programs addressing perceptions of police injustice and moral disengagement may help reduce aggression among youth involved in the juvenile justice system.
Researcher Benjamin J. Perrin is advancing knowledge of age-related hearing loss by exploring the function of sensory cells in the inner ear. He hopes to develop a maintenance-of-living-cells approach to prevent or restore hearing loss, with implications for millions of people.
A new IUPUI study found that African-Americans in lower-income brackets have a lower risk of binge drinking during adolescence, but a higher risk at older ages. Higher incomes show comparable risks across racial groups.
A new mass spectrometry-based screening method enables quick turnaround of drug screens and can be used in emergency rooms to detect lethal compounds. The low-cost cartridges are estimated to cost less than $10 each, making them accessible to health facilities of any size.
Research finds high levels of lead exposure at firing ranges, with risks similar between indoor and outdoor ranges. The study recommends reevaluating allowable lead levels, improving education on lead-exposure risks, and finding lead-free substitutes for bullets and primer.
Researchers found that ocean-derived fog accounted for more than half of total fog events in the Namib Desert. Soil water and groundwater-derived fog were also unexpected sources of moisture.
Researchers from IUPUI have developed a machine-learning model to predict the probability of home sales, utilizing data from real estate websites. The model accounts for various features such as price, location, age, and size, enabling informed decisions for both sellers and buyers.
Researchers developed a computer machine-learning model that accurately predicts which AML patients will go into remission following treatment. The model was trained using bone marrow data and medical histories of AML patients, achieving 100% accurate predictions for remission and 90% accurate predictions for relapse.
Researchers from IUPUI reconstructed 2,100 years of temperature and precipitation data, pointing to climate change as a primary cause of the disappearance of the Mississippians. The study found that drought conditions due to changed atmospheric circulation undermined agricultural production, leading to the destabilization of sociopolit...
Researchers developed a novel-machine learning method to distinguish people with common names, focusing on relational features, text features, and venue features. The new approach is an improvement over existing methods, enabling the identification of previously unencountered individuals.
Psychologists analyzed links between provider burnout, quality of care, and patient safety across various medical disciplines. The meta-analysis found a consistent relationship between higher levels of burnout and lower levels of both quality and safety.
IUPUI chemists have developed a new molecular binding technique that can shorten or abridge the human and animal drug discovery and development process. The new method, which uses site-selective C-H arylation of primary aliphatic amines, has potential benefits for both the pharmaceutical industry and patients.
Researchers developed a method to alter plant enzymes, producing new natural compounds with disease-resistance properties and potentially useful as anti-foaming agents or natural sweeteners. This breakthrough could revolutionize the production of complex compounds in the lab.
The black blow fly genome sequencing project provides a major resource for researchers studying unusual or dangerous insects. The study may benefit human health by advancing wound care and estimating postmortem interval, while also improving pest management through better understanding of insecticide sensitivity and resistance.
Ecohydrologist Lixin Wang investigates the impact of non-rainfall water sources on drylands, focusing on fog and dew. He aims to better understand ecosystem functions and interactions with limited knowledge of these sources in dryland environments.
Researchers at IUPUI have successfully identified cellular processes related to glaucoma using stem cells derived from human skin cells. The study found that skin cells from individuals with glaucoma became unhealthy and died off faster than those of healthy individuals when reprogrammed into retinal ganglion cells.
A critical review of over 100 studies on pain experience among Hispanic Americans reveals lower rates of chronic pain, but also greater pain sensitivity and less tolerance compared to non-Hispanic whites. The study highlights gaps in current research and calls for further investigation into the role of cultural factors and acculturation.
A meta-analysis of 19 studies found that blacks employ pain-coping strategies more frequently than whites, with blacks using praying and catastrophizing as common techniques. This study highlights the need for culturally sensitive medical care and could inform chronic pain care.
Lisa M. Jones, an assistant professor of chemistry at IUPUI, has received the NSF CAREER Award to study cell membrane proteins in their native environment. The award supports cutting-edge research training for undergraduate students from historically black colleges and universities as well as IUPUI students.
Researchers at IUPUI have developed a new technique to detect illicit treatment of racing tires with volatile chemicals, finding approximately 15% of tires tested positive for banned substances. The method uses Headspace Solid Phase Microextraction (SPME) and Gas Chromatography/Mass Spectrometry (GC/MS), and has the potential to be app...
Researchers at IUPUI developed a nanotech-based sensor to detect microRNAs in blood, enabling early cancer diagnosis and potentially improving treatment outcomes. The sensor's ultrasensitivity allows for the detection of minute changes in microRNA concentrations.
Indiana University-Purdue University Indianapolis researchers led by Jesse Stewart are conducting a randomized controlled trial to investigate the effect of depression treatment on heart attack risk. The study aims to confirm that treating depression is cardioprotective, lowering cardiovascular disease risk.
Researchers studying sleep apnea aim to understand the link between breathing patterns and blood pressure control in the brain. The IUPUI study may lead to innovative treatments for hypertension.
A new mass spectrometry method developed by IUPUI chemist Nicholas Manicke can rapidly detect drugs and poisons in blood samples. The method, known as paper spray mass spectrometry, has potential use in various fields such as biomedical research, clinical testing, and forensic science.
Researchers are developing a biologically plausible model of the whole system to predict outcomes of future experiments and provide more information about the brain's ability to learn new motor movements. The goal is to understand how people execute, control and learn movements to lead to new treatments for Huntington's disease.
Researchers at IUPUI are conducting a study on how alcohol affects the brain's reward system, using a unique blend of mathematical modeling and experimental neuroscience. The goal is to gain a better understanding of how alcohol hijacks dopamine release, a key factor in addiction.