Researchers at MD Anderson Cancer Center have made significant breakthroughs in the treatment of endometrial and ovarian cancers. A Phase II trial combining everolimus, letrozole, and metformin shows a 67 percent clinical benefit rate for patients with recurrent endometrioid endometrial cancer. Additionally, hormonal maintenance therap...
A phase II clinical trial found that pembrolizumab reduces tumor size in four types of soft tissue sarcomas and three types of bone sarcomas. Undifferentiated pleomorphic and osteosarcoma subtypes showed particularly promising results, with 44% and 30-40% reductions in tumor size, respectively.
A clinical trial found that patients with tumors overexpressing DLL3 responded better to the experimental drug rovalpituzumab tesirine (Rova-T), achieving stabilization of disease and significant tumor reductions. The results suggest Rova-T may be a promising treatment option for advanced small cell lung cancer.
Researchers from Tomsk State University have discovered that bats can act as transmitters of infections, including those caused by bacteria and nematodes. The study found gamasid mites in bat samples, which are common among rodents, indicating close contact between the two species.
LA BioMed researchers find a new study on aromatase inhibitors to prevent breast cancer recurrence is reassuring. The study's findings have direct application for clinical practice, with implications for cardiologists and oncologists.
A clinical trial shows atezolizumab, a checkpoint inhibitor, is effective in treating advanced bladder cancer, shrinking tumors and stopping new growth. The drug was well-tolerated, with mild side effects, and half of patients responded within 15 weeks.
A global review of systematic reviews found that people under 35, particularly women, are disproportionately affected by anxiety disorders. The study also highlighted the importance of understanding how common these disorders are and which groups are at greatest risk, especially those with chronic health conditions.
A Phase II clinical trial conducted by MD Anderson Cancer Center found that nivolumab significantly improves outcomes for patients with squamous cell carcinoma of the anal canal, with a control rate of 70%. The study enrolled 39 patients and demonstrated efficacy in both HIV-positive and non-HIV positive populations.
A University of Colorado study found that Hispanic white and non-Hispanic black young adults are more likely to die from cancer than their white counterparts, with mortality risks ranging from 1.36 to 1.77 times higher.
Researchers from UH Seidman Cancer Center will present data on a new online tool for estimating individualized survival probabilities in patients with newly diagnosed glioblastoma. The studies also explore promising new treatments, including pembrolizumab for head and neck squamous cell carcinoma, and improve patient participation in c...
A phase II clinical study found a 32% clinical benefit in pancreatic cancer patients with BRCA mutation, including one complete response and two partial responses. The drug's acceptable safety profile suggests it may be an option earlier in the treatment course for some patients.
A recent study published at ASCO found that gene dysregulation causes immune T cells to turn back to an immature state, making them less effective against metastatic melanoma. The researchers discovered over 60 epigenetic changes and 10 changes in gene activity that were most common among patients who didn't respond to immunotherapy.
A study found that while overall colorectal cancer rates are decreasing, the incidence of late-stage cancer in young patients is increasing. The study, which analyzed data from Colorado patients, reveals a significant rise in late-stage CRC diagnoses among those under 50.
A study found that genes involved in the Wnt signaling pathway are more frequently altered in younger patients with colorectal cancer. This pathway drives the growth and proliferation of cancer stem cells. The research suggests targeting this pathway may be a promising strategy for treating aggressive CRC in young patients
A crowd-sourcing strategy leveraging social media and advocacy groups has connected over 2,000 patients from all 50 states with the Metastatic Breast Cancer Project. This approach empowers patients to directly participate in research, improving outcomes for advanced breast cancer patients.
Researchers at UT Southwestern Medical Center discovered that between 14 to 25 percent of lung cancer patients also have immune disease, making them unsuitable for immunotherapy treatments. This finding raises critical questions about the effectiveness and toxicity of these treatments among patients with autoimmune diseases.
A new study from MD Anderson Cancer Center found substantial variation in costs of breast cancer treatment for different chemotherapy regimens, with insurer costs varying by as much as $20,354. Choosing equally effective but less costly regimens could impact the cost of breast cancer care nationally by $1 billion every year.
A clinical trial has found that twice-daily radiotherapy is as effective as once-daily radiotherapy in treating small cell lung cancer, with similar survival rates and fewer side effects. The study's results have already changed clinical practice worldwide.
A new pre-surgery technique using an expandable tube may make colostomy bags redundant for emergency bowel cancer patients. The study found that less than half of those who had their bowel unblocked needed a colostomy bag, while more than two-thirds required one after emergency surgery.
Researchers at H. Lee Moffitt Cancer Center report a safe and effective treatment regimen for recurrent high-grade glioma brain tumors, with durable disease control in three patients. The combination of pembrolizumab, bevacizumab, and radiation therapy shows promise as a potential new approach to treating these patients.
Researchers develop Bend-Induced-Oscillatory-Shearing (BIOS) process to produce hundreds of meters of polymer opals on a roll-to-roll process, exhibiting chameleon-like color-shifting properties. The material has potential applications in smart clothing, building coatings, and banknote security.
Insilico Medicine scientists will present advances in deep learning for biomarker development and drug discovery at the ISFA-Columbia University Actuarial Science Workshop. The workshop aims to integrate deep learning with actuarial science to assess risk in finance, insurance, and other industries.
A phase III clinical trial found that giving chemotherapy after radiotherapy delays further growth of anaplastic glioma and increases the number of patients alive at five years. The treatment improved survival for patients with this rare type of brain tumour, now being considered standard care.
A UK survey found that overweight very young children consume larger meals than healthy weight children, consuming approximately 11 calories more per meal, but eating less frequently. This disparity in meal size, not frequency, appears to be a significant risk factor for childhood obesity.
Researchers at St. Jude Children's Research Hospital are presenting promising preliminary results from clinical trials of an experimental monoclonal antibody for treating high-risk pediatric patients with neuroblastoma. Additionally, studies suggest that high-dose methotrexate may leave some survivors at risk for attention problems, wh...
A Phase II clinical trial has shown an 80% success rate in shrinking tumors in newly diagnosed, high-risk neuroblastoma patients treated with a new monoclonal antibody. The experimental agent was found to have reduced treatment-limiting pain compared to other anti-GD2 monoclonal antibodies.
A study by Dr Anu Molarius found that obesity rates increased from 13% to 17% among women and 12% to 17% among men between 2000 and 2012. The prevalence of obesity was highest among middle-aged individuals with a middle level education.
Dartmouth College scientists have discovered a new way to produce sustainable feeds for tilapia and other farmed fish. They found that replacing wild fish oil with marine microalgae increases the nutritional value of the fish while reducing environmental impact.
Researchers at Kiel University and Forschungszentrum Jülich have predicted that skyrmions can be produced for applications at room temperature with specifically adjusted magnetic layer structures. This enables the potential for high-density, energy-saving data storage and processing.
New Horizons team members used computer models to determine the depth and rate of Pluto's convective cells, which are 10-30 miles across and less than a million years old. These cells help support Pluto's atmosphere by refreshing its surface.
Researchers found dopamine signaling in the cerebral cortex predicts changes in brain network communication during working memory. This study may lead to better treatments for schizophrenia and other psychiatric disorders by optimizing dopamine signaling.
Research by Sebastian Vetter and colleagues found that personality traits of female wild boars impact their ability to raise offspring. Shy females, with more careful behavior and high maternal care, had greater success in rearing offspring in good mast years.
A study published in Journal of Traumatic Stress found that PTSD is a strong predictor of lower sexual satisfaction in both male and female veterans. In contrast, male veterans with PTSD had similar sexual activity rates as those without the condition.
Scientists at Aarhus University used X-rays to study eculizumab's mechanism. They found the antibody creates a physical barrier preventing C5 cleaving enzymes from forming contacts.
Research found that agriculture led to rapid male population expansion in Neolithic Time, with a 10- to 100-fold increase in population size. This growth occurred after the advent of agriculture, suggesting that it was a driving force behind the initial male population expansion.
Researchers used tadpoles to study sensory integration in the brain, finding that immature brains overreact to simultaneous stimuli. As brains mature, inhibitory neurons gain balance with excitatory neurons, allowing for more refined discrimination between simultaneous and non-simultaneous inputs.
A study by North Carolina State University researchers reveals that zebrafish bred for boldness display sleeker bodies and faster swimming abilities compared to those bred for shyness. The findings suggest a link between personality traits, body shape, and locomotion, challenging the idea of independent animal traits.
A new study by Ben-Gurion University of the Negev found that medical marijuana users report improved pain, nausea, anxiety, appetite, and mood, with only minor side effects. The study involved over 2,000 patients using medical marijuana for cancer and non-cancer treatment.
A $1.7 million NIH grant will help a Florida State University scientist uncover how cancer-causing viruses manipulate cell communication through exosomes. The research could lead to more effective and less harmful ways to treat diseases like cancer.
A novel algorithm reduces surface-level environmental impacts from shale gas development by more than a third, at a relatively small additional cost. The study, published in Conservation Biology, found that developers can avoid significant environmental disturbances by steering development away from habitats associated with rare species.
In a phase 3 study, Lutathera treatment results in improved progression-free survival and higher objective radiographic response rates compared to Octreotide LAR. The safety profile of Lutathera was also favorable with low-grade adverse events.
Research found that crows on a university campus carried high rates of Campylobacter jejuni, suggesting they could play a role in transmitting the bacteria to humans. The study tracked crow movements and behavior, revealing that their foraging habits often bring them into close proximity with livestock and humans.
A Korean research team developed a graphene-based transparent electrode structure, achieving high efficiency and flexibility in flexible OLEDs. The new device architecture maximizes the efficiency of graphene-based OLEDs by inducing a synergistic collaboration between high- and low-index layers.
Researchers have discovered a new protein compound that binds to two HER2 receptors simultaneously, preventing growth signals and killing cancer cells. This innovative solution shows great promise in treating invasive breast cancer more effectively.
Researchers found that anti-DNA antibodies preferentially bind to damaged double-stranded DNA (dsDNA) over native DNA, contributing to the pathogenesis of autoimmune diseases. This study provides mechanistic insight into the formation and properties of pathogenic anti-DNA antibodies.
Researchers at the University of Rochester Medical Center found that exercise can significantly reduce neuropathic symptoms in cancer patients undergoing chemotherapy. The study, which involved over 300 participants, showed that a six-week walking routine with gentle resistance-band training reduced pain and sensitivity to cold. Exerci...
Dr. Glen Weiss presents five innovative cancer studies at ASCO, including liquid biopsies for predicting treatment improvements and promising results with avelumab against recurrent-refractory ovarian cancer. Brigatinib shows substantial antitumor activity in ALK non-small cell lung cancer patients.
Researchers found that Zika virus infects about 20% of brain progenitor cells, which can become neurons, and continues to replicate for weeks without stimulating an immune response. The study provides insights into the severe neurological effects caused by Zika, such as microcephaly and impaired growth in infants.
A study published at the American Society of Clinical Oncology Annual Meeting found bacteria in women's ovaries and fallopian tubes. Women with ovarian cancer have distinct bacterial profiles, suggesting potential links to cancer development or progression.
A team of physicists and mathematicians has developed a statistical technique to simulate small-scale phenomena in computer simulations, allowing for more accurate predictions. The method, published in Physical Review Letters, can capture the influence of cloud formation and reduce uncertainty in climate models.
Research found that early institutional care was associated with lower DNA methylation at specific stress-related genes. This epigenetic modification can have long-lasting impacts on biological and behavioral processes.
A new study finds that delivering genetic test results to patients at risk for cancer-causing mutations over the phone reduces costs and access burdens. Patients who received phone counseling reported fewer barriers to accessing genetic counseling services than those who received in-person counseling.
Scientists at The Institute of Cancer Research have developed a new method to assess cancer treatment efficacy by measuring blood metabolite levels. This approach has the potential to speed up the development of targeted drugs and tailor treatment for patients, offering a quick and simple way to monitor cancer therapy.
Researchers found that both dose and infusion regimen are crucial to maximize response and safety for CAR T cells. Optimal doses and regimens showed high complete remission rates, with no treatment-related deaths in some cases.
Researchers at Kyoto University have identified a genetic mechanism that could predict effectiveness of cure for certain cancers. Genetic alterations affecting the PD-L1 protein allow cancer cells to escape immune detection, but these abnormalities were found in many common cancer types.
A new study presented at the European Obesity Summit found that a procedure-free gastric balloon, called Elipse, is safe and leads to similar weight loss as other balloon procedures. The device, swallowed and excreted over 4 months, resulted in significant weight loss, improvements in blood sugar control, and quality of life.
Researchers develop hydrogel-based platform to mimic human vocal fold tissue, enabling study of development and disease. The model will facilitate testing of new treatment options for voice disorders, a common condition affecting millions of Americans.
Researchers at the University of Sussex found that a circuit comprising just two neurons in a snail's brain drives complex decision making. The system enables energy-efficient behavior by reducing brain activity when food is not found.
Researchers found that patients who used metformin before diagnosis had a higher risk of death, while those who started using it after diagnosis were more likely to survive. Metformin also showed promise as a treatment for endometrial hyperplasia, with 56% of patients responding to treatment.
HTLV-1, a retrovirus that co-exists with humans, infects 30 million people worldwide. Persistent infection is attributed to CTCF, which controls viral DNA integration into human DNA. This discovery may lead to new prevention and treatment strategies for refractory leukemia.