A new study reveals that spinocerebellar ataxia type 7 (SCA7) originates from metabolic dysregulation leading to altered calcium homeostasis in neurons. The research also identifies Sirtuin 1 as a key player in promoting calcium regulation and reducing neurodegeneration.
Researchers found that rTMS improved working memory performance in both young and older adults, with the effect most pronounced when participants were actively using the information. The study suggests that brain stimulation may be a viable treatment option for individuals with Alzheimer's disease and other forms of dementia.
Researchers developed an antisense oligonucleotide therapy to halt or reverse SCA7-induced vision loss. Studies in mice and humans show promise for treating the rare condition with fewer side effects than existing medications.
A study found that a cancer medication can improve symptoms of Huntington's disease in mice, including increased mobility and longer lifespan. The drug targets mitochondrial health and protein removal, also relevant to other neurodegenerative disorders.
A new study published in Human Brain Mapping found that older adults' brains show more bilateral communication than younger brains. This increased communication helps maintain healthy cognitive function despite the negative effects of aging.