Researchers found that MAP1A connects NMDA glutamate receptors to microtubules, stabilizing receptor transport and preventing derailment. This discovery offers new insights into the neural mechanisms underlying memory and learning.
Vitamin B6 plays a crucial role in nitrogen metabolism, informing plants of their ammonium content and helping regulate its use. This discovery could lead to the development of new methods to prevent overuse of nitrogen-containing fertilizers, which harm the environment.
A new study by Mayo Clinic reveals that only one-third of patients receive preemptive or early living donor kidney transplants, despite research suggesting improved patient outcomes. The study highlights the need for education and access to information about living donor kidney transplantation to improve long-term outcomes.
A team of researchers led by Catherine Housecroft and Edwin Constable developed a water oxidation model that simulates fuel cells powered by light radiation. The model uses compounds of ruthenium as a catalyst, enabling the self-assembly of individual components in a hierarchical structure.
Researchers visualized the mechanism of cell polarity maintenance using a super-resolution microscope, revealing its relationship to exocytosis and microtubules. The study used a fungal model to clarify the behavior of polarity markers, shedding light on their role in site-specific growth and cell function.
Research-based climate scenarios predict catastrophic consequences of rising carbon emissions, including sea-level rise and coastal submersion affecting 1.3 billion people. The long-term view underscores the urgency to curb emissions within decades.
A Finnish study found that arthroscopic knee surgery does not alleviate sensations of knee catching or locking associated with degenerative knees. Physical therapy and sham surgery showed similar effectiveness in reducing symptoms.
A new model examines the relationship between factors impacting African Americans' advance care planning, revealing limited knowledge on improving this population's care. The study highlights the need for personalized approach to end-of-life care and encourages increased awareness.
Researchers aim to uncover mechanisms that regulate plants' defence against stress factors, leading to the development of new crop species. Fluctuating protein structures may be essential for carrying out specific functions.
A long-lasting cooling in the northern hemisphere coincided with the Justinian plague pandemic and contributed to the decline of the eastern Roman Empire. The researchers found that a series of volcanic eruptions led to a dramatic cooling, affecting food supplies and causing major famines.
Two new fossil fish species of Rhinconichthys have been discovered from the Cretaceous Period, with a greatly expanded geographical range. The newly named R. purgatoirensis and R. uyenoi have tripled the number of species in the genus.
Researchers found that mild stress increases brown fat activity, linked to higher cortisol levels and potential heat production. This discovery has implications for preventing obesity and diabetes through sustainable interventions.
A Yale-led research team develops a pricing framework for natural capital assets, including groundwater, forests, and fish populations. The study finds that the Kansas High Plains' groundwater aquifer lost $1.1 billion in value between 1996 and 2005 due to over-extraction and poor management.
A new implantable device delivers a toxic 4-drug cocktail directly to pancreatic tumors, limiting widespread side effects and increasing drug delivery by at least three times. This innovative approach shows promising results in halting tumor growth and shrinking tumors, offering new hope for patients with this deadly cancer.
Adult brain neurogenesis is increased by sustained aerobic exercise, particularly in genetically predisposed rats, indicating a potential improvement in learning abilities. The study suggests that aerobic exercise, but not high-intensity interval training or resistance training, enhances hippocampal neurogenesis.
A highly sensitive and disposable Indium Tin Oxide (ITO) based biosensing tool was developed for the determination of Haptoglobin in human blood. The new biosensor features a low detection limit of 0.2 fg/mL and demonstrates high analytical performance.
Researchers at JQI develop interface between photons and single electrons, enabling fast interaction and scalable integration on a chip. This breakthrough advances quantum networks and enables entanglement distribution, secret communication, and complex quantum devices.
Researchers at PTB have demonstrated non-destructive state detection technique for molecular ions, enabling novel spectroscopy methods with applications in chemistry and fundamental physics. The technique enables direct observation of quantum jumps in isolated molecules.
A new method called 'ADPr-ChAP' allows researchers to identify chromatin sites modified by ADP-ribosylation in response to cell stress, enabling a better understanding of the cellular stress reaction. This breakthrough could lead to new ways of intervening in disease-making processes such as chronic inflammation and cancer.
Detlef Weigel has made significant contributions to the field of genetics, including the identification of florigen and development of genomic tools. He is recognized for his tireless service to the community and his ability to excel science.
A multi-institutional report presents the first known experience of robotic nephrectomy for inferior vena cava tumor thrombus, achieving favorable outcomes and reproducibility in surgeons with adequate robotic experience. Complications were relatively minor, but some patient deaths occurred despite minimally invasive approach
A group of researchers created a unique 1D nano electronic system on the surface of a solid and observed its electronic state using photo-emitted electrons. This discovery will help elucidate the mystery of unique electronic properties of 1D nano metals.
A research team at Toyohashi University of Technology has developed a wireless power transmission device that can supply electricity to a neural interface implanted on the brain. The device features a flexible antenna and a silicon chip, allowing for minimally invasive implantation and efficient energy transfer.
Research by University of East Anglia suggests that African agricultural policies aimed at alleviating poverty may be making things worse for the poorest. The 'green revolution' policies in Rwanda have been shown to strip smallholder farmers of their main productive resource, land, and exacerbate poverty.
A smartphone app developed by Cambridge researchers maps Swiss-German dialects through crowdsourcing, gathering data on dialect spread and changes over time. The app has been downloaded over 90,000 times and reveals that younger generations are adopting more geographically widespread variants of the language.
Researchers discovered that stars undergo sharp stellar brightening caused by gravitational instabilities in massive gaseous disks, leading to a new understanding of star formation and evolution. The discovery may imply that our Sun experienced several such episodes, affecting the formation of giant planets.
A new pilot study suggests that meditation can help US veterans manage chronic pain by reducing pain intensity and interference with daily life. The study used Integrative Restoration Yoga Nidra (iRest) mindfulness meditation, which is already being used at Veterans Health Administration medical centers nationwide.
A special issue of Pediatric Blood & Cancer establishes evidence-based standards for pediatric psychosocial care, addressing topics like monitoring psychosocial health and supporting siblings. The standards aim to improve quality of life outcomes for children with cancer and their family members.
Researchers are testing whether recycling and repurposing building materials can revitalize a distressed Great Lakes community. The project aims to create an economic cluster by identifying industries that can maximize material reuse and resale. By doing so, it could provide jobs and boost local economy.
Purdue University researchers have discovered that pollen-derived carbon architectures can be used as anodes in lithium-ion batteries. The study found that the cattail pollen-based carbon performed better than bee pollen, with a higher theoretical capacity of 200 milliamp hours per gram.
Four recent studies found companies with best-in-class workplace health programs outperformed the Standard & Poor's index by 7-16 percent per year. Employers investing in employee health can see a positive impact on their bottom line.
A new study published in Nature Biotechnology reports that a 2D-NMR spectroscopy method can reliably assess the atomic structures of biologically similar products, yielding equivalent fingerprints. The method's precision is demonstrated through an interlaboratory comparison of four versions of a therapeutic protein drug.
A study of 678 women found that frequent bed-sharing with infants and a strong motivation to breastfeed were linked to longer breastfeeding durations. This challenges recommendations against bed-sharing due to SIDS fears, suggesting these practices may hinder some mothers from achieving their breastfeeding goals.
The article presents findings from the first reported autopsy of a patient with MERS coronavirus infection, revealing diffuse damage to lungs and identification of anti-MERS-CoV antibodies in specific cells. These results contradict previous assumptions and suggest that lung targeting is crucial for infectious control strategies.
Scientists have identified four classes of nerve cell involved in calculating directionally selective signals in fruit flies, unlike previously proposed models. These cells, including T5 cells, perceive the direction of motion and receive input from four upstream cells.
A new study reveals that countries emitting the least amount of greenhouse gases are most vulnerable to climate change effects such as natural disasters and habitat changes. The highest-emitting nations, however, are less vulnerable despite contributing significantly to global emissions.
Researchers at Johns Hopkins University found a possible marker for recurring HPV-linked oropharyngeal cancers. The study suggests that an increase in E6 antibody levels after treatment may indicate a higher risk of cancer returning.
Researchers have discovered a molecular link between psychiatric disorders and type 2 diabetes, with the DISC1 gene playing a critical role in pancreatic beta cell function. The study found that disrupting the DISC1 gene led to increased beta cell death, impaired glucose regulation, and reduced insulin secretion.
University of Georgia researchers are developing intervention methods to help athletes report concussions without fear of team repercussions. The study aims to change the culture of sport from concealing to reporting concussions, promoting a safer and healthier environment for athletes.
Researchers have discovered a striking genomic signature shared by colon, lung, breast, stomach and endometrial cancers, which may be used to diagnose the disease at early stages. The methylation signature could lead to the development of a non-invasive blood test for cancer detection.
Researchers develop small molecule inhibitor to address hypertrophic cardiomyopathy, a common cause of sudden death in young athletes. The treatment has shown promising results in mice bred with the mutation, preventing the disease from surfacing.
The study reveals that forest clearing substantially affects local climate by altering average temperature and maximum summer temperatures. Evapotranspiration plays a key role in these impacts, with arid areas experiencing the most pronounced effects.
A team of researchers has revealed the molecular motions behind elastin's flexibility, showing how scissor-shaped molecules assemble into long chains that give tissues their stretchability. The study provides insights into the material's durability and could lead to new materials for engineering applications.
Researchers found nearly half of IPF-related websites recommended medications with no proven benefit, while more than a third suggested harmful treatments. The top two accurate sources were Wikipedia and Medscape.
A new electrochemical detection strategy can identify bacteria in wounds in under a minute, allowing for targeted therapies and reduced healthcare costs. The method uses pyocyanin, a molecule produced by Pseudomonas bacteria, to detect infections.
Analyzing tumor DNA fragments in the bloodstream can give a more complete picture of a patient's cancer. Researchers found that standard practice of performing molecular testing on a single metastatic lesion may be inadequate, and circulating tumor DNA testing may better capture the molecular diversity in a patient's tumor.
The study introduces a super element modeling method for petroleum reservoir simulation, which speeds up calculations by hundreds of times. This allows for rapid development of oil fields with improved accuracy.
The NASA GPM satellite examined violent thunderstorms in the southern US on February 2-3, with one powerful storm in North Carolina dropping rain at an extreme rate of 112.96 mm (4.4 inches) per hour. The satellite's radar instruments measured precipitation within the area and created a 3D cross-section through the storms.
A new study published in the International Journal of Obesity suggests that 34.4 million Americans considered overweight by BMI are actually healthy, and 19.8 million who are considered obese are also healthy. The research reveals that BMI mislabels millions of individuals as unhealthy, while overlooking those with 'healthy' BMIs who a...
Research from the University of Southampton found that man-made sounds can alter the behavior of seabed creatures, impacting nutrient recycling and carbon storage. Exposure to certain sounds can cause species to reduce irrigation and sediment turnover, leading to reduced oxygen levels and potentially affecting seabed productivity.
Researchers found four Ly6 genes are overexpressed in various cancers, leading to poorer survival rates and drug resistance. The study uses big data analysis to identify novel targets for new drugs.
The LouLou Foundation and Penn Medicine's Orphan Disease Center have established a Program of Excellence to tackle the severe neurodevelopmental impairment and seizures caused by CDKL5. The program aims to develop effective treatments through collaboration with academic labs, companies, and biopharma industry.
Research published in The FASEB Journal found that prunetin, a plant-derived compound, prolongs lifespan and enhances overall health in male fruit flies by increasing glucose balance and fitness levels. The effect was not observed in female fruit flies.
By 2050, older adults representing minority groups are projected to rise to 39% globally, with significant increases among Asian and Native Hawaiian populations. To address this growing need, the American Geriatrics Society recommends culturally sensitive indicators to improve healthcare outcomes for diverse older adult populations.
Scientists discovered that PAD4 works with BRD4 to switch E2F-1 from promoting cell growth to inducing inflammation in cancers. Inhibiting both proteins reduced arthritis symptoms and decreased inflammatory products in mice.
A recent study evaluated the impact of a pay-for-performance program on pediatricians under a full-risk Medicaid accountable care organization (ACO) for children. The results show that the program was partially responsible for higher performance on quality measures, with significant improvements seen in independent incentivized provide...
The PPPL-led collaboration achieved a significant breakthrough in fusion energy research by creating a hydrogen-fueled superhot gas called a plasma on the W7-X stellarator. The achievement marks a major step forward for understanding plasma and demonstrates the potential of stellarators as a model for future fusion power plants.
Biologists from Moscow State University found new luminescent creatures in the Red Sea, with unique fluorescent patterns that can help identify different species. The study published in PLOS ONE reveals insights into the role of glow in attracting prey and exploring symbiotic relationships.
A multi-year regional study at the University of Delaware suggests that home shopping has a greater impact on transportation sector than previously believed. The study found that online shopping leads to increased wear and tear on pavements and higher environmental pollution due to more delivery trucks on the roads.
A new study from the University of Eastern Finland found that children who drink at least three glasses of milk per day have higher serum vitamin D levels than their peers. The use of vitamin D supplements and regular exercise also contribute to improved vitamin D levels in children.