A team of researchers has established a molecular link between Fanconi anemia and the PTEN gene, strongly associated with uterine, prostate, and brain cancer. The discovery improves understanding of Fanconi anemia and could lead to improved treatment outcomes for some cancer patients.
A recent study by Paula England found that highly skilled women with high wages lose an average of 10% in their wage per child, while those with lower skills and wages experience a smaller penalty. The penalties for black women are lower than for white women, but do not vary significantly by skill or wage level.
A metabolite called D-2-hydroxyglutarate (D-2HG) has been identified as a promising target for future cancer therapies due to its ability to promote cancer cell transformation and increase the likelihood of tumor spread in colorectal cancer patients.
Researchers at Chalmers University of Technology have developed a novel treatment for phantom limb pain, reducing symptoms by 50% in over a dozen amputees. The new approach uses augmented reality and machine learning to control virtual environments with muscle signals from the missing limb.
A new study found that US tornado clusters are becoming more frequent and intense over the past 50 years, with an estimated doubling of extreme outbreaks from 1965 to 2015. The data suggests that climate change is not a primary driver of this trend, and other factors such as low-frequency climate variability may be at play.
A 69-year-old Vietnam war veteran was diagnosed with pleomorphic liposarcoma, a rare type of cancer, after exposure to Agent Orange during his service. The patient's cancer has a high rate of local recurrence and ability to spread to other parts of the body, making early detection crucial.
A recent study by Guimarães et al. found that patients with atypical cutaneous leishmaniasis (ACL) in northeast Brazil have distinct genetic variations and higher levels of inflammatory cytokines. ACL is characterized by longer disease duration, more lesions above the waist, and reduced effectiveness of antimony treatment.
Astronomers detected carbon monoxide gas indicating large quantity of molecular hydrogen, suggesting formation of a single, gigantic galaxy. The cloud of cold gas is estimated to be three times the size of the Milky Way Galaxy.
The new guidelines aim to reduce SSI risk through patient education, lifestyle changes, and improved hospital management. Target blood glucose levels are set at 110-150 mg/dL for all patients before surgery, while smoking cessation and weight loss are encouraged.
Researchers at Harvard University and Novartis have discovered that Zika virus can infect neural progenitor cells by grabbing onto a specific protein called AXL on the cell surface. This finding contradicts previous studies suggesting that targeting the AXL protein alone could defend against the virus.
A recent study has found that the frequency of US tornado outbreaks is increasing, but the trend does not resemble those expected under global warming. Instead, researchers attribute the rise to trends in storm relative helicity, a factor not previously linked to climate change.
Researchers found that brain cells in specific columns cycle independently between active and inactive states during both sleep and wake. This cycling is linked to improved attention and response to external stimuli.
A study published by Chapman University researchers found that higher psychological well-being is associated with greater levels of physical activity in older adults. The study, which followed 9,986 English adults over 11 years, suggests that boosting mental health may encourage physical activity and improve overall well-being.
Researchers at Newcastle University found that hackers can hack a credit card account in as little as 6 seconds by guessing the card number, expiry date, and CVV. The 'Distributed Guessing Attack' method allows hackers to circumvent security features and validate card details across multiple websites.
A new portable use-of-force simulator, CBTsim, is being rolled out by Washington State University to launch a science-driven era in police training. The device projects realistic video scenarios where officers must make rapid decisions in tense situations, tracking every movement and action.
Dr. Ami Radunskaya, a professor at Pomona College, received the 2016 AAAS Mentor Award for launching initiatives that increased female Ph.D. degrees in mathematics. She has mentored 82 students, including many women and underrepresented minorities, to earn doctorates.
Researchers at MIT's CSAIL develop a sound-recognition system that outperforms predecessors without requiring expensive hand-annotated data. The system is trained on video and achieves high accuracy rates, with applications in improving mobile device context sensitivity and situational awareness of autonomous robots.
Tropical Cyclone Nada has shown minimal strength with no associated deep convection or strong thunderstorms. The storm is forecast to move west-northwest over southern India before dissipating over land.
Research challenges traditional views in insect evolution, finding that female orchid mantises increase in size and color to gain advantage over large pollinators. This study suggests female predation strategy led to the differing male and female ecologies in the orchid mantises.
A study comparing four tests for PD-L1 expression has found that three tests cluster together, but the results vary with different scales. The goal of the ongoing study is to determine which test predicts treatment response most accurately.
Researchers at Goethe University Frankfurt discovered a new ubiquitination mechanism in Legionella bacteria that affects cellular processes and causes cell death. This mechanism reveals a broader role of ubiquitin in regulating life processes and may lead to new strategies for developing antibacterial agents.
A small study found that augmented reality and serious gaming therapy significantly reduced phantom limb pain, improving quality of life. The therapy involved training a virtual arm, racing, and copying movements, leading to halved pain intensity and frequency.
Researchers at Einstein College of Medicine and Penn State University will use smartphones to assess cognitive changes in seniors with Alzheimer's disease. The five-year study aims to develop personalized interventions to prevent dementia by analyzing risk factors such as stress, pain, and sleep.
Researchers at the University of New South Wales achieved a 12.1% efficiency rating for a 16 cm2 perovskite solar cell, making it the largest single certified with the highest energy conversion efficiency. The team has also demonstrated an 18% efficiency rating on smaller cells and plans to extend durability.
Researchers found that molybdenum sulfide (MoS2) holds more promise as a catalyst for producing hydrogen than previously thought. By engineering sulfur vacancies across the material's surface, they achieved catalytic efficiency comparable to previous MoS2 technologies.
A study of 62 studies with over 13,000 individuals found that narcissism correlates with a range of social media behaviors, including the number of friends and selfies posted. Grandiose narcissism positively relates to time spent on social media, while vulnerable narcissism does not show a relationship.
A new theoretical model shows that dense networks evolve differently depending on the rate of second-neighbor connections. Networks with high copying probabilities exhibit densifying behavior, growing faster than themselves, and an unlimited number of growth transitions related to copying are discovered.
A team of planetary scientists suggests that dramatic climate cycles on early Mars could have created the planet's deep canyons and extensive valley networks. The researchers propose a glacier-covered Mars with long warm periods lasting up to 10 million years, producing enough water to form these features.
A team of researchers used functional magnetic resonance imaging (fMRI) and acoustic analysis to study how children's brains respond to emotional speech cues. They found that lower frequency characteristics in voice spectra may play a significant role in understanding brain activity and differentiating emotional processing.
Researchers used CRISPR/Cas9 to remove an enzyme that regulates the diabetes-associated TXNIP gene, leading to reduced cell death and increased insulin production in genetically modified pancreatic beta cells. The study also found that histone acetyltransferases play a crucial role in regulating the TXNIP gene.
French researchers have discovered that Streptomyces bacteria can be used as an environmentally friendly alternative to pesticides. The bacteria promotes plant growth and controls pests in the soil. This study could lead to sustainable agricultural practices and reduce harm to human health and the environment.
ADC MI130110 shows remarkable antitumoral activity in CD13-expressing tumor cells, impairing tubulin polymerization and disrupting the microtubule network. The treatment resulted in significant reduction in tumor size, complete remission, and increased median survival time.
A study published in Nature found that mated pairs of wild shorebirds have diverse schedules for parental care of the nest. The researchers used geolocators to track the birds' movements and timing, revealing a range of incubation bouts from every other hour to two days.
Researchers at the University of Arizona will lead a collaborative project to develop the framework for a larger long-term study of cancer in firefighters, focusing on measuring exposures and determining mechanisms. The goal is to reduce cancer risk in firefighters through improved occupational health and safety practices.
A national study led by Baylor College of Medicine aims to understand the link between antibiotic use and improvements in autism symptoms in some children. The research, funded by N of One: Autism Research Foundation, will examine the gut microbiome and metabolome for two years to identify potential causes and effects.
Patients with a history of cancer who experience severe heart attacks have a three times higher risk of noncardiac death but not higher cardiac death rates. They also face increased risks of cardiogenic shock and need more intensive treatment.
A Mayo Clinic study comparing thousands of overlapping and non-overlapping surgeries found no difference in postoperative complications or deaths within a month. Overlapping surgeries provide greater access to qualified surgeons and more efficient use of operating rooms.
Researchers at Caltech discovered a novel link between the gut microbiome and Parkinson's disease, finding that gut bacteria promote hallmark pathology, neuroinflammation, and motor dysfunction. The study suggests targeting the gut microbiome may provide a new approach for diagnosing and treating PD.
A research team at the University of Georgia has discovered that a pathogen's ability to move through the body triggers an immune response. The study found that bacterial motility induces the formation of neutrophil extracellular traps, which are web-like structures of DNA associated with antimicrobial molecules.
A new study by University of California San Diego School of Medicine scientists discovered the Hippo pathway's unexpected function in subduing cancer immunity. Deleting LATS1/2 from mouse cancer cells enhanced anti-tumor immune responses, suggesting a potential therapeutic approach to improve immunotherapy efficiency.
The GREGOR solar telescope has demonstrated its potential with high precision measurements of magnetic fields and material motion. High spatial resolution imaging data have also provided unprecedented details of the Sun's photosphere, revealing features smaller than 100 km in sunspot light bridges.
New treatments show promise for AL amyloidosis, with overall survival on the rise. Researchers found an effective alternative to bortezomib and promising results from monoclonal antibodies like NEOD001.
A new study published in Nature Communications presents evidence suggesting that a low-mass supernova played a crucial role in the formation of our solar system. The research team analyzed short-lived radioactive nuclei found in meteorites and discovered unique 'fingerprints' that point to a low-mass supernova as the trigger.
A large-scale study found China's smaller parks in warmer regions were more heavily modified, while larger parks in colder areas remained pristinely untouched. The research provides valuable insights into the conservation value of protected areas and will aid in achieving international recognition for China's conservation efforts.
Scientists discover Bismuth is superconducting at extremely low temperatures, defying expectations due to its low carrier density. The finding opens new avenues for research into the fundamental laws of superconductivity.
Rice University biologist Julia Saltz found that fruit flies' genotypes and behaviors affect their social environments. In experiments, she observed that males in preferred groups were more aggressive than those in nonpreferred groups, while losing an encounter made them less aggressive.
A young bodybuilder's use of non-prescribed injections, including coconut oil and insulin, led to severe complications, including a ruptured triceps and multiple cysts. The case highlights the risks of self-administered natural oils and steroids used to achieve a desired body image.
A new study aims to explore the challenges faced by teenagers at high risk for HIV who are required to obtain parental permission to participate in prevention trials. The research will examine parents' views on consent and teens' willingness to engage their parents in the process.
IUPUI chemists have developed a new molecular binding technique that can shorten or abridge the human and animal drug discovery and development process. The new method, which uses site-selective C-H arylation of primary aliphatic amines, has potential benefits for both the pharmaceutical industry and patients.
Researchers successfully developed a vaccine against influenza using genetically modified live virus that activates the immune system but cannot replicate in healthy cells. The new vaccine proved effective in mice, guinea pigs, and ferrets, offering an antibody response comparable to existing vaccines.
A Phase III study published in NEJM shows the dapivirine ring safely reduced HIV infection by 31 percent overall among all women in the trial. The risk of HIV infection was reduced by at least 56 percent among women who used the ring consistently, with subgroup analyses suggesting a 75 percent or more reduction with near-perfect use.
Research at Ohio State University found that prisoners' written communication changes are linked to reduced reoffending rates in substance-abuse programs. The study analyzed tens of thousands of messages exchanged between participants and found that those who showed greater language change were less likely to return to prison.
Researchers at UGA aim to expand and refine the use of CRISPR-Cas for research and biomedicine, particularly in combating pathogenic bacteria and diseases such as cancer and diabetes.
UTSA has received a prestigious $5.29 million grant to advance its brain health research, focusing on the basal ganglia region and potential treatments for Parkinson's disease. The funding will support local cell signaling research to develop a model of basal ganglia function.
Researchers mapped the structure of a portion of the NMDA receptor, which recognizes zinc and glutamate. The study provides insight into the regulation of NMDA receptors and their role in mental health disorders.