Researchers at Duke-NUS Medical School and Genome Institute of Singapore have identified altered promoters in gastric cancer that change gene expression profiles, enabling tumors to evade the immune system. The study's findings may lead to new approaches for cancer immunotherapy treatment.
According to a new analysis, health spending is expected to increase rapidly in high-income countries, while low-income countries are projected to see relatively slow growth. This could lead to rising out-of-pocket costs for people in emerging economies, leaving the poorest unable to afford care.
A University of Illinois study reveals which production attributes matter most to consumers when buying beef and chicken, with 'no growth hormones' topping the list. The study found that organic was ranked lowest in importance, sparking surprise among researchers who attribute this to a lack of understanding about the term's meaning.
Researchers found that defective forms of HIV create proteins recognized by cytotoxic T cells, which can distract the immune system from functional viruses. This discovery could help develop a vaccine to boost immunity against HIV.
Scientists assessed the state of space weather research, including geomagnetically induced currents (GICs) that can disrupt power systems, railroads, and pipelines. GICs can cause temporary blackouts and mis-operation of railway signaling systems.
A new study found that drinking beetroot juice before exercise improves brain connectivity and efficiency in older adults, similar to those of younger brains. The researchers also discovered higher levels of nitrate and nitrite in the blood after exercising with beetroot juice compared to placebo groups.
A study found that outpatient laparoscopic appendectomy is safe and effective, with shorter hospital stays and decreased healthcare costs. The study showed no differences in complications, post-discharge ER visits, or readmissions between the outpatient and hospital-stay groups.
The Isle Royale wolf population has remained unchanged for the second year in a row, with only two wolves left on the island. The moose population is expected to double over the next three to four years, leading to increased vegetation consumption and potentially altering the island's ecosystem.
The Consortium for Advanced Simulation of Light Water Reactors (CASL) developed a model of the Watts Bar Unit 2 reactor core before startup and simulated its initial cycle. The simulations confirmed engineers' predictions on safe operation and provided detailed hour-by-hour behavior during power escalation. CASL's high-fidelity code su...
Researchers at ETH Zurich have discovered that vaccine-induced IgA antibodies 'enchain' bacteria in the intestine, forming clumps that prevent disease and genetic exchange of resistant genes. This approach could lead to a new strategy for intestinal infections, including farm animal vaccination and potential human applications.
Researchers at Cincinnati Children's Hospital Medical Center discovered a small molecular compound, RCM-1, that blocks the transcription factor FOXM1 and its pro-inflammatory activity in asthma. The compound prevented overproduction of mucous-generating goblet cells and reduced lung inflammation.
Researchers identified cyclic GMP-AMP synthase (cGAS) as the protein responsible for detecting viral infection, but dengue virus counteracts this by degrading cGAS. This study sheds light on a novel mechanism by which viruses evade immune detection and may inform techniques to dampen pro-inflammatory responses.
University of Oklahoma College of Law student Aaron Fournier has been selected for the Udall Foundation's Native American Congressional Internship, focused on tribal sovereignty and public policy. He will work with federal employees in Washington, D.C., to promote increased tribal sovereignty after completing his studies.
A team of scientists has developed an algorithm called PhenomeNET Variant Predictor (PVP) that can identify genetic changes in patients with genetic disorders. PVP uses data from non-human model organisms and a large database of gene-to-phenotype associations to prioritize variants with their likelihood of involvement in human disease.
A new study by Michigan State University found that well-kept vacant lots can help reduce crime rates in urban areas. The research analyzed nine years of crime data in Flint, Michigan, and discovered a correlation between greening efforts and decreased crime rates, including violent and property crimes.
Researchers have identified the neural basis for password-based species recognition in cowbirds, a behavior that resolves the paradox of species recognition in brood parasites. The study reveals that young cowbirds use a specific chatter call as a 'password' to identify conspecifics and avoid imprinting on host species.
Researchers at Northwestern University developed a new method, GAMERS, to extract the static and dynamic structure of complex chemical systems. This four-dimensional coherent spectroscopic method reveals hidden features of molecular structure, enabling insights into quantum phenomena and potential applications in solar cells.
Researchers at CU Anschutz Medical Campus found that cannabinoids may be effective in treating eczema, psoriasis, and other skin diseases. Topical cannabinoid drugs with little psychotropic effect could provide relief for patients with itchy skin conditions.
FAU researchers identified Zeb1 as a key factor that activates embryonic programme, leading to rapid dissemination and metastasis in pancreatic cancer. They also found that blocking Zeb1 reduces metastatic capacity in other tumour types.
A study in Berkeley, California found that a tax on sugar-sweetened beverages reduced sales of these drinks by 9.6% while increasing water consumption by 15.6%. The effects of the tax varied by store type, with larger chains passing through the tax more consistently than independent stores.
Climate change is causing Arctic river ice deposits to melt nearly a month earlier than they did 15 years ago, with most icings disappearing 26 days earlier in 2015 than in 2000. This rapid decline could have significant impacts on Arctic river ecosystems.
A new vaccine called Zoonoses Barrier Vaccine (ZBV) aims to prevent the spread of highly pathogenic zoonotic diseases. The vaccine targets deadly pathogens in animal species and has shown promise in preventing devastating diseases such as Lassa haemorrhagic fever, SARS, MERS, plaque, Rift Valley Fever Virus and Q Fever.
Research found that birdsong duration and frequencies are adjusted in response to traffic noise, with songs returning to natural state after road closures. Temporary road closures can help mitigate this effect, providing birds with an opportunity to sing optimally.
Scientists are developing novel molecules to target RAS, a common driving mutation in pancreatic and lung cancer. The collaboration aims to create gold standard tests for analyzing these inhibitors.
Researchers found that barnacle geese cannot accurately anticipate climate change due to the unpredictability of polar region warming. The birds' reproductive success will be reduced if they continue to mistime their arrival at breeding grounds, despite some compensation from a longer breeding season and smarter migration strategies.
A study led by Georgia State University found that cytokine IL-36γ promotes the development of pro-inflammatory T helper cells and inhibits regulatory T cells in humans. This discovery could lead to new therapeutic approaches for inflammatory bowel disease, particularly ulcerative colitis.
Kristin Umland receives the 2017 AMS Impact Award for her work on illustrating mathematics standards and creating professional development resources. Her efforts have improved math education for millions of teachers and students across the US.
Researchers at UNH have developed a new tool to measure both carbon and nitrogen footprints, aiming to reduce campus activities' impact on water quality and climate change. The Nitrogen Footprint Tool Network includes seven institutions, tracking emissions from food waste, energy consumption, and transportation.
A collaborative effort between psychologists and economists reveals that combining both disciplines leads to better understanding of decisions. The research focuses on individuals' expectations for major life events, such as finding work or having children, and shows that teens are capable of estimating numerical probabilities with acc...
A novel optical technique enables rapid sorting of amino acid sequences in living bacteria, revealing structural properties crucial for materials development. This technology uses femto-pico second lasers to inspect proteins without heating them up, enabling non-lethal screening and separation.
Researchers found that nutrition label users tend to select healthier foods, such as fruits, vegetables, and beans, while avoiding refined grains and fried foods. The study suggests that dining facilities can encourage healthy eating behaviors by increasing nutrient-dense food options and product reformulations.
Tropical Storm Maarutha's intense rainbands were detected by the Global Precipitation Measurement mission, showing rainfall rates of over 134 mm per hour near its center. The satellite imagery provided valuable insights into the cyclone's powerful convective storms, which reached altitudes of over 10.9 miles.
A Johns Hopkins Medicine study found that air pollution directly causes inflammation in the nasal and sinus tissues of mice. The researchers exposed mice to polluted air for 16 weeks, showing increased white blood cells and biomarkers of inflammation.
A new study finds that inflammatory bowel disease (IBD) cases are rising rapidly among young Canadian children, particularly those under five years old. The incidence of IBD has stabilized for children over five but continues to rise in younger age groups, with an estimated 600-650 children diagnosed annually.
A Danish study found that working-age people with fainting spells have a 1.4-fold increased risk of occupational accidents and a 2-fold higher risk of job loss compared to those without the condition. Younger individuals with poor socioeconomic status or additional health conditions are particularly at high risk.
A study published in Scientific Reports found that a high-fat, high-carbohydrate diet rich in saturated fatty acids can weaken cartilage in joints, leading to osteoarthritis. The research suggests that diet may play a significant role in the onset of osteoarthritis, rather than wear and tear.
A study published in Journal of Health Economics found that drinking by pregnant women is down 11 percent in states requiring point-of-sale warning signs. The benefits to heeding the warnings show up in fewer extremely premature births and very-low-birth-weight babies.
A research team at St. Jude Children's Research Hospital has revealed a previously unknown immune machinery underlying neutrophilic dermatosis, a group of autoinflammatory skin disorders. By mapping the biological pathways involved, the researchers identified key molecules and signaling nodes that drive inflammation and tissue damage.
A large study found no link between azithromycin and ventricular arrhythmia, an irregular heartbeat that can be life-threatening. Compared to amoxicillin, azithromycin was associated with a lower risk of this condition.
Research by British American Tobacco found that e-cigarette vapour has a limited effect on gene expression in human lung cells compared to cigarette smoke. The study exposed MucilAir 3D models to equivalent or higher doses of nicotine and measured the genes affected, revealing significant differences in response.
Researchers at Sandia National Laboratories have developed a new technology that mimics imprint processes used in industrial manufacturing, creating nanowire-array structures similar to those found in touch-screens for sensors, computers, phones, and TVs. The pressure-based fabrication process is faster and more environmentally friendl...
A recent study by UCSF found that young adults experience greater pleasure from smoking cigarettes while under the influence of alcohol compared to marijuana. The study, which used self-reported data from 500 participants aged 18-25, suggests that co-use of cigarettes and alcohol may be more pleasurable than co-use with marijuana.
New studies published in JAMA Network report no increased risk of autism spectrum disorder and attention-deficit/hyperactivity disorder among children exposed to antidepressants during pregnancy. The research suggests alternative explanations for previous findings may be responsible.
Researchers discovered that motor cortical neurons adapt to optimize movement encoding, enabling more precise neural prosthetics. The findings have potential applications in improving brain-machine interface performance and reliability.
A new study by Oxford University reveals that homing pigeons can accumulate knowledge and improve their flight paths over time, mirroring human cumulative culture. The birds' collective intelligence enables them to streamline their routes, outperforming solo or group flights with no membership changes.
A study published in JAMA finds that adhering to the 2016 USPSTF recommendations for statin therapy could lead to a lower number of individuals recommended for primary prevention statin therapy. This is due to a higher estimated ASCVD risk threshold and required presence of at least one cardiovascular risk factor.
Researchers discover bacteriophages that can effectively reduce bacterial levels and improve health in mice infected with antibiotic-resistant 'superbugs.' The study's findings suggest phages could be a promising alternative to antibiotics, with potential benefits including fewer side effects and the ability to evolve against resistance.
A recent meta-analysis of 57 studies involving over 25,000 participants found a weak to moderate link between social media activity and narcissistic tendencies. Grandiose narcissists are more likely to frequent social networking sites, whereas vulnerable narcissism is associated with insecurity and social withdrawal.
Researchers have identified a frog peptide, urumin, that can destroy many strains of human flu and protect mice against infection. The peptide targets the hemagglutinin protein on the virus, destabilizing it and killing it.
Researchers discovered a birth-and-death cycle of neurons in the adult mouse gut, with about five percent of nerve cells regenerating daily or a third every week. This finding has profound implications for understanding and treating digestive system disorders and diseases.
A new study offers good news for pork producers, providing research-backed management recommendations. The study found that quality in one part of the pig does not predict quality in other parts, and that individual differences account for most variability in pork products.
A study found that urban house finches are better at solving new problems than their rural counterparts due to adaptation to human presence. Rural birds who experienced high levels of human disturbance performed poorly on the problem-solving task.
Researchers at the University of Alberta have found that sea scorpions likely used their serrated tail spines to kill ancient early vertebrates. The study suggests that these prehistoric predators could slash their tails from side to side, using a horizontal slashing motion to capture and dispatch their prey.
Researchers identified a compensatory mechanism in bacteria that can be used as a new therapeutic target against multi-drug resistant bacteria. The study found that the pace of adaptation in multi-drug resistant Escherichia coli strains is faster than for strains with single resistance mutations.
A new study published in the Journal of Pediatrics suggests that both low and high birth weights are linked to nonalcoholic fatty liver disease (NAFLD) in children. The study found that advanced scarring of the liver is associated with low birth weight, while more inflammation is linked to high birth weight.
Researchers from the University of Guelph and collaborators identified four valid Calinaga species, which originated in southeast Tibet during the Eocene epoch. The study revealed that the genus diversified due to geological changes caused by the collision between Indian and Asian subcontinents.
Dr. Beverly Davidson has been elected to the American Academy of Arts and Sciences, a testament to her outstanding contributions to neuroscience. Her research focus on understanding molecular basis of neurodegeneration in inherited brain disorders has made significant impact.
The article highlights that climate change threatens the sustainability of the fossil fuel industry, with emissions accounting for two-thirds of greenhouse gas emissions. The industry faces increasing pressures due to carbon-based businesses and economies facing impediments to consumption, according to Jim Krane and Ritchie D. Priddy.
Researchers at University of Arizona discover diffuse hydrogen gas surrounding Milky Way, accounting for large part of galaxy's baryonic mass. This finding confirms predictions from simulations and provides new insights into the nature of dark matter.
A large-scale analysis suggests that mothers' use of antidepressants during early pregnancy does not significantly increase the risk of autism or attention deficit hyperactivity disorder (ADHD) in their children. However, a slightly higher risk for premature birth was found among exposed offspring.