A study led by Columbia University Medical Center has shown that chronic pain may occur when pain receptors migrate from the nerve cell's surface to the cell's inner chambers. This discovery may lead to the development of a new class of medications for chronic pain that is more potent and less prone to side effects.
Researchers from Arizona State University have decoded the Mojave Desert tortoise's genome, which could aid in its survival by understanding genetic adaptations to disease and harsh environmental conditions. The study's findings may also inform conservation strategies to preserve this threatened species.
Researchers from Lomonosov Moscow State University develop new equations to conduct XRF analysis with higher accuracy, reducing the need for reference materials and enabling analysis of complex composition samples. The method uses internal standardization and computations to compensate experimental factors and operate in wider ranges.
A team led by the Department of Energy's Oak Ridge National Laboratory has discovered a novel microbial process that can break down toxic methylmercury in the environment. This process could reduce mercury toxicity levels and support health and risk assessments, particularly in fish consumption.
Researchers found that immigrants to a new environment can survive and even reproduce better than the local population when they are rare. This is due to their unique immune system, which allows them to avoid competition for food and evade parasites. The study has implications for species restoration and conservation efforts.
Tropical Depression Two-E forms near southwestern Mexico, with maximum sustained winds of 30mph and higher gusts. The depression is expected to strengthen during the next 48 hours and become a tropical storm on June 1.
A phase 2 clinical trial of scyllo-inositol found the treatment to be safe and tolerable in young adults with Down syndrome. The study suggests further investigation into its potential for treating Alzheimer's disease in this population.
Researchers discovered that fish can modulate fin stiffness by applying a u-shaped curvature at the base of their fins, altering force generation on the water. This allows them to swim with varying speeds and maneuverability in different currents. The study's findings could inspire the design of more agile robotic swimmers.
In a Phase 2 clinical trial, adding an experimental drug to standard chemotherapy improved progression-free survival by four months in patients with metastatic pancreatic cancer and high levels of hyaluronic acid in their tumors. The results suggest the benefit of the treatment is restricted to patients with this specific biomarker.
At ASCO 2017, SWOG investigators reported trials involving more than 10 cancer types and presented results on treatment-resistant metastatic colorectal cancer, breast cancer chemotherapies, high-risk prostate cancer, and the benefits of public funding for cancer research. The group's research has led to the approval of 14 cancer drugs,...
A recent study found that high blood sugar following leg surgery is common and associated with poorer outcomes, including increased infection rates, hospital stays, and mortality. Patients without diabetes were also at a higher risk of complications, highlighting the importance of glucose management in surgical interventions.
A new study by University of Waterloo researchers found that smart meters and time-of-use pricing reduced residential energy demand during peak periods by only 2.6% and 2.4%, respectively. The modest changes in behavior raise concerns about whether the cost of installing smart meters has been justified.
A study published in the journal AIDS Care found that supportive housing programs significantly improve the health outcomes of previously homeless individuals living with HIV/AIDS. The research analyzed biometric data and showed a positive relationship between program stay length and viral suppression, highlighting the importance of st...
Neurofibromatosis type I, an inherited disorder affecting brain development and function, will be studied by Assistant Professor Seth Tomchik. The disease predisposes individuals to behavioral symptoms such as ADHD, autism-like symptoms, learning disabilities, and chronic pain.
The AI system uses machine learning techniques to estimate pain levels in sheep based on five distinct facial expressions. It can detect conditions such as foot rot and mastitis with high accuracy, enabling early treatment and pain relief.
A Canadian clinical trial has discovered that minocycline, a common acne medication, can slow the progress of relapsing-remitting multiple sclerosis in people experiencing their first symptoms. The treatment offers a safe and affordable alternative to current therapies, which can cost up to $40,000 per year.
Social emotional learning interventions show promise in early childhood, with training for teachers, embedded instruction, and family engagement being key factors. Longer-term studies are needed to understand long-term effects on academic success and social outcomes.
A new study shows that preschool kids who share their own accord are happier than those who are obliged to do so. When given stickers, children aged 3-5 years old exhibited greater happiness when sharing voluntarily rather than being forced to do so.
The University of Michigan has received a $58 million grant to support clinical and translational research, partnering with Michiganders of all ages and backgrounds. Over 50,000 volunteers have signed up for the MICHR registry, allowing researchers to reach out when a study needs participants.
Researchers at Kansas State University used ultra-intense X-rays to break up molecules, creating a molecular 'black hole' that pulls electrons away. This discovery may help scientists understand the damage caused by X-ray radiation in biological systems.
The study reveals that Echinolittorina snails have a unique enzyme structure that enables them to maintain protein stability at high temperatures, allowing them to thrive in hot environments. The researchers found that subtle differences in amino acid sequences between the snail proteins enabled them to remain functional and stable at ...
A new study published in the Journal of Allergy and Clinical Immunology found that 3.6 percent of the population studied had a documented food allergy or intolerance. Shellfish was the most commonly reported food allergy, with the highest rates among females and Asians.
A study by Penn State researchers suggests a possible link between the partial meltdown at Three Mile Island Nuclear Power Plant and thyroid cancer cases in nearby areas. The study found an increase in genetic mutations caused by low-dose radiation exposure in patients who developed thyroid cancer after living in at-risk regions.
A new wearable system uses a 3D camera to identify surfaces and objects, providing tactile signals through vibrating motors and a reconfigurable Braille interface. The system significantly reduces obstacles other than chairs from being contacted by visually impaired users, and minimizes cane collisions with people.
A recent study found that permafrost thaw in northern peatlands can lead to a five-fold increase in nitrous oxide emissions. The emission rates matched those from tropical forest soils, highlighting the significant impact of Arctic warming on the global N2O budget.
Researchers discover zinc's anti-inflammatory effects in treating liver disease, inhibiting IFN-λ3 protein that causes tissue damage. Serum zinc levels are genetically linked to chronic hepatitis C progression.
A doctoral student is studying how soil microbes drive plant invasion in the Galapagos Islands, a biodiversity hotspot. The researcher aims to understand the role of mycorrhizal fungi and plant pathogens in shaping plant community structure and diversity.
Scientists using LRO data identified bright areas near south pole craters that are cold enough for frost to be present. The analysis combined surface temperatures with light reflection information.
The IRIDIS app assesses physical aspects of design impacting on older people's quality of life, recommending changes such as lighting and colour contrast improvements. It provides a simple 20-minute assessment of home suitability for an older person.
Researchers found that HDAC3 inhibitors increase expression of aquaporin-3, a channel that transports glycerin, helping to improve skin health and reducing inflammation. The study's findings suggest that HDAC inhibitors could be an effective therapy for psoriasis.
A new study found that participants in the PROSPER program showed a significant reduction in lifetime use of methamphetamine, cocaine, and marijuana. The program also reduced prescription drug misuse and reported lower levels of drug-related problems among young adults.
A team of physicists has implemented a new measurement method that reveals traffic is the major polluter of nitrogen oxide emissions in European cities, accounting for over 80% of emissions. The study's findings highlight the need for revised atmospheric models and air quality management strategies to address the underestimated emissions.
Researchers discovered that cane toads increase active re-uptake of salts and transport proteins to maintain internal salt levels when shedding their skin. This adaptation helps them regulate water and salt balances, which is crucial for their survival.
Researchers at Concordia University have developed a low-temperature process using psychrophilic bacteria to break down food waste, producing methane comparable to traditional anaerobic digestion processes. The study shows promise for reducing the global impact of food waste on climate change and energy demands.
Researchers from McGill University and the University of Minnesota warn that humans are driving the sixth mass extinction, threatening biodiversity. However, they offer specific strategies to turn this tide, suggesting investments in conservation could provide economic benefits.
A new review of pest management strategies for bed bugs highlights the importance of early detection and regular monitoring. Nonchemical methods such as clutter reduction, mattress encasements, and heat treatment can help reduce risks associated with chemical methods.
An international team of astronomers led by University of Warwick discovered a giant gas planet up to 50x Jupiter's mass with rings, causing regular eclipses of the young star PDS 110 in Orion constellation. The next eclipse is predicted for September, allowing amateur astronomers to witness and gather new data.
Scientists predict radical shifts in coral reef configurations as they struggle to cope with climate change, pollution, and human impacts. The window of opportunity to save reefs remains open, but urgent action is needed to secure a future for these ecosystems.
Patients discharged from psychiatric facilities face a marked risk of suicide in the immediate period and for years afterward. The study's findings suggest that mental health professionals should prioritize post-discharge care to mitigate this risk.
New research reveals the brain is a co-operative continuum for learning and memory, with different regions working together to reduce ambiguity. This understanding could lead to new treatments for cognitive diseases like Alzheimer's, where interference may be the cause of memory loss rather than forgetting.
The university will investigate genetic determinants of Barrett's Esophagus and esophageal adenocarcinoma, developing a new molecular marker for detection. The research aims to improve non-invasive diagnostic approaches and treatment of esophageal cancer.
New research reveals that women are 'damned' either way on maternity leave, with negative perceptions of competence in both work and family domains. The study suggests that policies allowing women to balance work and family life are crucial, but may have unintended consequences.
Researchers at Brigham and Women's Hospital discovered a link between complement C3 signaling and neurodegeneration in Alzheimer's disease. In preclinical models, mice with C3 deficiency showed improved cognitive function despite accumulating amyloid plaques, suggesting modulating immune response could combat the disease.
CHOP researchers report universal liver fibrosis in survivors of the Fontan operation, a serious complication of the surgery. The study highlights the need for improved medical surveillance and less invasive methods to measure liver fibrosis.
A recent University of Miami study found that mindfulness training benefits college football players' attention and well-being over high-demand intervals. The research, conducted by neuroscientist Amishi Jha, showed that greater practice engagement in a mindfulness program leads to more stable attention and fewer lapses.
Researchers discovered conductive hearing loss is the most common type of hearing loss in Alagille Syndrome patients, affecting nearly one-third of all ears. CT scans revealed structural defects in the middle ear that vary in effect on hearing.
Professor Sang Yup Lee was elected as a foreign associate to the US National Academy of Sciences (NAS) and previously to the US National Academy of Engineering (NAE). He is the first Korean to be elected to both prestigious academies, recognized for his leadership in microbial biotechnology and metabolic engineering.
A University of Washington study found that people who believe in climate change and see economic or environmental benefits to tidal energy are more likely to support projects. Residents support tidal energy more when it's connected to the grid and benefiting their community.
Researchers found that biochar application successfully reduced soil acidity and made heavy metals less bioavailable, converting them into less toxic forms. This locally sourced biochar can be used to prevent metal accumulation in soils near abandoned mines, potentially reviving degraded ecosystems.
A study published in PLOS ONE found that individuals who experience digital-behaviour problems exhibit significant physiological changes, including increased heart rate and blood pressure, when terminating internet use. These changes are accompanied by heightened anxiety levels.
This review article showcases the potential of biomass and its derived wastes in producing sustainable bioproducts and fuels. The authors highlight various conversion processes, including bioethanol, biodiesel, and biomethane production, as well as activated carbon manufacturing from bioresources.
Adolescents with autism face barriers to health care independence due to lack of support from providers, caregivers, and themselves. Caregivers feel uncertain about their role, leading to confusion over guardianship decisions.
Researchers use ultra-bright X-ray light to ionize a molecule, creating a 'molecular black hole' that explodes within a trillionth of a second. The study provides crucial information for analyzing complex molecules with X-ray lasers.
A new study reveals that Teleocrater rhadinus, a 3-meter-long, crocodile-shaped dinosaur, challenges earlier hypotheses on early dinosaur evolution. The discovery suggests that the most ancient dinosaurs' ancestors were quadrupedal, contradicting the long-held image of bipedal, chicken-like creatures.
Researchers from Turku, Finland have discovered new information about the mechanisms regulating gene activity in human embryonic stem cells. The study sheds light on indirect genomic regulatory mechanisms that maintain gene expression and self-renewal of stem cells.
Researchers at Umeå University have successfully mapped the structure and function of a transient enzyme state using X-ray crystallography and NMR spectroscopy. The study reveals that the transient state is essential for enzyme function and provides clues on how enzymes speed up reactions with incredible specificity and efficacy.
A new trial combining ibrutinib with personalized cellular therapy CTL119 achieved complete remission in nine out of ten high-risk CLL patients. The treatment showed limited toxicity and improved disease outcomes compared to existing therapies.
A large study published in the Journal of the American Academy of Child and Adolescent Psychiatry found that a diagnosis of autism alone is not associated with an increased risk of violent offending. Instead, conditions like ADHD that co-occur with autism may increase this risk.
Researchers found that radiation therapy can improve the delivery of cancer nanomedicines up to 600% by attracting macrophages to tumor blood vessels, leading to increased nanoparticle uptake. This combination strategy shows promise for enhanced treatment efficacy and could be tested in clinical trials quickly.
Exposure to common anesthesia drug sevoflurane in infancy results in visual recognition memory impairment, which emerges after the first year of life and may persist long-term. Researchers used a rhesus monkey model to investigate the effects of repeated anesthesia exposure on neurocognitive function.