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Science News for December 6, 2017


Precision medicine test may help detect coronary artery disease

A blood-based precision medicine test incorporating age, sex, and gene expression score (ASGES) helped evaluate older outpatients with symptoms of obstructive coronary artery disease. The study found higher incidence of major adverse cardiovascular events in those with high ASGES scores compared to low ASGES scores

SourceWiley·JournalJournal of the American Geriatrics Society·DateDec 6, 2017

Bristol scientists turn beer into fuel

Scientists from the University of Bristol have developed technology to convert widely-available ethanol into butanol, a more efficient fuel alternative. The breakthrough uses catalysts to convert beer's ethanol content into butanol, paving the way for sustainable petrol production.

SourceUniversity of Bristol·JournalCatalysis Science & Technology·DateDec 6, 2017

Hydrogen gas from enzyme production

Scientists at Freie Universität Berlin and Ruhr-Universität Bochum have discovered how enzymes produce molecular hydrogen. The process involves two electrons being transferred to two hydrogen ions through proton-coupled electron transfer, a mechanism that could explain the production of hydrogen gas in other enzymes.

SourceRuhr-University Bochum·JournalAngewandte Chemie International Edition·DateDec 6, 2017

Study finds evidence that a protein, MCP-1, may determine bone loss responses to parathyroid hormone

A new study published in Scientific Reports found that monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in bone loss responses to parathyroid hormone (PTH) in hyperparathyroidism. Elevated MCP-1 levels have been correlated with elevated serum PTH levels, and its presence may serve as a marker for PTH's effects in humans.

SourceNew York University·JournalScientific Reports·DateDec 6, 2017

Routing gene therapy directly into the brain

Scientists have made a breakthrough in treating neurodegenerative disorders and lysosomal storage diseases by transplanting hematopoietic stem cells directly into the brain, achieving therapeutic benefits faster than traditional methods. This innovative technique could pave the way for new treatments for Parkinson's, Alzheimer's, and o...

SourceBoston Children's Hospital·JournalScience Advances·DateDec 6, 2017

A risk factor for drug-induced skin disease identified

A type of human leukocyte antigen (HLA) gene, HLA-DQB1*03:01, is associated with an increased risk of developing bullous pemphigoid (BP) in diabetic patients taking DPP-4 inhibitory drugs. The gene was found to be present in 86% of non-inflammatory BP patients administered with DPP-4i, compared to 18% in the general population.

SourceHokkaido University·JournalJournal of Investigative Dermatology·DateDec 6, 2017

Quantifying the greenhouse gas footprint of crop cultivation

A new study proposes a generic methodological framework to accurately quantify the greenhouse gas footprints of crop cultivation systems. The framework takes into account direct and indirect contributors, providing example values of emission factors and emphasizing the combination of measurements and model simulations.

SourceInstitute of Atmospheric Physics, Chinese Academy of Sciences·JournalAtmospheric and Oceanic Science Letters·DateDec 6, 2017

Flipping the electron spin

Researchers at TUM and Jülich Institute have developed a novel EPR spectroscopy process to investigate lithium plating in lithium-ion batteries. This allows for the detection of metallic lithium deposits on anodes, which can reduce battery capacity and lifespan.

SourceTechnical University of Munich (TUM)·JournalMaterials Today·DateDec 6, 2017

Needle in a haystack

A new method developed by Harvard Medical School researchers can tease out cause-and-effect relationships between gut bacteria and disease, a major hurdle in microbiome research. The approach identified a previously unknown gut microbe that protects against severe colitis.

SourceHarvard Medical School·JournalNature·DateDec 6, 2017

Study: Surgery-related opioid doses can drop dramatically without affecting patients' pain

A new guideline based on patient data and education has been shown to effectively reduce opioid prescribing in surgery patients by up to 66%, while maintaining similar levels of pain control. The study's findings have the potential to significantly impact the national opioid crisis, with estimates suggesting over 13,000 excess pills ha...

What makes a happy working mom?

A happy working mom is one who feels competent and has a warm relationship with her child. Her sense of well-being depends on meeting her own psychological needs, rather than her baby's temperament. Mothers should prioritize their daily needs to interact with their children in a more sensitive and positive way.

SourceSpringer·JournalJournal of Happiness Studies·DateDec 6, 2017

Seizure study sheds light on lasting brain effects in children

A study published in The Lancet Child and Adolescent Health found that prolonged convulsive seizures in childhood can lead to lasting neurological conditions, including epilepsy, learning disabilities, and movement problems. Children with pre-existing neurological issues were more likely to experience chronic problems after a seizure.

SourceUniversity of Edinburgh·JournalThe Lancet Child & Adolescent Health·DateDec 6, 2017

Seeing through walls of unknown materials

Researchers have devised a method to scan walls without prior knowledge of their material composition, exploiting symmetry for effective resolution. This approach enables inexpensive devices to locate conduits, pipes, and wires in construction, with potential applications in security and industry.

SourceDuke University·JournalOptica·DateDec 6, 2017

Go with the flow (or against it)

Researchers at Queen's University have successfully used magnetic fields to direct magnetotactic bacteria against strong currents, opening up the potential for these microbes to deliver pharmaceuticals directly to tumors. The team aims to bind therapeutic drugs to the bacterial bodies and release them once they reach their destination.

SourceQueen's University·JournalSmall·DateDec 6, 2017

Living on thin air -- microbe mystery solved

Researchers have discovered that microbes in Antarctica can scavenge hydrogen, carbon monoxide and carbon dioxide from the air to sustain their energy needs. This discovery has significant implications for the search for life on other planets, suggesting that extra-terrestrial microbes could also rely on trace atmospheric gases.

SourceUniversity of New South Wales·JournalNature·DateDec 6, 2017

Wheat gets boost from purified nanotubes

Researchers at Rice University found that purified carbon nanotubes enhance wheatgrass growth by up to 13% in water solutions. However, contaminated particles can concentrate toxins and hinder plant development. The study highlights the need for understanding nanomaterials as part of a system rather than in isolation.

The human race has peaked

A recent review suggests humans have biological limitations that cannot be exceeded, despite advances in nutrition, medicine and science. Environmental changes, including climate change, could lead to decreased physical abilities and life expectancy.

SourceFrontiers·JournalFrontiers in Physiology·DateDec 6, 2017

New approach measures early human butchering practices

A team led by Purdue University anthropology professor Erik Otárola-Castillo used 3D imaging, shape analysis, and Bayesian statistics to accurately measure animal bone cut marks with an 88 percent success rate. This technique improves upon existing archaeological methods, enabling a more accurate understanding of human evolution.

SourcePurdue University·JournalJournal of Archaeological Science·DateDec 6, 2017

Compound eyes a continuous feature of evolution

Researchers discovered the structure and functioning of a half-billion-year-old fossil trilobite's compound eye, showing similarities with modern compound eyes. The ancient eye consists of 100 subunits with eight sensory cells each, but lacks a lens, suggesting its development may have predated modern forms.

SourceUniversity of Cologne·JournalProceedings of the National Academy of Sciences·DateDec 6, 2017

Researchers 3-D print lifelike artificial organ models

A team of researchers from the University of Minnesota has created lifelike artificial organ models through 3D printing, featuring integrated soft sensors. These patient-specific models can enhance pre-operative practice, allowing surgeons to better plan and execute surgeries, potentially reducing medical errors and saving lives.

SourceUniversity of Minnesota·JournalAdvanced Materials Technologies·DateDec 6, 2017

Brain changes following childhood limb loss may be reversible

A recent study found that certain brain changes following limb amputation in children can be reversed through bilateral hand transplantation. The lead author suggests that the brain preserves functional areas and reactivates them upon recovery of the hands.

SourceWiley·JournalAnnals of Clinical and Translational Neurology·DateDec 6, 2017

What's that smell? The advantage of sniffing

Researchers found that precise timing patterns of brain activity distinguish between airflow-driven mechanical signals and those generated by odors. This discovery demonstrates the neural code underlying olfaction, revealing how neurons differentiate between air-flow information and odor information.

SourceRIKEN·JournalNeuron·DateDec 6, 2017

A new gene therapy transplantation technique could improve treatment of neurodegenerative diseases

A new gene therapy transplantation technique could improve treatment of neurodegenerative diseases by generating genetically engineered microglia-like cells in the brain. This technique has been tested on an experimental model for a metabolic disease and may have future therapeutic applications for other neurodegenerative diseases.

SourceBoston Children's Hospital·JournalScience Advances·DateDec 6, 2017

Cell tissue must not freeze!

Researchers have introduced polyproline as an effective cryoprotectant for monolayers of cells, doubling cell recovery after freezing compared to dimethyl sulfoxide. The proline/polyproline combination minimizes solvent exposure and retains cell functions.

SourceWiley·JournalAngewandte Chemie International Edition·DateDec 6, 2017

'Green' cataract surgery model drastically reduces environmental footprint

A new study by NYU Langone Health finds that a healthcare center in India has developed a sustainable cataract surgery model, emitting 96% less carbon than the UK while producing comparable health outcomes. The model's key practices include shorter surgery durations, better re-use of surgical materials, and more efficient sterilization.

SourceNYU Langone Health / NYU Grossman School of Medicine·JournalJournal of Cataract & Refractive Surgery·DateDec 6, 2017

Towards data storage at the single molecule level

A research team from Kiel University has successfully placed a new class of spin-crossover molecules onto a surface and improved their storage capacity. The result could theoretically increase the storage density of conventional hard drives by more than one hundred fold, enabling data carriers to be made significantly smaller.

SourceKiel University·JournalNano Letters·DateDec 6, 2017

Forests are the key to fresh water

A recent study by UBC researchers found that forest vegetation can have a substantial impact on global water resources, with alterations to ground cover changing annual water yield by up to 31%. The study suggests that both climate change and vegetation loss should be considered when assessing and managing future global water resources.

SourceUniversity of British Columbia Okanagan campus·JournalGlobal Change Biology·DateDec 6, 2017

Some video games are good for older adults' brains

Researchers found that playing 3D video games like Super Mario 64 increased gray matter volume in the hippocampus and cerebellum of older adults. This led to improved short-term memory and cognitive function. The study suggests that learning new things, such as through video games or piano lessons, can reverse age-related brain atrophy.

SourceUniversity of Montreal·JournalPLOS ONE·DateDec 6, 2017

Prior exposure to smoking may affect infants' respiratory health

A Pediatric Pulmonology study of 376 infants found that increasing hair nicotine levels were associated with prior parent-reported smoking exposure and potential increased risks of wheeze and asthma. Higher levels of hair nicotine were also linked to smoking in pregnancy, although associations at older ages were non-significant.

SourceWiley·JournalPediatric Pulmonology·DateDec 6, 2017

Spinal tap needle type impacts the risk of complications

A recent study published in The Lancet found that the use of pencil-point atraumatic needles during lumbar punctures significantly reduces the occurrence of headaches and other complications. The research team analyzed data from over 30,000 patients across 29 countries, showing a more than 50% reduction in headaches and readmissions.

SourceMcMaster University·JournalThe Lancet·DateDec 6, 2017

A head start through human intervention

An international research team led by Mark van Kleunen found that plant species from European habitats altered by humans have a head start in spreading to other continents. The study investigated over 10,000 plant species and found that those from human-made environments were more successful in naturalizing on other continents.

SourceUniversity of Konstanz·JournalProceedings of the National Academy of Sciences·DateDec 6, 2017

When a common cold may trigger early supportive care

A new study by Children's National Hospital suggests that severely premature children are more susceptible to human rhinovirus infections and may require earlier and more intensive supportive care. The research found a 'dose effect' of prematurity, with children born more prematurely having a higher risk of wheezing and retractions.

SourceChildren's National Hospital·JournalPediatrics & Neonatology·DateDec 6, 2017