A researcher at IUPUI is studying how glaucoma develops in stem cells created from skin cells genetically predisposed to the disease. The goal is to identify the cause of damage and develop customized strategies to fix it, potentially leading to repairing existing cells and restoring vision.
Researchers will investigate how depression affects cardiovascular disease in HIV-infected adults and test whether antidepressants or psychotherapy can reduce the risk of heart attacks. A randomized controlled trial will also examine whether depression treatment can effectively lower cardiovascular disease risk in HIV patients.
The university's forensic geneticist will use the grant to develop and improve 'DNA intelligence' tools that can predict eye, hair, or skin color from genetic material. This technology will aid investigators in identifying unknown suspects and solving cold cases.
Researchers have developed a theoretical methodology to solve the 'counting problem,' allowing for the analysis of protein groups in living cells. The study's findings could lead to advancements in disease diagnosis and understanding of protein function.
Researchers discovered that enzymes dissipate heat by rapidly accelerating immediately after a reaction, generating a pressure wave called a chemoacoustic wave. This finding explains how proteins cope with the immense heat generated during enzyme reactions without breaking apart.
A new study found that walking workstations significantly improve both physical and mental well-being during work hours. Participants showed increased satisfaction and reduced stress, boredom, and weight-related issues despite having varying levels of exercise habits or body mass index.
A $470,350 NSF award will support research on how proteins form groups or clusters within cells, which is associated with cancer and heart arrhythmias. The project aims to gain a better understanding of normal and abnormal protein grouping to prevent or correct abnormalities.
Haibo Ge, a chemist at IUPUI, has received a $600,000 NSF award to support his research on efficient methods for preparing organic molecules with potential impact on medicinal and agricultural chemistries. The grant also supports the development of an interdisciplinary course linking organic and medicinal chemistry.
Roland Roeder will receive funding to support his research on dynamics in complex variables and train graduate students. He aims to provide talented high school students with advanced math education and research opportunities.
Researchers at IUPUI used computer vision to study neurons in model organisms like fruit flies, revealing new insights into brain motor circuits. The study's findings may one day inform therapies for conditions such as stroke, schizophrenia, and Alzheimer's disease.
A recent IUPUI study found that dogs react best to actual explosives and not mimic compounds, challenging the use of products designed to replicate C-4's odor. The research team recommends training dogs with real explosives instead.
Despite lower levels of drinking, African-Americans encounter more problems due to social sanctions within the community, resulting in negative consequences at lower consumption levels. Very low-income African American men face the highest risk for problematic drinking and related issues.
A new IUPUI study found that treating depression before cardiovascular disease onset can decrease the risk of future heart attacks and strokes. The study followed 235 older patients with depression, finding a 48% lower risk among those receiving collaborative care.
A recent study by IUPUI faculty and undergrad researchers evaluates peer-led team learning in cyberspace, focusing on its newest iteration – cyber peer-led team learning. The study finds that the cyber version of PLTL offers improved grades and enhanced student collaboration.
A new study led by Steve Pressé reveals a preferred strategy for picking mathematical models with the greatest predictive power, emphasizing simplicity and avoiding unnecessary complexity. The study's findings support Occam's razor principle, suggesting that simpler theories are more likely to be correct.
Researchers have discovered a novel protease complex in bacteria that operates as a molecular motor, with a constant revolutions per minute (RPM) and varying gears to shred proteins. This 'cellular shredder' plays a crucial role in DNA damage repair, gene expression, and protein quality control.
Researchers at IUPUI have achieved a drastically reduced measurement of the Casimir effect, a fundamental quantum phenomenon experienced between two neutral bodies in a vacuum. The study uses nanostructured metallic plates to suppress the force to a much lower rate than ever recorded previously.
A team of IUPUI researchers will investigate the impact of staff burnout on mental health treatment and outcomes, implementing an intervention program that incorporates traditional stress-reduction techniques and cognitive behavioral practices. The goal is to reduce burnout and improve clinician engagement in patient care.
Researchers discovered a unique DNA repair mechanism that utilizes a 'desperation strategy' to patch breaks in chromosomes. This process, called break-induced replication, can lead to increased mutagenesis and potentially drive cancer formation.
A new invasive fly species, Chrysomya megacephala, has been discovered in Indiana, threatening forensic investigations and local ecosystems. The species, native to Asia and Africa, is breeding in the state's warmer climate, raising concerns about its impact on native fly species.
The IUPUI research collaboration used advanced mathematical models and laboratory testing to examine the effects of simulated drug addiction on neural circuits. The study found that recurrent stimulant injections caused neurons to lose their ability to engage supervisory control over brain function and behavior.
Professor Murat Dundar will use the award to refine machine learning models for more accurate data classification and adaptation. His research aims to improve bio-detection, medical monitoring, and data sorting technologies.
Researchers at IUPUI have successfully differentiated human induced pluripotent stem cells into retinal cells using chemical methods, eliminating the need for animal products. This breakthrough could lead to new treatments for retinal diseases and expand the clinical use of regenerative human cells.
Researchers used mathematical modeling to better understand the causes of debilitating diseases like glaucoma, which could lead to more efficient treatments. The model helps doctors measure blood flow and oxygen levels in fine detail, improving their ability to treat root causes.
The IUPUI-launched Institute for Mathematical Modeling and Computational Science aims to train a new generation of researchers to identify and solve scientific issues. The institute focuses on areas such as drug delivery, pollution, and brain mapping, using mathematical modeling and computational science approaches.
Researchers at IUPUI have created a line of lab mice that prefer alcohol over water and binge drink like humans. These mice can reach blood-alcohol levels of over 260mg/dl, allowing scientists to study the genetic and behavioral determinants of alcoholism.
Three Indiana high school students co-authored a paper on waveguide lattices with localized eigenstates published in Physical Review A. The students, mentored by IUPUI assistant professor Yogesh Joglekar, advanced to the national finals of the Siemens Competition in Math, Science & Technology.
Researchers developed a mathematical model of the brain's neural circuitry to better understand how Parkinson's disease patients' brains transmit information incorrectly. The model reveals that repetitious neuron firing can lead to overly synchronized brain activity, which could aid in developing therapies for Parkinson's disease.
Researchers found that low concentrations of carbon nanoparticles can cause leakage in the cellular lining of the renal nephron, leading to potential harm. The study highlights the need for further research into the effects of CNPs on human health and the environment.
A new study reveals that measurable amounts of mercury emitted by coal-fired power plants are deposited in local soil, contaminating regional watersheds and affecting fish populations. The research found hot spots of mercury contamination tied to specific power plants, highlighting the need for better energy production choices.
Researchers have successfully used induced pluripotent stem (iPS) cells to correct a genetic defect in gyrate atrophy, a rare blinding disorder. The study demonstrates the potential for iPS cells to repair damaged retinal pigment epithelium cells and restore vision.
A new study by Elizabeth M. Poposki explores how individuals attribute work-family conflict, finding that most (64%) blame work and few (6%) blame themselves. The study suggests scheduling conflicts in advance may reduce negative emotional reactions.
Researchers at IUPUI are conducting a pilot study to evaluate the effectiveness of treating depression before a heart attack in reducing future heart disease risk. The study aims to investigate whether an evidence-based computerized treatment for depression can effectively lower heart disease risk.
Stephen L. Boehm II, Ph.D., a behavioral neuroscientist at IUPUI, has been awarded the 2011 Young Scientist of the Year by the International Behavioural and Neural Genetics Society for his research on binge drinking's impact on gamma-aminobutyric acid neural circuits. His lab is also recognized for its mentorship of students.
Jason S. Meyer, assistant professor of biology at IUPUI, is honored by the Association for Research in Vision and Ophthalmology (ARVO) for his groundbreaking study on modeling early retinal development using human embryonic and induced pluripotent stem cells.
A study found that Break-induced Replication, a method of DNA repair, is up to 2,800 times more likely to cause genetic mutations than normal cell repair. Researchers think four changes in replication machinery may contribute to its accuracy issues.
The IUPUI School of Science has received a $943,000 NSF grant to establish an Undergraduate Research Mentoring in the Biological Sciences program. The two-year fellowships will provide students from underrepresented groups with research experience and mentorship in biosignaling.
The Louis Stokes Alliances for Minority Participation (LSAMP) program at IUPUI is successfully encouraging minority students to select STEM majors and pursue careers. Students like Kathryn DelaCruz and Tomás Meijome are thriving in research projects, internships, and graduate programs.
A high school senior from Indiana collaborated with a professor and graduate student on a top-tier peer-reviewed scientific journal, publishing a study on PT-symmetric phases in a tight-binding chain. The research was made possible by new mathematical computing software with user-friendly interfaces.
Jeff Watt, a mathematical sciences professor at IUPUI, has been recognized for his exceptional teaching and commitment to undergraduate students. His approach focuses on critical thinking skills and engaging students in discussions of key concepts.
Researchers report that pioglitazone, a commonly used diabetes medication, slows down the growth of fluid-filled cysts in polycystic kidney disease (PKD). The study found that pioglitazone inhibits a chloride channel in cells, which can help control PKD cyst growth.
Researchers at Indiana University-Purdue University Indianapolis are developing an interactive computer simulation framework to improve watershed management practices. The new $410,000 grant will enable community members to participate in restoring ecological balance and make informed decisions about water management alternatives.
Researchers developed a novel approach to automated detection and classification of harmful bacteria in food using machine-learning. The method can identify known and unknown classes of food pathogens, improving the ability to detect bacterial contamination in tested samples.
African Americans tend to favor their own race and identify with it more than whites, but this difference is reversed when non-conscious feelings are considered. Both groups experience positive gut feelings about themselves.
The $2 million grant from the National Science Foundation aims to encourage more students to pursue STEM careers and provide support for their success. The program seeks to increase STEM degrees by 782 undergraduates by 2015, targeting retention and persistence to graduation among diverse student groups.
A new tool developed by Elizabeth Poposki measures preference for multitasking, which may help employers identify employees who can handle job demands without burnout. The study found that individuals who prefer to work on multiple tasks simultaneously enjoy the experience of multitasking more.
The Discovering the Science of the Environment (DSE) program transforms school ground natural areas into outdoor laboratories, allowing students to explore and learn about their environment. Through interactive technology tools and computerized mapping capabilities, DSE aims to inspire future leaders in science, technology, and environ...
Indiana University-Purdue University Indianapolis researchers have developed a new methodology to improve identification of breast cancer tissue by pathology laboratories. Their work, recognized internationally, has been selected as the best scientific paper in the
Researchers at Indiana University-Purdue University Indianapolis are exploring the potential of echinacea in petrochemicals and agriculture. The study aims to understand the plant's metabolic processes, which could lead to the creation of novel bio-derived compounds with diverse applications.