Recent studies identified targeted therapies that improved benefits for patients with pancreatic cancer, including one with an ALK gene mutation. The assessment of actionable alterations is now part of routine care at UPMC.
Researchers discovered that plastin, an actin-bundling protein, plays a crucial role in facilitating polarisation and cytokinesis in embryonic cells. The study revealed that plastin functions as a molecular rivet, enabling the cell cortex to withstand forces generated during filament contraction.
A Yale University study found that 32% of new drugs were flagged for a safety issue after approval, with biologic therapies and accelerated approvals being more likely to be associated with concerns. The findings highlight the need for ongoing surveillance of new drugs in the post-market period.
The study develops a process to grow very small nanorods with precise separation, allowing for specific patterns in devices like gas sensors. This method reduces fabrication costs and enables more precise gas detection.
Researchers at the University of Bristol have developed a spatially adaptive broadcast system that enables broadcasters to adapt their geographical coverage in real-time, reducing energy consumption by up to 35%. This technology has the potential to improve the energy efficiency of wireless and broadcast networks.
Scientists at Linköping University have directly observed dislocation-pipe diffusion, a phenomenon that has eluded materials scientists for decades. The movement of atoms between layers of a thin film was captured using high-resolution scanning transmission electron microscopy.
A recent study reveals that microRNA-223 plays a crucial role in regulating intestinal inflammation in inflammatory bowel disease. Synthetic versions of this microRNA can reduce inflammation in mice and may hold promise as a future therapy for IBD patients.
Computer scientists and social scientists collaborate to create Collaborative Interaction Corpus (CIC) dataset, featuring 135 participants' online activity and discussion data. The dataset can be used to address various computer-science questions, including predicting user behavior and machine learning.
Researchers reveal breakthrough method to release glucose from cellulose in rice straw, improving ethanol production without chemical treatment. The approach could benefit various cereals and grass species worldwide, reducing lignin content and increasing biomass digestibility.
A new study found that nearly half of seniors in Ontario who visited a family doctor for a non-bacterial infection received an unnecessary antibiotic prescription. The majority of prescriptions were for broad-spectrum antibiotics, which are associated with increased risk of adverse outcomes and antibiotic resistance.
Numerical simulations by Everton Santos Medeiros provide a better understanding of the characteristics of tipping points in natural and social systems. The study highlights the persistence of system dynamics after irreversibility, masking the transition itself.
A new study reveals that blood vessels in the brainstem constrict when oxygen levels rise, unlike other parts of the body. This specialized response helps maintain proper breathing and is made possible by astrocytes releasing signaling molecules.
A new position paper provides consensus recommendations for ionizing radiation dose optimization in pediatric patients with congenital and acquired heart disease. The guidelines focus on strategies to minimize radiation exposure while maintaining effective imaging procedures.
A study found that the DASH diet reduced gout incidence in men with similar dietary patterns, while a Western diet increased risk. The diet's emphasis on fruits, vegetables, and low-fat dairy products may help lower uric acid levels and reduce cardiovascular problems.
A team of researchers has uncovered a hidden world of water conduits and sediment ridges beneath the Antarctic ice sheet. These features are five times larger than those seen in deglaciated landscapes, shaping the ice hundreds of kilometers downstream.
A phase 1 pilot study is examining the feasibility and safety of administering a second T-cell product to increase the long-term persistence of CAR T cells. The goal is to reduce the relapse rate, which is currently around 50%.
Cases of drug-resistant tuberculosis are expected to rise significantly in India, the Philippines, Russia, and South Africa between 2000 and 2040. The growing epidemic is predicted to be driven by person-to-person transmission, rather than strains acquiring resistance to anti-tuberculosis drugs.
A new species of giant bird-like dinosaur, Beibeilong, has been discovered in Henan, China. The fossilized remains include large eggs weighing up to five kilograms and an embryo found inside, revealing a previously unknown species of oviraptorosaur.
Researchers use machine-compiled data to construct a microbial supertree, addressing the challenge of accessing and synthesizing scientific literature. The study demonstrates the potential of high-throughput machine extraction in tackling the vast amount of published science.
The fossil hominin Homo naledi lived between 335,000 and 236,000 years ago, overlapping with the emergence of modern human behavior in southern Africa. The discovery challenges previous predictions of its age and raises questions about human evolution.
The petitSat mission aims to study the link between plasma enhancements and Medium-Scale Traveling Ionospheric Disturbances (MSTIDs) in Earth's ionosphere. The satellite will measure plasma densities and ion distributions using two instruments, providing valuable insights into the transmission of GPS and radar signals.
The Tsimane Health and Life History Project found that many individuals reach a social and economic peak between the ages of 40 and 60. They adapt by devoting less time to hunting and more to horticulture, producing the majority of calories for their extended families.
The Massachusetts Wildlife Climate Action Tool has received a national award for its exemplary leadership in addressing climate change impacts on fish and wildlife species and their habitats. The tool, launched in 2015, provides information on climate change vulnerabilities and offers adaptation strategies to protect natural resources.
A study found that nearly 1 in 3 FDA-approved drugs had postmarket safety events, with biologics and psychiatric disease treatments being most affected. The study highlights the need for ongoing safety monitoring of approved medications.
Researchers are using innovative approaches, such as a scientific journal for kids, to convey complex nutrition research on infant brain development. The goal is to inspire critical thinking in young readers and make science more accessible to the broader public.
A study by University of Washington researchers found that federally subsidized shrubs and grasses play a crucial role in sage grouse survival in Eastern Washington. Without these lands, the species' habitat would be reduced by two-thirds, putting it at risk of extinction.
The annual killifish has evolved to survive in temporary ponds without water, allowing embryos to arrest development and survive for months. The new study provides an updated methodological guide for scientists studying this fascinating vertebrate model system.
A Duke University study reveals that larger patches of tropical forest are being lost worldwide due to industrial-scale agricultural expansion. The trend is most pronounced in Southeast Asia and South America, where clearings for large-scale agriculture account for more than half of all observed forest loss between 2000 and 2012.
Researchers created uniform 3.2 nm platinum-zinc particles with twice the catalytic activity per surface site, outperforming larger particles containing the same amount of platinum.
Behavioral economists argue that straight salary-based compensation could reduce over-provision of medical services, benefiting patients. Several high-quality health systems already use this model, which may also improve physician job satisfaction.
The researcher is studying calcium channels in gonadotropes to understand their role in reproductive disease. This knowledge can lead to the development of new treatments for infertility, tumor growth, and other disorders.
A diet high in fruit, vegetables, and whole grains, but low in salt, sugary drinks, and red meat, is associated with a lower risk of gout. The DASH diet has been found to reduce blood pressure and uric acid levels, suggesting it may also lower gout risk.
The ORION project aims to explore ways to open up research funding, organization, and processes to the public. It will develop good practices and concrete actions for research organizations to implement Open Science and Responsible Research Innovation (RRI). The project will generate new training content, share lessons learned, and dis...
This special issue explores various topics in family medicine, including cancer treatment decision-making, palliative care, and patient-centered care. Research articles highlight the importance of providers' assessment, awareness, and discussion of patient preferences for their participation in their own care.
Researchers at Osaka University investigated the geometry of single molecule-electrode contacts on thermoelectric behavior. They found that the largest thermoelectric effect was observed for structures containing a stretched thiol linkage, which shifts the energy level to a more favorable position.
A Norwegian University of Science and Technology study found that herniated disc surgery can bring relief to patients 65 and older, with the condition improving more in this age group than younger patients. However, complications were more common and hospital stays longer among seniors compared to younger patients.
A new study warns that natural disasters like volcanic eruptions and tsunamis could wipe out the world's only population of Javan rhinoceros. The authors urge establishing additional rhino populations away from disaster zones to increase survival odds for at least part of the population.
A study found that commonly prescribed NSAIDs increase the risk of heart attacks, with a 20-50% increased risk compared to non-users. The risk is highest with higher doses and in the first month of use.
Researchers found that psychological interventions like relaxation and stress management reduced pain in several studies, while two dietary interventions and antibiotics also showed effects on abdominal pain. However, further research is needed due to the small and non-conclusive nature of most studies.
A research group from India used Raman scattering to study the vibrational properties of heavily boron-doped diamond, revealing a Fano resonance that is sensitive to impurity band evolution with boron doping. The study aims to increase the superconducting transition temperature in boron-doped diamond.
Researchers found transmission of dengue, chikungunya and Zika is highest at around 84 degrees Fahrenheit, a temperature previously considered peak-transmission. Climate change causes temperatures to climb, potentially impacting more northern regions.
A new school-based program called SPARK has been shown to promote resilience and prevent depression in 11-12 year old girls. The program, which provides tools to identify stressful situations and learn to control negative reactions, increased self-reported resilience and decreased depression symptoms after its implementation.
Invasive fiber-like red seaweeds have covered up to 90 percent of some areas, changing the ocean floor landscape. The new habitat supports two to three times more small creatures at the base of the food chain.
A computer-generated physician is being developed to explain medical test results to patients in layman's terms, using graphics and videos. The system aims to improve health literacy and patient engagement, particularly among older adults with lower health literacy levels.
Researchers at Kansas State University found that astronauts' exercise capacity decreases by 30-50% due to decreased oxygen transport efficiency. This decrease can impact astronaut performance and has implications for understanding blood vessel function in older patients with heart failure.
Researchers find that Varroa mite populations are growing and spreading in managed bee colonies due to close proximity and lack of swarming. The study suggests new integrated pest management strategies are needed to control the migratory pest.
A recent study by UT Southwestern researchers reveals ghrelin's role in preventing hyperglycemia and hypoglycemia in Type 1 and Type 2 diabetes. The hormone helps regulate blood sugar levels when glucagon activity is blocked, suggesting a potential new treatment approach for diabetes.
Researchers have developed a new tool called ModelFinder to study the evolution of proteins. The program allows for more accurate scientific estimates of evolutionary processes, which will help unravel the mysteries behind life's diversity on Earth.
A new study suggests that a mother's cells can directly act as part of her child's immune system, even after birth. Babies born to mothers infected with malaria during pregnancy have higher levels of maternal microchimerism, which may confer some protection against the disease.
Between 2001 and 2010, nearly a third of FDA-approved pharmaceuticals and biologics experienced postmarket safety events. These events, including withdrawals and boxed warnings, affect patient care and decision-making. Postmarket risks are often only apparent in larger patient populations and longer durations.
A new study found that sign language users' speed of comprehension depends on their conversation partners' handedness, with left-handers responding better to fellow left-handers and right-handers to right-handers. The research suggests that how signers produce their own signs plays a role in understanding others' signing.
A study by Emily Howell at Iowa State University suggests that playing Pokémon GO can enhance students' writing and research skills. By incorporating different modes of communication, such as gestures and visuals, the game provides a unique platform for students to practice multimodal text and develop their communication skills.
Researchers at the University of Illinois Chicago have discovered a natural compound in grape seed extract that can strengthen dentin and increase the life of resin fillings. The study found that the extract can make composite-resin fillings stronger, allowing them to last longer.
Researchers found that bilingual people's reading strategies are affected by the languages they speak, leading to a different pattern of reading than monolingual speakers. This discovery has implications for clinical and education practice, including diagnosing dyslexia and developing tailored reading strategies.
A new study found that older adults who experience physical abuse are more likely to be abused again if they live with their abuser. Repeat victims were often abused by a relative and faced broken reporting systems.
Joseph Paton, a neuroscientist at the Champalimaud Centre for the Unknown, has been awarded a $650,000 grant to further study how the brain processes time. His work aims to understand how internal signals are converted into action, enabling animals to interact with their environment in a more informed and calculated manner.
A series of studies shows that Black participants who hold suspicious views of Whites visualize White faces as less trustworthy, authentic, and sometimes more hostile. The authors suggest both potential advantages and drawbacks to these biases. Recruiting minority group participants is crucial to understanding intergroup dynamics.
A clinical trial funded by the National Eye Institute shows that monthly eye injections of Avastin improve visual acuity on average from 20/100 to 20/40, comparable to Eylea. Macular edema decreased significantly in both groups, with higher resolution rates in the Eylea group.
Gustavo Scuseria, a renowned chemist at Rice University, has won the Royal Society of Chemistry S F Boys - A Rahman Award for his outstanding innovative research in computational chemistry. He will share his exciting new results during a lecture tour in the U.K., focusing on solving the strong correlation problem.
A new system of oxide materials can be used to create actuators that function at temperatures above 500 degrees Celsius, enabling devices to open and close valves in hot environments. This technology could revolutionize maintenance tasks in nuclear plants and other high-temperature settings.