Researchers developed a new method to capture and analyze individual cells from a small sample of blood using graphene oxide sheets. The system demonstrates high efficiency in capturing specific immune cells that are markers for certain cancers, with an estimated production cost of $5 per device.
Researchers at Hiroshima University developed a smart genetic reference library to determine disease-causing mutations in populations. The technique and database estimated naturally occurring rare-variants in the STAT1 gene and determined associated diseases. This will assist doctors in diagnosing primary-immunodeficiency in patients, ...
A pilot study published in the journal Cancer found that neurofeedback training reduced symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors. The study used electroencephalogram (EEG) neurofeedback to retrain brain activity and resulted in measurable changes in targeted brain regions.
Researchers have developed a new tool called CRISPETa, which allows for easy and efficient DNA deletion using CRISPR-Cas9. The software can design optimised pairs of sgRNAs for deleting specific regions of non-coding DNA.
A new biosimilar called CT-P13 has been found safe and effective in treating Crohn's disease and ulcerative colitis, with a clinical response achieved in over 70% of patients at short-term follow-up. The treatment offers a cost-effective alternative to infliximab, a costly biologic therapy.
A recent study by Louisiana State University's Parichehr Saranjampour found that dibenzothiophene, a chemical class of PAHs not on the EPA's list, undergoes evaporation and oxidation at rates faster than previously thought. This discovery has implications for oil spill cleanup and exposure to toxic pollutants.
A study by Oregon State University researchers found that long-term ecological and environmental studies (LTEES) are disproportionately valuable compared to short-term research, yet receive limited funding. The collaboration of 36 researchers highlighted the growing demand for LTEES in policymaking and scientific communities.
The Rutgers team has developed a microfluidic platform that detects membrane permeabilization in cells exposed to electric fields, allowing for efficient delivery of biomolecules. The technology improves transfection efficiency and cell viability, enabling the study and engineering of fundamental cellular processes.
A study published in Science Immunology reveals that a variant of the SP140 protein, an essential epigenetic reader protein, is lacking in patients with Crohn's disease. This deficiency triggers intestinal inflammation and impairs the immune system's response to microbial signals. The researchers found that patients with reduced SP140 ...
A recent study reveals that rare microbial species, making up only 1% of the community, contribute significantly to ecosystem functioning. These species hold a large reservoir of genes that can degrade organic pollutants, enabling the community to maintain stability in the face of changing conditions.
A new framework uses math to understand how genetic information and cell interactions give rise to tissue function, potentially aiding in understanding diseases like cancer. Researchers aim to apply this approach to real-world genome and cell biology experiments to inform future work on cancer and cell reprogramming.
A study by Centre for Addiction and Mental Health found that implementing a completely tobacco-free environment led to positive changes in attitudes and reduced patient agitation. The findings also showed no change in fire-related incidents.
Scientists at Umeå University discovered a protein interaction that slows down a key chemical reaction in the bacteria Yersinia pseudotuberculosis. This finding opens up new avenues for studying the regulation of bacterial virulence, which can help develop new treatments for infections.
Professor Shiho Kawashima has received a $500,000 NSF CAREER Award to develop concrete systems for 3D printing, which could revolutionize infrastructure construction and repair. Her research aims to improve the processing and rheology of concrete and cement.
Excess emissions from Volkswagen's diesel cars sold between 2008 and 2015 will cause approximately 1,200 premature deaths across Europe. The countries hardest hit include Germany, Poland, France, and the Czech Republic.
The Oxford University Press will publish the Journal of Crustacean Biology, a scientific journal covering crustacean biology and marine arthropods. The journal has undergone a facelift with a new format and style, expanding article types to include Research Notes and comprehensive reviews.
Chronic administration of nandrolone decanoate in albino mice increased serum aldosterone and sodium ion levels, indicating possible steroid-related cardiovascular disorders. The study suggests a correlation between altered aldosterone concentrations and cardiovascular diseases.
A recent study by Georgia State University researchers found that female brains have more active immune cells in pain processing regions. This leads to improved response to opioid pain medication, often less effective in females.
DeepStack, a computer program developed by the University of Alberta's Computer Poker Research Group, has defeated professional poker players in heads-up no-limit Texas hold'em poker. The program uses a technique called continual re-solving to determine the correct strategy for each situation, allowing it to play at human speed.
Scientists at Tohoku University simulated the formation of super-deep diamonds using high-pressure and high-temperature experiments. The study suggests that these rare diamonds can form through the reaction of Mg-carbonate and silica minerals at extreme depths, offering new insights into Earth's interior conditions.
Coral ecosystems in West Maui's northern reefs have declined by 20% due to sediment runoff, compromising corals' ability to photosynthesize. Researchers found that cooperation among landowners results in more cost-efficient and ecologically effective outcomes than individual actions.
Researchers at UC San Diego have successfully printed a functional blood vessel network using 3D bioprinting, addressing a major challenge in tissue engineering. The technology enables the creation of complex microstructures with high resolution, using inexpensive and biocompatible materials.
A new study reveals that patients with pre-existing donor-specific antibodies experience better kidney survival rates compared to those with de novo antibodies. Understanding the timing of antibody responses can guide matching and prevent rejection.
Scientists from NASA and NCAR have shown that tracking coronal mass ejections can help detect solar energetic particles earlier than current forecasting techniques. This could provide critical warning time for astronauts in low-Earth orbit or interplanetary space.
The University of Texas Health Science Center at Houston has received a $2.4 million grant to create the Healthy Cities Research Hub, exploring drivers of diabetes and other chronic diseases in urban settings. The hub will facilitate knowledge exchange and evaluate community-based interventions aimed at improving public health in cities.
A study analyzing nearly 30,000 liver transplant patients found elevated death and organ loss rates among those with high opioid use while waiting for a transplant. Transplant candidates requiring high levels of opioids should be carefully assessed before and after transplantation.
The Trump administration's policy changes put women's access to effective contraception and abortion care at risk. Professor Daniel Grossman warns that the re-imposition of the Mexico City Policy and proposed legislation could severely limit access to reproductive healthcare services, particularly for low-income individuals.
Scientists have identified a metabolic weakness in triple-negative breast cancer cells that may be exploited to quell their resistance to chemotherapy. Targeting this pathway could lead to increased cancer cell death and improved treatment outcomes.
Researchers developed an RNAi-based strategy to study the link between genes and host-finding behaviors in Steinernema carpocapsae. The method successfully knocked down a gene that codes for FLP-21, inhibiting jumping and sensory perception behaviors.
A placebo-controlled trial shows that both audiology best practices and OTC models improve outcomes for older adults with mild-to-moderate hearing loss. The study's findings have implications for better hearing healthcare for millions of Americans.
Research discovered that black carbon alters bacteria's ability to survive and combat antibiotics, increasing the risk of infection. The study also found that air pollution can change the way bacteria behave and cause disease.
Researchers at Oak Ridge National Laboratory have developed innovative methods for creating complex patterns, accelerating gas separation, and optimizing manufacturing processes. The lab's expertise in additive manufacturing has enabled the rapid prototyping of components, while membrane-based gas separation has shown promising results.
Researchers at CCNY Energy Institute developed a sustainable, high-energy-density battery using manganese dioxide and copper. The unique material allows for both high cycle life and high areal capacity, making it suitable for practical applications.
Biophysicists at JILA measured protein folding with unprecedented detail, identifying 14 intermediate states in bacteriorhodopsin. The discovery reveals previously unknown dynamics, shedding light on the complex behavior of membrane proteins.
Despite progress in implementing primary and secondary prevention measures, Europe still has a long way to go to eliminate viral hepatitis by 2030. The authors highlight the need for improved data collection and monitoring of interventions along the continuum of care to track progress and reduce mortality.
Scientists discovered that obesity disrupts the balance of 'guardian immune cells,' which maintain a delicate balance between immune systems. In healthy states, these cells protect against inflammation and metabolic disease, but in obese individuals, they lose their regulatory function.
The discovery of two partial archaic human skulls from the Lingjing site in central China reveals a complex mix of biological trends among early modern humans. The fossils, dated to around 100,000 years ago, show a blend of features with late archaic and early modern humans, as well as Neandertals.
UKCRIC will enable academia, industry, government and end users to collaborate on upgrading UK's infrastructure, reducing its cost and increasing resilience. The initiative will focus on developing new materials, techniques and technologies, as well as research into smart sensors and systems.
Researchers at Karolinska Institutet and KTH Royal Institute of Technology discovered hydraulic forces aid heart filling. The study suggests reducing atrium size can improve heart function in patients with heart failure.
A Japanese research group has identified a newly-identified autoimmune endocrine disease caused by thymomas, which leads to hypopituitarism. The study found that abnormal expression of PIT-1 in thymoma cells triggers immune tolerance breakdown, resulting in autoimmunity.
Researchers found that breast cancer cells express reelin, a protein typically found in the brain, to disguise themselves and avoid detection. This allows them to form new deadly brain tumors, leading to high mortality rates among women with HER2-positive breast cancer.
Researchers at Tohoku University found 19 common Japanese color categories, including 11 basic colors and eight additional named categories. The study also showed that traditional expressions from classic poetry have been retained despite modern linguistic changes.
A rheumatoid arthritis drug has been found to block a metabolic pathway that drives tumor growth in aggressive cancers with the PTEN gene mutation. Leflunomide kills human breast cancer cells in mice by damaging DNA produced through the pathway.
A team from the University of Pennsylvania has demonstrated a new method to deliver safer and more cost-effective therapeutic antibodies using messenger RNAs. The technique involves injecting modified mRNAs into cells, which then produce the therapeutic proteins in a controlled manner.
A team of neuroscientists has found that somatostatin-expressing (Sst) interneurons play a key role in controlling the flow of information in the brain. The researchers discovered that these cells operate like a switchboard, selectively blocking or encouraging the flow of information to help animals make informed decisions and guide th...
A systematic review and meta-analysis of horseback riding interventions found significant improvements in balance, motor function, and quality of life for children and adults with neuromotor disabilities. The studies also showed benefits for patients with cerebral palsy, multiple sclerosis, and stroke.
Researchers at Toronto Western Hospital's Canadian Concussion Centre discovered CTE in a brain without head trauma or concussion history. The finding suggests that the cause of CTE might be more complex than previously thought, with Dr. Lili-Naz Hazrati stating that there are more questions than answers about the definitive causes of CTE.
Researchers are developing a new robotic system to map and analyze radioactive sites using advanced sensing technologies, including optical spectroscopy and radiation detection. The project aims to improve the decommissioning process and reduce costs.
Researchers at the University of Exeter have developed a pioneering technique to engineer computer chips more easily and cheaper than conventional methods. The breakthrough could revolutionize the production of optoelectronic materials, enabling advancements in renewable energy, security, and defence technologies.
Researchers at Michigan State University are studying the effect of hormones on ovulation and reproduction in cows to develop better fertility treatments for women. The study aims to improve fertility response rates by understanding how increased doses of fertility hormone impact ovarian function and egg quality.
Researchers at University of Cambridge create structure resembling mouse embryo in culture using two types of stem cells and 3D scaffold. The artificial embryo's development follows the same pattern as naturally developing embryos, but it lacks key cells needed for further growth.
The new guidelines emphasize avalanche avoidance as a primary tactic for preventing injuries and deaths. They also provide detailed recommendations for rescue protocols, including the use of transceivers, probes, and shovels, as well as guidelines for resuscitation in burial situations.
Researchers at Ohio State University Comprehensive Cancer Center have identified a mechanism by which cancer cells develop resistance to FGFR inhibitors. By inhibiting the regulatory protein Akt, they found that cell proliferation, migration, and invasion could be slowed in lung and bladder cancer cells.
A recent study found that automated journalism lacks the context and complexity of traditional reporting, citing issues with programming news angles in advance. However, journalists believe robo-journalism can reduce costs and increase specificity in some reporting areas.
A new study suggests that warmer water temperatures may not accelerate leaf litter decay as much as previously predicted, with an estimated 5-21% increase in breakdown rates. This could imply a more consistent balance between carbon dioxide release and retention in solid form.
Researchers found that trolls form 'anti-social networks' that reinforce their behaviour and are attracted to attention from media reports, highlighting the need for social media platforms to take responsibility for negative content
Researchers will measure circulating biomarkers in over 17,000 persons enrolled in the Framingham Heart Study to identify new biomarkers for cerebral small vessel disease. The goal is to develop a gold standard for early detection and intervention with treatment.
Researchers at Utah State University are part of a NASA project to develop technology for growing food and producing necessities on Mars. The team will focus on nitrogen fixation using bacteria and exploring the challenges of food production in a closed system.
A large study of Medicare beneficiaries found the high-dose flu vaccine was 36% less likely to result in death following hospitalization or emergency department visits with a flu diagnosis compared to the standard-dose vaccine. However, its effectiveness varied by season and type of influenza virus.
A new study proposes a risk-based approach for classifying road surface conditions under winter weather events, aiming to improve current road classification systems. The approach estimates driving risk using a collision model calibrated with detailed hourly data of weather, road conditions, traffic, and accidents.