Researchers have found the lock for a cellular 'trap door' that could lead to more efficient and less harmful delivery of proteins into cells. This breakthrough has potential applications in treating diseases such as HIV, cancer, and regenerative medicine.
A new study found that online information about pancreatic cancer is often written at a reading level beyond the sixth grade, making it inaccessible to the general population. The research highlights the need for accurate and understandable health information to empower patients in making informed decisions about their care.
Researchers at the University of Missouri have developed a gene replacement therapy to treat and control Spinal Muscular Atrophy with Respiratory Distress Type 1 (SMARD1). The therapy, administered in a single dose, has shown significant improvements in muscle strength, protein expression, and life span in SMARD1 mice. This study provi...
A recent Temple University Health System study analyzed over 600 reports and studies on elastic compression stockings, finding no significant reduction in post-thrombotic syndrome development. The results highlight the need for new and more effective therapies for this condition.
Researchers found that pre-treatment with an Alk5 inhibitor enhances the delivery of ferumoxytol to tumors, allowing for improved imaging. The study demonstrates potential for Alk5 inhibitors to improve tumor imaging and diagnosis of solid tumors.
The Gruber Foundation Cosmology Prize recognizes the first observation of gravitational waves by the LIGO team, confirming a key prediction of Einstein's theory of general relativity. This achievement opens up new means of studying the universe and provides direct evidence for the existence of black holes.
Researchers at UC Berkeley discover that antibodies in mother's milk help promote a healthy balance between gut microbes and the mammalian host, preventing chronic inflammatory conditions. The study sheds light on how these antibodies interact with the newborn's immune system to establish lifelong immune responses.
Physicians urge sweeping single-payer reform with publicly financed system, citing high administrative costs and profits in private insurance. The proposal aims to save $500 billion annually by eliminating overhead and profits.
Researchers found a direct correlation between increased life expectancy and the rise in type 1 diabetes cases globally. The study suggests that advances in medical care have reduced natural selection, allowing the underlying genetics of the disease to be passed from one generation to the next.
A team of researchers developed a CRISPR-based technique to rapidly identify gene variants, improving efforts to map genes and determine their function. The method induces mitotic recombination, allowing for detailed mapping of trait variants, as demonstrated by identifying a genetic mutation affecting yeast sensitivity to manganese.
Research suggests that climate change and resulting water shortages are linked to an increase in chronic kidney disease caused by dehydration and heat stress. The study found that rural hot communities are disproportionately affected, with risks increasing for cognitive dysfunction, malnutrition, and other conditions.
Researchers developed a rapid diagnostic method for Niemann-Pick disease type C using bile acid measurement in biological fluids. Early diagnosis is critical to limit neurological damage and treatment should be initiated promptly.
A recent study by Oregon State University researchers found an unprecedented abundance of juvenile sea star offspring along the Oregon coast, but warns that a second wave of the deadly 'sea star wasting disease' could be disastrous. The disease nearly wiped out the population in 2014 and its impact on the ecosystem is still unknown.
A research team from Northwestern University and Lund University has identified a sensory system in fruit flies that directly detects air humidity, allowing them to adapt to changing environments. Understanding this ability could lead to new tools for mosquito control and inform the prediction of species distribution under global warming.
A study from Kings College London and Oxford University found that training in concrete processing can reduce PTSD symptoms by altering the way people think about traumatic memories. Concrete processing involves focusing on how a situation is unfolding, whereas abstract processing involves analyzing why something is happening.
A study published in PLOS Neglected Tropical Diseases describes a suitable small animal model for testing ZIKV interventions. The A129 mouse model accumulates virus in the brain and other tissues, exhibiting symptoms similar to those in humans.
Researchers use ALMA's high-resolution data to map the rotation of cold molecular gas and dust orbiting a giant elliptical galaxy, determining the massive supermassive black hole at its center has a mass 660 million times greater than the Sun. The precise measurement is among the most accurate for a galaxy's central black hole.
A University at Buffalo study found that a smartphone app for monitoring heart palpitations provides comparable performance to traditional 14-day event monitors. The AliveCor app was found to be significantly easier to use and more acceptable to patients, with 94% compliance rate compared to 58% for the event monitor.
A review of over 1.5 million people found that daily meat consumption, especially red and processed meat, increases all-cause mortality. The study recommends limiting animal products and consuming more plants to promote preventive care.
Researchers discovered that intestinal worm infections trigger a significant increase in lymph node size and B-cell production, leading to enhanced antibody response. The study provides new insights into the complex interactions between the host and parasites.
Research at Gladstone Institutes found that the apoE4 protein disrupts brain activity in mice, impairing memory replay and consolidation. The study suggests that disrupted slow gamma activity during ripples is a major consequence of apoE4 expression, likely leading to impaired memory loss.
Researchers discovered a key mechanism driving a bacterium that kills male insects, which could be exploited to control pest species. The study found that the bacteria targets the dosage compensation complex, leading to genome-wide misregulation of gene expression.
A new study published in Cell Reports identifies microRNA molecule miR551b as a promising candidate biomarker and therapeutic target for treating ovarian cancers. The research found that targeting miR551b expression could block STAT3 activity, offering potential for treating the most common and deadly form of ovarian cancer.
Researchers found that 5-year survival for older lung cancer patients is favorable, with median survival at 6.7 years, and long-term patient outcomes including reduced hospital readmission rates and reinterventions.
Researchers at CSU have made a groundbreaking discovery by imaging RNA translation in real time, shedding light on the fundamental cellular process. They observed proteins forming and maturing at a rate of 10 amino acids per second, and found polysomes to be globular rather than elongated.
Researchers at the University of Nottingham are using synthetic biology and microorganisms to ferment methane gas into valuable nutritional supplements. The project, called PUFA, has the potential to provide an alternative source of Omega 3 fatty acids that are both sustainable and economical.
Researchers identified a vital supply route for cancer cells to obtain nutrients, blocking this pathway led to significant tumor growth reduction. The discovery offers new hope for developing targeted treatments with fewer side effects.
Researchers found that hospice services don't lead to higher care costs for long-stay nursing home residents, despite concerns about cost shifting. Instead, avoidance of costly hospitalization and post-acute care offsets hospice costs.
The study found that fisheries management types, distance to fish markets, and water temperatures are crucial in predicting fish biomass levels. It also suggests a recovery time of 8.1 years for individual reef systems to reach a critical level of 1,150 kilograms of fish biomass per hectare.
A portable artificial vision device improved daily living tasks for 12 legally blind participants, who performed better when using the device than with their best-corrected visual acuity alone. The device recognizes text, faces, and objects, providing an effective low-vision aid despite technical limitations.
A Dartmouth-Princeton study found that people can intentionally forget past experiences by altering the context of those memories. Participants who were told to forget random words showed a 'flushing out' of scene-related activity from their brains, while remembering led to increased recall.
A new NASA analysis of satellite data suggests that the expansion of the tropics is causing high altitude clouds to shift towards the poles. This shift affects Earth's climate by altering the amount of sunlight reaching the surface.
A new antibody, CSL362, specifically targets and depletes plasmacytoid dendritic cells and basophils involved in systemic lupus erythematosus (SLE). This depletion reduces production of type 1 IFN and prevents expansion of antibody-producing cells, showing promise as a potential therapeutic target for SLE treatment.
Researchers found that increased insulin signaling reduces atherosclerosis development and improves aorta function in atherosclerosis-prone mice. The anti-atherogenic effects were linked to induction of nitric oxide and activation of downstream pathways, including endothelin receptor B (EDNRB).
Researchers found that large storms move about 50% more sediment than typical rainfall, but the overall contribution to erosion is smaller. River channels adjust their size to accommodate flow, setting a speed limit on erosion.
A new staging system aims to explain revision rhinoplasty complexity and manage patient expectations. The PGS Staging System assesses three components: problem, graft, and previous surgical procedures, as well as a 'patient expectations' component.
A study compared four PD-L1 IHC diagnostic assays in lung cancer, demonstrating similarities and differences. The findings support the use of each assay according to its specific indication, recommending utilization for distinct scoring algorithms.
Researchers have built a computer model that mimics bees' ability to detect motion and navigate complex environments. The model uses optic flow to control flight and avoid obstacles, paving the way for more efficient autonomous flying robots.
Researchers at Rice University have successfully absorbed 35-37% of incident light in atomically thin MoS2, paving the way for efficient and inexpensive photovoltaic solar panels. The team's findings enhance light absorption by 5.9 times compared to using MoS2 on a sapphire substrate.
A study in GENETICS identifies the first gene associated with temperature-dependent sex determination in reptiles, highlighting the role of genetic variation and climate change. The research found that a specific DNA sequence variation at the CIRBP gene influences sex ratio in snapping turtles.
A new UVM study examines the trade-offs between IVF financial savings and medical complications from multiple embryo transfers. The research found increased rates of cesarean-section deliveries, premature births, and low birth weight with two or more embryos transferred into the mother at one time.
Researchers found that increasing blood flow to the legs through revascularization procedures halted scarring progression and allowed patients to walk longer. However, neither exercise nor revascularization reversed scarring in muscles already damaged by PAD.
Researchers found that moderate floods have a significant impact on river shaping, increasing erosion rates. However, extreme floods have limited additional effect on channel geometry, suggesting that landscapes can stabilize over long-term climate shifts.
The primary threat to vultures is the presence of toxins in carrion they consume, leading to declines or extinctions of most vulture species worldwide. In their absence, other scavengers proliferate, causing a cascading effect on food webs and human populations.
Researchers from NIST and Georgetown University have deciphered the mechanisms behind 'oobleck''s switch between liquid and solid states. They found that shear-thickening fluids are driven primarily by frictional contacts, with hydrodynamic forces playing a supporting role at lower concentrations.
A recent review article synthesizes theoretical and empirical work on sex differences in sport involvement, finding females' underrepresentation reflects their lesser sports interest. The authors propose adaptive hypotheses for sports, including the importance of social skills and courtship displays.
A study found that vaccination under the influence of estradiol enhances protection against genital herpes by shifting the immune response in the vaginal mucosa toward a more effective antiviral one. Estradiol accelerates and increases the response of T helper cells, promoting inflammation.
A team of astronomers used ALMA to measure the speed of carbon monoxide gas orbiting a supermassive black hole, calculating its mass as 660 million times greater than our Sun. This precise measurement is crucial for understanding these cosmic behemoths and their role in galaxy evolution.
Researchers at the Boyce Thompson Institute discovered that potato plants boost chemical defenses in their leaves when Guatemalan tuber moth larvae feed on their tubers. This response protects against leaf-eating pests like beet armyworms, allowing plants to maintain sugar production and grow more tubers. The study may help reduce pota...
A new study from Queen Mary University of London found that historic UK landfills in England and Wales contain high levels of contaminants that could harm marine life if eroded or flooded. The analysis of two landfill sites in Essex revealed pollutants at concentrations exceeding marine sediment quality guidelines, posing a significant...
A new study of over 10,000 patients with atrial fibrillation (AF) and those without found that AF patients treated with warfarin had higher rates of dementia, Alzheimer's disease, and vascular dementia. The study suggests that the efficacy of therapy is strongly associated with dementia risk.
Researchers discovered that African trypanosomes use repetitive 70-bp regions to select new coat protein genes from an archive, evading host antibodies. This process could be crucial for reducing chronic infections of sleeping sickness if deactivated.
A new study by researchers at the University of Pennsylvania's Abramson Cancer Center found that testing non-breast cancer genes in high-risk women does not add clinical benefit. The study analyzed a large panel of genes and found that many variants were of uncertain significance, adding complexity to genetic counseling.
Research reveals that type 2 diabetes drug trials frequently exclude women who are pregnant, breastfeeding, or may become pregnant without clear justification. The criteria most often excluded women who were currently pregnant or breastfeeding, but more than 50 studies excluded all women of childbearing potential.
Using clinical data from over 7 million US armed forces members, researchers identified patients with Crohn's disease and found that specific antimicrobial antibodies in their serum samples were associated with increased risk of complications. These biomarkers could potentially predict IBD development and inform preventive strategies.
A study using stem cell therapy to treat refractory angina (RA) demonstrated promising results, including improved exercise time, reduced angina, and lower mortality rates. The treatment showed potential for difficult-to-treat RA patient population, offering a new approach for patients with limited treatment options.
Researchers at the University of Sheffield developed a computer model to understand how bees use vision to avoid collisions. The model suggests that adding speed detection capabilities to existing motion-direction detecting circuits could enhance the navigation and routing algorithms for autonomous flying robotics.
A new study by Cardiff University found that combining insulin with metformin reduces mortality and heart attacks in people with type 2 diabetes. The researchers tracked 12,020 patients for three and a half years on average, finding no difference in cancer risk between single-insulin therapy and combination treatment.
Carnegie Mellon researchers have developed SkinTrack technology that converts the entire lower arm into a touchpad, providing continuous touch tracking and discrete location detection. The system allows for functionality similar to buttons or slider controls, while maintaining high accuracy.
A Penn State geoscientist is joining the NASA Mars rover team to investigate whether environmental conditions on Mars were ever favorable for microbial life. He will analyze Martian rocks and compare them to Earth rocks to search for signs of life, including sulfur and organic matter.