A new study reveals that cancer cells can adapt to treatment by actively co-opting blood vessels from nearby tissues, leading to drug resistance. The researchers hope their findings will lead to the development of new therapies targeting vessel co-option, which could be particularly effective when used alongside existing treatments.
Researchers developed nanoparticles that target CD98, a glycoprotein promoting inflammation in IBD. These particles showed anti-inflammatory capacity without toxicity, offering an alternative treatment to existing medications.
Researchers found that IL-1β increases insulin levels in healthy human islets. In contrast, islets from obese individuals with type 2 diabetes were not responsive to IL-1β stimulation. The study suggests that IL-1R signaling plays a crucial role in glucose homeostasis.
Research from the University of Cambridge finds that babies of obese women with gestational diabetes are already abnormally large by 20 weeks, suggesting current screening may be too late. This could lead to lasting health impacts on the offspring, including obesity and diabetes in later life.
A recent mouse study reveals that scar-forming cells called astrocytes are required for repair and regrowth following spinal cord injury. The research supports axon growth through astrocyte scars, challenging the long-held idea that scars hinder neuronal regrowth.
Researchers created a dynamic model of microbial species interactions in Lake Mendota, understanding the effects of environmental factors on sub-communities and individual species. The model can predict interactions as conditions change, offering insights into healthy lakes and potential cures for sick ones.
Researchers found that common treatments for prostate cancer can suppress the immune system, preventing immunotherapies from working effectively. The study suggests careful regulation of treatment timing and dosage to maximize anti-tumor effects and prevent relapse.
Research suggests that bilingual speakers can avoid language-switching costs by consistently using the same language throughout a conversation or task. In experiments, participants were shown to respond faster when they stuck with a language rather than switching mid-sentence.
A recent study reveals that single mutations can inhibit HIV-1 replication using CRISPR/Cas9, but some also lead to unexpected resistance. Targeting multiple viral DNA regions may be necessary for the antiviral aspect of CRISPR/Cas9 to be effective.
PolyU has achieved the world's fastest optical communications speed for data centres by reaching 240 G bit/s over 2km, reducing transmission cost per unit to one-fourth. This breakthrough enables widespread use of immersive videos and new IoT applications.
Researchers analyzed a complete Neanderthal Y chromosome, revealing differences with modern human Y chromosomes that may have discouraged interbreeding. The findings suggest that genetic incompatibilities, such as those affecting male-specific antigens, played a role in the divergence of humans and Neanderthals.
Researchers successfully mapped spatial distribution of excitonic coupling in well-defined arrangements of zinc-phthalocyanine molecules. They also observed enhanced single-molecule superradiance for in-line arrangements of up to four molecules.
David Zhang's lab at Rice University is developing novel therapeutic tools and diagnostic methods using next-generation sequencing, including probes that identify disease-causing DNA sequence variants and a platform capable of detecting rare single nucleotide variants in biological samples.
Researchers at Boston University School of Medicine discovered a new gene, FOXF2, linked to ischemic stroke caused by small vessel disease in the brain. The study suggests that unraveling the mechanisms of small vessel disease could lead to better treatments for this major cause of stroke and dementia.
A new NIH study has identified the protein calpain 14 as a possible cause of tissue damage in patients with eosinophilic esophagitis. The researchers found that calpain 14 regulates another protein, desmoglein 1, which is critical for maintaining the integrity of esophageal tissue.
A new article analyzes recent changes in UK asylum accommodation, revealing how economic interests prioritize competition and profit over social justice. Local authorities' expertise in supporting asylum seekers has been lost due to contracting out, leading to diminished services and charitable provision.
Researchers found that impaired Nrf2 activity leads to increased hemolytic anemia, vascular inflammation, and lung injury in SCD mice. Pharmacological activation of Nrf2 improved survival and reduced age-related adverse effects.
Young arthritis patients experience physical, emotional, social, and vocational consequences from treatment, emphasizing the importance of discussing concerns with healthcare providers. Active encouragement is necessary to achieve balance between disease control and treatment burden.
A team of researchers, led by IU biologist Armin Moczek, will systematically study proposed extensions to the theory of evolutionary biology. The $1.25 million grant aims to test assumptions and predictions of a new framework that recognizes environmental signals in organism development.
Researchers found that loss of specific genes induces osteochondroma formation in mice, identifying a population of cells responsible. The study suggests therapeutic strategies targeting these cells could treat related skeletal diseases.
A multi-site clinical trial is assessing the safety and effectiveness of bariatric arterial embolization in treating patients with morbid obesity. The procedure targets ghrelin, reducing hunger sensation and promoting weight loss.
Researchers found that daily deal websites gain an advantage by tracking and displaying sales numbers, attracting new customers and promoting merchants' businesses. This strategy lowers the risk for consumers trying new merchants and addresses a fundamental problem with traditional discount promotions.
Researchers at Cornell University and Bar-Ilan University discovered a novel mechanism for mutation in primates triggered by the APOBEC family of virus-fighting enzymes. These enzymes can rapidly generate large changes in genes through 'friendly fire' events, which may have been passed on to subsequent generations.
Soil has the potential to sequester more carbon than the current atmosphere, and climate-smart agricultural practices can reduce greenhouse gas emissions and improve soil fertility. Several methods, including reducing tillage and applying biochar, can be used by land users to abate emissions and sequester carbon.
A new study suggests that global climate models have underestimated the impact of clouds on warming, leading to lower projections. Clouds and aerosol particles significantly influence atmospheric temperatures, and recent data show that certain ice formation processes are less common than previously thought.
Researchers at the University of Innsbruck have successfully measured long-range magnetic interactions between ultracold erbium atoms in an optical lattice. This achievement marks an important step towards understanding exotic quantum phases and the behavior of dipolar atoms.
The AMP study aims to assess the safety and efficacy of VRC01 in reducing HIV-1 acquisition among at-risk populations. The randomized, double-blind trial will enroll 2700 participants and follow them for up to 72 weeks.
Scientists discover sediment cores from Lomonosov Ridge, revealing a window into Arctic Ocean climate history. The cores show that the central Arctic was ice-free during summer, with sea surface temperatures reaching 4-9 degrees Celsius.
The USDA has awarded $6.6 million in grants for research focused on improving animal nutrition and growth, with a goal of enhancing animal health, reducing production costs, and minimizing environmental impacts. Funded projects include studies on starch digestion in cattle and nutrient delivery to pigs facing disease challenges.
Scientists have created a rechargeable battery driven by bacteria, addressing safety issues and high costs associated with conventional lithium-ion batteries. The microbial battery successfully stored energy for 16 hours and discharged it over the next 8 hours, mimicking day-night patterns typical of solar energy production.
A team led by Julie Huber has discovered an active microbial community in cold oceanic crust at North Pond, an isolated sediment pond on the western flank of the Mid-Atlantic Ridge. The microbial community is oxygenated and heterogeneous, with distinct differences from that found in ocean bottom seawater.
A St. Michael's Hospital study found that women with low or high body mass indexes who smoked and drank had a two-fold higher risk of being diagnosed with asthma. The research included data from approximately 175,000 people aged 18 to 44 across 51 countries.
The SALOME study found that injectable hydromorphone is as effective as diacetylmorphine for long-term street opioid users not currently benefiting from available treatments. Participants reported significant reductions in opioid use and illicit activities, with over 80% retained in treatment at six months.
A survey of older American men who frequent sex work websites found that those over 60 paid for sex more frequently as they aged. The study also revealed that these men sought out specific experiences, such as the 'girlfriend experience', and were willing to pay for non-sexual activities with providers.
Researchers at UCSB have identified specific defects in LED diodes that result in reduced efficiency, but not all defects are alike. The characterization of these point defects could lead to the fabrication of even more efficient and longer-lasting LED lighting.
A new study has found that moss can be a useful bioindicator of cadmium air pollution in urban areas. Researchers used moss to track down previously unknown pollution sources in Portland and created a fine-scale map of cadmium deposition across the city.
Researchers tracked female turtles by satellite from Cyprus, finding that they are dying in fishing nets used by small-scale operations. The study highlights an 11% mortality rate per year, a higher rate than expected for this long-lived species.
A Concordia University study found that greater informal social support was associated with lower inflammation, while formal support services were related to better self-rated health. The impact of support on the parents' inflammation levels increased with the age of the affected child.
Researchers at EPFL developed a microchip using graphene that can filter out unwanted radiation, ensuring data integrity. The discovery could lead to faster data uploads and improved wireless communication in the Terahertz frequency band.
A University of Guelph study finds that introducing invasive round goby fish does not help conserve endangered native mollusks, but rather hampers their reproduction. The research team discovered that the fish essentially 'wastes' mussel larvae, further threatening the species' survival.
ORNL researchers have found a potential path to improve solar cell efficiency by understanding the competition among halogen atoms during perovskite synthesis. The study reveals that bromine, chlorine, and iodine ions facilitate growth but only iodine gets into the final crystal structure.
Many restaurant kids' meals meet calorie criteria, but fall short on fat, saturated fat, and sodium levels. Researchers call for restaurants to market healthier options and parents to guide children toward healthy choices.
State RPS policies have contributed to over half of US renewable electricity growth since 2000. The report finds that RPS policies will require a substantial increase in US renewable electricity supplies by 2030.
A new study analyzes hailstorm distribution and characteristics over a 13-year period, finding distinct seasonal cycles and wind direction correlations. The research provides high-resolution insights for weather forecasting, climatology, agriculture, economics, and insurance.
Researchers have developed a new trap to monitor and control Aedes aegypti mosquitoes, the primary transmitters of Zika, dengue, chikungunya, and yellow fever. The plastic ovitrap infused with pyriproxyfen has been shown to be 100% effective in preventing larvae from developing into adults.
A pioneering technique using cold blasts has shown promise in improving the quality of life for patients suffering from phantom limb pain. After treating 20 patients with cryoablation therapy, researchers found a significant reduction in pain scores, from an average of 6.4 to 2.4 points.
Researchers argue that network governance models can help big conservation alliances govern themselves and strengthen connections through communication. This approach emphasizes inclusivity, allowing disparate stakeholders to envision common goals and choose metrics for measuring progress.
A new immune-suppressing drug regimen has led to the longest survival yet for a cross-species heart transplant, involving pig hearts in baboons. The study's results could lead to increased use of xenotransplantation and potentially help severe organ shortage among human patients.
A massive solar storm could disrupt communications satellites, knock out GPS systems, and shut down air travel and lights in millions of homes. The US government is taking the threat seriously, increasing support for research and forecasting to mitigate the impact.
Kitt Shaffer, MD, PhD, received the 2016 Alliance of Medical Students Educators in Radiology (AMSER) Excellence in Education Award. She has made significant contributions to medical student radiology education through her work on curriculum development and faculty mentorship.
Researchers found that physical exercise significantly improves cognitive performance in individuals with schizophrenia, particularly in areas such as memory, emotional intelligence, and problem-solving skills. The study suggests that early intervention and combined cognitive training with aerobic exercise may lead to long-lasting impr...
Researchers have discovered regulatory sequences in zebrafish that can turn on genes involved in regeneration, which also exist in humans. These 'tissue regeneration enhancer elements' or TREEs may hold the key to improving human regenerative capabilities through genome editing technologies.
Researchers from MedInsight Research Institute analyze studies detailing gadolinium toxicity mechanisms, contradicting the longstanding belief that patients with normal kidney function are not at risk. The study calls for FDA action to address the gap in scientific knowledge about treatment for gadolinium toxicity.
A study by researchers at the Heart Failure Center of the University of São Paulo suggests that wearing a respirator mask can lessen the impact of vehicle emissions on people with heart failure. The results also indicate that this type of mask can reduce the risk of developing cardiovascular disease for healthy individuals.
Researchers at the University of Bonn discovered that cyclodextrin promotes the breakdown of cholesterol deposits in arteries, reducing inflammation and plaque formation. The ring-shaped sugar increases natural mechanisms for cholesterol breakdown and reduces inflammatory response, offering a potential new treatment for atherosclerosis.
A hospital-based study found carriers of MC1R variants were at higher risk of melanoma, regardless of sun exposure. The study suggests a potential molecular mechanism underlying melanoma development.
Researchers found that over 70% of mentioned exemplars represented practical wisdom, which includes insight into real-life issues and strategic problem-solving. The study identified three prototypes: practical, philosophical, and benevolent, with practical wisdom being the most frequently mentioned.
Tropical Cyclone Zena intensified in the South Pacific Ocean near Vanuatu on April 5, 2016, causing sustained winds of over 35 knots. The GPM satellite measured intense downpours dropping rain at a rate of almost 154 mm per hour
A new study found that achieving ideal cardiovascular health factors, such as healthy blood pressure and cholesterol, is associated with a reduced risk of new-onset kidney disease. The study included 14,832 adults aged 45-64 and followed them for an average of 22 years to develop chronic kidney disease.
Researchers have developed a new method for gene transfer using an array of carbon nanotubes, overcoming limitations of existing technologies. The device successfully delivers DNA into tens of thousands of cells simultaneously with minimal toxicity and no restrictions on genetic payload.