Aggressive breast cancer cells exploit the natural stress protector heat shock protein 70 (HSP70) to thrive and evade cell death, says a new study. The finding highlights how cancer cells manipulate tumor necrosis factor alpha (TNFα), which normally promotes self-destruction, to aid their survival.
The International Journal of Molecular Sciences has released a special issue to commemorate Zijian Xie's 20-year-old discovery of the scaffolding/signaling function of the Na/K-ATPase sodium pump. This significant finding has had tremendous applications in biology and medicine.
Researchers identified key strategies to differentiate practices with improved performance for chronic disease patients, including fostering intrinsic motivation among providers and staff. These findings inform payers and primary care practices seeking evidence-based strategies to foster a stronger delivery system.
Researchers at NTU Singapore have developed a smart technology that enables two robots to work in unison to 3D-print large concrete structures. This allows for unique concrete designs currently not possible with conventional casting, and structures can be produced on demand and in a much shorter period.
Testosterone treatment over 10 years can improve or reverse type 2 diabetes in men with low testosterone, leading to significant weight loss. The study found that average fasting blood glucose levels decreased and HbA1c levels fell in the testosterone-treated group, while worsening in the control group.
Researchers found that extending specialized care to patients with advanced kidney disease before their kidneys fail could save the US healthcare system more than $1 billion annually. Improving care coordination among these patients is crucial for reducing costs and improving health outcomes.
Researchers from UC Berkeley used statistical analysis of 740 supernovas to conclude that primordial black holes can make up no more than 40% of the universe's dark matter. This finding suggests that heavy black holes or MACHOs do not exist as a type of dark matter.
Researchers found a new dynamic between mother's genome and their offspring's genome influencing development and adaptation to ecological conditions. Genetic mismatches can hinder adaptation in some species.
A researcher at UCF College of Medicine has discovered a way to make immunotherapy viable for thousands by using the body's own natural killer (NK) cells in a new way. Activated NK cells can change the cellular makeup of tumors, allowing the immune system to attack cancer more effectively.
A study found that weak magnetic fields stimulate the production of reactive oxygen species in human cells, which can be beneficial or harmful. The protein cryptochrome is involved in this process, helping to explain the effects of PEMF-based therapies on diseases like depression and Parkinson's disease.
Scientists at University of Toronto's Leslie Dan Faculty of Pharmacy have developed a combination approach using nanoparticles to improve chemotherapy response and boost anti-tumor immunity in breast cancer. The treatment resulted in a 60% cure rate and enhanced life expectancy by five-fold compared to treating with chemotherapy alone.
Researchers at Graz University of Technology have achieved a breakthrough in observing the reaction of a quantum fluid to photoexcitation of dissolved particles. By applying femtosecond spectroscopy, they were able to describe the processes in an approximately five-nanometer sized superfluid helium droplet after photoexcitation of an a...
Researchers at DTU Bioengineering have developed a high-tech antivenom against black mamba venom using human antibodies, which can potentially save thousands of lives annually. The breakthrough antivenom uses a biotechnological method to discover human antibodies, allowing for large-scale production and industrial use.
A new study by Cedars-Sinai finds that stress is a major contributor to sudden cardiac arrests, which are now more likely to happen outside of previously identified peak times. The research analyzed data from the Oregon Sudden Unexpected Death Study and found no evidence of increased cardiac arrests on Mondays
A Kanazawa University-based collaboration developed a microscopy approach to visualize real-space charge distribution at interfaces. The technique, called 3D open-loop electric potential microscopy (OL-EPM), overcomes challenges in measuring lateral charge distribution at solid-liquid interfaces.
Researchers, led by Penn State's Steven Schiff, will develop innovative models to predict outbreaks of epidemic disease and provide real-time preventive treatment. Their approach aims to improve patient outcomes by incorporating historical microbiological surveillance data, geographic location, and environmental factors.
A team of scientists has detected a faint glow in the Lyman-alpha line across the entire sky, revealing extensive masses of gas around primitive galaxies. This discovery connects previously detected gas feeding galaxies with newly observed Lyman-alpha emission, providing new insights into the universe's infancy.
Kanazawa University researcher Hajime Moriya shows that the extended Nicolai supersymmetric fermion lattice model breaks supersymmetry and has a strictly positive energy density for any homogeneous ground state. This contradicts previous claims that supersymmetry may be restored in the infinite-volume limit.
A new NYU study used text message surveys to track maternal health services during the 2015 Ebola outbreak, finding a drop in hospital-based births and similar declines in both public and private facilities. The method's accuracy was validated through propensity score matching with national survey data.
Researchers at University of York and British Museum discovered traces of opiates in a sealed vessel dating back to Late Bronze Age. The presence of opiate alkaloids suggests that the vessel may have been used for medicinal or ceremonial purposes.
The UTHealth Homeless Outpatient Mental Health Expansion Services Program provides treatment and recovery support to 500 individuals ages 18 and older with serious mental illness experiencing homelessness.
Strong graduates from more educated and wealthy families are more likely to enroll in a university far from home. Socioeconomic factors, including academic performance and family background, inhibit student migration. Students' expectations, ambitions, and views towards human capital also play a role.
A controlled trial found that women who drank an additional 1.5 liters of water daily experienced 48 percent fewer repeat bladder infections compared to those who drank their usual volume of fluids. This increased fluid intake may help reduce the use of antibiotics and combat antibiotic resistance.
Researchers at Umeå University discovered that Vibrio cholerae uses nitrate respiration to control its population expansion and survival, even in the absence of oxygen. This smart metabolic mechanism allows the bacterium to thrive in the intestine's low-oxygen environment.
A study published in eBioMedicine found that the absence of four particular genes in the Leishmania infantum parasite makes it less susceptible to miltefosine, an oral drug used to treat visceral leishmaniasis. This discovery could lead to a new prognostic test to predict treatment outcomes and tailor medicines accordingly.
Researchers at Penn discovered a new, rare mechanism that allows leukemia cells to relapse after CAR T cell therapy by masking the target protein CD19. This finding emphasizes the need for precise manufacturing processes to ensure the effectiveness of this treatment.
A study of 140 premenopausal women with recurrent cystitis found that those drinking more water (1.5 liters daily) experienced less frequent infections (average 1.7 vs 3.2 episodes). Drinking more water may be a safe and inexpensive alternative to antimicrobial treatment.
A comprehensive review by the European Psychiatric Association recommends exercise as a key treatment for mental health conditions, reducing symptoms of depression and schizophrenia. The guidelines suggest structured exercise, two to three times a week, can improve cognition, cardiorespiratory health, and overall well-being.
Researchers at Rutgers Robert Wood Johnson Medical School identified a crucial step in the immune system's defense against viruses, which also sheds light on autoimmune disorders. The study found that an immune receptor called RIG-I 'flutters' to detect viral RNAs, triggering an antiviral response.
A phase II clinical trial shows that DFMO, an oral medication, improves the nearly 50 percent rate of relapse in children with High Risk Neuroblastoma. The two-year survival rate for these children is 97 percent, a large increase compared to previous treatments.
A new study reveals that cardiac implants in the US are significantly more expensive than those in European countries, with prices ranging from $340 to $4,200 for a single device. The research suggests that health system-level factors contribute to these price differences and may influence hospital incentives to contain costs.
Mortality rates for infants and children in the US have declined significantly since 1999, according to a study analyzing death certificate data. The study found decreases in deaths from sudden infant death syndrome and unintentional injuries among young people, but increases in suffocation and strangulation deaths in infants.
A new study from George Washington University Cancer Center found that nanoparticle-encapsulated doxorubicin is promising in treating triple-negative breast cancer. The smallest nanoparticles with slowest release of medication showed increased cell kill in resistant cancer cells, offering potential strategies to overcome drug resistance.
The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) has released new best practices for verifying the correct placement of nasogastric tubes in pediatric patients. These guidelines aim to improve patient safety by standardizing education, tube verification methods, and radiographic evaluation.
Research shows that weight gain between childhood and adulthood increases type 2 diabetes risk more than a stable high body mass index. Children who were overweight at age 10 and remained so have lower T2D risk compared to those who were normal weight but became overweight later in life.
A special issue of Health Physics journal highlights women's contributions to and experiences in radiation protection and safety. The articles showcase the historic roles of women pioneers and their diverse roles in health physics, including research on approaches in monitoring radiation exposure.
A team of researchers has created a systematic method to produce defects with desired optical properties in SiC, enabling its potential use in quantum computing. They discovered three previously unreported signatures and found that producing defects follows a pattern.
Researchers at UC Berkeley have developed protective suits for bacteria that allow them to thrive in environments without oxygen. The hybrid system mimics photosynthesis and captures carbon dioxide, producing various chemical compounds that can be used by industry or in space colonies.
A recent study by Stevens Institute of Technology found that both men and women favor female politicians, with men rating them significantly higher than male politicians. The survey of 1,400 voting-age Americans revealed that men, particularly Democratic men, assess women politicians more favorably than male politicians.
After implementing a rule change to move kickoffs and touchbacks, the number of concussions decreased significantly. The study found that the average annual concussion rate per 1,000 kickoff plays dropped from 10.93 before the change to 2.04 after.
Research at University of British Columbia and Harvard University found distinctive methylation differences in DNA of adult men who experienced child abuse as kids. The study suggests that methylation could be used as a biomarker for investigators or courts in weighing allegations of child abuse.
A new poll by Michigan Medicine found that over half of older adults (50-64) are interested in DNA testing to guide medical care, understand health risks or know their ancestry. However, two-thirds expressed concern that genetic testing could lead to worrying about future health.
Tropical Storm Leslie has strongest storms northwest of its center, generating heavy rainfall. The storm is expected to strengthen and become a hurricane on October 2.
A study by Johns Hopkins Bloomberg School of Public Health found that Maryland Health Enterprise Zones linked to significant reductions in inpatient stays (18,562 fewer) and overall health care cost savings ($93 million). Despite a jump in emergency room visits, the initiative brought large net cost savings.
Researchers developed a simpler method to generate multiple frequency combs using small devices called optical microresonators. The technology generates up to three frequency combs simultaneously, reducing the need for complex synchronization electronics and enabling faster acquisition times.
A 130-year-old brain coral's skeleton provided evidence that the North Atlantic Ocean has significantly less nitrogen pollution than previously estimated. The study found no signs of increased human-made nitrogen emissions, suggesting U.S. pollution control measures are effective in limiting ocean impact.
A study by Oxford University found that individual personalities of male great tits influence their bonding with future breeding partners. Bold, proactive males choose partners sooner and invest more effort in relationships before breeding begins.
The University of Texas at San Antonio has received a $500,000 NSF grant to develop a machine-learning algorithm that can recognize and unmask malicious software. This technology will also categorize the large number of malware in the wild, estimated to be over 669,000 in 2017.
A team of researchers has used cryo-electron microscopy to study how microtubule-associated proteins regulate cell structure and transport. They found that MAP4 stabilizes microtubules while blocking kinesin's movement, which could lead to new treatment strategies for cardiac hypertrophy and neurodegenerative diseases.
A new USC study reveals that sudden price hikes for some generic drugs are becoming more common, reflecting emerging strategies by generic manufacturers to target therapeutic areas with limited competition. The study found that prices for most generic drugs declined over time, but the fraction of drugs with prices that at least doubled...
A team of researchers from CU Boulder has discovered that stagnant slabs, which form when oceanic plates are forced deep underground, may be caused by a thin layer of weak material at the boundary of the planet's upper and lower mantle. This discovery could change how scientists think about tectonics and volcanism on Earth's surface.
The new global marine environmental forecasting system will provide accurate predictions of ocean temperature, salinity, velocity, and tidal currents with a horizontal resolution of 10 km. The system's accuracy is expected to reach an advanced international level, enabling clear identification of ocean mesoscale phenomena.
Scientists developed a new method to analyze and reconstruct super-resolution images into a 3D volume with multiple colors. This technique enables the observation of complex molecular structures in cells, resolving protein complexes previously invisible.
Groundcherries, a wild fruit native to Central and South America, may be domesticated for large-scale production through genome editing. The groundcherry's drought tolerance and enticing flavor make it an appealing candidate for the next major berry crop.
Researchers found that SHBG levels at baseline can predict insulin resistance years later in both men and women. Lower SHBG levels are associated with higher insulin resistance, a precursor to type 2 diabetes.
Racial and ethnic minorities in the US are disproportionately exposed to industrial air pollution, but face lower employment rates. The study found that strict environmental regulations may not necessarily harm employment opportunities.
A study published in European Neuropsychopharmacology found that up to half of people with Alzheimer's disease use a psychotropic drug, with those receiving first-line anti-dementia drugs showing a decreased risk of polypharmacy. The most common combination included antidepressants with antipsychotics or benzodiazepines.
Researchers from Cornell University and the Boyce Thompson Institute found a way to overexpress a key chaperone enzyme called RuBisCO Assembly Factor 1 to increase RuBisCO content in corn. This discovery has the potential to improve photosynthetic efficiency, leading to increased biomass production and reduced environmental footprint.
A new study warns that HLH diagnoses can hide underlying malignancies, leading to delayed curative therapy for cancers. Researchers recommend using alternative diagnostic techniques to identify cancer prior to administering HLH therapy.
A Florida State University research team has developed a unique organic-inorganic compound containing zero-dimensional molecular clusters that emit highly efficient blue light. The newly discovered material has an efficiency of over 80%, making it a promising candidate for photon-related technologies.