A study published in Neurobiology of Disease found that neurons with a defective DJ1 gene experience oxidative stress and immune response imbalances due to disrupted glutamine and serine metabolism. This knowledge could lead to novel therapeutic strategies by targeting affected metabolic pathways.
A study evaluated organic trailing blackberry production practices, recommending weed mat management to increase production and profits. Soil pH, organic matter content, and macronutrient concentrations were affected mainly by year and weed management strategy.
Researchers have found that adding carbon nanotubes to aluminum can slow down the breakdown process caused by radiation exposure, allowing it to last longer. The new material has been shown to retain its strength and resilience even after prolonged irradiation, with reduced embrittlement and pores.
Researchers at Cedars-Sinai Medical Center have made a breakthrough in treating heart failure with preserved ejection fraction, a difficult-to-treat condition affecting millions. Cardiosphere-derived cells (CDCs) infused into laboratory rats reversed the condition, improving heart function and filling capacity.
The STARS4ALL project aims to reduce light pollution in European night landscapes, promoting environmental protection and economic savings. The initiative includes 10 projects, such as broadcasting astronomical events, creating a logo for sustainable lighting, and involving citizens in change-making movements.
Researchers at The Ottawa Hospital and University of Ottawa identified a compound called GSK-J4 that can kill a severe form of childhood leukemia. By targeting the TAL-1 gene, the compound stops cancer cell growth, showing promise for personalized treatment.
Researchers at Oak Ridge National Laboratory are developing experimental pretreatments to improve the cost-effectiveness of biofuel production. A new app, FuelEconomy.gov, helps consumers make informed buying decisions and save fuel. Meanwhile, a heat pump technology developed by ORNL can reduce energy consumption in cold climates by u...
The Ambulatory Diagnostic and Treatment Center (ADTC) Outpatient Clinic at Boston University School of Medicine emphasizes education alongside patient care, offering complex diagnoses and literature review opportunities. This model aims to reduce costs and readmissions by concentrating health care efforts on unstable patients.
Researchers have solved the first three-dimensional structure of a deoxyribozyme, a flexible DNA molecule that can act as an enzyme. This breakthrough challenges the long-held perception of DNA's stiffness and has significant implications for understanding molecular reactions and potential applications in medicine.
A study by researchers at Bradley Hasbro Children's Research Center confirms that a brief educational program can effectively curb dating violence among teens. The Katie Brown Educational Program's five-session curriculum showed significant changes in students' attitudes, behaviors, and knowledge about relationships.
Researchers at WashU Medicine used whole brain scans to discover that different groups of neurons become active at different times of day, despite being on the same molecular clock. This reveals a new mechanism for encoding daily rhythms in neural signaling.
A University of Delaware professor studied how permafrost thawing impacts vegetation and the carbon cycle in Alaska's North Slope. The study found that increased snow accumulation leads to warmer soils, greater methane emissions, and changes in plant species.
Researchers linked high C-Reactive Protein levels to increased ischemic stroke risk, identifying gene variations that drive these risks. A new discovery may allow doctors to predict patients' risk of having a second stroke using a commonly performed blood test and their genetic profile.
Researchers used low-frequency Raman spectroscopy to decipher stacking patterns in 2D materials, revealing unique effects of vibrations between layers. The study provides a platform for engineering materials with optical and electronic properties strongly dependent on stacking configurations.
Researchers found that pregnant rats fed antioxidants had longer telomeres and slower aging in adulthood, while those with low oxygen levels aged more quickly. Antioxidants also benefited offspring of mothers without complications during pregnancy.
Researchers developed a novel brain tumor model in mice with DNA damage-repair problems, which can help test new treatments for children's brain cancer. The model shows that treating tumors with DNA-damaging drugs can shrink them more effectively and improve survival.
A study found that an instant blood pressure app underestimated higher BPs and overestimated lower BPs, raising concerns about its accuracy. The app's inaccuracy may lead to false reassurance for individuals with hypertensive BP levels.
Scientists have developed a method to transform CO2 from smokestack emissions into high-value materials for lithium and sodium batteries. The process produces carbon nanotubes with stable performance, offering a potential solution for reducing environmental impact of current power plants.
Researchers at Kyushu University developed a modification to increase the lifetime of organic light-emitting diodes (OLEDs) by nearly 8 times, making them more suitable for practical applications. The modification involves adding thin layers of a lithium-containing molecule, reducing degradation and increasing efficiency.
A study has identified three key risk factors that predict violent behavior in adults with mental illness, including past victimization and substance use. These findings can help mental health professionals intervene and create safer communities for individuals with mental illnesses.
The university is leading an independent study on the association between changes in Flint's water system and public health issues, including a recent Legionnaires' disease outbreak. Researchers will conduct enhanced surveillance and engage with the community to investigate potential connections.
Goddard's Network Integration Center coordinates communications for Near Earth and Space Networks, ensuring reliable data transmission from space to ground. The center has been operational since Project Mercury and supports human spaceflight missions, including those in low-Earth orbit and beyond.
A new study found that vitamin D supplementation during pregnancy can increase bone mass in babies born during the winter months, potentially leading to stronger bones and a reduced risk of osteoporosis. The supplement showed no difference in overall bone mass but had a positive impact on children born during the colder months.
A multinational trial found that injecting a new long-acting insulin with another drug, IDegLira, improved glucose control in Type 2 diabetes patients. Participants on the combination product lost weight and experienced fewer episodes of hypoglycemia compared to those receiving basal insulin alone.
A study found that degludec/liraglutide was associated with greater HbA1c level reduction, weight loss, and lower hypoglycemia rates compared to glargine. The medication also had more nonserious gastrointestinal adverse events.
A large twin study found no significant association between major surgery and general anesthesia with long-term cognitive decline in older patients. Preoperative cognitive levels and underlying diseases are more important for cognitive functioning in aging patients following surgery.
A study involving skydiving participants found that acute stress can cause molecular alterations in the immune response, leading to increased risk of stress-related conditions. The researchers identified specific genes and pathways involved in both innate and adaptive immune responses that were dysregulated after the jump.
Researchers have developed a new way to controllably manipulate biomolecules like DNA using acoustic force spectroscopy. The technique stretches molecules by applying varying forces in a precise way, shedding light on chemical bonding and mechanical properties.
A new study published in American Anthropologist reveals the transformation of Egyptian and Nubian culture through cultural entanglement. The researchers found that individual choices played a significant role in shaping the development of the Nubian state, allowing it to eventually conquer Egypt.
Direct-to-consumer genetic testing raises concerns about physicians' preparedness to discuss test results and potential downstream effects on the healthcare system. A study found that only a minority of consumers share their results with their doctor, often due to physician's inability to answer questions and address patient concerns.
Paul Lee examines the USPSTF's latest report on vision screening for asymptomatic older adults. The study highlights strengths and challenges in the current recommendation process, emphasizing the need for more rigorous clinical trials to inform treatment decisions.
A new bird species, Chongmingia zhengi, discovered in China's Early Cretaceous Jehol Biota, sheds light on the early evolution of birds. The species is basal to dominant Mesozoic avian clades and represents a new avialan lineage.
The study proposes a multi-criteria decision aid framework to assess water storage systems, prioritizing farmers as key stakeholders. Outranking assessment is suggested to facilitate systematic planning and inclusion of various criteria, ensuring more effective water storage investments in Sub-Sahara Africa.
A recent phase II clinical trial found that prucalopride significantly reduces the duration of intestinal paralysis after abdominal surgery. In the study, patients taking prucalopride experienced a reduced risk of prolonged ileus compared to those receiving a placebo.
Researchers at NREL have improved the maximum voltage available from CdTe solar cells, breaking the 1V barrier and enabling more efficient electricity generation. The innovation could significantly reduce manufacturing costs and make solar energy more cost-competitive with traditional energy sources.
Researchers found a promising adjuvant, chitosan, induces immune response through a DNA-sensing pathway in cells. This discovery provides a roadmap for developing vaccines that trigger 'cell-mediated immunity',
Researchers at Ohio State University found that sustained stress impairs memory and cognitive function in mice, with inflammation caused by the immune system being a key factor. The study suggests potential targets for pharmacological or behavioral treatment to interrupt inflammation and improve memory.
A new study found that El Niño events transport waterborne diseases like cholera thousands of miles across oceans. The research suggests links between organisms causing illnesses in Asia and those emerging in Latin America.
A new study using MRI found that adult earthquake survivors with post-traumatic stress disorder (PTSD) had greater cortical thickness in certain brain regions and reduced volume in others compared to healthy survivors. Cortical thickness was positively correlated with PTSD severity, particularly in the left precuneus region.
The Zika Response Working Group provides recommendations for countermeasures against the Zika virus, highlighting the need for open-minded responses and collaboration. Key findings include the potential of currently marketed drugs to have anti-Zika activity and the challenges of rapid vaccine development.
A new biomarker, PRAME mRNA, has been identified as a key indicator of high-risk uveal melanoma patients who are more likely to develop metastasis. This discovery may lead to the development of precision medicines for melanoma patients.
A new study finds that climate change is becoming noticeable at mid-latitudes, especially in summer, with extreme events more frequent due to rising temperatures. The researchers argue that a carbon fee is needed to spur the transition to clean energy and reduce fossil fuel emissions.
Researchers at UC Riverside have found a more environmentally friendly way to control the spread of Argentine ants by adding their pheromone to bait. The pheromone-infused gel bait reduced ant activity by 74%, compared to 42% with traditional baits, and is an inexpensive modification to existing products.
A new study developed a unique formula to predict the potential for cognitive deficits in former professional football players. The formula combines concussion severity, frequency, game-related data, and mental abilities, revealing that a strong cognitive reserve is the most important factor.
Researchers have developed a new method to acquire three-dimensional atlases of tissue that provide much more information, incorporating data on tissue structure and molecular profile. The new technique enables doctors or researchers to peer into the tissue and identify specific proteins within cells throughout the whole tissue.
A new study by NYU Tandon School of Engineering found that Craigslist identifies less than half of scam rental listings, with suspicious postings lingering for up to 20 hours. The researchers mapped the listings into seven distinct scam categories, most involving credit card payments.
Researchers found that TXA reduced the need for a blood transfusion by more than 50% in hip and knee replacement surgery. Topical versus intravenous administration of TXA showed similar effectiveness in reducing blood loss and transfusion rates.
A Kansas State University engineer has received a $300,000 NSF Manufacturing Machines and Equipment grant to improve the manufacturing of ultra-thin precision parts for high-performance products. The new process will enable efficient machining of brittle materials without compromising part quality.
Researchers identified complex brain connectivity patterns in individuals with chronic TBI, explaining long-term higher-order cognitive function deficits. Interactions among networks are critical for daily life tasks like planning and problem-solving.
Scientists have found that a social amoeba uses both phagocytosis and DNA nets to defend against bacteria, similar to the human immune system. This discovery could lead to new treatments for chronic granulomatous disease and other immune disorders.
Researchers found that genetics play a major role in the bilateral parietal lobes and left temporal lobe, while environment dominates other brain regions. This study provides insights into how nature and environment interact to shape our brains, potentially informing the development of neurological and psychiatric disorders.
A new study assesses genome-sequencing technologies and finds medically significant regions prone to systematic errors. The researchers call for methods to benchmark performance in all sequenced regions, essential for accurate diagnosis and prevention of false positives and negatives.
Researchers discovered that common drugs for psychosis and depression can prevent certain viruses from infecting cells by blocking potassium ion channels. This breakthrough finding has potential to stop deadly viruses from spreading and causing human disease.
A University of Michigan team proposes customer loyalty programs in healthcare to enhance both health and financial benefits. They suggest perks for patients based on how long they've stayed with the same doctors or received care from network sites.
A study from the University of Otago suggests that low levels of chlorpyrifos in bees can lead to severe learning and memory deficits. Researchers found that even 'safe' doses of the pesticide affect odour-learning abilities and recall, potentially threatening bee survival.
A study published in JAMA found that severe anemia is associated with a significantly increased risk of necrotizing enterocolitis (NEC) in premature infants. The researchers discovered this link after analyzing data from over 600 VLBW infants enrolled in the study.
Current gene sequencing methods struggle to decipher medically important genes in troublesome genome regions, leading to false positives and false negatives. Researchers call for more accurate sequencing to optimize medical care and prevent unnecessary surgeries.
Whitehead Institute researchers develop hydrogel scaffolds that support human mammary tissue growth from patient-derived cells, providing insights into normal breast development and cancer progression. The scaffold responds to hormones and allows for the study of gene perturbations.
A study of 15,863 people found that nighttime light exposure was significantly associated with sleep duration and disturbances. People living in urban areas with intense street lights were six percent more likely to sleep less than six hours per night.
A clinical study from Mayo Clinic found whole-exome sequencing to be a viable diagnostic approach for identifying rare genetic conditions, resolving diagnostic odysseys and improving patient management. The study reported a success rate of 29%, twice that of conventional genetic evaluations, with insurance coverage existing for the test.