A team of computational biophysicists has identified a hydrophobic dewetting mechanism that blocks intracellular access to the selectivity filter in BK channels. This finding represents a paradigm shift in understanding the regulation and gating process of these channels, which play a crucial role in various health conditions.
Researchers mapped the evolutionary journey of animal guts to defend against microbial attack. They discovered that tunicates, a simple animal related to vertebrates, had an intermediate gut lining with both chitin and mucous coexisting. This finding suggests a missing link between invertebrate and mammalian gut defenses.
A team of researchers from Case Western Reserve University discovered a way to stop immune cell death associated with multiple diseases, including sepsis, IBD, and arthritis. They identified a chemical, necrosulfonamide, that potently inhibits inflammatory cell death by preventing pyroptosis, a type of cell suicide.
Researchers developed a new model explaining the interactions between small copper clusters and water molecules in producing molecular hydrogen. The study shows that copper-water complexes synthesized in ultra-cold helium nanodroplets can catalyze hydrogen production.
Warm-water kelps alter ecosystem functioning, with faster food production and processing, but may reduce biodiversity. Kelp forests are expected to survive, unlike in other regions where they are disappearing.
The team developed a multi-degree-of-freedom multiplexed solid-state quantum memory with high multimode capacity and demonstrated photon pulse operation functions with time and frequency DOFs. The device enables coherent manipulation of quantum states and can serve as a quantum mode converter with high fidelity.
Michigan Medicine researchers created the most complete catalog of cells in the male gonads by analyzing over 30,000 individual cells from mouse testes. The study reveals a continuous sperm cell developmental program and identifies new cell types and molecular features that can help understand the causes of male infertility.
A new UBC study analyzed 825 marine fish species and found that 499 are projected to face very high extinction risks due to overfishing and climate change. Effective fisheries management and low greenhouse gas emissions can reduce this risk by up to 63%, saving hundreds of fish stocks from becoming endangered.
A new study by University of Turku researchers found that individuals with higher levels of peace of mind reported more positive dream emotions, while those with anxiety experienced negative dream emotions. The study suggests a link between peaceful mind and better emotion regulation during both waking life and dreaming.
NASA's Aqua satellite detected an extra-tropical cyclone, Cimaron, crossing central Japan and weakening. The storm showed cloud tops warming as it lost strength, with temperatures reaching -50°F (-45.5°C) in two areas.
Chemical engineering researchers at Brigham Young University have developed a physical model that can accurately predict soot and smoke emissions from wildfires. The model provides foundational elements for validating more efficient models, which will aid in predicting smoke emissions and related health effects.
Hurricane Lane is expected to produce total rain accumulations of 10 to 20 inches, with localized amounts up to 40 inches possible over Hawaiian Islands. The slow movement of the storm increases the threat for prolonged heavy rainfall and extreme rainfall totals.
Scientists at University of Copenhagen find thawing permafrost releases high diversity of VOCs, harming human health and forests, but also producing clouds that may cool climate.
University of Bristol researchers have discovered a way to exploit hypoxia to kill cancer cells without harming healthy tissue. The study found that a specific receptor, GPRC5A, can be targeted using genetic techniques to trigger cancer cell death.
Recent advances in organocalcium-catalyzed hydrofunctionalization reactions of element-H bonds are summarized. The use of calcium compounds as catalysts has been shown to be effective and environmentally friendly, providing a cost-effective solution for industrial applications.
Researchers developed a software program that uses an avatar to predict energy expenditure during walking, considering parameters like stride length and foot lift. The tool has potential applications in designing custom exoskeletons and prosthetics to reduce user effort and optimize calorie burn.
The study found that state Medicaid expansions under the Affordable Care Act led to a decline in uninsured hospitalizations for major cardiovascular events. Cardiovascular disease is a leading cause of death in the US, and this study examined the association between Medicaid expansion and changes in uninsured hospitalizations.
A new MSU study links a malfunctioning gene to the loss of vital immune cells, which may prevent ankylosing spondylitis. The findings put researchers closer to uncovering the role of this gene in the disease.
Researchers at Vanderbilt University created a structure that concentrates light powerfully, nearly indefinitely, using a simple equation. The bowtie-funnel combo amplifies input light in a small region, enabling low-power manipulation of information on computer chips.
Rice University engineers discovered that weak van der Waals forces between nanotubes and water molecules can align into a square rod. The research provides valuable insight on ways to leverage atomic interactions for fabricating nanochannels and energy-storing nanocapacitors.
In ancient Rome, politicians ruthlessly insulted each other, while the public was allowed to insult them, showing a unique balance of power. The culture of conflict had a politically stabilising effect, with few limits on what was considered acceptable.
Researchers at Hebrew University of Jerusalem have developed a new biological drug that has shown a 50% cure rate in lab mice with acute leukemia. The single-molecule drug targets multiple leukemic proteins, making it difficult for cancer cells to evade therapy and reducing the need for multiple treatments.
A study by Carnegie Mellon University and partners found that contacting customers' friends can help reduce churn rates by 1.3-1.9%. This approach leverages social networks to identify likely churners and offer personalized deals, increasing profits for the company.
Researchers are developing a biodegradable and bioactive hydrogel material that can be injected into the heart to promote cardiac repair after a heart attack. The goal is to significantly increase stem cell recruitment, accelerate cardiac repair and improve cardiac function.
A series of articles and commentaries highlights the importance of process improvements, team culture, and enterprise cybersecurity in preventing cyberattacks. Healthcare executives discuss key components of effective cybersecurity strategies, including organization-wide training and shared responsibility.
A recent EU research project ALEC found that all age groups have declined in starting to smoke except for 11-15 year olds, who increased significantly over the last decade. Young women in Western Europe are particularly at risk, with 40 per 1000 starting to smoke annually.
A recent study has identified 24 genes that are differentially expressed in rats with cerebral aneurysms compared to those without. These genes may enable the development of diagnostic biomarker tests for patients at increased risk of cerebral aneurysm formation.
Researchers at the University of Colorado Boulder have developed a shape-shifting material that can transform into complex, pre-programmed shapes via light and temperature stimuli. The controllable material could have broad applications for manufacturing, robotics, and biomedical devices.
A study by Rutgers physician Ehimare Akhabue found that states expanding Medicaid eligibility in 2014 saw fewer uninsured patients among major cardiac-related hospitalizations compared to those not expanding the program. This suggests that Medicaid expansion may have contributed to a decrease in these hospitalizations.
A team from NCBS has identified a set of three proteins - PI4KIIIα, Efr3, and TTC7 - crucial for maintaining PIP2 levels on the surface membranes of cells. This helps maintain the signaling system going by rapidly resynthesizing essential molecules.
A new study published in PLOS ONE suggests that polluted air may be a threat to your kidneys, increasing the risk of chronic kidney disease. Air pollution contains fine particulate matter (PM2.5), which can cause serious health effects when inhaled regularly.
A new study from the University of Cologne found that market share has limited influence on a company's financial performance. Instead, customer relationships and brand equity deliver six times the effect and three times the effect of market share gains alone.
Researchers at NUST MISIS have developed a system that improves cancer diagnosis accuracy and provides opportunities for targeted therapy. The magnetoferritin compound, introduced into the body before diagnosis, enhances contrast signals in imaging and targets tumor cells for destruction.
A Kaiser Permanente study found that patients with hypertension who experience unusually low blood pressures are twice as likely to experience a fall or faint. The study suggests that physicians should weigh the risks and benefits of aggressive blood pressure lowering on an individual basis, especially in older patients.
Researchers study how male fruit flies generate their courtship song using cutting-edge imaging techniques and genetic tools. They discover that the song serves as an honest signal of a male's fitness, with flaws indicating neuromuscular deficits, which can affect flying abilities.
A new study by Dr. Andrew Dix found that referees called more personal fouls against female basketball players from historically black colleges and universities (HBCUs) compared to those from predominantly white institutions (PWIs). This bias is a recurring pattern, with HBCU teams facing an average of 1.5 extra personal fouls per game.
The British Heart Foundation is launching a £30 million global cardiovascular challenge to identify and solve the biggest problems in heart and circulatory disease. The Big Beat Challenge will bring together world-leading researchers and innovators to accelerate breakthroughs that could transform lives across the globe.
A new study reveals that Amazonian wetlands are home to an astonishing 3,615 tree species, exceeding expectations by three times. This comprehensive list of tree species was compiled from forest inventories and botanical collections, providing valuable insights into the region's biodiversity.
A recent study by the University of Illinois at Urbana-Champaign found that nearly a third of young adults are financially precarious due to poor financial literacy and income instability. These individuals often rely on alternative financial services, which can lead to high interest rates and fees.
Researchers developed an immunotherapy that induces antitumor immunity by provoking necroptosis in cancer cells, destroying tumors while protecting against secondary tumor formation. The treatment provides protection against disseminated tumors and stimulates the immune system to attack persistent surviving cancer cells.
Mount Sinai researchers discovered a novel epigenetic mechanism causing drug resistance in melanoma patients with BRAF gene mutations. A biomarker called IGFBP2 was also identified, which could benefit from combination therapies that inhibit BRAF and IGFBP2-driven pathways.
A new study published in the Journal of Clinical Investigation - Insight found that cardio exercise increases the production of the hormone FGF21, which has positive effects on metabolism. In contrast, strength training with weights had no significant impact on this hormone or another muscle-building hormone called FGF19.
Researchers have developed a new subcutaneous intrathecal catheter system (SIC) to deliver nusinersen to SMA patients, significantly reducing hospital stays and costs. The SIC method allows for faster and more efficient administration of the drug, with an average hospital stay of less than 55 hours.
Researchers identified a unique microbial signature in the guts of malnourished children, characterized by widespread presence of bacteria normally found in noses and mouths. The study, part of the Afribiota project, aims to improve treatment and diagnosis of chronic malnutrition.
Researchers at INRS have developed a cost-effective approach to rapidly identify molecules capable of eliminating Leishmania, a parasite responsible for the deadly tropical disease. The innovation, led by Professors Albert Descoteaux and Steven LaPlante, aims to overcome obstacles in finding effective treatments.
Researchers captured detailed images of TRPV3, a skin-cell ion channel involved in temperature sensation. The study reveals how a mutation in the woolly mammoth's TRPV3 gene may have helped them adapt to cold environments and provides clues for new treatments of human skin diseases such as eczema and vitiligo.
Brigham and Women's Hospital researchers have developed a method to bioprint complex tubular structures that mimic native vessels and ducts in the body. The 3D bioprinting technique allows for fine-tuning of printed tissues' properties, enabling potentially viable replacements for damaged tissue.
A team of Penn State mechanical engineers developed a self-healing membrane that screens out smaller objects while allowing larger ones to pass through. The membrane responds to an object's kinetic energy and can be optimized for various applications, including medical devices and sanitation systems.
Billi London-Gray, a UTA art lecturer, has won a Puffin Grant for her ongoing project, The Loop and Saw Choir. She collaborates with volunteers of all ages and abilities to create music using unique instruments such as musical saws and analog synthesizers.
A new analysis found that antibiotic use in children leads to an estimated 69,000 emergency room visits each year for allergic reactions and other side effects. The risk varies by child age and type of antibiotic used, with younger children aged 2 or under being at highest risk.
A study published in the Journal of Animal Science found that fresh and raw diets for dogs can be more digestible than traditional kibble, leading to lower blood triglyceride levels. The diets also showed major shifts in the microbiota of the dogs' gut, but all diets were considered healthy and palatable.
Scientists developed a model to accurately predict the transmission dynamics of various viruses, enabling optimized vaccination programs. The analysis analyzed over 100 enterovirus serotypes and demonstrated patterns in their transmission cycles.
A new study identifies HIF1A, a gene that regulates metabolic changes and oxygen levels in cells, as a potential therapeutic target for treating myelodysplastic syndromes (MDS). The researchers found that inhibiting HIF1A reversed a broad spectrum of MDS symptoms in genetic mouse models.
Researchers at Rice University have discovered the first example of Dicke cooperativity in a matter-matter system, which could lead to faster information processing and lower power consumption. The discovery uses a magnetic field to prompt cooperativity among spins within a crystalline compound made primarily of iron and erbium.
A team of multidisciplinary researchers provides novel insights into parenting and diversity, identifying common themes and future directions for research. The study sheds light on the impact of increasing population diversity on parenting adolescents, offering new ways of thinking about parenting.
A recent study has found that consuming more phosphate with food increases blood pressure and pulse rate in healthy young adults. The study, published in the Journal of the American Society of Nephrology, suggests that increased phosphate intake can lead to an increased risk of developing cardiovascular disease.
Charité researchers Dr. Klose, Dr. Polansky-Biskup, and Dr. Triantafyllopoulou receive funding for projects on enteric nervous system regulation and epigenetic fine-tuning of T cells to improve adoptive cell therapy
Effective medical treatment and surgery prevent esophageal cancer in people with severe heartburn. The study used health data from 1964 to 2014 and found a significant decrease in cancer risk after treatment.
Virginia Tech researchers have developed a new method to 3D print complex graphene structures with high resolution, unlocking possibilities for applications in various industries. The breakthrough enables the creation of any size or shape of graphene, preserving its strength and conductivity.
A study published in Cell describes the discovery of a molecular link between aging and two major genetic causes of neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The findings reveal possible new targets for treatment and highlight the need for a better understanding of the biology of...