Studies reveal that up to 31 percent of people with ICDs receive shocks in their last day of life due to lack of deactivation. Researchers stress the importance of informing patients about the benefits of deactivating ICDs when death is near, highlighting communication gaps and cultural challenges around end-of-life planning.
A new drug, Arimoclomol, has shown promise against muscle wasting disease inclusion body myositis (IBM) by reversing key symptoms in mice and improving muscle strength. A patient safety trial also found the drug to be safe and well-tolerated.
A recent survey found that nearly three-quarters of women have one or more heart disease risk factors, yet only 16% were informed by their doctors about these risks. The study highlights the need for physicians to adopt prevention guidelines and focus on monitoring blood pressure and cholesterol levels.
Researchers have made a major breakthrough in understanding how cells find the right DNA to copy, revealing the role of TFIID and its ability to recognize different sequences for different genes. This finding paves the way for understanding and treating various malignancies.
A recent survey by the American College of Cardiology found that women are underrepresented in adult cardiology, comprising less than 20% of cardiologists who see adult patients. Women also face challenges related to child care and family leave policies, with more likely to report needing additional child care during nights and on-call...
Research by Minjung Koo and Ayelet Fishbach found that giving something personal, such as blood or a signature, increases people's self-perception of generosity and commitment. This change in self-perception leads to increased likelihood of future donations.
Researchers at University of Oregon developed a line of transgenic mice expressing green fluorescent protein to visualize neural activity. The technique allows for real-time imaging of brain-wide activity across cortex, enabling studies of sensory processing, cognition, and brain development.
A University of Houston study suggests that traditional internship lengths of one semester are insufficient for experiential learners, who require structured support and time to navigate the challenges of a professional workplace.
Research suggests that men who prioritize traditional masculine values, such as toughness and self-reliance, are less likely to be honest with their doctors about symptoms. This can lead to delayed diagnosis and poorer health outcomes compared to women or men with less traditional views of masculinity.
Researchers have identified a link between adult-onset diabetes and certain cancers, highlighting the role of bromodomain (BRD) proteins. The study suggests that targeting BET proteins may be beneficial for both conditions.
Women experiencing suspected heart disease exhibit similar classic symptoms to men, including chest pain and shortness of breath, but differ in diagnosis and risk assessment. The study found that women have more risk factors for heart disease than men, yet are often assessed as lower risk.
Researchers at King's College London found that brain stimulation reduced core symptoms of anorexia, including the urge to restrict food intake and feelings of fat. Participants who received real transcranial magnetic stimulation (rTMS) showed more prudent decision-making by waiting for larger rewards.
Researchers at Ohio State University have found that deleting microRNA-155 in female mice prevents weight gain on a high-fat diet. The study shows a 56% reduction in obesity and a 74% reduction in fat accumulation.
A new study has identified a significant link between intermittent explosive disorder and exposure to the common toxoplasma gondii parasite. Individuals with IED were found to be twice as likely to have been exposed to toxoplasmosis, which is typically carried by undercooked meat or cat feces.
A recent NUS study found that international trade causes significant economic losses in tropical countries, with annual losses totaling US$1.7 trillion. The researchers suggest implementing measures such as an ecosystem services tax or price premiums for environmentally friendly agricultural produce to reduce deforestation and environm...
A study found high-intensity 'sprint' training causes muscle tissue stress, weakened antioxidant defenses, and reduced mitochondrial function in untrained individuals.
A UBC study found that high-speed and inexperience are top contributing factors to injuries on the Whistler sliding track. The study also revealed that more experienced sliders had lower injury risks, with those logging over 150 runs showing reduced risk.
The NYU Steinhardt School of Culture, Education, and Human Development study found that New York City retailers' decisions to sell organic food are linked to neighborhood demographics and store size. Approximately 60% of stores sold no organic foods, while about a third offered one or less than half of the available products.
A new study found that prolonged daily sitting is responsible for 3.8% of all-cause mortality deaths, with reducing sitting time estimated to increase life expectancy by 0.2 years. The study analyzed data from 54 countries and found that sitting had a higher impact on mortality rates in certain regions.
A new study by Ohio State University researchers suggests that the distance between coworkers in terms of status is more important than their relative positions when it comes to helping each other. This finding challenges traditional assumptions about how status affects workplace relationships.
Researchers at Aalto University found that acoustic concert halls play a significant role in the emotional impact of music. Identically selected performances of classical orchestra music evoked stronger emotional responses when presented in acoustics of Vienna Musikverein or Berlin Konzerthaus, shoebox-type concert halls.
Researchers discovered a new genetic cause of CMT1, a type of inherited neuropathy, linked to mutations in the peripheral myelin protein 2 gene (PMP2). The study found that 49 mutations in PMP2 could be responsible for the disease, leading to weakness and numbness in hands and feet.
A study using transcranial magnetic stimulation found that temporarily inhibiting a specific brain region can alter the way people look at others. This technique offers new therapeutic possibilities for individuals with autism who often struggle to maintain eye contact.
A Dartmouth-led study found that stream insects consumed by spiders transfer methylmercury to terrestrial predators, highlighting the importance of dissolved organic carbon in mediating mercury bioavailability. The research reveals a broader reach of mercury contamination than previously recognized.
Scientists at Scripps Research Institute (TSRI) have developed a 19-step process for synthesizing phorbol and its derivatives, providing access to powerful compounds for the development of new therapies. The method enables pharmaceutical researchers to make tiglianes in the laboratory, which are known for their biological activity and ...
A study by Northwestern University found that higher oxytocin levels during pregnancy can predict the severity of postpartum depression symptoms. The research suggests that screening for depression biomarkers in pregnancy could lead to preventive treatment, reducing the likelihood of women seeking help and accepting treatment.
Scientists have detected internal movements in LOV photoreceptors using neutron spectroscopy, which can control biological processes with light. The study highlights the potential of neutron scattering experiments for analyzing cellular processes and provides unique insights into protein functionality.
The Sterile Box, a mobile container, sterilizes surgical instruments to minimize risk of infections in patients. The system's performance was nearly perfect in trials, and it addresses issues with unreliable power and inadequate quality control in developing countries.
A new study found that treating withdrawal symptoms can help cannabis users quit, with 85% of participants relapsing within 16 days. The study also showed that people who experienced withdrawal symptoms had difficulty staying abstinent, highlighting the need for immediate treatment.
Researchers have developed a new framework to understand the evolution of sun-like stars, which can help determine their age with more precision. The model predicts that younger stars will vary significantly in x-ray emission intensity, but convergence occurs after a certain age, making them more predictable.
A new study reveals that bacteria in biofilm form are stronger than single-celled bacteria and outcompete them for nourishment. This challenges the traditional view of bacterial infections and highlights the importance of treating biofilms as a distinct entity.
Saint Louis University researcher Fran Sverdrup is developing a treatment for Facioscapulohumeral Muscular Dystrophy (FSHD), a disease that causes muscle degeneration in 15,000 or more people. Ultragenyx will fund the process of turning SLU's initial discoveries into a drug that could demonstrate proof of concept.
Researchers from the University of Surrey developed a breeding strategy to reduce the risk of Chiari malformation in toy dogs. By cross-breeding Brussels Griffons with Australian Terriers, they created puppies with reduced symptoms of the debilitating condition, which affects 1 in 1280 humans.
Researchers found that vitamin C intake was associated with clearer lenses and a reduced risk of cataract progression. The study suggests that increasing fruit and vegetable consumption through a healthy diet may help protect against cataracts, particularly in older adults.
A new study at Rockefeller University uses magnetic forces to control neurons in mice, finding the brain plays a vital role in glucose metabolism. By targeting specific cells, researchers can activate or inhibit neural activity, offering potential therapeutic applications for metabolic and neurologic diseases.
Researchers discovered that prooxidants can repair a metabolic flaw in T cells that drive rheumatoid arthritis. Treating arthritic mice with ROS-inducing drugs restored the T cells' redox balance and reduced joint inflammation.
A meta-analysis of middle- and high school intervention programs found that while programs increased knowledge and changed student attitudes, they did not reduce dating violence. Small reductions in victimization were observed but not sustained over time.
Researchers used high-definition video cameras to track strangers forming groups in a covered stadium. They found individuals joined groups with similar physical traits, including levels of attractiveness, and attractive women were more likely to be in the center of social groups.
The Community College Innovation Challenge has named 10 finalists for its second annual competition, which aims to develop crucial innovation skills among students. The projects focus on sustainable water resources, renewable energy, and food waste reduction, with the potential to contribute to a more sustainable future.
By regulating protein complexes in blood vessel walls, researchers have identified a method to suppress leakage and edema formation. This discovery may lead to improved cancer therapy by allowing drugs to reach tumors more effectively and reducing metastatic spread.
A randomized controlled trial found that education support, gender rights awareness, and livelihoods skills training significantly reduced child marriage rates. Girls participating in the program were also more likely to attend school and earn an income.
Regular recreational football training significantly improves health profiles in 63-75 year old untrained men, reducing body weight and risk of cardiovascular diseases and diabetes. The study also found that football preserves muscle mass, which is essential for maintaining a physically active lifestyle in older adults.
Researchers at Purdue University have found that the fungus Moniliophthora roreri reproduces clonally rather than sexually, producing billions of spores that destroy cocoa pods. This discovery could help improve cacao breeding programs and develop resistant cultivars.
Daniel Deocampo, Georgia State University's chair of Geosciences, is part of the White House Water Summit to discuss sustainable water use and workforce development. The summit aims to create new jobs and economic growth through innovative technologies, with a focus on indirect potable-water reuse.
A study found that a drug combination of sulindac and erlotinib effectively reduced duodenal polyp burden and number in familial adenomatous polyposis patients. However, the treatment was associated with acne-like rash and other adverse events.
Research by University of Exeter found that providing early life perches to young pheasants can improve their survival rates and fitness. This is because raised perches help develop essential survival characteristics such as stronger legs, better spatial awareness, and memory. As a result, more pheasants are likely to thrive in the wild.
Researchers have identified 11 molecules capable of binding to the PSMA biomarker, making them potential treatments for prostate cancer. These ligands are suitable for synthesizing and have good pharmacokinetic parameters, increasing their effectiveness in clinical trials.
The study reveals that Plasmodium falciparum, the deadliest malaria parasite, has a limited genetic diversity compared to its chimpanzee and gorilla cousins. The team found an expansion of a multi-gene family in Laverania parasites that helps them evade host immune cells and clear the spleen, contributing to severe malaria pathology.
Researchers have developed a nickel-carbon-based catalyst that replaces platinum in producing hydrogen from water, offering a cheaper alternative for renewable energy technologies. The new catalyst exhibits highly efficient hydrogen evolution performance and impressive durability.
A study published in The BMJ found that adherence to Japanese dietary guidelines is associated with a lower risk of death. Balanced consumption of grains, vegetables, fruits, fish, and meat contributes to longevity in the Japanese population.
Researchers will analyze data from DECAMP consortium to advance targeted therapeutics for COPD and lung cancer using molecular biomarkers. The goal is to screen people at risk, predict disease progression, and intercept disease.
Researchers discovered an individual motor signature, a blueprint of subtle differences in movement, which can indicate personality traits. The study shows people with similar movements tend to coordinate better during interactions.
Researchers have created tiny particles that can be precisely controlled by magnetic fields and generate electric fields, revolutionizing medicine and regenerative therapy. These 'Janus' particles can target cancer cells with precision and efficiency, eliminating side effects.
A new University of Michigan-led study concludes that meeting the goal of reducing levels of algae-promoting phosphorus in Lake Erie by 40 percent will require widespread use of strong fertilizer-management practices, significant conversion of cropland to grassland and targeted conservation efforts.
Researchers at Empa combined direct measurements with a transport model to validate statistics on greenhouse gas emissions in Switzerland. The study confirms estimated annual emission of approximately 200,000 tonnes of methane, with livestock farming contributing 70% of emissions.
The frog foam has been shown to release model dyes and prevent in vitro growth of Staphylococcus aureus for extended periods, indicating its potential as a non-toxic antibiotic delivery system.
A Michigan State University study found that protesters in Ferguson believed police perceive black people as suspects before considering them as civilians. The research aimed to investigate racial typification and its impact on police-community relations.
A Finnish study found that vegans often follow an unbalanced diet, leading to deficiencies in vitamin B12, D, selenium, iodine, and essential fatty acids. Vegans tend to use recommended supplements, such as calcium-fortified drinks and vitamin D supplements, but may need closer monitoring of their nutrient intake.
A new study compared over 611 trials to find the most effective methods for inducing labor. Oxytocin, artificial rupture of membranes, and vaginally administered misoprostol were found to be more successful in achieving vaginal delivery within 24 hours.
Competition among malaria parasite strains in human hosts can influence the spread of drug resistance, according to a new study. The research found that when hosts are co-infected with drug-resistant and drug-sensitive strains, both strains are competitively suppressed, potentially leading to the emergence of resistant strains.