New studies examine rheumatoid arthritis patients' mortality, disease activity, and physical function over 20 years. Early treatment has been shown to have a significant impact on long-term outcomes, with patients experiencing relatively good results.
A review of eight studies found no link between low-dose aspirin and reduced cognitive decline. Researchers are calling for more research on the potential benefits of long-term aspirin use at younger ages.
Researchers developed fCLIP-seq to analyze DROSHA's impact on miRNA fragments, revealing hundreds of new cleavage sites and alternative processing patterns. The study uncovers additional end modifications important for miRNA biogenesis, shedding light on its regulation in diseases like cancer.
NASA's Suomi NPP satellite observed the remnants of Tropical Cyclone 02W dissipating southeast of Taiwan due to strong vertical wind shear. The system was torn apart as it moved north-northeast through the Luzon Strait, resulting in its demise.
Researchers at the University of Oxford have discovered that FIB can fundamentally alter a material's structure, affecting its entire sample. The team developed new X-ray techniques to assess this damage and will focus on developing strategies to mitigate FIB damage.
A mouse study reveals that Clostridia bacteria provide key protection against infection, in addition to aiding digestion. Newborn mice lack these beneficial bacteria, making them more vulnerable to pathogens. The findings suggest that the introduction of protective bacteria may hold promise for preventing gut infections in human newborns.
Researchers at UCSF discovered a specialized enzyme that destroys chitin, a tough natural material found in the environment, which accumulates in the lungs and triggers inflammatory lung disease. Mice with this enzyme deficiency developed severe lung disease, but restoring its activity cleared up symptoms.
Research finds high levels of lead exposure at firing ranges, with risks similar between indoor and outdoor ranges. The study recommends reevaluating allowable lead levels, improving education on lead-exposure risks, and finding lead-free substitutes for bullets and primer.
The AGU journal commentaries emphasize the critical role of Earth and space science research in addressing pressing issues like climate change, water scarcity, and asteroid threats. The collection highlights the need for evidence-based policymaking, science education, and research funding to support a thriving society.
Scientists have created a model to analyze irregular atomic structures at grain boundaries, where two materials meet. The Polyhedral Unit Model identifies patterns of atomic shapes and can help determine how these structures affect material properties.
Researchers found that strokes damage immune cells, making patients more susceptible to life-threatening infections like pneumonia. Therapies targeting damaged immune cells or bypassing their dysfunction could help recover from stroke, the study suggests.
Scientists have identified nerve cells in the skin of genetically engineered mice that sense both touch and motion, enabling active perception of the environment. This discovery advances the search for better prosthetics with natural sensory feedback for people.
A study of over 152,000 asthma patients found that current use of inhaled corticosteroids significantly increases the risk of hospitalization for pneumonia. The highest risks were observed with higher doses of fluticasone-equivalent and budesonide.
A team of astronomers used the Hubble Space Telescope to analyze four images of a gravitationally lensed Type Ia supernova, measuring the expansion of the Universe without theoretical assumptions. The discovery provides clues about the Universe's expansion rate and has implications for cosmology.
Astronomers have captured images of a Type Ia supernova appearing in four different locations on the sky due to gravitational lensing. This rare event has opened up new possibilities for measuring the rate of the Universe's expansion with unprecedented accuracy and understanding the distribution of matter.
Nematodes, microscopic worms that control diseases in humans and kill insects, secrete deadly cocktails of proteins to infect hosts. Researchers developed a method to work with nematodes outside their host, identifying 472 proteins involved in parasitism.
Researchers developed a new virtual drug screening platform to predict interactions with TNF and RANKL proteins. Two promising molecules, T23 and T8, were identified as strong TNF inhibitors with low potential for side effects.
New research shows children's ability to cross roads without incident develops around age 14. Children under 12 often underestimate traffic gaps, leading to accidents, and lack fine motor skills to step into the street quickly, making it hard for them to gauge when it is safe to cross.
Research published in Infection and Immunity found that Giardia infection changed the mouse microbiome, leading to more aerobic bacteria and less diversity of anaerobic species. The study suggests that Giardia may be an ecological disease that disrupts the gut's stable ecology.
A study published in Science reveals how bacteria can exhibit different behaviors despite having the same genes. Researchers found that protein complexes play a crucial role in this phenomenon, and biased partitioning of these complexes can lead to the emergence of extreme phenotypes.
Research found that drinking at least one artificially sweetened beverage a day increased the risk of developing ischemic stroke by three times and Alzheimer's disease dementia by 2.9 times compared to less frequent consumption. The study highlights the need for more research into this area.
Research found that men with precarious manhood beliefs use sexist and anti-gay humor to distance themselves from traits they want to disconfirm. The study suggests that workplace settings where women occupy positions of authority may trigger masculinity threats for these men, leading to sexist joking.
A new study from the University of Georgia found that 10 minutes of stair walking boosted participants' energy levels, even surpassing the effects of 50mg of caffeine. The research aimed to simulate office settings where workers spend hours sitting and don't have time for longer exercise sessions.
Researchers found that brain regions for missing body parts are repurposed in congenital one-handers, suggesting a new understanding of brain organization based on function rather than body part. This discovery reveals remarkable brain plasticity and holds potential for developing prosthetic limbs.
A new study reveals that newborns are more prone to intestinal infections due to underdeveloped gut microbiomes. Colonization with healthy adult microbes significantly reduces disease in infected infant mice, highlighting a potential way to boost their immune system.
The journal's 10th Anniversary Collection highlights the progress made in controlling or eliminating NTDs, with a focus on disease elimination. Despite mixed success stories, researchers remain optimistic about achieving breakthroughs for at least five NTDs within a few years.
Researchers found that tarantulas primarily rely on their anterior lateral eyes to measure distances and navigate. By covering these eyes, the spiders have difficulty determining distance and can become disoriented. The study highlights the crucial role of the lateral eyes in a spider's ability to return to its burrow.
A new study on UHT milk has found a link between protein clusters and age-related diseases like Alzheimer
Researchers at HSE discovered that men with a higher 2D:4D ratio tend to be better educated. The study analyzed data from the Russian RLMS survey and found positive correlations between male respondents' finger length ratios and levels of education.
Researchers have published a detailed geological history for Northeast Syrtis Major, a region on Mars known for its striking mineral diversity. The study maps the extent of key mineral deposits across the surface and places them within the region's larger geological context. This work could help inform NASA's decision on potential land...
A recent study examines how new kidney specialists feel their training has prepared them to care for patients, highlighting areas for improvement in nephrology fellowship structure and content. The findings suggest that fellows may be underprepared for home dialysis modalities and emphasize the need for more education in core nephrolog...
Researchers discovered that naked mole rats can survive extreme oxygen deprivation due to their ability to metabolize fructose. This alternative energy source supplies vital organs with energy when glucose is scarce, allowing them to thrive in low-oxygen environments.
Scientists have developed a new drug, PEG-2S, that combats two priority pathogens with limited treatment options. The drug specifically targets the NQR pump, preventing proliferation of harmful bacteria like Chlamydia trachomatis, and is highly targeted without toxic effects on normal cells.
Children and adolescents have a higher risk of dying from second cancers compared to older adults. The study found that survival rates are significantly lower for second cancers in young patients, particularly those under age 40.
Researchers at Clemson University are working on a technology to improve gasoline direct injection engines' cleanliness, reducing hazardous fine-particle emissions. The team aims to develop engine-control strategies that work together with filters and three-way catalysts to minimize particulate emissions.
Researchers from Canada and GEOMAR discover fossil oil mobilized uranium, forming complex-structured gold and uranium ore. High-resolution imaging techniques reveal an intimate spatial relationship between oil products and metals.
Scientists at Columbia University's Mailman School of Public Health report elevated levels of Babesia microti, a pathogen responsible for babesiosis, in Suffolk County, New York. The new test can strengthen surveillance for tick-borne illnesses, which are underreported and growing rapidly.
A prospective study in patients with cirrhosis found that severe periodontitis strongly predicted higher mortality, mainly due to complications of cirrhosis. The study also showed a strong association between gum disease and risk of death in liver patients.
Researchers discovered that macrophages aggregate around cardiac cells to facilitate electrical conduction, helping the heart beat in rhythm. This finding suggests a new role for immune cells in electrophysiology and may lead to new therapeutics for heart disease.
Empyema is a potentially deadly accumulation of pus around the lungs, with a high mortality rate. New AATS guidelines provide evidence-based clinical recommendations for diagnosis, treatment, and management of empyema in adults and children.
Scientists have discovered thousands of rare genetic mutations contributing to cancer growth, focusing on shared protein domains. These findings could guide the development of treatments targeting multiple mutated proteins simultaneously.
A new study found that firms with weak financial and social performance use integrated reporting to conceal their true performance. The report is longer, less readable, and more optimistic than those from stronger performers. This 'greenwashing' tactic undermines the effectiveness of integrated reporting.
Scientists have discovered that nearly half of the mammoths' bones show signs of serious pathologies, including 'articular mouse' disease and abnormal vertebrae. These findings support the hypothesis that geochemical stress led to the mass extinction of mammoths.
A study found that pretreatment HIV levels and immune activation are linked to persistent inflammation during treatment, contradicting previous results. The research suggests that diagnosing HIV early may prevent elevated immune activation, leading to health problems like heart disease.
A six-year study finds that the BP Deepwater Horizon oil spill caused $17.2 billion in damage to the Gulf of Mexico's natural resources. The study uses a survey to determine household willingness to pay for measures that would prevent similar damages in the future.
Researchers at McMaster University have identified post-biotics, by-products of bacteria, that lower blood glucose and allow insulin to work better. This discovery could lead to new therapies for obesity-related diabetes, as more than half of Canadians are overweight or obese.
A team of scientists has found a way to distinguish a naked singularity from a black hole using the precession frequency of a gyroscope orbiting around it. The frequency increases as matter approaches a rotating black hole, but decreases or becomes zero for a naked singularity.
A recent study found that qualified female scientists were disproportionately overlooked by organizing committees at neuroimmunology conferences in 2016. Despite having published high-impact papers recently, women were less likely to be invited as speakers compared to their male counterparts. The study highlights the need for more wome...
Researchers at the University of Pennsylvania have shown that electrical stimulation delivered when memory is predicted to fail can improve memory function. The study found that stimulating the brain during periods of poor function significantly improves memory, likening it to restoring normal traffic flow.
A new study at the University of Nevada, Reno has found a potential way to reduce triclosan's presence in the environment, which is linked to antibiotic resistance. The research discovered that a combination of metal-reducing bacteria and natural organic matter can degrade triclosan faster.
A multicentre, randomised, controlled study found that long-term oral antibiotic therapy with norfloxacin improved prognosis in patients with life-threatening advanced liver disease. Norfloxacin administration for 6 months was associated with reduced risk of death and infection at 6 months.
A worldwide analysis of over 3,000 patients reveals that those with alcoholic liver disease (ALD) are nearly 12 times more likely to be referred at an advanced stage than early. Early liver disease was defined as liver disease without evidence of advanced fibrosis or cirrhosis.
Researchers studied halogen-bonding interactions in co-crystals with bromide ions, leading to honeycomb structures and variable geometry. The findings suggest potential gas storage applications and facilitate directional multidentate interactions.
A study published in Science puts a monetary value on injuries to natural assets caused by the BP oil spill, with an estimated cost of $17.2 billion. The research used a nationally representative stated preference survey to assess people's willingness to pay for prevention programs.
Scientists discovered that naked mole-rats can survive up to 18 minutes without oxygen by converting fructose to fuel in their vital tissues. This process allows them to avoid tissue damage associated with heart disease and stroke in humans.
Saiful Chowdhury, UTA assistant professor, develops new mass spectrometry techniques to identify prenylated proteins linked to cancer, aging, and genetic disorders. His work may lead to more efficient analysis of modified proteins and improved understanding of cancer mechanisms.
Researchers used virtual reality to identify balance impairments and train people to improve their balance. The study found that virtual reality can reveal balance deficits that are not apparent during normal walking, providing an important roadmap for detecting balance impairments.
Recent reimbursement data shows significant variability in access to direct-acting antiviral therapy across European countries, particularly for patients with severe liver fibrosis or substance use. Many countries have restrictions on prescribing by specialists, limiting access to life-saving treatment.
Recent studies present contrasting evidence on DAA therapy's association with liver cancer. A study found a higher recurrence rate of hepatocellular carcinoma in patients who received DAAs, while another found no difference in HCC occurrence or recurrence between DAA and interferon-based therapies.
Researchers have identified a new approach to protect patients from graft-versus-host disease by activating signal paths in the gut. The key to preventing GVHD is protecting the epithelial cells, which can be achieved by using RIG-I and STING proteins.