Researchers identified a potential new approach to combating rheumatoid arthritis by blocking the effects of the disease using epigallocatechin-3-gallate (EGCG), a molecule with anti-inflammatory properties found in green tea. The compound markedly reduced ankle swelling in an animal model of human rheumatoid arthritis.
Dr. Mark Soucek, a professor at the University of Akron, has been awarded the Roy W. Tess Award in Coatings for his outstanding contributions to coatings science and technology. His research focuses on bio-based feedstocks, alkyd technology, and reactive diluent technologies.
Researchers at The Wistar Institute found that hypoxia in tumors lowers STAT3 activity, allowing myeloid-derived suppressor cells to differentiate into tumor-associated macrophages. A combination of an experimental STAT3 inhibitor and sialidase showed substantial antitumor activity
Researchers at the University of Chicago and Tel Aviv University have discovered a new chemical modification that can boost gene conversion to proteins. The study enriches the epitranscriptome, a critical new dimension in molecular biology, suggesting an even larger cellular control panel.
A study by University of Stirling scientists found beaver dam building skills improve stream habitats, increasing species diversity by 28% and reducing pollutants. Beaver dams also store flood water and increase organic matter retention.
A new study reveals that viewing photographs combined with listening to music can significantly reduce patients' anxiety before surgery. The findings suggest playing videos with photos and music in preoperative waiting rooms as a simple and affordable way to improve care without medications or invasive treatments.
The Center for Infection and Immunity at Columbia University's Mailman School of Public Health is studying tick-borne bacteria and viruses to better understand their role in human disease. The $1.9M grant will support research into potential pathogens, such as Borrelia burgdorferi, which causes Lyme disease.
A large German health insurer study found that long-term use of proton pump inhibitors (PPIs) may be associated with an increased risk of dementia in older adults. The study included over 218,000 individuals and found that regular PPI users had a 44% higher risk of developing dementia compared to non-users.
Scientists have discovered that deactivating the MYC oncogene can induce a dormant state in embryonic stem cells, similar to diapause, allowing them to survive without growth or metabolism. This finding has implications for controlling cancer stem cells and metastasis.
Researchers assembled largest mammalian phylogenomic dataset to test models of molecular evolution and confirm findings that Atlantogenata is the sister group to all other placentals. The study resolves the controversy over placental mammal family tree, revealing that Afrotheria and Xenarthra diverged from each other around 90 million ...
Current diagnostic techniques make aggressive treatment unnecessary for many patients with metastasized skin cancer. The Sunbelt Melanoma Trial found that interferon therapy offered no benefits for stage III melanoma patients with minimal lymph node involvement.
Researchers at EPFL have developed a highly innovative research tool: a 2cm by 2cm 'chip' with 32 independent compartments, each holding a nematode. This device enables the monitoring of individual worms and allows for precise control over nutrient concentrations and temperature.
Researchers found that pay-for-performance measures disproportionately penalize hospitals caring for poor, minority, or publicly insured patients. Adjusting for social determinants of health reduced penalties for these hospitals.
Previous lactation performance and weather can predict colostrum quality in dairy cows. Researchers found that warmer temperatures improve colostrum quality by increasing blood vessel permeability.
Researchers uncover fossil flowers from the genus Strychnos, a family of plants that produced poisonous strychnine and curare. These ancient plants are found to have evolved toxic alkaloids for defense against herbivores.
Scientists at University of Southampton have developed a new form of eternal data storage that can record the history of humankind for billions of years. The technology uses nanostructured glass and can store unprecedented amounts of data, including major documents from human history.
The study analyzed 10-year survival rates among European populations aged 75-84 to see if they reached 85-94 years of age. Geographical variations in old age survival rates were found, with areas like Madrid and Salamanca in Spain showing high survival rates, while Glasgow and Manchester in the UK showed low survival rates.
Cybathlon is a global competition that awards teams of disabled pilots and scientists for developing novel assistive technologies. It includes disciplines such as prosthetic limbs, exoskeletons, wheelchairs, and brain-computer interfaces, aiming to improve the quality of life for people with motor disabilities.
Researchers introduce technique to calculate and understand angular momentum in complex systems, simplifying the 'angulon problem'. The novel canonical transformation removes complex algebra, offering insights into atomic, condensed matter, and chemical physics.
A Cornell study found that incentivizing managers to promote healthier work environments can boost employee wellness. The researchers surveyed 270 adults with manager roles, discovering that 68% supported being evaluated for their employee wellness actions.
Researchers at Vanderbilt University Medical Center have discovered a new compound that is more effective against the tuberculosis enzyme and maintains activity against resistant forms. The findings could lead to a more effective treatment for the deadly disease, which killed 1.5 million people in 2014.
Geologists have discovered evidence to explain the origin of the Wilcox Formation, one of Mexico's most productive oil plays, and support for a theory that water levels in the Gulf of Mexico dropped dramatically as it was separated from the world's oceans. The study also offers insight into extreme warming around 55.8 million years ago.
Researchers at UNSW Australia discovered a way to produce tenfold more methane gas from naturally occurring microbes, extending coal seam gas wells' lifespan and improving food waste use. The innovation uses synthetic dye forming needle-like crystals to boost methane-producing microbes' growth.
A new multilayered photoelectrode boosts the ability of solar water-splitting to produce hydrogen by absorbing visible light from the sun. The two-dimensional hybrid metal-dielectric structure shows significant enhancement in photo-catalytic applications, making it a promising technology for efficient hydrogen production.
Researchers at University of Utah have discovered a new kind of 2D semiconducting material that could lead to much speedier computers and smartphones. The material, made of tin and oxygen, allows electrical charges to move through it faster than conventional materials.
Lena Struwe, a Rutgers University botanist, has identified two flowers encased in ancient amber as belonging to a newly discovered species within the Strychnos genus. The discovery highlights the existence of many undiscovered plant species hidden away in natural history collections worldwide.
A new study suggests that optimized rain use and irrigation can increase crop yields globally, particularly in water-scarce regions like China, Australia, and Mexico. This approach to crop water management could make a crucial contribution to filling the plates of the poor and increasing climate resilience for smallholders.
A new study suggests that caregivers providing substantial health care assistance experience emotional, physical and financial challenges. The study highlights the importance of supporting family caregivers who provide most assistance with everyday activities.
Organic milk and meat contain more beneficial omega-3 fatty acids, lower saturated fats, and higher concentrations of iron, Vitamin E, and carotenoids compared to conventional products. This switch can improve intakes of nutritionally important fatty acids, potentially reducing cardiovascular disease risk.
A study found that heart attack patients who experience cardiogenic shock have a higher risk of death or rehospitalization in the first 60 days post-discharge. However, by the end of the first year, the gap between the two groups narrows.
A new study at Hospital for Special Surgery finds that low-dose EOS imaging system performs as well as conventional CT scans in assessing limb length. The system provides less radiation exposure and allows for better assessment of limb alignment compared to CT scans.
The DengueTools consortium has accumulated knowledge on controlling the spread of Dengue fever by targeting its mosquito carriers. The global collaboration aims to develop practical tools for diagnosing and monitoring the virus in affected areas, as well as prevent infections in school children.
Researchers have discovered that complex brain divisions in vertebrates evolved before the emergence of jaws, contradicting previous assumptions. The study found similarities between jawless fish and jawed vertebrates in brain development patterns.
Research suggests that joining social groups after retirement can reduce the risk of death and improve quality of life, with effects comparable to those of regular exercise. The study found that maintaining social connections is crucial for retirees, emphasizing the importance of social planning in retirement planning.
A study published in PNAS reveals that genetic variations in the Tie2 gene are associated with an increased risk of developing life-threatening vascular complications following infections. Higher Tie2 levels provide protection against these complications.
A study led by St. Jude Children's Research Hospital scientists has identified four inherited NUDT15 gene variations that alter thiopurine metabolism, leaving patients sensitive to the drugs and at risk for treatment-disrupting toxicity. The research paves the way for personalized chemotherapy tailored to each patient's genetic makeup.
Researchers found that aerobic fitness protected against metabolic dysfunction in the liver, reducing inflammation and fatty deposits. Chronic alcohol ingestion did not cause significant changes in blood insulin or glucose levels, contrary to expectations.
A new Florida State University study refutes a 2007 Science study claiming that shark declines led to increased cownose ray populations, which collapsed oyster and shellfish industries. The research shows that shark populations were not as depleted as reported, and most species have recovered or are recovering.
Researchers from the University of Pennsylvania School of Veterinary Medicine have identified how the parasite <em>Toxoplasma gondii</em> infects the brain by tracking its movement and reproduction in living tissues. The study provides insights into treatment strategies to combat the parasite, which can be life-threatening for people w...
Researchers at ETH Zurich have discovered how dendritic cells advance from capillary vessels towards the lymph node. They found that the cells orient themselves with the help of a molecular mediator named CCL21, which creates a directional gradient.
A new study found no change in epilepsy incidence among younger patients over the past 40 years, while an increase was observed among older patients. This suggests that progress in preventing new cases of epilepsy has not been made, particularly among the elderly population.
Researchers solved the first X-ray crystal structure of full-length PAH, an enzyme defective in PKU patients. The structure will help understand molecular origins of PKU and inform drug development.
Eating fish more than three times a week during pregnancy was associated with increased risk of rapid growth in infancy and childhood obesity. Women who consumed high amounts of fish had children with higher BMI values at various ages compared to those who ate less.
Researchers develop a vaccine vector based on cytomegalovirus expressing Ebola virus glycoprotein, demonstrating protection in rhesus macaque model. The study's findings suggest a unique immunological response, producing high levels of antibodies with minimal T cell responses.
Researchers found isomaltulose reduces GIP secretion and increases GLP-1 secretion, preserving insulin secretion. This helps prevent severe fluctuations in blood glucose levels.
Researchers at the University of Pennsylvania School of Medicine found that financial incentives framing were crucial to motivating participants. The loss incentive group, which risked losing $42 per month for not achieving their daily goal, saw a 45% increase in success rate compared to the control group.
A critical discovery about how bacteria feed on an unusual sugar molecule found in leafy green vegetables could hold the key to explaining how 'good' bacteria protect our gut and promote health. Leafy greens are essential for feeding good gut bacteria, limiting the ability of bad bacteria to colonise the gut.
Researchers at St. Jude Children's Research Hospital have identified 17 new genes that regulate hematopoietic stem cell transplantation in mice. The study found that the Foxa3 gene plays a crucial role in repopulating blood-forming stem cells after transplantation, offering hope for improving transplant outcomes and reducing mortality.
Experts argue that drug discovery should focus on 'validity', predicting results in sick people, rather than industrialization or fashion. Mathematical tools show that small changes in validity can have a bigger effect than running more experiments.
A UK project will provide an estimated size of the lesbian, gay and bisexual community in England, enabling Public Health England to address their health needs. The research team will develop a robust method to measure the LGB population size on an ongoing basis.
Researchers investigate sex differences in hypertension mechanisms and explore potential therapeutic strategies for premenopausal women. Studies suggest that obesity leads to increased aldosterone levels, contributing to cardiovascular problems.
Researchers at McGill University found a connection between noradrenergic neurons and depression vulnerability. Increased dopaminergic neuron activity corresponds to depression, while noradrenergic neurons control this activity, influencing resilience or vulnerability.
Researchers use light to measure the 'big stretch' in spider silk proteins, shedding light on biological events such as cancer metastasis. The tool allows for real-time measurement of forces acting on proteins in live cells.
A personalized approach to acupuncture has been shown to decrease pain levels and improve functional capacity in individuals with chronic pain, known as fibromyalgia. Fibromyalgia is characterized by widespread pain, fatigue, and depression, affecting up to one in twenty people.
Researchers at ETH Zurich developed a versatile polymer coating with covalent bonds to various materials, preventing biofouling in biomedical diagnostics and medical technology. The 'Swiss army knife' molecule offers simple dip-and-rinse application and withstands harsh conditions.
A team of researchers led by Daniel Bodony from the University of Illinois at Urbana-Champaign is working on making jet engines quieter. They are using supercomputers, including XSEDE's Stampede, to analyze aerodynamics and resolve multi-scale problems in turbulent flows.
Regenerative medicine scientists at Wake Forest Baptist Medical Center have developed a novel 3D printing system that can produce living tissue structures with functional blood vessels. The system uses bio-degradable materials and water-based gels to promote cell growth, enabling the creation of complex tissues such as bone, muscle, an...
A randomized controlled trial found that threatening to lose a reward is more effective than earning one in increasing physical activity among overweight and obese adults. The study also suggests that the way financial incentives are framed is important to their effectiveness.
The bed bug's genome shows significant changes in receptor types for smell and taste, leading to increased resistance to pesticides. The decoded genome also reveals insights into the species' evolution from bat parasite to human feeder, highlighting genetic adaptations for chemosensation and traumatic reproduction.
Researchers at Kansas State University confirm that freezing certain steak cuts, like strip loin and inside round, can improve their tenderness by up to 10%. Moisture loss plays a key role in this process. Higher quality cuts are more likely to benefit from freezing.